One of the main themes of The Witcher series is that humans can be the biggest monsters, and in the game, this is true. Geralt's human, elven, and dwarven enemies are far more evil that the mindless monsters that he is contracted to kill as his profession as a Witcher. At times, Geralt struggles with the idea of killing humans, but has no qualms killing those who become worse than monsters. Many characters in this game clearly fall under this trope despite their sometimes good intentioned ends. The worst is Salamandra, the main antagonists of the game who use rape, murder, torture, and treason to further their agenda. They even kidnap children to experiment on them, mutating them and sometimes even just discarding them if they die during experiments (such as Raymond's son). The Order of the Flaming Rose systematically discriminates and persecutes elves and dwarves, even killing innocent women and children. In the end, they massacre nonhumans to provoke them into a bloody revolt in order for the Grandmaster to take power among the chaos. The Scoia'tel nonhuman resistancem howeverm have no problem killing and terrorizing innocent human civilians, in one instance leaving innocent humans to be eaten by the ghouls in a crypt. It's more notable who aren't Complete Monsters in those factions, for example, Siegfried of the Order and Toruviel of the Scoia'tel.
In the end, the main antagonist Jacques De Aldersberg's Karmic Death occurs when Geralt runs him through with the monster killing Silver Sword after he knocks Geralt's Steel Sword (better suited for killing humans) out of his hands. His final words are "That sword is for monsters!"
Azar Javed, the leader of Salamandra, not only leads the despicable organization, but also murderers Raymond and takes his place in order to get to Geralt, tricks Shani into giving the prisoner a poisoned drug, and turns the mortally wounded White Rayla into a freakish mutant and sics her on Geralt.
The Professor, an underling for Azar Javed, wanted in several kingdoms for 17 murderers, gleefully kills Leo, a Witcher in training, in the beginning. He later meets a Karmic Death in the hands of a kikimore queen.
White Rayla, a potential allied example if you side with the Order for Act V, finds pleasure in killing elves and even to stage a contest to see if she or Geralt can kill more elves. Her worst action (unless you side with the Scoia'tel in Act V) is after she captures the elven commander Toruviel, when she orders her men to torture and rape her repeatedly before she is executed. A female commander using rape as a weapon is even more despicable. It makes it harder to feel bad when she is shot by an arrow in the chest by Scoia'tel leader Yaevinn and then turned into a mutant by Azar Javed.
The Reverend, the spiritual leader of Vizima's Outskirts. Seemingly a fair, if slightly rude priest, he is actually a Knight Templar psychopath who had his own pregnant daughter thrown out of the village because she refused to follow the psycho-cult religion he did, forcing her to become a prostitute just to get by, and then, for no reason aside from petty spite and prejudice, tricks his own people into believing that the innocent, kindly mage Abigail is responsible for the recent rise in monster attacks, forming them into a howling lynch mob. And if Geralt (rightfully) prevents the lynching, even after saving the village from the monsters, the Reverend will try to have him killed, again purely out of petty spite. Oh, and he doesn't fight Geralt himself at first. He first sends dozens of innocent villagers that he manipulated to attack. Yes, that's right, he's willing to sacrifice the lives of his own village just because Geralt didn't let him murder an innocent woman.
The Witcher 2 continues the trend of corrupt village hicks being complete monsters with Bernard Loredo, who can be best described as a greedy and selfish bastard with zero sense of empathy. This guy imprisoned, beat, and raped an elven woman, who was so broken by these tortures that she killed herself as soon as she gave birth. It also turns out that he was willing to sell Flotsam, the town he was dictating over, to the kingdom of Kaedwen, an act which would render him a traitor to the country. The in-game journal even describes him as "the greatest monster in the area."
Dmitri, a minor villain from the DLC Troll Trouble, also counts. He and his thugs dig out corpses from local graveyards and put Scoia'tael clothes on them so they can falsely claim that they killed Scoia'tael and get paid. He is also responsible for murdering the Troll of Vergen's wife. The in-game journal even states that comparing him to a hyena would be an insult to the poor animal.
King Henselt. This guy is probably the most ruthless and selfish bastard in the whole game. He tries to gain 'respect' among his people by using cruel oppression, most of the time executing non-humans. Not to talk about his brutal attempt to conquer Aedirn where you also see him literally crushing a peaceful priest, who wanted to stop him from massacring a Peace Delegation and raping Saskia, by the head on a stone wall.