Sibling Switch Squick
Let's say the main character's name is Alice. She has a brother named Bob. The creator writes a new series with a totally new character, also named Alice. Alice's love interest in the story just happens to be named Bob (or look exactly like him, or act like him), and even though they're new characters, it still causes a Squick reaction. Compare and contrast Brother-Sister Incest and Twincest, which don't even bother with the Expy bit.
- Lana Lang and Superboy, based on one cover on Superdickery.com, were siblings in one story, when in almost every other, she's his love interest.
- In the original Italian Martin Mystere comics, Diana was Martin's love interest, but in the French Martin Mystery cartoons she's his stepsister. Granted, they're Not Blood Siblings, but it's still pretty unnerving.
- Stephen King's Desperation and The Regulators, depending on which you read first. Either way, the Carver family from one version of the story reverts who are siblings and who is married. In other words, David and Kirsten/Pie would be brother and sister in Desperation, and their parents Ellen and Ralph, but in The Regulators, they're married, with Ellen and Ralph now their children.
- Toward the end of Arrested Development, Tobias starts dating a woman(?) named Michael. He doesn't seem to mind that this is also the name of his brother-in-law.
Buster: I'm leaving my mother for you. You're replacing my mother.
- Also, early on in Arrested Development, Buster dated a woman named Lucille, although it became increasingly apparent that he was using her as a stand-in for his mother Lucille, since "Lucille 2" was his mother's age and a close friend of hers.
- Variation in Scrubs. Dani dates a boy named Danny briefly, confusing other characters into thinking she shouts her own name during sex.
- Inverted in Wizards of Waverly Place. Alex and Justin were originally going to be bickering best friends, before being made siblings with a whole lot of Relationship Writing Fumble.
- In Dirk Gently's Holistic Detective Agency, Richard's in a relationship with Susan Way, sister of Gordon Way. In the TV series Dirk Gently, Richard's in a relationship with Susan Harrison, Gordon Way's ex-fiance.
- In Tensou Sentai Goseiger, the Black and Yellow Rangers are a Brother-Sister Team. In its American version, Power Rangers Megaforce, they're unrelated high school students and Black is always trying (and failing) to get a date with Yellow.
- A variation in an episode of The X-Files reveals that Mulder and Scully's souls always reincarnate into two people who have a close relationship, but there's no telling what relationship that might be, and they inevitably turn out siblings on a few occasions. In one incarnation that's described in particular detail they are father and son (and it's not clear who is which). It's pretty bizarre to think about.
- In the original minicomics that came packaged with the Masters of the Universe action figures, the bird-man Stratos has a human wife named Delora. In He-Man and the Masters of the Universe (1983), Delora is the name of Stratos' bird-woman sister. The 2002 cartoon corrected this by naming Stratos' sister Hawke, after an one-shot bird-woman from the 80's series, thus taking the squick factor away.
- The relationship between Mega Man and Roll differs from series to series. She is treated like his younger sister in the original series, a protective older sister in Mega Man Legends, and a love interest in Battle Network.
- In the Battle Network series, Rock is his human Operator's dead twin brother. This relationship does not exist in the anime. The two are shipped. It is about as squicky as it sounds.
- If you read Roll's Diary at the end of Mega Man Legends 2, Roll admits that she's in love with Mega Man.
- Due to the nature of the Legend of Zelda mythos, with several generations of Links and Zeldas with different relationships, this comes into play in installments when their relationship seems more romantic, while in others it comes across as familial (especially due to a translation of the SNES game making gamers believe she is Link's sister.)
- The Sims pulled this in reverse when The Sims 2 was released, with the new Family Tree feature which revealed that Bella Goth and Michael Bachelor were brother and sister - squicking out any player who'd had Bella leave her husband and marry Michael in The Sims 1.
- There's also Fran and Freddie Foofaraw in the first Sims game for console, who look very alike and are usually taken to be brother and sister... except for the fact that Fran's bio in the official game guide refers to Freddie as her "hunk". This sort of thing happened a lot in the first generation of Sims games due to the lack of formal family trees.
- The trope gets Inverted a couple of times in Veronaville, the town in The Sims 2 which is loosely based on a number of Shakespeare plays: Beatrice and Benedick are named after romantic leads but are twin siblings in the game, while Romeo and Mercutio go from being best friends with lots of Ho Yay undertones to brothers.
- It's a bit disconcerting to start on Safe Havens because you're a Kevin & Kell fan and discover that the geneticist with big hair is in a relationship with the dyslexic sports star who always wears sunglasses. The two K&K characters by those descriptions are only step-siblings, but still.
- Referenced in Roomies! with Joe's reaction to a change in Walt Disney's Hansel and Gretel.
- In the comics Minnie Mouse has an Uncle Mortimer Mouse, but in the cartoons Mickey's rival for her affections is an obnoxious cretin also named Mortimer Mouse (he's called Montmorency Rodent in the comics). In Mickey's Once Upon a Christmas, Mortimer Mouse is the name of Minnie's boss. What's more confusing is that Walt originally wanted to name Mickey "Mortimer", and that in the comics Mickey has a nephew named Morty, short for (what else?) Mortimer. No switching with siblings here...just everybody else.
- In the original Marvel comics, Silver Samurai and Mariko Yashida were half-siblings. Their Wolverine and the X-Men versions are a married couple.
- In the original Superfriends cartoons, Marvin and Wendy were apparently just friends. When they got adapted into the comics, they became fraternal twins. In Young Justice, they're back to being friends, and have a Relationship Upgrade by the finale.