Moyasimon: Tales of Agriculture (also spelled Moyashimon) is a still ongoing manga series, adapted to anime by Telecom Animation Film in 2007 (with a second season in 2012) and live-action in 2010, which tells the account of Tadayasu Sawaki. The son of a yeast maker and a first-year college student at an agricultural university, Tadayasu has the ability to see, touch and talk with all sorts of micro-organisms and bacteria. These microbes appear to him as bug-sized creatures that come in all sorts of shapes with whom Tadayasu can interact.
Tadayasu Souemon Sawaki - The main protagonist of the series. His middle name is usually omitted.
Kei Yuuki - Tadayasu's childhood friend, the son of a sake brewer who secretly thinks of herself as a girl trapped in a boy's body and is also in love with Tadayasu.
Green Aesop: But averted in some instances. On the one hand, the whole show is about ecology. On the other hand, treating fields with chemicals works (agricultural science!) and biofuel-powered tractors don't (it's still just an experimental model, and the coal-powered tractors work just fine).
Groupie Brigade: In the live-action adaptation, the UFO Club is depicted as this for Aoi Mutou.
Hilarity Ensues: When Tadayasu demonstrates his ability for Itsuki and Haruka.
Identical Stranger: The first thing Sawaki notices and the audience is told by A. oryzae about Marie is how she looks strikingly similar to Kei. The even both have the same Elegant Gothic Lolita fashion sense.
Irony: Oikawa is a neat-freak who has an issue with germs in general. Come the end of the second season however, as Sawaki soon finds out, she's apparently a microbe-magnet on the scale of the owner of the Hiyoshi Liquor Store, to the point Sawaki could no longer see her anymore under the cloud of microbes orbiting around her.
It Tastes Like Feet: Tadayasu describes hongeohoe (stingray sashimi pickled in urea) as tasting like toilet paper that's been soaking in a campsite urinal for weeks.
Kawaisa: All the bacteria and fungi are cute, even pathogens like O-157 E. coli and MRSA.
Pragmatic Adaptation: The live action series, which starts off the bootlegging sake scene much earlier and Kei appears later on as a student in his crossdressing guise, rather than joining the school with Sawaki at the same time.
The Professor: Itsuki, who goes to great lengths in the pursuit of agricultural science.
Sequel Hook: At the end of the second season, with the woman visiting the Hiyoshi Liquor Store with a box labeled Kanou Farms.
Shown Their Work: If you're willing to accept that the over-enthusiastic Itsuki tends to overstate the importance of microbes from time to time, most of the factual information given on microbes in Moyasimon is generally correct.
As amazing as it sounds, Itsuki's obsession with microbes Transforming The World is itself an example of Showing Its Work.note Specifically, it'd appear a lot of stuff Itsuki promotes as possibilities for future terraforming is in fact based on the Real Life science of bioremediation. And yes, Real Life researchers in terraforming ARE looking at bioremediation as a model for making worlds habitable.
For that matter, other than some of the "human drama" bits, the depiction of the agricultural university IS rather similar to what goes on in Real Life at agricultural research universities (or ag-research colleges of state universities).