In the BIT.TRIP series, the players themselves are forced to kill CommanderVideo to beat the Recurring Boss Mingrawn Timbletot. Given that the series is a metaphor for human life, it's believed this actually is symbolic of the protagonist being Driven to Suicide.
Each level in the six games is named for part of the player character's, and general human, development, and something it learns. In the fifth game, in which CommanderVideo dies, he is made to learn "patience, frustration, and anger" just before his death.
The sixth game begins with simple geometric shapes, representing each of the friends and love interest made during the course of life, drifting away as the player character futilely tries to keep them together as he dies.