The scientist named Yuna from Breath Of Fire IV, although, until you complete the dungeon of his lab, he comes off as little more than a self-righteous, smarmy little git. Once you see that he's taken Nina's sister and made her into some sort of genetically modified horror, things become a little clearer. It's when he tells you all about the 'wonderful gift' he's given her, looking for some kind of praise, that it's clear how irredeemably evil the guy actually is.
And, to add insult upon injury, he's a Karma Houdini, since you don't get to splatter that bastard's innards all over the place, and he is even there in the ending, smugly claiming he will do it all over again.
Yuna also built a weapon of warfare that launches Hex, basically a toxic gas, physically. However, it's really the souls of people tortured at the hands of Yuna. And the more anguish they have, the better the effect. You can see this in a side event and its effects are presented in the village of Chamba in the beginning of the game.
Although everything about his weapon is reprehensible, the way the player experiences its horror just drives the point home. At one point in the game, we are introduced to Mami, a genuinely likable love interest for Fou-lu. Just as it seems she's going to reform him, she's taken away and tortured to the point of insanity so she can be used to fuel an attack against the poor guy. When he discovers this, he decides that Humans Are Bastards and becomes intent on destroying them.
While nowhere near as nasty as Yuna was (seriously, how do you compare to that?), Colonel Rasso is still a grotesque piece of work. Ryu manages to scratch the guy (and break the Royal Sword on his face in the process) in an escape attempt at the start of the story, and Rasso takes up every opportunity to go after him just to wax the fledgling dragon - Disproportionate Retribution much? It isn't until you get to Chek that he shows just how nasty he is - because you have a hard time topping genocide in terms of pure evilness (and on top of that, the folks were pacifists). This deed was literally so bad that Ursula, who had just apprehended Ryu and party and only went to the refugees' campground just to ascertain their safety on the party's request, was outright disgusted with him! And unlike Yuna, thankfully, he gets what's coming to him - Ryu, finally fed up with all his crap, transforms into the Kaiser Dragon, decimates Ight, and then utterly frags Rasso out of pure unbridled rage. While what happens after that dives into Nightmare Fuel due to Ryu's lack of control over his power, you can count on one hand the number of people who would genuinely miss the douchebag.
Father Habaruku of Breath Of Fire II, founder of the church, which steals the souls of its believers in order to power up the Big Bad. His favorite method for winning followers seems to be replacing respected members of various communities with literal demons that disguise themselves as those people...Paranoia Fuel, much?
Not to mention his sermons...in which he publicly executes nonbelievers. Brutally.
That's nothing compared to what he did to the man who used to be in charge of the church, a priest who was such a compassionate, big-hearted, and lovable character, and your dad as well! He got booted off the scene so that Habaruku could take over. And then the poor guy gets strapped to a horrible demonic contraption and his life energy itself is used to power it for about ten years. TEN. WHOLE. YEARS.Definitely one of the biggest Player Punches in the game. Needless to say, kicking Habby's ass is so satisfying.
Then there's one of his subordinates, Aruhamel/Aruhameru. He has the ability to erase memories. And has full control over this ability...which he uses to cause people to forget anything "inconvenient". Like, for example, the fact that the town hero exists. Poor guy...
While Bosche of Breath of Fire: Dragon Quarter is quite the dick (what with the whole stabbing in the knee and then in the neck when you refuse to turn over a little girl to be executed), his father Vexacion is revealed in subsequent playthroughs to be the real monster of the family. A flashback shows Bosche as a little kid, no older than eight, being given a sword and forced into battle against a monster so big that it could crush him beneath its heel without even noticing. Bosche, terrified out of his mind, begs his father for help. Vexacion just stands off to the side and tells his son to live up to his 1/64 D-ratio. We then skip to after the fight, where we see Bosche with half his body covered in blood and a crazed, not-all-there look on his face. Talk about your Freudian Excuses, huh? For Bosche, I mean, not the rat-bastard father who thought that was a good training method.
