Doubly so if you're playing Maya. Whatever it is they're seeing? When you Phaselock them, they see it more.
A bit of Fridge Horror: Siren powers are all based on phasing things into another dimension. They're seeing into another dimension... The same one that Sirens can access, which may be where The Destroyer is from.
Knock off a Goliath's helmet and enjoy the resulting Body Horror: the flesh around their head flakes off, their skull bursts from their mouth suspended on their elongated spine. That's when it starts to chase you everywhere.
The log of Taggart, a Hunter who, well, hunted the Stalkers. It all starts out funny enough but the last log:
Lo.. Lo.. Log... Entry F... F.. F.. Fi... *pause* Henry... and its spawn.. killed my crew and the sadistic bastard chewed my hands off. I could see him smile. *Another pause* .. No.. Henry! Henry! Stay back! Henry! Ahhhh! MOMMY! MOMMY! MOOOOOMMMY! MOOOOOOOOMY! *Accompanied by chewing noises*
The concluding quip of the quest doesn't help, either:
You found Taggart’s missing chapter and, in so doing, discovered a soul-crushing truth: all the confidence in the world cannot prevent you from dying frightened and alone. But on the upside, you got PAID!
All of the player characters have a few different noises for when they're set on fire/corroding/being electrocuted. For the original four all of said noises are varying degrees of grunting in pain. Gaige, however, doesn't grunt. She screams in pain very loudly and very realistically. You get to hear a teenage girl scream in agony every time she's hit with an elemental weapon. It's...unnerving.
Handsome Jack, while undeniably an evil douchebag, manages to somehow be funny with his sheer mania and trolling. However, once you clear Opportunity, his smug, taunting personality suddenly becomes threatening and serious, and his dialogue from then on becomes surprisingly sinister, particular his line when he sicks the B4NK3R on you.
Handsome Jack (In a completely serious, low and seething tone) Now do me a favor...and die.
Worse is Handsome Jack's treatment of his daughter, which you learn from an audio tape in Fyrestone/Jackville. His sick, sick treatment of her...Not mention his real face. Pure Body Horror.
A double whammy awaits if you pay close attention during Bloodwing's death scene. Her explosive collar doesn't start beeping until you remove the chip from it. Implying that, indirectly, you kill Bloodwing. Worse, as soon as it starts beeping she cries out and tries to crane her neck away from it. She knows.
Several things the newest playable character, Krieg, says. When they say he's a Psycho, they mean it.
Krieg:I'm beginning to remember—STOP IT!Keep the memories down with a knife in its throat! Slash it until it bleeds thought juice across the dirt until it is absorbed intonothingnrrrsss...
Krieg:THE SILENCE! KILL IT! I'LL FIND YOUUUU! Quiet noises, and I'll STRANGLE the whispers out of you WITH A BONESAAAAAW!"
Playing as him is a strangely tragic experience. Whoever he was before Hyperion got him is lost. He was irrevocably broken, turned into a monster by Hyperion. Krieg emerged from the experimentation as a Badass Psycho, insane with a need to kill. Krieg's former psyche was sent to the deepest depths of his soul and out of control of his own body. His other personality knows this, and has seemingly given up on ever recovering. A player rips their way across Pandora, occasionally hearing the sane part of Krieg quietly commenting on the action, in an utterly mournful voice. Being a Badass Psycho isn't as cool as it seems.