Exaggerated: The Sword of Plot Advancement was picked up by Sir Bob Tropesalot, who stabbed the Evil Overlord with it, but he cannot unsheath it from his corpse because the Sword clings to anyone who makes physical contact with it. Lady Alice tries to help unstick the sword from Sir Bob and she too becomes glued to it.
Subverted: Alice puts on a Transformation Trinket that turns her into a Magical Girl Warrior, but she finds that she cannot remove it from her neck. After days of lamenting, Bob easily takes the necklace from her. Turns out that one of the rules of the trinket is that although anyone can put it on, they need to have someone else remove it for them.
Double Subverted: After the necklace is removed, she can still turn into a Magical Girl Warrior because now the power is inside of her.
Zig Zagged: The Sword only clings to Bob's hand for a few days to advance the plot, then falls off, and can be used or discarded normally—until the next time the plot needs to be advanced, at which point it becomes clingy again. This goes on for the entire series, at one point even jumping over to the Evil Overlord to force him to advance the plot.
Played For Drama: The macguffin in question has bonded itself to the character in question; it's removal is possible, but basically the same as removing an organ, or a limb. In short, painful. Verypainful...