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Manga: Variante

Variante is a horror manga by Ikura Sugimoto. When Hosho Aiko is killed, she should be dead. Instead, she wakes up three days later in the morgue, with an shiny new monstrous arm. Quickly confronted by the monster that killed her parents, she learns that this arm is perhaps the only weapon in the world capable of cleanly handling the creatures.

Of course, this makes her very interesting to a certain government funded company that is dedicated to keeping the monsters covered up, and cleaning up after them.

Having seemingly everything robbed from her, Aiko must decide whether she wants to die as a specimen, or live fighting the monsters, and her resolve is constantly put to the test as conspiracies and, ultimately, the truth behind the monsters is revealed.

This manga provide examples of:

And I Must Scream: It's implied that Chimera are completely aware, but are in extreme pain and unable to control themselves.
Applied Phlebotinum
Back from the Dead - And its not exactly a happy moment.
Barbie Doll Anatomy
Bittersweet Ending
Body Horror - She has a freaking monster arm that eats small dogs. And the arm is really tame compared to most of the rest of the series.
- The Chimaira are pretty much predatory Body Horrors.
Defector from Decadence: Sera AKA Oumi Yuji.
Downer Ending - YMMV, but it can certainly be interpreted as depressing.
Extreme Doormat: Aiko. She pretty much lives her entire life trying to please everyone around her. She gets better by the end.
Eye Scream - Nana.
Heroic BSOD: Aiko goes through quite a few. But the biggest one comes after she discovers that chimaera are humans.
Heroic Sacrifice
Hot Scientist
Immune to Bullets - There's a reason Aiko has to fight the Chimaera.
Luke, I Am Your Father: By way of memory recollection. Aiko's real father was a chimaera and the one that killed her real mother and adoptive parents. His arm grafted itself to her to protect her.
Mood Whiplash: Sachi. Just... just Sachi.
The Woobie: Oh, good God, Aiko. Possibly, Woobie, Destroyer of Worlds.
Unsound Effect - "Reach", "Grab"
What Measure Is a Non-Human?: The chimaeras used to be humans. This revelation triggers Aiko's above Heroic BSOD.