The Homestar Runner animation "In Search of the Yello Dello" is definitely full of this, especially with both Homestar and Coach Z's designs. The in-character commentary track for the cartoon indulges in a little Self-Deprecation:
Strong Bad: Little known fact, Homestar gained a hundred pounds and shrank two feet for this role.
Homestar Runner: It's true!
- Powered By The Cheat toons tend to be off model as well, though this is due to Stylistic Suck.