- The Jumbigs themselves. They leap towards you and take a buttload of shots to kill, and later ones are considered Advancing Wall of Doom enemies.
- The VERY last section of Wily Stage 4, which is a Womb Level created using the same holographic technology Wily used in Mega Man 2 to become the Alien.
- Eddie after getting sucked up by Dust Man's weapon. If you read the description of the Energy Splitter, it says that Eddie is screaming from inside of there.
Nightmare Fuel / Rockman 4 Minus Infinity
This game has its share of Nightmare Fuel as well, making it creepy compared to its original game.