Episode 5 features a true magician who can perform magic without a Phantom Book, who kills people by turning their blood to mercury, not to mention his "daughters", including one homunculus. And everything he does is For Science!. Granted, his victims got better, but it was still damn creepy.
Episode 7 continues this trend, focusing on Fantastic Drug users who go to extreme lengths to satisfy their addiction, repeatedly stabbing the creator of said drug (perfume). They also Feel No Pain, until they're hit with another perfume, which amplifies their sense of touch to an excruciating degree. Yet another perfume is able to actually drive people to commit suicide!
One of the first stories in the Light novels has this in spades. The head chef is using a phantom book to make the ultimate dish...her end result is to feed her master his own brain, while he's still alive! He doesn't notice that his soup is being served from his own cranium.