In Tsukihime, after the extremely violent awakening of Tohno SHIKI's(the real one) demon blood, he is "taken care of" by Synchronizer Kohaku. Meaning, in his insane state, he rapes her for the life energy that will help calm the demon blood. Kohaku responds by using drugs, lies, and turning him against his father to make him her puppet who has absolute zero chance of ever recovering from his insanity and demonic blood. In Hisui's True End, this all finishes with Kohaku manipulating SHIKI into killing his sister, and having the fake Tohno Shiki(he's adopted) finish off the heavily wounded, thoroughly broken, and completely insane SHIKI, ending the Tohno line completely.
Super Dangan Ronpa 2 has Junko doing this to the entire cast of the game in the real world (the game primarily takes place inside a simulation of the character's lives before she did this.) She transforms them from generally decent and friendly high schoolers to self-mutilating sadists with no intentions in life except to cause as much pain and despair as possible. The Ultimate Despairs are barely seen onscreen, but what we do see and know about them is rather unnerving.