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Film — Fictional
- My Favorite Year — the legendary Peter O'Toole plays fictional legendary early era action hero Alan Swann (though Swann is more of an actioner, and more than a bit of a lush)
- Notting Hill — megastar Julia Roberts plays fictional megastar Anna Scott (though Scott is more of a corset-wearing period-piece type actress)
- Tropic Thunder — movie stars Jack Black, Ben Stiller, and Robert Downey, Jr. play fictional movie stars Jeff Portnoy, Tugg Speedman, and Kirk Lazarus (with Portnoy as more of a wacky fart-joke comedy guy, Speedman as a monosyllabic actioner, and Lazarus as an Oscar-obsessed intensive method actor)
- The Artist — Jean Dujardin, best known for spy parody films, plays silent film star George Valentin
- The Hard Way — comedy actor Michael J. Fox plays famous action movie star Nick Lang
- Go West Young Man — saucy movie star Mae West plays saucy movie star Mavis Arden
- In & Out — big star Matt Dillon plays actor Cameron Drake, who kicks off the story by winning an Oscar for his role as a homosexual soldier, and declaring his inspiration to be his regular-guy drama teacher (played by Kevin Kline), who Drake announces is gay; Dillon himself has never won an Oscar, but got his first nom a few years later
- Bowfinger — occasional action star (and comedy superstar) Eddie Murphy plays action superstar Kit Ramsey, who happens to hew to a Scientology-like religion
- Get Shorty — instantly recognizable star Danny DeVito plays Oscar-winning superstar Martin Weir (a step up from DeVito's actual, if not ignominious, career)
- íThree Amigos! — comedy stars Steve Martin, Martin Short, and Chevy Chase play silent film western stars Lucky Day, Ned Nederlander, and Dusty Bottoms
- California Suite — Dame Maggie Smith, who had previously won an Oscar for The Prime of Miss Jean Brodie, plays Diana Barrie, an actress who has been nominated for an Oscar; ironically, Dame Smith won her second Oscar for this performance
- Inside Daisy Clover — 1960s child movie star Natalie Wood plays 1930s teen movie star Daisy Clover
- Spider-Man 2 — movie star Kirsten Dunst plays Mary Jane Watson as a rising Broadway star (in the comics, Mary Jane is a soap star for a time, so this character development was probably on the producers' minds when she was cast in the first film)
- Sunset Boulevard — silent film era star Gloria Swanson plays all-but-forgotten silent film ere star Norma Desmond (and silent film actor and director Erich von Stroheim plays Desmond's butler Max, also her former silent film director).
- What Ever Happened to Baby Jane? — famed actress Blanche Hudson was played by famed actress Joan Crawford (in the 1962 adaptation) and famed actress Vanessa Redgrave (in the 1991 adaptation); her fictional sister, famed (and then forgotten) vaudeville star Baby Jane Hudson was played by famed-and-never-forgotten Bette Davis in the original, and by real-life sister Lynn Redgrave in the remake.
- Forgetting Sarah Marshall — the eponymous title character is a famous for being an actress in weekly tv crime drama, played by Kirsten Bell, who became famous for being an actress in the weekly tv crime drama Veronica Mars.
- Lost in Translation — aging American movie star Bob Harris us played by aging American movie star Bill Murray.
- Galaxy Quest — former episodic TV star Tim Allen plays former episodic TV star Jason Nesmith (though Allen was a sitcom star and Nesmith was a sci-fi series star).
- No Strings Attached — former sit-com star Alvin Franklin is played by movie (and occasional TV) star Kevin Kline.
- Blazing Saddles, Broadway musical star Madeline Kahn plays the famous stage performer Lili von Shtupp, aka the "Teutonic Titwillow."
- In the movie version of Bewitched big star Will Ferrell stars as (washed-up, but still famous) movie star Jack Wyatt, who is looking to revitalize his career, which is why he's starring as Darrin in a revival of Bewitched. Highley lauded actress Shirley MacLaine also plays Iris Smythson, one of the world's greatest actresses of all time, who is also co-starring in the new series as the new Endora.
- Birdman — famous actor Michael Keaton (well-known for having twice played Batman in the 90s) portrays Riggan Thomson, a famous actor well-known for having twice played in-universe superhero Birdman).
- S1m0ne — Director Victor Taransky, played by Al Pacino, after falling out with famous actress Nicola Anders (played by Winona Ryder), finds and casts a Virtual Celebrity named "Simone".
- Repo! The Genetic Opera — Paris Hilton plays Amber Sweet, a bratty, surgery-addicted opera singer and Inadequate Inheritor to the CEO of GeneCo.
- V for Vendetta — Gordon Dietrich, beloved talk show host, is played by Stephen Fry, beloved panel show host. They even changed many aspects of his character compared to the comic to make them more in line with Fry.
Film — Biographical
- An upcoming biopic about George Romero, Dad of the Dead, will star iconic horror actor Robert Englund in the title role.
- Ed Wood — noted thespian Martin Landau played famous horror-film actor Bela Lugosi.
- In the biopic Chaplin, Robert Downey, Jr. plays the titular character.
- In the made-for-television film The Life and Death of Peter Sellers, the Academy Award-winning Australian actor Geoffrey Rush plays the famous English comedian Peter Sellers.
- In James Dean, James Franco plays the title role.
Live Action TV
- Entourage — B-list actor Adrian Grenier plays sometimes A-lister Vincent Chase (and, to a lesser extent, B-list actor Kevin Dillon plays C-list actor Johnny "Drama" Chase)
- Veronica Mars — once hugely famous star Harry Hamlin plays hugely famous movie star Aaron Echolls
- In the Friends two-parter The One with Monica and Chandler's Wedding, lauded character actor Gary Oldman plays lauded character actor Richard Crosby (and teaches Joey Tribiani to increase his dramatic range by spitting while speaking)
- 30 Rock — the stars of the show-within-the-show, TGS with Tracy Jordan, SNL alum Tracy Morgan plays Tracy Jordan, while Jane Krakowski plays Jenna Maroney; both characters are somewhat detached from reality due to their stardom
- The Dick Van Dyke Show — TV star Carl Reiner, well known from his appearances in variety shows, plays well known variety show host Alan Brady
- Gilligan's Island — knockout movie star Tina Louise played knockout movie star Ginger Grant; although ultimately four actresses played Ginger — a different one in the pilot (for which the character was not identified as a movie star), Louise throughout the series, and two others in later made-for-TV-movies, only Louise was already a genuine movie star when she took the part — and is generally regarded by fans as the real Ginger
- Californication — movie star Rob Lowe plays Eddie Nero, a deviant Brad Pitt expy.
- In the Star Trek: The Original Series episode "The Conscience of the King", longtime Broadway character actor Arnold Moss played Shakespearean troupe-leader Anton Karidian (who is in fact the disguised genocidal Governor Kodos of Tarsus IV).
- In the Babylon 5 episode "Day of the Dead", celebrity magicians Penn & Teller guest star as "Rebo and Zooty", who are basically expys of themselves. (Also, Harlan Ellison provided the "voice" for Zooty.)
- Hot in Cleveland invoked this in their promos for the series when it premiered; Wendie Malick certainly isn't a big A-lister or anything, but in promos, she acted like one, because the character she played was an egotistical and diva-ish former television star (much like Malick herself, and pretty much all of the castmembers of this show).
- In Extras, all the celebrity guest stars in play fictionalised versions of themselves, while sitcom star Ricky Gervais plays a fictional character, Andy Millman, who becomes famous as the star of the Show Within a Show When The Whistle Blows.
- In The Big Bang Theory, famous sitcom star Bob Newhart guests as Arthur Jeffries, Ph.D. (aka Professor Proton), a famous former host of a children's science show.
- In an episode of McCloud "McCloud Meets Dracula" John Carradine, an actor with a long history of appearing in horror films, plays Loren Belasco, an actor with a long history of appearing in horror films who has become convinced he's Dracula.