Made all the worse by the fact that the Roboticizer was originally invented to help people who are dying of sickness, by converting the infected parts to metal. The inventor(Uncle Chuck) has to live with the knowledge that his invention has effectively condemned almost everyone on the planet to a Fate Worse than Death, himself included.
In the time travel episode, we get to see that Sonic actually stood in line right behind Uncle Chuck and watched him get roboticized... when he was like FIVE YEARS OLD. Jesus, that's harsh.
In Sonic's Nightmare, Sonic envisions Sally being put in the roboticizer while he watches helplessly.
Not to mention that quote from Sally..."Where were you when the brains were handed out?"
It's likely that was just Sally taking a jab at Sonic's stupidity. Said quote is an actual way of insulting someone in real life for their alleged lack of intelligence.
Tails nearly getting trampled by a Terapod herd in "Sonic Past Cool."
The robot double from "Sonic and Sally" could very well have been a roboticized Mobian.
The glowing red eyes against a black background in the finale.
The end of "Ultra Sonic" where Uncle Chuck reverts back into an automaton with no free will and starts snarling at his nephew like a rabid dog, prompting Bunnie to drag Sonic away. Again, keep in mind that while this is going on, Uncle Chuck's completely aware of it and yet can't do a thing.