Sonic X: Dark Chaos is... hoo boy. Just to begin, Tsali the Ultimate Weapon is a Demon android two-tailed fox. Tephiroth is an angelic humanoid three-tailed cyborg fox. Maledict is a hedgehog-humanoid-reptile cyborgPhysical God. Venus the Seedrian is a Seedrian cyborg vampire.
The king of this trope has to go to the Tsali Androids; *deep breath* batshit-insane cannibalistic flesh-eating demonically-possessed fox robots.
Eridan slips into this in Dead Sexy when he dies and comes back as a Rainbow Drinker, making him a hope-sploding seadweller highblood vampire.
In It All Started With a Visit to Gringotts Nicholas and Perenelle Flamel do some rather...exotic crossbreeding as a sideline. One of the beasties Harry and his cousin have to fight is a "creepy snake goblin vampire creature."
Shinobi The RPG has a cyborg-ninja. It's a small bit, a guy with a prosthetic arm he controls through puppetry, but the main character freaks out at how cool it all is.