[[quoteright:350:[[ComicBook/CaptainAmerica http://static.tvtropes.org/pmwiki/pub/images/serum.jpg]]]]
[[caption-width-right:350:And be sure to drink it all, because sometimes the good stuff is on the bottom.]]

->'''Victor Mancha''': Wait, back up. Your secret origin is drugs? Doesn't that kinda set a bad example for little kids?\\
'''ComicBook/{{Cloak|AndDagger}}''': ''I am not your ROLE MODEL!''
-->-- ''ComicBook/{{Runaways}}''

A hero who doesn't have his powers or abilities naturally, but has to get them from a process of digestion or injection of a specialized compound. For obvious reasons, depictions of this took a nosedive due to MoralGuardians, as depicting heroes taking what seemed to be drugs became a strict no-no.

Heroes nowadays may get such treatments only once, often involuntarily (due to [[PlayingWithSyringes evil experimentation]]) or as formal medical treatments. You're most likely to see this being done by villains, with an {{Anvilicious}} [[DoesThisRemindYouOfAnything addiction metaphor]] in effect.

PowerUpFood is the case when the abilities come from common foodstuffs. Applied to enough people at once, and it becomes a MassSuperEmpoweringEvent. If (as in the case of ComicBook/CaptainAmerica, pictured right) only one person gets it, it's a DisposableSuperheroMaker. A SuperhumanTransfusion (especially if it's from someone who drank Super Serum) usually has the same effects.

Compare PsychoSerum and BottledHeroicResolve. See also PowerSource and HigherUnderstandingThroughDrugs. For a similar trope in commercials, see CerealInducedSuperpowers.



[[folder:Anime and Manga]]
* ''Anime/EighthMan'' was a CyberPunk SuperHero who recharged himself (and his powers) through special ''cigarettes''. His were the only [[CyberneticsEatYourSoul cybernetics that didn't eat ones soul]] in the series. The {{OVA}} {{revival}} ''Eight Man After'' used plain old experimental Super Serum -- in contrast to the PsychoSerum all the ''other'' cyborgs had to use.
* ''Manga/{{Naruto}}'': Although his abilities don't center around them, Chouji's food pills can increase his chakra supply dramatically, allowing him to use more powerful attacks more often. These leave him burnt out afterwards at best, in critical condition at worst.
** As do Kiba and Akamaru's battle pills, which had been mostly abandoned by the ninja corps due to the side effect of ''not being able to move for three days'' after a ten-minute dose.
* Creator/OsamuTezuka's superhero Big X (best known in the West for various cameo appearances he put in in various ''Anime/AstroBoy'' productions) got his powers from a SuperSoldier serum his father was forced to develop for the Axis Powers during WWII. The drug was injected and came in two stages, one shot to make him NighInvulnerable and another turned him into a giant. In the anime this was changed to a pendant that emitted special EM waves due to MoralGuardians' concerns about the similarity to the then-emerging Heroin epidemic.
* ''Manga/OnePiece''. There are badass normals everywhere, and they can frequently match up against the likes of the super powered individuals just fine. But after consumption of a Devil Fruit, you get some sort of super power. Logia allow you to control and turn yourself into an element, Zoans give you shapeshifting and increased physical abilities, and Paramecia grant random, often strange powers such as the [[HeartIsAnAwesomePower ability to produce wax or soap bubbles]]. But occasionally extremely powerful ones like Whitebeard's Quake Quake fruit show up as well.
** The Fishman Island arc has the FantasticDrug, Energy Steroid. One pill doubles the user's strength but cuts years off their life. [[spoiler:That last part is quite literal: constant abuse ages Hody's crew from their prime to old men within a day.]]
* The origin story of the hero of ''Manga/CityHunter'' is a bizarre instance of attributing cool powers to an actual illegal drug. According to the story, Ryo was born in poverty in Central America, and ended up [[PlayingWithSyringes used as a test subject]] and injected with a form of LSD. Rather than screwing with his mind, this instead gave him superhuman reflexes and a [[LovableSexManiac heightened sex drive]], including GagPenis.
* [[spoiler:Ako's artefact]] as revealed in chapter 304 of ''Manga/MahouSenseiNegima''.
* The drugs used by the Extended in ''Anime/MobileSuitGundamSEED'' and ''Anime/MobileSuitGundamSEEDDestiny'', which also double as a PsychoSerum. It has profoundly negative effects on the user; this includes fatal withdrawal symptoms, which were added on purpose in order to keep the Extendeds loyal (you can't rebel against the only people who can keep you alive).
* In ''Literature/{{Kurozuka}}'', the blood of the immortal vampire Kuromitsu can give both immortality and SuperStrength to those who take it--''if'' they survive, which most don't.
* ''Manga/BakiTheGrappler'' has X-4, a super steroid that increases muscular growth and overrides the effects of over-training. It turns Jack Hanma from a stick of a person to a [[http://www.youtube.com/watch?v=Q2dytcbHTR0 monster of a human.]]
* In ''Manga/AttackOnTitan'', a serum [[spoiler: made from Spinal Fluid]] is used in the process of giving a person Titan powers. This is first hinted when Eren has glimpses of his father with a needle, about to inject him with something. [[spoiler: The serum can be tailored to produce different results, modifying the size and function of the Titan as desired. While gaining the power of one of the Nine Titans requires ''eating'' one of the current owners, some of their abilities can be transferred via specialized serums. Eren gains the ability to harden his Titan's skin after consuming a serum labeled "Armor"]].
** If someone is injected with [[spoiler:Zeke (aka the Beast Titan)'s]] serum, [[spoiler:he can force them to transform into mindless titans by screaming]]. Nobody knows ''why'', but presumably it's due to [[spoiler:his royal blood]].

[[folder:Audio Play]]
* ''AudioPlay/TheElysiumProject'' has the eponymous Elysium formula, which grants those exposed to it [[RealityWarper the power to manipulate reality in accordance with their desires]].

[[folder:Comic Books]]
* In the Franchise/MarvelUniverse:
** Puny Steve Rogers became ComicBook/CaptainAmerica thanks to the Super-Soldier serum created by Dr. Abraham Erskine, and [[NoPlansNoPrototypeNoBackup failed attempts to recreate it]] are common plot points in both the regular and [[ComicBook/UltimateMarvel Ultimate]] universes.
*** For instance, the 1950s impostor Captain America used a Nazi German variant of the formula to enhance his body. However, he learned the hard way that is not enough; the subject taking the serum then has to have it activated and stabilized in his body by a radiological treatment using "Vita-Rays" in order to take it into his system safe. Without the stabilizing agent, the serum caused mental instabilities, including paranoia; in the imposter's case, fueled by the RedScare propaganda of that era, it caused him to see Communist enemies of America everywhere, leading to his being put on ice ([[HumanPopsicle literally]]) by the U.S. government and his fan-given nickname of "Commie-Smasher Cap".
*** Omega Red was a failed Soviet attempt at making the serum as well as giving Red tendrils in his arms made of carbonadium (an alloy intended as a more feasible substitute for the astronomically expensive and rare adamantium). While Omega Red did gain most of Caps powers, he is constantly dying and has to drain the life-force of others in order to live[[note]]Some issues have it that instead of (or alongside) life-draining, he has a "death spore virus" that will eat him alive if he doesn't transmit it to others.[[/note]] (fortunately for him his mutant powers along with his tendrils can do just that). Apparently something called the "Carbonadium Synthesizer" will cure him of his condition. It's his best weapon - your average opponent can't even ''try'' to fight him. He considers himself BlessedWithSuck (despite being the type who would not pick a different career if cured ''or'' feel bad about the fact that he must kill to survive.) and seeks the c-synthesizer, as carbonadium is the only thing that can neutralize the virus. However, it's hard to know if he was born with that or if that's part of what was done to him.
*** Interestingly, in ''[[ComicBook/AvengersTheInitiative Avengers: The Initiative]]'', it turns out that Erskine discovered similar results could be achieved with a perfect diet and an extremely specialized exercise program, which resulted in his great-grandson Michael Van Patrick having the same peak physical condition naturally. The research was not classified or ever used by the military because they wanted a quick fix; the natural super soldier would take a lifetime of dedication to produce. [[spoiler: Unless you get your hands on one and just clone him over and over.]]
** ComicBook/TheSentry is a metafictional send-up of many ComicBookTropes. Not only did he get his powers by taking "the Professor's secret serum", but comics-that-never-happened from the 1980s showed it blossoming into a full [[GRatedDrug addiction metaphor]]. Later, it's revealed that he originally drank it hoping to get high.
** Patriot (Elijah Bradley) from ''ComicBook/YoungAvengers'' is the grandson of Isaiah Bradley, the [[{{Retcon}} "first"]] Captain America, but his mother was conceived before Isaiah was experimented on, so he did not inherit his grandfather's powers. When Iron Lad came to recruit Elijah's brother, Elijah claimed to have gained superpowers through an emergency blood transfusion, but really was gaining powers artificially with MGH (Mutant Growth Hormone), an illegal street drug that causes brief periods of super-human abilities. Once discovered he stopped taking the MGH but went into battle anyway, was grievously wounded... and got an emergency blood transfusion from his grandfather, thus gaining superpowers.
** Vintage Heroes Comicbook/CloakAndDagger were phased out for a while because their back story involved pharmaceutical testing (of the extremely involuntary kind). This is [[LampshadeHanging Lampshaded]] brutally in [[RunningGag every scene]] they appear in when they make a comeback in the ''ComicBook/{{Runaways}}'' series. Every time they explain their back story another character says "So you got your powers from drugs, I bet the [[MoralGuardians parent groups]] love you" to which Cloak usually declares that he is [[AntiHero not supposed to be a role model]]. This is brought up again later where a modified version of the drug that gave Cloak his powers is mixed with mutant growth hormone and sold on the black market as the drug Darkforce, with the slogan "You wanna go night flying?" Superpowers are quite the buzz, apparently.
** A recent {{Retcon}} in ''ComicBook/UltimateXMen'' is that [[spoiler:this version of Colossus needs the mutant enhancement drug "Banshee" to be able to so much as move his limbs in his organic steel form.]]
** More in the superpower-causers-equalling-drugs: There was an article in one issue of Year In Review, a tongue-in-cheek in-universe magazine, about Pym poppers, kids who took Pym particles to shrink and grow. This always backfired.
** As far as anyone at this point is able to understand, everything in the ComicBook/UltimateMarvel universe involving superpowers are derived from attempted recreations of Captain America's Super Serum. Which in turn was reverse engineered from [[spoiler:Wolverine, in the same experiments that created mutants.]]
** The various [[ComicBook/NormanOsborn Green Goblins]] and Hobgoblins from Franchise/SpiderMan comics used a serum that involved this trope mixed with a little bit of PsychoSerum since the Goblin formula increased a person's strength and intellect but also made them AxCrazy.
** In [[ComicBook/SpiderGwen Earth-65]], Jesse Drew (a male version of [[ComicBook/SpiderWoman Jessica Drew]]) was bitten by alien moon spiders, and the antidote that saved his life also granted him the abilities of his Prime Earth counterpart. He was made to believe that he needed to keep taking regular doses of the "antidote" in order to stay alive, but in actuality it simply allowed him to keep his powers.
* In Franchise/TheDCU:
** Franchise/{{Batman}} villain ComicBook/{{Bane}} (who also appeared in ''WesternAnimation/BatmanTheAnimatedSeries'') got his superhuman strength from Venom, a steroid-like chemical derived from Miraclo. In a ContinuityNod, it later appears in ''WesternAnimation/BatmanBeyond'' as a street drug and future-Bane has become a wheelchair-bound invalid due to the damage a lifetime of Venom use wrought on his body. In the comics, he also suffered severe problems from continued Venom use, but eventually got himself clean and now relies solely on his (considerable) natural strength. Or at least he did, and he was forced back into it. He tries not to use it as much, though.
** Franchise/{{Batman}} villain Mark Desmond (Blockbuster) took an intelligence reducing but physically enhancing drug at the behest of his criminal mastermind brother. Later his brother Roland Desmond took the same drug and made a deal with the demon Neron to maintain his intelligence becoming the second Blockbuster and ComicBook/{{Nightwing}}'s [[ArchEnemy nemesis]].
** In yet another Batman-villain case, the mainstream comics continuity ComicBook/HarleyQuinn, although it isn't often mentioned in the comics, has mildly augmented strength, agility, and healing due to a herbal elixir Poison Ivy gave her in her first appearance. This is probably to give some justification for how a thin, petite woman can beat up guys who are much bigger than her and have martial arts training.
** B'Wana Beast used a mystic elixir from somewhere in Africa. His mask-slash-helmet allowed him to control animals, though the elixir allowed him to [[FusionDance fuse two animals into one]]... which he could control with the helmet.
** Also ComicBook/TheCreeper got his strength and agility from a super serum, later [[RetCon changed]] into nanocell serum. In ''WesternAnimation/BatmanTheAnimatedSeries'' his powers came from the very same acid bath that created the Joker, combined with a blast of the Joker's very own laugh gas.
** Slade Wilson, aka [[ComicBook/{{Deathstroke}} Deathstroke the Terminator]], received increased strength, speed and endurance through an experiment conducted by the US Army. In the TV version (Series/{{Arrow}}), he received these same enhancements through an experimental drug called Miracuru (The Miracle).
** ComicBook/ElongatedMan gets his stretchy power from a substance called Gingold -- usually fatal in its pure form, Elongated Man's [[SuperPowerfulGenetics metagene]] fortunately allowed him to drink it as much as he wanted.
** ComicBook/{{Hourman}} got his powers from the "miraculous vitamin" Miraclo, which gave those who took it superhuman strength and speed for exactly one hour. Miraclo turned out to be addictive, and both the Golden Age Hourman and his son who [[LegacyCharacter took up his mantle]] had to fight the addiction. (He currently takes a non-addictive "homeopathic" version of Miraclo.)
** Johnny Quick, The MirrorUniverse EvilTwin of ComicBook/TheFlash, uses an extract of his [[LegacyCharacter predecessor's]] ''blood'' to give him super-speed powers.
** [[HeroicDog Rex the Wonderdog]] got one suspiciously similar to that received by Captain America, complete with Nazi attack destroying the rest of the serum and killing the inventor. It made him strong and smart enough to win medals during the war (among other increasingly ludicrous accomplishments), and then survive for ''forty years'' naturally (after that, he drank from the Fountain of Youth and lives unnaturally).
** ComicBook/{{Static}} and the rest of the Dakota Bang Babies received their powers from being exposed to an experimental mutagenic gas during a massive gang fight. The police thought was tear gas meant to track the gangs to capture them later.
** Young revolutionary Dava Sborsc from ''[[ComicBook/RobinSeries Robin]]'' takes a mixture called Aramilla that gives her temporary superspeed, though it dulls the user's sense of morality.
* The French ''ComicBook/{{Asterix}}'' books concern a Gallic town which fends off Roman domination by use of a magic potion which grants superhuman strength.
** In one entry, Asterix entered the (original Greek) Olympic games, only to be penalised for use of the potion (rather like steroid use in the modern Olympics, which is sort of funny since the original Olympics ''encouraged'' the use of performance enhancing drugs since it made for more interesting competitions). [[spoiler:He finally won a race by tricking all opponents into using the potion previously mixed with a blue food colorant.]]
** Obelix is the only character who doesn't need the potion to have superhuman fighting powers... because someone dropped him in a cauldron of the potion when he was a baby, giving him its effects permanently. For whatever reason, the Gauls have not intentionally dropped any other babies in cauldrons to get more super-soldiers like him.
* The ComicBook/TopTen comic series, which is a {{Homage}} to comic book tropes to begin with, has a whole subculture of power-granting drugs, such as "goose juice" that gives SuperSpeed.
* ComicBook/{{Bamse}} gets his super-[[FunnyAnimal ursine]] strength from "dunderhonung", thunderhoney, which is disqualified from being PowerUpFood because it is not just regular honey, but has to be mixed correctly with various herbs and spices (the working ingredient is appearently a rare flower that only grows on a single island in the Aegean, guarded by a seven-headed monster). However, something like Ralph Dibney's metagene above must also be involved, since most people just gets three days of stomach cramps from eating dunderhonung, and it seems to run in the family.
* One of the ongoing plot threads in ''ComicBook/{{Empire}}'' centers around discovering the secret of the production of Eucharist, a highly addictive substance that supercharges the abilities of those who take it. People under its influence can dodge bullets, and the high is described as being "BetterThanSex."
* DanielClowes ComicBook/CaptainAmerica parody "The Battlin' American" has horrible addiction problems requiring him to take regular doses of the super serum. [[spoiler: The street thugs who steal it from him find this out the hard way.]]
* In the comic prequel to ''WebVideo/DoctorHorriblesSingAlongBlog'', [[MadScientist Doctor Horrible]] makes a super-serum using [[JerkJock Captain Hammer's]] DNA. However, while he does gain Hammer's SuperStrength and endurance, his intelligence is reduced to his level as well, resulting in a mindless series of {{Megaton Punch}}es, until Horrible takes the antidote, becoming smart again but also scrawny and weak.
* Nedor Comics character the Liberator was a chemist who discovered an ancient Egyptian potion called "Lamesis", which grants super-human strength and speed when ingested. Naturally, he also figured out how to make more.
* The comic ComicBook/{{Fly}} is about a drug that gives people super powers.
* During ''Comicbook/FinalCrisis'', Tawky Tawny was able to defeat Kalibak thanks in part to his legendary tiger tea, which briefly grants one the strength of ten.
* In ''Comicbook/TheBoys'', Compound V is what gives people superpowers. Usually, samples just give temporary powers but the pure kind gives you powers permanently. Guess which sort [[spoiler:Billy Butcher injects Wee Hughie]] with...?

[[folder:Fan Fic]]
* ''Fanfic/ChildOfTheStorm'' has Erskine's original serum in Steve [[spoiler: and his descendants, as it turns out - as Carol Danvers demonstrates, it just requires a sufficient kick in the genetic pants to do more than slow ageing and give a very slightly enhanced condition]]. On more than one occasion, it is observed that almost every attempt to replicate it has failed, however, there have been a few successes.
** Bruce turning into the Hulk, if you want to call that a success. Ditto the Abomination.
** The Russian Infinity Formula, given to Natasha, Ivan Petrovitch and [[spoiler: the Winter Soldier, in the latter case to stabilise his enhancements by Zola]].
*** SHIELD also has the Infinity Formula, implied to have been used by Nick Fury, who offers it to Coulson (who turned it down) and to [[spoiler: the Flamels in exchange for them working for him, a primary inducement being that the formula repairs everything... including reproductive systems.]]
** Maya Hansen's Extremis formula, [[Film/IronMan3 the basic version being the one seen in the film,]] though refined by Arnim Zola it becomes its infinitely more terrifying comic book variant - [[LegoGenetics it allows you to reprogram someone's genetics to, essentially, do whatever the hell you want them to, within certain ill-defined power limitations.]] [[MorallyAmbiguousDoctorate Zola]] being [[MadScientist Zola]], immediate uses include EliteMooks and a strange human... griffin... ''thing'' that mostly seems to want to be put out of its misery.
* Juicer from [[http://fanfiction.wikia.com/wiki/Hottie_3:_The_Best_Fan_Fic_in_the_World Hottie 3: The Best Fan Fic in the World]] gains SuperStrength from a super steroid, as well as [[Manga/GetterRobo Getter Ray]] treatment.
* ''FanFic/ChronomistressOutOfTime'': Sassafrass syrup, also known as "chronoserum". For most ponies it's just alcohol, but the Royal Order of Timekeepers knows meditation techniques which make it work as a CaffeineBulletTime-inducing SuperSerum.
* In the Literature/{{Worm}} fanfic, ''FanFic/{{Intrepid}}'', Panacea's ambrosia can be used to give a minor [[SuperStrength Brute]] power, along with other effects.

[[folder:Films -- Animated]]
* ''WesternAnimation/{{Megamind}}'': After defeating his arch-nemesis Metro Man, Megamind decides to give Metro Man's superpowers to a random guy who would become the next champion of Metro City. He extracts Metro Man's DNA from some dandruff on his cape and accidentally injects it into [[spoiler:Hal the cameraman]].
* In ''WesternAnimation/{{Turbo}}'', Theo the snail acquires SuperSpeed, and other car-like traits, after being dunked in nitrous oxide inside a race car's engine and swallowing some of it.

[[folder:Films -- Live-Action]]
* The lead character in the film ''Film/{{Senseless}}'' gained SuperSenses through a regimen of injections given to him as part of a pharmaceutical test.
* The protagonist John Grimm of the ''VideoGame/{{Doom}}'' [[Film/{{Doom}} film adaptation]] is injected with a [[LegoGenetics 24th chromosome]] which boosts his physical capabilities enormously, enabling him to plow his way through a building full of ravenous mutated monsters.
** To be sure, those monsters also have the chromosome. Apparently, said chromosome mutates you into a horrible monster if you're a bad person and turns you into a SuperSoldier if you're a good person. Oh, and they first tested it on a convicted murderer.
* In 2008's ''Film/TheIncredibleHulk'', Bruce Banner's mutation into the Hulk in the Franchise/MarvelCinematicUniverse is due to his experimentation with the original Rebirth Project super-soldier serum. A combination of the fact that he didn't know what he was doing (the military had told him the work was for radiation resistance) and his replacing [[TechnoBabble Vita-Rays]] with Gamma radiation led to his transformation. The source of the Abomination's powers is a double dose of the serum combined with a blood transfusion from Banner. This appears to have been done as part of an effort to provide visible ties between Marvel Studios' adaptations of their canon characters - in this case, laying groundwork for the ''[[Film/CaptainAmericaTheFirstAvenger Captain America]]'' film.
* In the Bowery Boys movie ''Hold That Line'', Sach mixes a bunch of random chemicals together and drinks down the mixture. The potion turns Sach into a super-athlete. Inverted later in the movie when Slip tries to replicate the formula. Slip gives the potion to the college Dean, who [[spoiler: shrinks in size]].
* In the 2011 movie ''Film/{{Limitless}}'' the main character uses a drug to become super smart.
* In ''Film/BigTroubleInLittleChina'', Egg Shen gives the heroes a potion just before the final showdown that will make them more heroic. It seems to work. Wang, at least, is able to jump superhuman distances. It at least somewhat overlaps with LiquidCourage, since they're all obviously drunk after drinking it.
* In ''Film/TheLeagueOfExtraordinaryGentlemen'', Dr. Jekyll keeps several vials of his serum that allow him to temporarily turn into Hyde. One vial is stolen by TheMole and copied by the BigBad in order to allow him to create a whole army of Hydes. One of his lieutenants drinks a lot of the stuff and turns into a huge monster that even Hyde has trouble fighting. Ditto for Skinner's blood, which is used to recreate the formula for Griffin's invisibility serum. Presumably, Mina's blood is used to figure out how to turn people into vampires.
* In ''Film/WonderWoman2017'', Dr. Poison gives General Ludendorff capsules with a gas that gives him temporary SuperStrength and toughness, enough to put up a fight against Diana.

* The mother of a [[AcceptableTargets Tour de France cyclist]] wheezes and pants as she brings a tomato the size of a pumpkin to the table. She looks at her son and says, "I thought I told you to stop pissing in the vegetable patch!"

* In the ''{{Literature/Alterien}}'' series, Theseus, a chemical genius, developed a serum through his company that produces enhanced soldiers. The Alterien businessman called it the Superion Serum. He worked with the British military to begin the Actualized Augmented Soldier Programme. The Actuals, as they're called for short, receive impressive enhancements to their senses, muscles, organs and tissue. The serum makes them as powerful as other super soldiers such as the [=SABERs=] of the US or the Red Hammers of Russia. However, they require regular monthly injections in order for them to remain at top level performance.
* ''Literature/CaptainUnderpants'' didn't have superpowers initially, but gained them after drinking some literal Super Serum off of an alien spaceship in book three. This simply complicated things further, naturally.
* ''Literature/WildCards'' plays the "SuperSerum = drugs" thing for all it's worth with Captain Trips, a genius biochemist, "the world's last hippie," and one of the most powerful Aces on the planet. He manages to bring each of his "friends" ([[SplitPersonality alternate personalities]] each with [[PersonalityPowers their owns set of superpowers]]) out with "special concoctions" he makes himself. His first accidental transformation was primarily fueled by his first hit of acid.
* Melange, or [[SpiceOfLife spice]], drives the ''Franchise/{{Dune}}'' series-- it not only extends lifespans, but in large doses, triggers [[PsychicPowers precognition]] which allows for FTLTravel to be done safely (without it, you end up inside a planet or star one out of five times).
* ''Literature/The39Clues'' series is all about gathering 39 ingredients, or "Clues", to [[spoiler:create a Super Serum that gives you the abilities of each of the four "branches" of the family searching for it - the cunning of the Lucians, the intelligence of the Ekaterinas, the strength of the Tomas, and the artistic talent of the Janus]] - feasibly allowing you to rule the world. These Clues include all kinds of ingredients, from harmless ones you can find in a grocery store such as [[spoiler:honey, salt, and mint]] to highly toxic substances like [[spoiler:mercury, lead, and king cobra venom]].
* One of the first things Penny does in ''Literature/PleaseDontTellMyParentsImASupervillain'' is create the "Super Cheerleader Serum," which her friend Claire uses to get athletic enough to join the cheer squad. Her friend Ray drinks the rest, gaining a much larger boost in his physical powers, to the point that he's at roughly ComicBook/CaptainAmerica's level despite being thirteen. Penny explains that enhancing musculature is actually easy, it's just that most villains insist on adding aggression and combat skills and whatnot, which always [[GoneHorriblyWrong goes horribly wrong]].
* The {{Literature/Blackcollar}} trilogy has several of these used to create the titular Blackcollar commandos, the most important one being "Backlash," which vastly enhances reflexes and motor control.
* In ''Literature/SuperheroesAnonymous'', Mobium is effectively a Super Serum, providing superpowers to the individual it's provided to. Unfortunately, it's adaptive nature makes subjects difficult to control and prone to insanity.
* In ''Literature/TheIronTeeth'' web serial people known as Vessels or more informally as Sloshers consume a special elixir created and sold by mages to gain superhuman abilities. The power granted by an elixir needs to be replenished by consuming more. Not everyone can use it though as some people who take it die and others can become addicted.
* Elixir in ''LightNovel/UndefeatedBahamutChronicle'', which has variable effects depending on dose and whether the user has undergone Baptism (a surgical procedure to prepare the body to better accept Elixir). A low dose and an un-Baptised user grants temporary resistance to the sanity-eroding power of Iblis. A high dose and an un-Baptised user results in a transformation into a Nocturnal, a creature with black skin, white hair, massively-increased physical abilities and also increased negative emotions. Oh, and Nocturnals also have a high probability of [[DeadlyUpgrade running out of life energy and dying]]. If the user ''is'' Baptised, the Elixir will heal any injuries they have and even restore stamina. [[spoiler:It's eventually revealed that Elixir is refined from the life energy of living things, and is more effective the closer the source of the life energy is to the user, so all of the Elixir seen in the series comes from the life energy of humans.]]

[[folder:Live-Action TV]]
* ''Series/BuffyTheVampireSlayer'': Forrest used this initially.
* Late in the third series of ''Series/TheFortyFourHundred'', the Government trained up a squad of [[SuperSoldier superpowered soldiers]] through a programme of injections of promicin, the [[AppliedPhlebotinum neurotransmitter]] that gives the 4400 their abilities.
* A subplot in the second season of ''Series/{{Arrow}}'' involves a drug called "Mirakuru", which was developed by the Japanese during UsefulNotes/WorldWarII in order to create an army of {{Super Soldier}}s. [[spoiler: It ends being what grants both [[Comicbook/{{Deathstroke}} Slade Wilson]] and Solomon Grundy their powers]].
* A live TV example would be the sixties show Mr. Terrific - essentially Hourman again (not related to the comic book Mr. Terrific). A government agency came up with a pill that made 99% of humans sick, but gave nerdy Stanley Beamish the buffs (BFS - [[FlyingBrick bulletproof flying strongman]]). Whenever a secret mission came along, Stanley would be given the 1 hour main pill and 2 15 minute boosters - one of which he would need [[OnceAnEpisode in every episode]] due to power cutout.
* By Season 3 of ''Series/{{Heroes}}'' [[spoiler:Mohinder has developed a serum that gives people powers and used it to give himself SuperStrength.]]
* In ''Series/TheSecretWorldOfAlexMack'', Alex is doused in the chemical GC-161, which not only gives her the power to melt, levitate things and shoot lightning bolts, but also sets the CorruptCorporateExecutive to hunting her down.
* The [[MeaningfulName Henshin One-Shot]] in Series/KamenRiderFaiz's [[TheMovie movie]] ''Paradise Lost'' allows the user to be able to use [[TheRival Kamen Rider Kaixa's]] [[TransformationTrinket Rider Gear]]. But, like it's name states, it's only good once. [[OhCrap After that,]] [[spoiler:it causes the Kaixa Gear to dissolve into dust]].
* An episode of ''Series/{{The Invisible Man}}'' had a scientist rob a sperm bank full of sperm of geniuses and make a serum out of it that gives anyone he injects with it enormous intelligence. It turns out that people weren't meant to be so smart, as all of them end up burning out within days.
* ''Series/StargateAtlantis'': The enzyme Wraith inject into their human victims during the feeding process actually makes the human much stronger, so the victim doesn't die as quickly and the Wraith can feed off of them longer. Lieutenant Ford begins taking the enzyme on a regular basis (and gathers his own group of human soldiers to take it, too) to help him fight the Wraith. Unfortunately, the enzyme turns out to be highly addictive.
* ''Series/AgentsOfSHIELD'':
** The Centipede serum, which is a cocktail containing Chitauri metal (from ''Film/{{The Avengers|2012}}''), Gamma radiation (from ''Film/TheIncredibleHulk''), the Super-Soldier Serum (from ''Film/CaptainAmericaTheFirstAvenger'') and Extremis (from ''Film/IronMan3'').
** In the second season, Mr. Hyde shows up with his own serum, made from a bevvy of experimental drugs, as well as [[ArsonMurderAndJaywalking gorilla testosterone and peppermint]]. A full dose gives him enough SuperStrength to break through bulletproof glass and enough SuperToughness to survive getting rammed into a wall by a car, with the only side effect being a minor physical transformation and [[PsychoSerum increased aggression]]. However, it's implied that using it has caused the effects to last longer and possibly even become permanent; even when not using the serum, he has performed feats of strength and endurance that might not be superhuman, but are definitely improbable.
** In the fourth season, it is revealed that the US government created a serum and gave it to [[spoiler:Jeffery Mace, in order to allow him to pretend to be an Inhuman so that they could put an Enhanced person with a good public face in charge of S.H.I.E.L.D.]] And the serum was based on Hyde's serum.
--->'''General Talbot:''' We took the bad stuff out! ...mostly.\\
'''Fitz:''' So you're only ''mostly'' idiots.
* The Source Blood in ''Series/{{Sanctuary}}'' is a vial of pure vampire blood (the vampires having been destroyed millennia ago) that the Five use to create a serum that gives each one different powers. Helen Magnus becomes TheAgeless, [[UsefulNotes/JackTheRipper John Druitt]] becomes a [[TeleportersAndTransporters teleporter]] (agelessness may also be included in the package), [[SherlockHolmes James Watson]] becomes a super-genius, Nigel Griffin becomes the [[{{Invisibility}} Invisible Man]] (the only one of the Five that appears to pass his core power to his offspring), and UsefulNotes/NikolaTesla becomes a vampire with electric powers. Later, the Source Blood is stolen by the [[AncientConspiracy Cabal]] and used to [[spoiler:make Helen's daughter Ashley and several "blank slate" humans into SuperpoweredMooks]].
* In ''Series/TheFlash2014'', the Velocity drug can not only temporarily boost a speedster's, well, speed, but can also be used to temporarily turn a normal human into a speedster. It does have some nasty side effects, however. In addition to hallucinations, speedsters who overuse it will eventually lose their speed entirely, while non-speedsters will not only be affected by the hallucinations faster, they will eventually disintegrate as they move faster than their bodies can handle.
* In ''Series/LegendsOfTomorrow'', the Nazis are given a sample of a super serum by [[spoiler:the Reverse-Flash]]. When used by a NaziNobleman named Baron Krieger, it temporarily turns him into a [[ComicBook/IncredibleHulk Hulk]]-like berserker immune to most damage ([[spoiler:but not to a barrage of bombs from a B-17]]). After capturing [[ComicBook/TheAtom Ray]] and [[ComicBook/{{Vixen}} Amaya]], Krieger threatens to kill Amaya, if Ray doesn't figure out how to make more of the serum for the entire Wehrmacht. While working on the serum, Ray modifies it slightly in order to use it on himself to gain superpowers (without HulkingOut). After Nate is badly hurt and is dying because of his hemophilia, Ray uses the serum on him to help his body heal. In the next episode, [[spoiler:Nate develops the ability to become a ChromeChampion and starts calling himself "Steel", also finding out that he is no longer a hemophiliac]].

[[folder:Tabletop Games]]
* In the ''TabletopGame/{{Rifts}}'' [[TabletopRPG pen-and-paper RPG]], the "Juicer" character class gain their superhuman abilities from a constant feed of intravenous drugs. The drawbacks are addiction, permanent organ damage in two years (making removal problematic), and death within seven. As most are shock troops and mercenaries, many die in combat long before that.
* Part of the extensive, complex, long and dangerous process of creating TabletopGame/{{Warhammer 40000}} SpaceMarines is being steadily injected with a serum derived from the gene-seed of the chapter's Primarch- in turn derived from [[PhysicalGod The Emperor]] himself (the other steps include bionics, numerous organ implants, and TrainingFromHell).
** The Apothecaries, the Chapter's group of medics, have their main role of reclaiming the gene-seed out of their fallen battle-brothers' bodies and monitor the gene-seed organs of recruits and neophytes. They also tend to the wounded but the survival of the gene-seed is more important then the Marine it's in considering that most Primarchs are either dead [[spoiler:save for Roboute Guilliman]], missing (such as Rogal Dorn and Jaghatai Khan), fallen to Chaos (such as Fulgrim), or am mixture of the above (Horus and Alpharius Omegon) so getting more gene-seed is nearly impossible.
** In Creator/JamesSwallow's ''[[Literature/BloodAngels Red Fury]]'', Rafen and his company come up against foes who inject themselves; Rafen is familiar with BottledHeroicResolve, and explicitly aware that this is far more. For one thing, they rise up from apparent death with them.
** Chaos Space Marines of Slaanesh and the Dark Eldar also have access to a variety of combat drugs which can boost their stats temporarily... or kill them.
* ''TabletopGame/{{Pathfinder}}'' has the Alchemist, which trades almost exclusively in super serums, with their JekyllAndHyde Mutagens, as well as many beneficial infusions (spells in potion form).
* ''TabletopGame/TheDraculaDossier'': Edom makes extensive use of Seward Serum. Billed as a combat drug, it boosts users to the physical equivalent of [[TheRenfield Renfields]] (people granted limited vampiric powers by Dracula or one of his servants). Which only makes sense, since it's derived from vampire blood ....

[[folder:Video Games]]
* ''VideoGame/{{Galerians}}'' centered around a [[{{Tykebomb}} boy]] named Rion, who had powerful latent psychic abilities he needed to consume drugs to use. His addiction caused him to waste away slowly.
* ''VideoGame/FinalFantasyVII'''s [[SuperSoldier SOLDIERs]] were "infused with [[MinovskyPhysics Mako energy]]"-- which gave them strength enough to lift their favoured [[{{BFS}} BFSes]], as well as GlowingEyesOfDoom, a hallmark side effect. Other side-effects involve the hearing of voices and general loss of sanity.
* In ''VideoGame/ResidentEvil5'', [[spoiler:Wesker]] needs a frequent and ''precise'' dose of the virus running through his body in order to keep his superpowers and still stay [[BishonenLine (relatively) human-looking]]. [[spoiler:This becomes the major gimmick of the penultimate boss fight, where the protagonists give Wesker [[PhlebotinumOverload an intentional overdose of the serum]], and send him into a VillainousBreakdown.]]
* In ''VideoGame/CityOfHeroes'' the enemy group The Freakshow are cyberpunks powered by a drug called Excelsior, the {{Troll}} gang by massive overdoses of street drug Superadyne (or superdyne, or just 'Dyne), and with the release of the Superscience booster pack, players can change their costume by way of emotes that have them either drinking a potion from an Erlenmeyer flask or shooting up in the arm with a vial of the titular trope.
* ''VideoGame/SuperMarioBros'': Mario's Fire Flower. And by extension, all other items that Mario characters can get upgrades from, from Super Mushrooms to Feathers to ''Doki Doki Panic'''s Hearts.
* VideoGame/{{Prototype}}'s Super Soldiers get their superhuman abilities from being injected with a strain of TheVirus that has beneficial properties and none of the downsides.
* ''VideoGame/RuneScape'' has the Combat Potion made from Harralander herbs which can improve your strength and reflexes but most of all the herb in general has energy stimulating properties.
* The {{final boss}}es of ''VideoGame/InazumaEleven'', Zeus, use a performance-enhancing serum dubbed Aqua of the Gods ([[{{Woolseyism}} or Ambrosia]]) to power themselves up [[AGodAmI to the level of "gods"]]. In gameplay, this translates into them being able to use their incredibly powerful techs as much as they want without consuming [[ManaMeter TP]].
* ''VideoGame/DeusEx'' has "physiopharmaceutical" augmentation for the Men in Black, which among others makes them seriously SuperTough.
* In ''VideoGame/FreedomForce'', the Domain's secret weapon is Energy X, which they have used to conquer all dimensions except this one. In order to have some fun, Lord Dominion decides to give Energy X canisters to Earth's worst criminals and watch them tear apart the planet. An alien named Mentor steals the ship containing the canisters and takes it to Earth, hoping to give it to good people to defend themselves and the others. The ship is shot down in orbit, and the canisters fall all over Patriot City and other parts of the world (Bullet is exposed all the way in Vietnam). Both good and bad people get hit with Energy X and transformed into superheroes and supervillains, respectively. Apparently, a super's blood can also act as super-serum, as Liberty Lad gets his powers from a transfusion of Minuteman's blood.
* "The Tyrany of King Washington" DLC for ''VideoGame/AssassinsCreedIII'' shows an AlternateHistory where UsefulNotes/GeorgeWashington got his hands on a Piece of Eden and, after the power went to his head, declared himself king and forced his army of "bluecoats" to subjugate the land. After Connor's mother (still alive in this reality) tries to steal the artifact, Washington is determined to destroy the Frontier and enslave or kill its inhabitants. The village elder decides to make tea from the boughs of the Great Willow in order to imbue its warriors with strength to resist the king's army. Connor's mother is against this, as the tea has some nasty side effects. Later, Connor drinks the tea and, after a vision quest, is imbued with the spirit of the wolf. He gains the ability (CastFromHitpoints) to become virtually invisible in plain sight and can also summon spirit wolves to attack enemies. It's implied that different people get different abilities from the tea. The tea is not mentioned in the original game, nor is the Great Willow present there, implying it's AllJustADream.
** The second episode of the DLC introduces another power granted by a second sip of the tea. This one allows Connor to literally turn into an eagle and fly to any ledge/branch/enemy in the vicinity. There are three episodes, so the third may bring yet another spirit power.
** The third episode has Connor gain the power of the bear with the ability to GroundPound. The end reveals that it was all a shared vision between Washington and Connor who both touch an Apple that a Templar has given to the general. Horrified, Washington has Connor get rid of the Apple (by tossing it in the ocean) and, later, gets angry when someone (supposedly) suggests that he declare himself king.
* ''VideoGame/{{Doom}}'''s Berserk Pack grants the Marine [[HealThyself full health]] and [[QuadDamage ten times more damage]] when using his fists for the remainder of the level. It also makes his eyes bloodshot, tinting the player's screen red for about 20 seconds.
** In the [[Comicbook/{{Doom}} comic,]] it has a bit of a PsychoSerum effect as well:
* In addition to ''VideoGame/{{Fallout}}'''s smorgasbord of experimental drugs to military-grade combat enhancements, certain varieties of [[BlandNameProduct Nuka Cola]] deliver a fair bit more than a carbonated sugar rush.
* In ''VideoGame/{{Starcraft}}'', Terran infantry have access to stimpacks, drugs that increase movespeed and attack speed at the cost of 10 hitpoints (and have long-term effects in the novels). When they had no way of healing their troops, this was slightly risky (Marines only have 40 HP), but Brood War introduced medics that made them pretty much mandatory. In the sequel, the much tougher Marauders get them as well ([[GameBreaker though not in the campaign]] and at the cost of double the health), allowing them to do horrible things to enemy vehicles and structures and kite combined with their concussive grenades, kite or chase down nearly anything.
* The Goblin Alchemist from ''VideoGame/WarcraftIII'' has an ability called Chemical Rage which greatly empowers his Ogre ride.
* Parnell from ''Videogame/{{Evolve}}'' has a Rage Trooper serum injector built into his armor. While CastFromHitpoints, it increases firing speed, jump height, and movement speed, while decreasing reload time. In-universe, it causes long term adrenal failure, something debated about by Parnell and his teammates.
* ''VideoGame/LuxarenAllure'' has its {{StatBoostItem}}s be called Serums.
* Many games have stat-boosting powerup potions, but the sheer number of them in ''VideoGame/KingdomOfLoathing'' makes it a notable example; it's not uncommon to boost yourself to over 1000% of your normal strength. Not all potions are, strictly speaking, ''potions'' (many are oddball things like horoscopes or trivia cards), but most of the actual potions consist of questionable substances like "gremlin mutagen," were-seal blood, or dangerously high-pressure spheres of something concocted by evil mer-people.

* Most of the heroes from ''Webcomic/HeroesInc'', a popular webcomic that makes use of public domain Golden Age characters, have taken serums that give them various powers and slow down their aging process.
* In ''Webcomic/GirlGenius'', the [[SuperSoldier Jägermonsters]] are the result of humans drinking a concoction first created by the Heterodyne family, brewed from the waters of a strange river that they built their castle over. The resulting "Jägerdraught" killed a significant number of the humans who drank it, but those who survived became nearly unkillable, immortal soldiers.
** The water of the river itself can also grant superhuman strength and stamina, but it's even more likely to kill anyone who bathes in it, let alone drinks it.
* ''Webcomic/ScaryGoRound'': The [=VitRx=] potion makes you big, strong, and attractive, even if you are an [[http://scarygoround.com/sgr/ar.php?date=20070208 animal]]. Mayor Davies's body was too old to handle it, so instead of improving his musculature, it made him prone to outbursts, and barely intelligent enough to communicate.
* The [[EverythingsBetterWithRainbows Rainbow Reverie]] from ''Webcomic/SlightlyDamned'' is a five piece set of [[AlchemyIsMagic magic potions]] with each colored potion having a different temporary effect (Red gives {{Superstrength}}, Blue gives {{Superspeed}}, Yellow improves [[AmplifierArtifact magic]], Purple makes your body [[MadeOfIndestructium invulnerable]] and Green is a powerful HealingPotion), it was used by medians during the great war to even the battlefield with the demons but is near impossible to make now due to it's most important ingredients being extremely rare in Medius [[http://www.sdamned.com/comic/447 until recently]].
** It also has different effects on certain groups, for instance the red potion causes demons to [[spoiler:enter a more controled and nonlethal version of their typically [[CastFromLifespan fatal]] [[OneWingedAngel berserk form]]]] and the yellow potion can [[spoiler:make someone who's [[DivineParentage descended]] from one of the [[PhysicalGod twelve]] [[ElementalEmbodiment guardians]] [[{{Semidivine}} reconnect]] to the [[SuperpowerfulGenetics bloodline.]]]]

[[folder:Web Original]]
* Several characters from the ''Roleplay/GlobalGuardiansPBEMUniverse'' gained their powers through one of these. Most noable would be [[TheCowl Achilles]], leader of the titular superteam, and Alloy, a [[ChromeChampion shiny metal]] supervillain with superhuman strength.
* Every single character in ''Roleplay/SurvivalOfTheFittest'' Evolution that takes part in the game gets their power via an injection of chemicals. Some of the powers are... questionably useful, though.
* In ''Literature/{{Worm}}'', one of the major ongoing plot threads deals with [[spoiler:Cauldron]], a manufacturer of these. The Serum is [[spoiler: derived from pieces of the corpse of [[SufficientlyAdvancedAlien a dead Cthulhu-like alien god]] ]].
* ''Roleplay/WeAreOurAvatars'': As part of his training to be a Feccian Bladesman, Zeke was given alchemical infusions that increased his strength and durability (and, by proxy, a certain degree of his other physical attributes) to preternatural levels. Both were already heightened by the training itself, however, with his infusions simply raising the bar further.

[[folder:Western Animation]]
* ''WesternAnimation/RogerRamjet'' got his powers from "Proton Energy Pills".
* Super Chicken, in his segment on ''WesternAnimation/GeorgeOfTheJungle'', had even more fun with this. The hero drinks a concoction known as Super Sauce... [[PowerUpFood from a martini glass]]. Whether it really gives him any powers is also up for debate.
** The double-strength and triple-strength varieties of Super Sauce definitely have ''some'' effect. They cause the mild mannered Henry Cabbot Henhouse the Third to ''explode'', hospitalizing him and any schmuck who happens to be standing at Ground Zero with him.
* As ''WesternAnimation/{{Underdog}}'' tells us, "The secret compartment of my ring I fill / With my Underdog Super Energy Pill." The film, naturally, opted for the FreakLabAccident origin.
** Sometimes, Underdog says "Energy Vitamin Pill" instead of "Super Energy Pill." This may have been an exhortation for children to take their daily vitamins. Then, perhaps because the notion of popping pills for speed and strength became bad, later broadcasts omitted the pills and had Underdog spontaneously (without explanation) recovering his superpowers.
* One episode of ''WesternAnimation/MightyMouse'' ends with the titular hero contently smelling a flower. Some over-zealous Self-Appointed MoralGuardians, however, asserted that the Mouse was snorting opium poppies, and this eventually snowballed into the urban legend that Mighty Mouse gets his powers from cocaine (!).
* The ''WesternAnimation/GummiBears'' are a target for all number of villains because their magical Gummiberry juice temporarily grants [[CerealInducedSuperpowers superhuman strength to humans who drink it]]. (The juice allows the bears themselves to bounce much like Tigger from ''Franchise/WinnieThePooh''.)
* Parodied in the fourth season episode of ''WesternAnimation/{{Futurama}}'', "Less Than Hero", where an alien "Miracle Cream" temporarily gives Fry and Leela super powers.
* An explosion of "meta-gas" during a gang feud on ''WesternAnimation/StaticShock'' gave Static and a bunch of other troubled teenagers in Dakota different powers. One TeenGenius MonsterOfTheWeek learned how to control it, and could grant himself different short-term powers through short-term exposure.
* Parodied in the classic [[WesternAnimation/LooneyTunes Bugs Bunny]] WartimeCartoon "Super-Rabbit", among other places.
** Not to mention the Road Runner cartoon "Stop, Look, and Hasten" where Wile. E. Coyote takes "leg muscle vitamins".
* ''WesternAnimation/{{Popeye}}'': It's not technically SuperSerum, but Popeye gets his powers explicitly by eating a can of spinach. Why no one else tries is this is unknown.
** The movie implies that the ability to get super-strength from spinach was a family trait. In the original comics, the Sea Witch ''does'' try it on Alice the Goon. It's uncertain if it actually worked, partly because Popeye added milk to his spinach diet to make himself even stronger and [[spoiler:partly because the Goon [[HilarityEnsues fell in love with Wimpy]] shortly after, leading the way to her sympathizing with Popeye and the gang. The last fight she has with Popeye breaks up rather quickly, as he sees the Goon has a child and won't hit a mother.]]
** There actually was one episode where after Bluto starts sobbing about how he Popeye always beats him up, Popeye responds by feeding Bluto some of his spinach, causing Bluto to power up, and he immediately launches into a song about what a great guy Popeye is, while pausing to clobber him at every pause in the Melody.
*** Furthermore, there are cartoons where OliveOyl and a mouse each eat spinach (accidentally in the latter case). Olive instantly develops feminine but obvious bulging biceps and promptly uses them to bring the squabbling Popeye ''and'' Bluto to heel: the mouse ends up jamming Popeye into its hole in the wainscotting and takes his bed for the night.
* In the ''WesternAnimation/TomAndJerry'' episode "Dr. Jekyll and Mr. Mouse", Tom tries to do away with Jerry by putting various poisonous substances in his milk, but it makes Jerry strong enough to violently body-slam Tom instead.
* In ''WesternAnimation/TheVentureBrothers'', Sgt. Hatred is a product of a ComicBook/CaptainAmerica-style serum given to him by the O.S.I. It turned out to be a bit more of a PsychoSerum, as it gave him pedophilic tendencies, which led him to defect from the O.S.I and join the [[LegionOfDoom Guild Of Calamitous Intent.]] After defecting ''[[HeelFaceRevolvingDoor again]]'' from the Guild to become Dr. Venture's new bodyguard, the O.S.I. supply him with "Nomolestol" to calm those urges, but the new side effect of that was... [[BreastExpansion breasts]].
** The Action Man of original Team Venture was also generally on a serum during his heyday. It is implied to have been addictive, and possibly to have had psychotic side-effects. For instance, a tipsy Col. Gentleman baits him about the time he killed a baby, which the Action Man insists was a werewolf. There is no indication of whether this serum is related to Sgt. Hatred's.

[[folder:Real Life]]
* In their origins, steroids were looked as if they were this: some magic serum that gave new soldiers muscles with no training whatsoever. As it turns out, [[PsychoSerum there is]] [[PowerDegeneration a price]].
* During the UsefulNotes/WarOfThePacific Chilean soldiers developed a toxic drink nicknamed "La Chupilca del Diablo" (The Devil's Booze), which consisted of a mix of strong Aguardiente and ''black gunpowder''. According to that era's records, the unholy mixture caused the Chilean soldiers to go absolutely ''berserker'' and able to ignore pain or fatigue, but because of the toxic nature of the drink, this SuperSerum was only used on extreme situations. For the record, that war had Peru and Bolivia teaming up against Chile, and Chile ''won that war.''
* Scientists have actually developed a reliable supersoldier serum. However, it [[http://www.msnbc.msn.com/id/45890174/ns/technology_and_science-science/t/scientists-make-supersoldier-ants/#.TxCQ4G-vLTo only works on ants]].
* The [[UsefulNotes/NazisWithGnarlyWeapons German military]] from 1938 throughout UsefulNotes/WorldWarII used liberally a compound of the dreaded methamphetamine (then known as [[http://www.spiegel.de/international/0,1518,354606,00.html Pervitin]] and often laced into chocolate to mask its bitter taste), in the hopes it would give the soldiers and most importantly airmen superhuman performance. While it certainly did not grant ''super''human powers, it really did enable levels of wakefulness and concentration similar to that achieved by caffeine and increased levels of aggressiveness. Germany was particularly dependent upon Pervitin because the blockade meant she was unable to acquire coffee or caffeinated tea in the requisite quanties. The Wehrmacht actually cut back on the issuing of pervitin in 1941-2 due to the adverse side effects of hyperaggression and addiction, but ended up issuing more of it than ever before from 1943 onward as things went from bad to worse in Ukraine and then Belarus.
* During UsefulNotes/WorldWarII, the British, American and Japanese militaries all issued amphetamine pills to their troops (Benzedrine for the Allies, Philopon for the Japanese), in varying quantities and dosages. [[IncrediblyLamePun Which gives new meaning to the phrase "War on Drugs"...]]
* In the years before [=WW2=], Finland was one of the world's largest users of medicinal heroin. When the war began, and the Soviet Union invaded Finland, beginning the Winter War, Finnish soldiers were issued with heroin pills. At least one Finnish historian has said that the Finnish army's exceptionally level-headed defence of Finnish territory was in part due to the fact that Finland's soldiers were, shall we say, feeling no pain.
* Despite all objective studies showing that it was most certainly ''not'' a super serum, the Western Allies [[InvokedTrope touted Amphetamine and Methamphetamine as Super Serums anyway]]. The Royal Air Force, British Army, and US military used significant quantities of both drugs from early 1942 onward even though they knew fine well they were no better for warding off fatigue than caffeine - and caused recklessness, addictiveness, and sometimes outright delusions. The rationale for this seems to have been partly medical, as it was the only known anti-depressant which might possibly reduce incidences of 'psychological casualties' from "combat stress" - about half of which had physical causes, and the rest mental. But for the most part the adoption seems to have been driven by the militaries themselves, which valued the morale boost. In the USA, pharmaceutical companies' commercial interests were also a significant factor. British businesses were literally unable to profit from promoting the drug due to the 'excess profit' tax (of 100%), but US businesses didn't have this problem and so seem to have played a big role in their early adoption.
* Usually performance-enhancing drugs are a technological and biological dead end. They can enhance one ability (stamina, when stimulants like methamphetamine or cocaine are involved, awareness with psychoactive drugs, or lack of inhibitions with marijuana) at great cost, they are addictive, they lose potency over time due to habituation, and, worse, they give a sense of false security. This is the reason evolution never pushed a species in the wild to consume a performance-enhancing plant: two animals fighting to a gruesome death because they lack the feel of pain both lose the possibility to reproduce themselves.
* Adrenaline, used in emergencies by medical professionals trying to stabilize/revive a patient and useful for allowing super human strength performance too. For as long as the stuff holds or until the body burns out anyway.
** It also [[MundaneUtility combats swelling]] (it's easier to run away if the bruises don't kick in yet), hence its use in treating anaphylactic shock. The stimulant ephedrine is chemically similar, which is why ''pseudo''ephedrine is best known as the decongestant Sudafed. Swelling serves a purpose, though, reducing bleeding and closing off orifices from infection; between the body burning out and curtailing those two functions, an adrenaline-based super serum would need to strike a delicate balance to avoid BlessedWithSuck (or need to be supplemented with, e.g., immune-boosting nanorobots).