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Anime and Manga
- In K, the Weismann twins were this, as the head scientists working on the Slates, even at a young age. Claudia dies and Adolf becomes immortal, but retreats to live in a blimp for 70 years because of his grief. When he does return and must solve a new problem with the Slates, he relies on Claudia's notes a lot, and says she was always the smarter one and it's incredibly hard for him to do this without her.
- In Project Arms, there are Al and Jeff Bowen, evil genius identical twins until Al's Heel–Face Turn and Jeff's death, and also Katsumi and Kei, who are identical female twins; Kei's The Chick, and Katsumi's a Damsel in Distress and a major plot point.
- In Harry Potter fan works, Luna Lovegood's twin sons, Lorcan and Lysander, are often depicted as this. Not surprising, as their parents are both world-renowned naturalists and their mother at least was in Ravenclaw House during her schooling (the House that values intelligence above all else).
Film - Animation
Film - Live Action
- The twins in Men in Black
- Fred and George Weasley from Harry Potter, even though they're more Trickster Twins, it did take a certain amount of brain power to make all the Weasley Wizard Wheezes.
- Beltira and Belkira of the Belgariad and Malloreon. They spend most of their time in the Vale of Aldur trying to decipher a multitude of complex prophecies, while the other sorcerers act on what little information they can find.
Live Action TV
- Power Rangers RPM had genius twins Gem and Gemma, though their intelligence was heavily overshadowed by the fact that they were Cute and Psycho Cloud Cuckoolanders. They instead collectively filled the Sixth Ranger role, leaving Mission Control duties to Dr. K.
- The Edison Twins.
- The Bynars from Star Trek: The Next Generation are an entire alien species of cyborg Think Twins.
- Though they aren't related, Leopold Fitz and Jemma Simmons (colloquially known as Fitz-Simmons) on Agentsof SHIELD qualify.
- Doug: Al and Moo Sleech
- Detention: Orangejella and Lemonjella LaBelle
- The "tweebs" from Kim Possible. Granted, basically everyone in their family is a genius, including Kim (who's simply not as into science as the rest of her family is). They also end up starting high school at only twelve.
- Johnny Test: Susan and Mary Test, Johnny's older sisters.
- A set of overachiever twins seen in one episode of Static Shock.
- Thunder Cats had Wily Kit and Wily Kat, who, as their names suggest, were quite wily. Lion-O had to face the pair of them to overcome the Trial of Cunning.
- The Platypus Brothers from Tazmania.
- Rhona and Andy in Iron Man: Armored Adventures. Subverted in that Rhona turns out to be an only child and that Andy's an android she built.
- Can be truth in television, as research studies of twins can attest.