Even before the show started, it was already being called Simon's Daughter vs. Rossiu's Daughter due to Ryuko and Satsuki's character designs being pretty reminiscent of Simon and Rossiu. It doesn't help that their personalities are somewhat similar, what with Ryuko's obsession with revenge for a dead loved one and Satsuki's obsession with order and control.
An offshoot of that, Hakodate Omiko, Honnouji's tennis captain, has been called Viral's daughter for similar reasons due to her having the same blonde hair and pointy teeth as him.
Speaking of Shadow, she's usually seen with other "edgy" characters like him or Dante of DMC: Devil May Cry in a sort of sliding scale of edginess. Take this picture◊ for example.
Due to some surprising similarities and songs that fit Kill la Kill, the series has also been compared consistently with Metal Gear Rising: Revengeance, complete with little submemes like "Life Fibres, girl!" in the vein of the Nanomachines meme.
Plus, the series has often been likened to the much-longed second season for Panty & Stocking with Garterbelt. Add the fact that Ryuko and Satsuki are often compared to Panty & Stocking's titular characters...
Amongst fans who are also into Touhou, Ryuko is often compared to Seija Kijin due to their very similar hairstyles.
Hype la Hype, an affectionate Fan Nickname given to the series.
"Kill la Kill is going to save anime," and "ANIME IS SAVED!". These lines being parroted constantly on /a/.
"CHRISTMAS IS SAVED!" or "KILL LA KILL SAVED CHRISTMAS", following the leak/release of the official soundtrack on December 23rd-25th.
Not just the soundtrack; during the lead-up to Episode 12 there was a great deal of speculation that Mako would die, with the meme "Trigger is going to ruin Christmas" emerging. When the episode aired, Nui seems to be about to attack Mako and the recovered Ryuko, but Satsuki stops her, leading to variations on "Satsuki saved Christmas!"
After a three week hiatus, Episode 13 finally came out, and upon seeing Ryuko get defeated and Senketsu getting sliced and diced by Nui, it led to some people musing that Trigger could've ruined Christmas if the hiatus never happened.
And as of Episode 18, Ryuko and Satsuki became more of a woobie when its revealed that Ragyo used Ryuko as guinea pig for life fiber experiments, disposed her through a garbage chute when she was thought to be dead, Satsuki being savagely beaten by her mother while demeaning her, and Ryuko's heart being torn from her chest by Ragyo. Some fans jokingly or seriously exclaim that Trigger ruined Valentine's Day because of it.
WAY STATUSExplanation Based on the Leitmotif above, fans have created a way status symbolizing the "main" idea of the episode. Common choices are [ ]LOST, [ ]NOT LOST, [ ]IN LIMBO, and [ ]NANI SORE (see below).
Satsuki found another paperclip. Explanation Refers to Satsuki smiling◊ in episode 7; posters pointed out that her expression resembled this screenshot◊ of Kyle from Hotel Dusk, and it's since become common for any scene of Satsuki smiling to provoke responses of "she must have gotten another paperclip."
A variation of this is No Stars, No Fucks. Explanation A demoted Gamagoori and Inumuta sitting on a bench next to Mako and being completely unmoved by the earth shattering fight between Ryuko and Nonon.
People predicting Mako's death with each new episode, then re-predicting it for a later episode when she survives.
Inumuta being Kill la KillTumblr fans' spirit animal, after threatening Mako with death if she did anything to his laptop.
"PING PONG CIRCULATE"Explanation Referencing the seemingly random choice of squaredancing lyrics for the music that plays whenever Aikurou's stripping.
Overanalyzed Scissors.Explanation Quite a few people were unhappy with the revelation of the killer being Nui Harime, and have gone to great lengths to try to poke holes in her confession. First they claimed that the Scissor blades didn't fit together properly and Nui was using a counterfeit. When a flashback showed they did they claimed that the color was wrong, ignoring the fact that the coloring in each of the flashbacks is inconsistent, let alone that Isshin himself stated only one pair are in existence.
After Shinjiro Nagita revealed "himself" to be Nui Harime in disguise, many people made jokes comparing it to Vince McMahon's reveal of himself as the Higher Power. This has led to many spoofs.
"Aw, son of a bitch!"
After episode 13, many jokes have been made about Kill la Kill being Panty & Stocking with Garterbelt season 2 Spoilers for both! Senketsu being cut into many small pieces is similar to Panty being diced into 666 pieces at the very end of the show; Ryuko may have to collect the pieces of Senketsu like Brief would have had to collect the pieces of Panty in a proposed season 2.
Takarada's got LOADSAMONEY. Explanation Takarada's's first appearance was enough to ignite a wildfire of different memes, with image macros using lyrics from Harry Enfield's Lods of Emon - err, Loadsa Money being among the most popular.
Relatedly: SHUT CHOUR MOUF AND TAKE MY ZENI!◊ Explanation A mutation of the classic Futurama SHUT UP AND TAKE MY MONEY meme, replacing parts of it with the "zeni" emblazoned on Takarada's grills as well as a lyric from Loadsa Money.
GODDAMMIT NUI!Explanation The usual reaction of the audience at Harime Nui's appearances, given her habit of showing up literally out of nowhere when you least expect it.
BAKANA! (and its variation BANANA!) Explanation A Sanageyama-centric meme which was originally a Catch Phrase for Viral in Tengen Toppa Gurren Lagann; since they share a voice actor, posting this phrase along with images of Sanageyama became common (especially those of his defeat by Ryuko in episode 7 or Nui in episode 13). "BANANA" is a predictable mutation stemming from the character for "monkey" being part of his surname.
After the reveal that the source of the life fibers are aliens that have shaped mankind, many jokes relating to ancient aliens theories and Giorgio A. Tsoukalos began to surface.
Rainbow underhair/Disco milf Explanation Ragyo's hair, which has, well, a luminous rainbow underlayer. This combined with its' shape has lead to a lot of image manips with Ragyo's hair shopped onto various things.
Mako's Bizarre Adventure.Explanation (spoilers!) When Mako ends up fighting Ryuko, her Goku Uniform happens to resemble a certain Jojo.
Happy Valentines Day from Trigger! Explanation Episode 18 aired the day before Valentines and features Ryuko getting her heart literally pulled out of her chest.
Life Fibers, daughter!Explanation, spoilers to episode 18 and Metal Gear Rising Revengeance! Ragyo has been compared to Senator Armstong of Metal Gear Rising fame thanks to episode 18. This involves her being able to recover from fatal wounds, having her arm cut off and even decapitation thanks to Life Fibers (i.e. nanomachines), being able to break a sword in half with her bare hands◊ and giving a No-Holds-Barred Beatdown to Satsuki. Though instead of having her heart ripped out, she delivers this to Ryuko instead.
Y'all be welcome to Ragyo's Rape Cage!Explanation As if Ragyo wasn't creepy enough, episode 19 features Satsuki chained to the ceiling of a spiked cage while Ragyo taunts and molests her. Understandably, the fandom can't quite unsee that.
Dotonbori Robo? DTR!Explanation Aikurou vigorously insists that his Nudist Beach mech be referred to as "DTR" rather than Dotonbori Robo. It's not openly specified why, but is likely referring to Osaka's Dōtonbori street having a reputation as a former red-light district. It could also be a gag involving the Dual Tension Restorer (DTR), which is a, well, foreskin-stretching device.
Netorare? NTR!◊Explanation Fans were quick to notice that Mako's mom seems way more interested in Aikurou than her own husband. Naturally, Aikurou's Insistent Terminology is invariably invoked.
Mom ofthe Year everyone!Explanation Fans have sarcastically bestowed this title to Ragyo.
BroketsuExplanation Senketsu's devout Undying Loyalty and Platonic Life Partners status with Ryuko garnered him much sympathy, especially at the end of episode 19, when she starts taking her self-loathing out on him, after he tries to celebrate her waking from month-long coma.
Because of ep. 23, Nui is now prone to suddenly popping up in videos and hijacking them. "Welcome to the runway of death!"
Nui World OrderExplanation Nui's Memetic Badass status after episode 22 kicked off with a blast when her fans declared open war on anyone who dares keep spamming the same stale old arm puns long after they stopped being witty. Then she ends episode 23 with undoing her Game-Breaking Injury and initiating a Last Villain Stand, which immediately whipped her devotees into a frenzy of victorious clamor, exalting her as goddess and claiming she could easily launch her own successful Take Over the World plan, then backing it up by launching an overwhelming seizure of several community boards later that afternoon.
Orgy EndingExplanation The last scene before Episode 24's credits has Ryuko, Satsuki, Mako, the Elite Four, Mako's family, and all of Honnouji Academy piled naked on top of each other with Ryuko, Satsuki, Mako, and the Elite Four all hugging tightly. Ryuko and Satsuki's tender smiles don't help much.
"I'm crying over a sailor uniform."Explanation Senketsu's death hit Tumblr pretty hard◊
Bully La BullyExplanation One of many anime parodies based on 4Kids dubs. Bully la Bully originated as a tumblr post made by Izzy Golden (tumblr: danganronpahentai) on December 23, 2013, and was simply titled "Kill la Kill 4Kids." A few months later, on March 14, 2014, Tony Le (tumblr: phokingreal) created a thread on voiceactingalliance.com seeking voice actors to play in a video version of the parody. Tony made minor changes to the original idea, including the new title, and created the video in Camtasia Studio 8. Since Bully la Bully was uploaded to YouTube on March 31, 2014, it has received huge amounts of attention. It passed 100,000 views just days after its release and was even featured in an article on Crunchyroll.
No homo, Ryuko-chan!Explanation The finale caused a lot of Ship-to-Ship Combat, with Ryuko and Mako going on a date and kissing. Due to many Ryuko/Mako opponents claiming that girls kiss and go on dates all the time without any romantic feelings, there were posts satirizing this claim by making up deliberately ridiculous arguments as to why they aren't gay, and variations of "no homo" were often used in said posts.