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- Preacher: Odin Quincannon runs the meatpacking plant that's a major source of income to the people of Salvation. We see little of how the plant's run day-to-day, but Quincannon is undoubtedly a depraved, corrupt little monster who buys off local politicians and is a card-carrying KKK member. And then there's what he's secretly doing with the meat in his private shed...
- In Tintin book Tintin in America a slaughterhouse along the Upton Sinclair's The Jungle style...
- The Texas Chainsaw Massacre
- In the original The Texas Chain Saw Massacre (1974), Grandpa Sawyer used to work in a slaughterhouse, before changes in technology either made him obsolete or freaked him out too much to continue working (most of his family seems to be a bit high strung, possibly due to inbreeding). This drove his family into cannibalism.
- The Texas Chainsaw Massacre 2 has the family turning an abandoned theme park into a giant Cannibal Larder. A character notices blood dribbling from drywall in the funhouse, kicks the wall open, and we're treated to a lovely shot of lights spilling out onto the ground.
- The Texas Chainsaw Massacre (2003). The Hewitts operate out of an abandoned (but, thanks to them, not disused) example.
- The Naked Gun has a chase scene inside a hot dog factory, where the bad guy falls into one of the vats. This sets up a Brick Joke during the scenes at the baseball game later, where everyone keeps finding body parts inside their footlongs.
- In Razorback, the Petpak facility, which doubles as a Nightmarish Factory.
- Queenshithe Slaughterhouse in Sherlock Holmes (2009), one of several businesses owned by Big Bad Lord Blackwood, which causes Holmes to remark that he's "had a hand in every business ruinous to the soul". Blackwood attempts to kill Irene Adler by handcuffing her to a Conveyor Belt of Doom which will deliver her through several flamethrowers and into a band saw, and is using the bellies of his pigs to manufacture cyanide gas as part of his plan for a mass assassination of politicians.
- The Midnight Meat Train features a serial killer who's a butcher at the local meatpacker's in his day job, and who applies his work technique to his murders. Clive Barker, who wrote the original short story it's based on, meant the disturbing imagery as a way of explaining why he's a vegetarian (and his queasiness towards big cities).
- Hannibal: Mason Verger is heir to a meatpacking industry in Baltimore, and it's made abundantly clear that he's a sadist and a child molester. The novel raises the possibility that the abysmal safety conditions in his factories led to the public being exposed to trace amounts of his workers' flesh (contrasting with Dr. Lecter, who takes care to prepare human meat exquisitely before he feeds it to people).
- The Jungle: The plant Jurgis works at (with most of his family). The first half of the book consists mostly of showing how bad the conditions in the plant are. Workers who are wounded on the factory floor get no medical attention (or fired if they can't keep working), nothing is ever appropriately cleaned, and one kid gets locked in after hours and is found the next morning, dead and covered in rat bite marks.
- You don't want to know what really goes on in the slaughterhouse in Matthew Stokoe's Cows.
Live Action TV
- The Architects sketch in Monty Python's Flying Circus, where John Cleese plays a hapless architect who has confused the purpose and intent of a luxury residential development - with an abbatoir. Cleese describes, with pride, an apartment block that will seek to slaughter its occupants in the most humane way possible, emphasising an awful lot of incidental Gorn. Brought to a halt by the consternation of the interview panel, he apologises: "Oh. I hadn't fully divined your attitude towards the tenants. You see I mainly design slaughter houses." To be fair, he does make a point of mentioning how comfortable the tenants would be before reaching the rotating knives, and the measures he would take to ensure proper sanitation. If not for his misapprehension concerning the tenants, it could well have been an aversion.
- Rupture Farms from Oddworld: Abe's Oddysee, Oddworld's largest meat factory and manufacturer of such products as paramite pies, scrab cakes and meech munchies (no longer available since the meeches were hunted to extinction). There's No OSHA Compliance, the Mudoken employees are treated like slaves and kept in line with beatings from the security guards, and the Bad Boss who runs it is secretly planning to butcher his employees and sell their meat as "Mudoken Pops" because the regular product lines just aren't appealing to customers as much as they used to.
- Invoked in Warcraft III, where the Slaughterhouse is the Undead building that produces Abominations (reanimated giants made of multiple corpses sewn together) and Meat Wagons (siege weapons that catapult rotting corpses into buildings and units for huge damage).
- The eponymous plant in Adult Swim Games Sausage Factory.
- The titular machine in Amnesia: A Machine for Pigs. Not only is it a filthy, bloody, kilometric slaughterhouse with a raving lunatic of a controller, but it's alive, it intends to pull a Mercy Kill on the entirety of humanity, crafts Manpigs out of still-living humans and intends to become a god by way of industrialized human sacrifice.
- There's the old American addage "Laws are like Sausage - if you enjoy them, it's best not to see how they are made." No one is quite certain if it's Meat Packers or Politicians who should be more offended by the comparison.