Later on they start showing an... obsession with Red. The Snapshots who usually take photos of you to distract you during combat now seem to be taking them because they want to.
The Spine, a massive, implacable beast that hunts Red as she climbs a tower in order to find answers. Even worse, its very presence causes the Transistor to start losing his mind, drunkenly rambling and losing memories. At times, he can't even tell if Red is still there. It gets bad enough that she logs into a message board to type messages to him, begging him to hold on long enough for her to kill the Spine.
And that is not the only one... Luckily you don't have to fight it again.