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Anime And Manga
- The Slicer Brothers in Fullmetal Alchemist—they were criminals/murderers in life, and were turned into an undead guard—one forms the head and the other forms the body.
- Hansel and Gretel of Black Lagoon.
- The Toguro Brothers.
- Luke and Jan Valentine in Hellsing who are Polar Opposite Twins while still both being psycho villains.
- Sakon and Ukon of Naruto. They're both sadistic, violent psychos, but hey, they have family values. Brothers stick together. In this case, to the point where they share a body...
- Kinkaku and Ginkaku fit as well. Two brothers who used to be respected in Kumogakure as Two Shining Lights. But they fell from grace and committed many horrible acts, and from then on, were seen as the worst criminals in Kumo history. Samui even stating she wants no affiliation with them. Both brothers feel lying and betrayal are great tactics. Both brothers kill Zetsu clones, who are their comrades, in battle when trying to get to an enemy, and neither seems to care that zetsu are caught in the crossfire. However, they are very close brothers who seem to respect and love one another. Ginkaku's most said word in his life is his brother's name, and when in trouble, he calls for his brother to help him. And Kinkaku flies into rage if anyone seriously hurts his brother.
- In the backstory of Darker Than Black, Hei and his little sister, Pai. She was essentially drafted as an assassin by The Syndicate, and her Badass Normal brother wound up tagging along out of protectiveness. Then she went missing in the Heaven's Gate incident and he somehow ended up with her superpowers, and things went downhill from there.
- In Magical Girl Lyrical Nanoha StrikerS, the twelve Numbers are sisters who are built by Jail Scaglietti and did many crimes for him. Most of them aren't actually evil, and eleven of them go to prison in the end while the last one died, but seven of them rehabilitate and four of them prefer to stay in prison. Since StrikerS Sound Stage X, three of them are working for the Saint Church now and the other four are adopted by the Nakajima family. Even though they have now a normal human life, all seven Numbers are still under (not so strict) observation, especially the eldest of them, Cinque, will have to work for the TSAB for the rest of her life.
- Earlier, Magical Girl Lyrical Nanoha A's has the Wolkenritter who can be considered as siblings since they have the same origin and are members of the Yagami family. They are working for the TSAB to atone their sins and crimes they had done.
- In Magical Record Lyrical Nanoha Force, the Hückebein family members consider themselves more as siblings than anything else since nobody of them fit the father or mother part.
- Sword Art Online: The serial killer "Death Gun" was actually two brothers and a third accomplice working in concert. The elder brother was an SAO survivor and member of laughing coffin. The younger brother has a Villainous Crush on fellow player Sinon. Both are sons of a doctor, with ample access to the drugs needed to commit the actual murders.
- Cross Ange: In episodes 9 and 10, Julio and Sylvia planned a trap to execute their sister Ange.
- Fenris (Andrea and Andreas von Strucker) in the Marvel Universe.
- The X-Men meet a lot of these: in the Silver Age Brotherhood of
EvilMutants and the Ultimate Universe version of same, it was the ambivalently villainous siblings Quicksilver and the Scarlet Witch; in the Acolytes, the successor to the Brotherhood, it was the Kleinstock Brothers; even X-Men Spin-Off team X-Factor once clashed with the siblings Slab and Thumbelina, who were usually on two entirely different teams of baddies.
- The X-Men meet a lot of these: in the Silver Age Brotherhood of
- In the Bronze Age, Captain America battled a pair of brothers, the Eel and the Viper, who were part of the first Serpent Squad.
- The Blood Brothers, a pair of minor alien villains in Marvel Comics, actually increase in strength the closer they are to one another.
- Spider-Woman and Iron Man respectively battled two pairs of villains called the Brothers Grimm, though only the second version are actually brothers—and twins, at that.
- Superman's demonic enemies Blaze and Satanus are brother and sister.
- Strontium Dog had two separate groups of these: The Weerd Brothers; Hiss, Cuss, and Silent, and the Creepy Mutant Twins known only as Stix.
- Disney Ducks Comic Universe: The Beagle Boys. Not just brothers but cousins as well, a whole extended family of crime.
- Judge Dredd: Dredd has frequently contended with the surviving sibling members of the Angel Gang, a clan of murderers from the radioactive wastelands beyond Mega-City One. In their first appearances, they were The Family That Slays Together.
- Invincible has recurring minor villains the Mauler Brothers, who are not actual brothers; they're clones.
- The Dalton brothers from Lucky Luke. They may not be especially competent, but they're determined to stick to their life of crime. They are the inept cousins of the historical Dalton brothers (another example of the trope), who appeared in a single early episode and were hanged at the end.
- Sin City: The Roark brothers, one a Senator and the other a Cardinal, don't seem to like each other much but they are still the heads of the most powerful and evil family in Sin City. There's a third brother mentioned who's an Attorney General, but he has never appeared.
- Minor Batman foes, the Trigger Twins.
- The Flash supervillains Captain Cold and Golden Glider are brother and sister and frequently team up together.
- In the Discworld of A.A. Pessimal, the Krayfish Twins run a mob operation in Ankh-Morpork. Ronnie and Reggie are feared for their ruthless qualities and general nastiness. But they love good floristry, chocolate and well-tailored clothes and accessories; Veronica and Regina Krayfish remain very feminine and stylish crime overladies.
- In The Vow we have as minor villains two leopard martial artists working with Haun's gang. They're revealed to be a brother and sister.
- Quentin Tarantino's storied universe has an interesting, somewhat unintentional subversion with Vic and Vincent Vega. Both characters are hardened criminals, Word of God makes it clear that they're supposed to be related to each other and have had a history together, but the two characters have never been seen together in movies. For a while, Tarantino was apparently working on putting together a Vega Brothers movie, but he ended up abandoning such a project around 2007 when he concluded that the principle actors, Michael Madsen and John Travolta, would be too old now to reprise their roles.
- Charlie and Mikey Burns in The Proposition
- The Gruber brothers, Hans and Simon, from the Die Hard movies. Like the Vegas, they're a bit of a subversion in that they turned up separately and apparently didn't like each other much in real life.
- In the Korean film The Crucible, Headmaster Lee Gang-bok and Admin Head Lee Gang-seok (who are Creepy Twins to boot) inflict horrific sexual abuse on the female students of their Boarding School of Horrors. Their adoptive sister, Yun Ja-ae, is also complicit in their crimes, and deals out plenty of (physical) abuse herself.
- In Face/Off, Castor and Pollux Troy appear to work together as this, based on a police file at the beginning that states that the two together are suspected of assassinating a Croatian ambassador (it reads "Number of hits suggests that Troy had a second shooter; possibly his younger brother Pollux").
- Lockout: The two inmates who lead the prison riot on the space station are two Scottish brothers, Alex and Hydell. It ends tragically with the Ax-Crazy Hydell murdering his own brother, who tried to take care of him.
- The Legend of Frenchie King: The fearsome gang of outlaws led by Frenchie King consists of five half-sisters. Frenchie King herself is the eldest sister. At the end they add another set of siblings consisting of four brothers and their eldest sister to the gang.
Live Action TV
- Buffy the Vampire Slayer: Adam views Riley as his brother (since they were both Professor Walsh's "favorites") and wants to be this with him.
- Criminal Minds
- The Hunter unsubs of the episode "Open Season" turn out to be a pair of brothers who abduct other humans, set them loose in the middle of the woods, and have a blast chasing and killing them. They basically get discovered due to the elder brother petting the dog (the younger is severely wounded when their prey fights back, and he starts a fire to signal for help), and this is actually somewhat made a point.
- "To Hell..."/"...And Back" had this with a horrible twist,one brother is quadraplegic, the other is physically able but seriously mentally impaired. The former manipulates the latter, who doesn't really know what he's doing, into all the crimes.
- My Name Is Earl Earl and his brother Randy, until Karma got to Earl. At one point Randy was expecting that after Earl finished doing all the stuff on The List they'd go back to stealing stuff.
- Day 3 of 24 has the Salazar brothers Ramon and Hector.
- Peaky Blinders is based on this trope. It's about the Peaky Blinders street gang, led by brothers Tommy, Arthur, and John Shelby… plus their aunt, The Consigliere.
- Monty Python's Flying Circus: The Piranha Brothers.
- Mr. Cain and Mr. Abel in "Meltdown", the Reservoir Dogs homage episode of The Pretender
- A "two brothers, one not all there" type is true of Ryan and Cyril O'Reily in Oz. Before Cyril's accident (which caused severe brain damage, leaving him in that state), they were a more typical example of the trope as described above.
- Danny and Albert Cho (respectively, Kamen Riders Spear and Imperer) in Kamen Rider Dragon Knight.
- Simon and River Tam in Firefly. In their case it was hardly their fault.
- A relatively rare positive version of this trope is sibling con artists Emma and Sean Kennedy in Season 5 of Hustle.
- Danny and Tony Driscoll in Only Fools and Horses and The Green Green Grass.
- Tales from the Crypt had a pair of brothers, in the episode People Who Live in Brass Hearses. Billy and Virgil Deluca. Virgil is handicapped, and usually just goes along with his brother. Billy is a hot-tempered and thuggish guy, who just got out of prison recently, having served two years. He insists that he and his brother are a team. He leans toward being a Jerk Ass. He has no problem with murder, and is prone to getting violent, even with his brother on occasion. But usually when he sees he has really scared, or upset his brother, he calms down and apologizes.
- On Justified crime tends to be a family affair so there are multiple groups of criminal siblings
- The Bennett brothers Doyle, Dickie and Coover help their mother run her marijuana business and act as her primary mooks in other criminal enterprises. Dickie and Coover occasionally pair up to commit crimes on their own.
- Boyd and Bowman Crowder follow in the footstep of their arch-criminal father Bo though their run their own independent criminal enterprises rather than teaming up. Bowman is killed before the start of the series so Boyd later teams up with his cousin Johny.
- The head of the Miami drug cartel likes to use two siblings, his own niece and nephew, to represent him for important deals.
- On Breaking Bad The Cousins are two twin brothers who work as hitmen for a Mexican drug cartel. Their cousin Tuco is a major drug dealer in Albuquerque.
- In "The Deductionist" Patricia Ennis was in on her brother Martin's plan to get back at Kathryn Drummond. She poisoned her liver so Martin could escape when donating his, and then tried to kill Drummond with a pair of scissors.
- In "Dead Man's Switch" Anthony Pistone killed Charles Augustus Milverton, so he and his brother could take over the blackmail business.
- Altered Carbon gives us secondary villain Dimitri Kadmin, also known as Dimi the Twin, who is his own brother. Not exactly a clone, Dimi uses the series' gimmick of creating a digital copy of his mind and personality to create illegal copies of himself in multiple bodies, known as double-sleeving. Though technically the same person, the copies consider themselves to be brothers. Series protagonist Takeshi Kovacs uses the same technique at one point, but doesn't consider his double to be a brother.
- The fourth Kitty Norville book contains a very nasty case of this. The sister is a skinwalker, a practicioner of one of the most evil kinds of magic. She killed one of her sisters to get the power. Her twin brother is a werewolf; she became a skinwalker essentially to keep him company when he turned wolf, with none of the drawbacks of lycanthropy. Both are muderous and out of control.
- Dave and Banjo Lilywhite in Hogfather
- In the second Circle of Magic book, the pirate queen Pauha and her chief mage Enahar are sister and brother.
- The Ashford Twins from Resident Evil – Code: Veronica—sister Alexia is the Big Bad of the game while brother Alfred is her devoted Dragon.
- Eventually subverted by Carlito and Isabela Keyes in Dead Rising. The two originally cooperate in a plan mostly Carlito's to turn all of America into zombies in vengeance for their Doomed Hometown. Isabela was actually conflicted about the whole thing and goes through a Heel–Face Turn shortly after meeting Frank. She tries to confront Carlito and tell him to stop the operation only to get a bullet in her shoulder for her trouble, and spends the rest of the game trying to do the next best thing by aiding Frank.
- Ace Attorney has Dahlia and Iris, although Iris was only trying to help her sister.
- Gol and Maia Acheron, the original Jak and Daxter's Big Bad Duumvirate.
- The Mendez Brothers in Grand Theft Auto: Vice City Stories.
- The Go-Rock Quads in Pokémon Ranger, each with signature bent-to-my-will Pokemon and matching musical instruments.
- Packie, Derrick and Gerry McReary from Grand Theft Auto IV are a non-antagonistic version.
- Knowing that their father used to be the gang leader and that their mother has a criminal record, too, qualifies the McRearys as The Family That Slays Together. The only person in the family without a criminal record is Kate and Francis(Though he is a corrupt cop).
- Wick features the Weaver children, a family of ghost children who work to murder the player over the course of six hours.
- Ashlynn Harris and her half-brother Jake Myers from Strange Little Band fit this trope more than that of the Sibling Team inspite of being protagonists. For example one of their escapades is non-consensual experiments on humans with recreated alien technology. Once their parents get over their personal issues the entire family becomes The Family That Slays Together.
- Icee and Flare from Waiting For A Miracle.
- Hyena and Jackal in the cartoon Gargoyles.
- Tomax and Xamot from G.I. Joe.
- Young Justice has the Tommy and Tuppence, aka the Terror Twins, and another set of twins, Mammoth and Shimmer.
- Who can forget the Beagle Boys from Disney's DuckTales?
- The Powerpuff Girls has the Rowdyruff Boys: Brick, Boomer and Butch.
- The Wu Sisters in Kung Fu Panda.
- Small-time tech thieves, Evan and Myles of Transformers: Rescue Bots.
- Frank and Jesse James
- The James-Younger Gang had several sets of siblings
- Cole, Jim, John, and Bob Younger and their Brother-in-Law Bill Chadwell AKA Bill Stiles
- Robert and Charles Ford (Joined the James Gang after the Younger Brothers were arrested and Bill Stiles killed at the Northfield Bank Robbery)
- William (Bud) and Thomas Mc Daniels (Thomas did join after Bud was killed)
- A heroic version of this Trope were Hans and Sophie Scholl, members of the anti-Nazi White Rose resistance movement in Germany who printed pamphlets denouncing the ongoing Holocaust.
- The Krays, subjects of a movie by the name, twin London gangsters famous in the 60's.
- The Richardson Brothers ran the other half of London and there were frequent turf wars.
- The Dougherty family—Ryan, Lee and half brother Dylan were wanted for an alleged bank robbery in Georgia and the attempted murder of a Florida police officer.
- The main strength of the Loomis Gang was the sons… and some daughters… of the family patriarch and matriarch, who were both reputedly criminals themselves.