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Anime & Manga
- In the episode of Cowboy Bebop where Spike meets Faye, a casino chip with a microchip in it is to be exchanged in one of these. For added fun, it takes place in a casino/space station shaped like a roulette wheel.
- In Descendants of Darkness, Tsuzuki actually had to pretend to be a dealer on a cruise ship's casino in order to investigate murders.
- Rosette and Chrono first meet Azmaria in a casino owned by her adoptive father in Las Vegas (Atlantic City in the anime).
- City Hunter has at least one storyline centered on underground casinos in Tokyo.
- From the same author, Cat's Eye has a storyline where the owner of the targeted painting also owns at least three underground casinos.
- One Piece Film: Gold is set to take place on a cruise liner which houses what is virtually the city of Las Vegas in it.
Films — Live-Action
- The film Casino.
- A few James Bond films, such as Casino Royale (2006) and Diamonds Are Forever.
- In the movie 3000 Miles to Graceland, there's a shootout in one of these, featuring robbers wearing Elvis outfits.
- Both the original Oceans11 and the remake with George Clooney are about schemes to rob a Vegas casino.
- Ocean's Thirteen feature the titular team rigging all the games in one of these for revenge.
- When Tony Stark is given an award at a ceremony held in Las Vegas, he misses accepting the award because he's busy working. And by busy working, we mean having some fun gambling.
- Biff Tannen's Pleasure Paradise from Back to the Future Part II.
- In Cars 2, the Lemons actually use an old casino in Italy as their evil lair.
- The Thieves centres around a Caper Crew put together to heist a $20 million dollar from a casino in Macau.
- The plot of Monte Carlo centers around Countess Helene Mara's attempt to escape from a Marriage of Convenience by gambling her way into a fortune.
- Vampire Academy:
- Rose, Lissa, Eddie Castile, Victor Dashkov, Adrian Ivashkov, and Robert Doru spend time in various Las Vegas' casinos in Spirit Bound. They do not have much time to enjoy the sights are they are hunted down by Dimitri the Strigoi and his subordinates.
- The same book establishes that there is a Moroi-owned casino in Las Vegas, called the Witching Hour. It figures out again in the plot of Last Sacrifice. Eric Dragomir met his mistress Emily (Mastrano) there, fifteen years before the events of the book.
- In "The Theft of the Cuckoo Clock", Nick Velvet is hired to steal a broken plastic cuckoo clock. What makes the theft challenging is the clock's location: inside the manager's office at the centre of a well-guarded casino.
- Dortmunder: In What's the Worst That Could happen?, the final crime in the escalating series of crimes committed by Dortmunder in his attempts to regain his ring is an Ocean's Eleven style heist on Max Fairbanks' casino in Las Vegas.
- In Heroes, there's Linderman's casino, and it's a plot point for much of the first series.
- These pop up pretty frequently in CSI.
- As well as the series Las Vegas, which is set in one.
- The episode "Double Down" in NUMB3RS revolves around card counting in a casino. Larry is revealed to be a former card counter, and he, Charlie, and Amita gamble at a casino.
- The Hustle take down a Vegas casino for $5 million in "Big Daddy Calling" after the owner has Albert roughed up.
- The first half-season of Mr. Lucky takes place largely in (and/or aboard) these.
- In Criminal Minds Reid goes undercover, and fails to blend in, at a casino looking for an Unsub after proving his experience by being banned from casinos in three cities.
- Viva Las Vegas, of course.
- In Rocket Age the Rocket Cat nightclub in Emancipation, Mars, has a secret casino hidden in the back, available by invitation only.
- Pokémon Red's Game Corner, while a Minigame Zone, is also the front for Team Rocket's base of operations.
- Baccarat in SaGa Frontier. At least three characters go there during their quests, but none of the games can be played
- In Paper Mario: The Thousand-Year Door, there's the Pianta Parlor, owned by the mob. E Rating, indeed.
- Glittertown/Neon City in Wario Land Shake It is this kind of area, with multiple casino type areas in two levels set in an extremely obvious fictional pastiche of Las Vegas especially given that you go through a couple desert levels first.
- The third mission in Bonanza Bros. takes place in a casino. Depending on whether or not you're playing a Bowdlerized version, either the Casino Executives are corrupt and you're stealing evidence, you're testing an elaborate security system, or it's just a straight-up heist.
- In Action Doom 2: Urban Brawl, as you're riding an elevator upwards through the corporation building and punching out everyone you meet along the way, one of the floors you come upon is a casino, complete with snazzy casino music and mini-games to play.
- Sonic Adventure's third stage is casino themed, but the focus is on pinball, with Sonic as the ball. The main wagering you do is hoping to collect 100 rings in a game to avoid being dumped into the sewer, and one pinball game has a slot bonus, where one set of symbols (Dr. Eggman's face) will steal all of your rings.
- The Fallout series has several of these starting with Gizmo's casino in Junktown and The Hub's Maltese Falcon in the first game
- Fat Cat's Casino from Chip 'n Dale Rescue Rangers, which is based on the TV series episode, "Adventures in Squirrel-Sitting". The boss is one of Fat Cat's henchmen, who tosses coins from a slot machine.
- The Golden Grin Casino in PAYDAY 2. Your mission is to rob the place blind, but you can also play the slots while you're there.