Dealing with spiritual creatures, even natural ones, can lead to some pretty frightening things.
- Remember the episode where the little girl's eyes were infected with mushi? Remember when she finally opened her eyes and...
- Or what about the mushi that made emotionless, fake children? Or perhaps the Mushi that re-animates corpses? Or the ones that infest your ears, make you deaf, and then kill you? Or the one that eats memories, leading to what is essentially Alzheimer's, and that is completely invisible so long as it is in shadow, so all it takes to get infected is to sit in the shade of the wrong tree?... Really, all of the mushi can be pretty horrific if you aren't careful with interacting with them.
- How about the mushi that gave prophetic dreams/made them real? Sure it started out beneficial, but then it got to the point where the dreams started happening in real life... including everyone except the dreamer being covered in green mold and crumbling away like dust.
- The concept of mushi in itself is rather disturbing - ethereal creatures which are neither animal, plant or human - and as such are so very like and unlike the world they influence in myriad ways and reasons, often simply by chance events or encounters.
- Everything about the "Cotton Spores" story. The mushi itself is creepy enough...I mean, "Hitotake"? That means "mushroom person". Arrrgh! But the reactions of the three humans in the story are almost worse. The husband's anguish, the wife's increasingly deranged behavior, and normally compassionate Ginko coldly telling a sentient mushi that he fully intends to kill it dead...brrr. Ginko carrying it off as a horrible little face in a jar is just icing on the creepy cake.
- The manga has some more Eye Scream fun that was left out of the anime. Including a story where the Tokoyami in Ginko's left eye cause him intense pain and the empty socket starts leaking eternal darkness.