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Anime and Manga
- The Snake Way in Dragon Ball Z could be seen as this. Goku had to travel along this path to get back to Earth from the afterlife in time to fight the Saiyans.
- A variation of this takes place in One Piece: the ultimate goal for all pirates searching for the titular treasure is Raftel, the last island in the Grand Line, where Gold Roger is believed to have hidden the treasure. Each pirate crew's navigator has a Log Pose (a compass worn on the wrist like a watch) that points out the direction to the next island along the journey...but it's a variation because there are several winding paths along the Grand Line beginning from Reverse Mountain, all of which have in common Raftel as the final stop. Therefore, the specific pathway that the Straw Hats have been traveling from Reverse Mountain is just one of several routes they could have sailed.
- In both Jumanji and Zathura, once the protagonists have started playing the eponymous games, they must play the game all the way through in order to escape and undo the damage done.
- Labyrinth: Although she is of course running around (and often getting lost) in a deadly maze, Sarah has only one goal: to find Toby in the center of the labyrinth and every step she takes is to try to get her further towards that goal.
- The Trope Namer comes from The Wonderful Wizard of Oz, and led the protagonists to the Emerald City, as the page image shows.
- John Bunyan's The Pilgrim's Progress. Stick to the straight and narrow, or you will regret it. Even leaving it for an easier road that parallels it is bad, as Christian is quick to find out.
- The Mississippi River functions as this in The Adventures of Huckleberry Finn. At first, they were floating down to reach Cairo, Illinois, from whence they could sell the raft and buy tickets up the Ohio into the free states, but after they miss Cairo in a fog, they keep heading south...kinda just because.
Live Action TV
- Played straight in Milton Bradley's Game of Life. There is only one end goal but the path there can branch or double back again.
- BioShock 2: Maps of the Atlantic Express essentially plot out the entire game.
- Lemmings 3D has a level called "Follow The Yellow Brick Road", where you have to do just that (it's a bit harder than it sounds).
- The Stanley Parable: At one point the narrator gets so frustrated with the player's refusal to play the game in his way that he creates "The Stanley Parable Adventure Line" which is simply a thick yellow line which the player must follow.
- Slave.In.Utero's Tower of God knows only one way. Up, from testing area to testing area.
- The Hanna-Barbera Alice in Wonderland has Alice following the Unwinding Road, which unscrolls before her like a carpet (not yellow, though).