Gender Flipped: Alice is mocked as being a prude because of her virginity.
Subverted: Bob reveals his virgin status, and no one makes fun of him.
Double Subverted: But they really don't accept him until he's gotten laid.
Parodied: Bob's friends keep Moving the Goalposts as to what makes them consider him a real man - once he's gotten laid, he has to have a threesome. Once he's done that, he has to do some other kink, et cetera.
Invoked: Bob avoids telling people he is a virgin, knowing they will disrespect him.
Exploited: The villain uses Bob's virgin status to emotionally manipulate him, possibly by a Femme Fatale.
"You know what? I don't care. I'm proud of my virginity."
Or perhaps Bob is asexual... And his peers are sensible enough to believe that asexuality actually exists and that Bob isn't just making up excuses/using it as a coping mechanism because he's unable to get laid (a common view as seen in Acceptable Lifestyle Targets).
Played For Drama: All of his peers are cruel to Bob for not being sexually active, although their own sexual escapades have brought them and their girlfriends nothing but trouble. In fact, everybody hates him for not sleeping around, because he's in a Crapsack World that loathes sexual purity and punishes it diligently.
Played For Laughs: All of Bob's friends are in hilariously unhappy relationships, while the single, unattached Bob is happy to be alone. All of his friends insist he's missing out.