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Unconscious, Dead, and Inanimate:
Anime & Manga
- Black Butler: Victims of Drocell's Puppet Permutation.
- Chobits (anime only): In the title sequence, a robot girl opens her eyes which are quite human, complete with gleam and detailed pupils. Then the Art Shifts so that they fade into her usual flatter brown irises with little glare. After that everyone's eyes are depicted this way. In the last episode, every robot gets normal-looking eyes during a worldwide upgrade.
- After Alfons is shot in Fullmetal Alchemist: The Conqueror of Shamballa, his eyes quickly turn a dull colour.
- Hunter × Hunter: Used when Neon Nostrade makes prophecy through automatic writing. For some reason, Chrollo uses the same superpower without affecting his eyes (except in the first anime).
- Kemono Friends: Little Bit Beastly Friends born from endangered or extinct animal species like Crested Ibis or Aurochs don't have eye highlights. Also, Kaban's eyes go dim upon hearing her species' alleged extinction.
- Mahou Sensei Negima!: Chachamaru is drawn with less detailed eyes (ranging from "less shiny" to "flat") to emphasize her robotic nature, and her puppet sister Chachazero consistently have no light in her eyes.
- Yu-Gi-Oh! 5D's: Bruno/Dark Glass has these naturally. It's a hint to the fact that he's actually a Ridiculously Human Robot.
Anime & Manga
- Armed Girl's Machiavellism: Tsukuyo Inaba's eyes are a dim brownish-red due to her blindness.
- Black Butler: Ciel's eyes go dull when blinded in the Emerald Witch Arc.
- Marin in Brigadoon: Marin and Melan after literally going Blind Without 'Em, though her eyes return to normal as long as she wears 'em.
- Cowboy Bebop: The only detail in Stella's blind eyes is a black-to-gray gradient.
- The titular character of Cutey Honey, when blinded by scales of a butterfly monster.
- In Fullmetal Alchemist, Roy Mustang has these (combined with Milky White Eyes in the manga) after a forced Equivalent Exchange costs his eyesight.
- Future Diary
- Minene Uryu's injured left eye is depicted as having a lusterless, crumpled iris.
- Tsubaki Kasugano has poor eyesight, being unable to see more than a few meters.
- Madoka Otowa, the Blind Musician from Get Backers.
- Hunter × Hunter
- Komugi keeps her blind Eyes Always Shut, except when she plays chess with these eyes.
- Pairo has these eyes, indicating his visual impairment.
- After Inuyasha gets his right eye gouged out, he regenerates this eye until it becomes fully functional.
- Inuyasha again, when blinded by the poison from Sesshomaru's claws.
- When Laguna Granscenic in Magical Girl Lyrical Nanoha StrikerS finally removes her eye patch (after having been accidentally shot in the left eye), we see that the eye under it is dull and unfocused. It is never indicated explicitly, however, whether this means that even the advanced medicine on Midchilda cannot restore lost vision, or that she has, in fact, received a cybernetic replacement eye.
- The Prince of Tennis: This signifies that Yukimura has taken away the opponent's sense of sight.
- Sket Dance: Sasuke Tsubaki's eyes lack highlights, signifying his poor vision.
- Amagi Brilliant Park: In the light novel and manga, Latifa Fleuranza's eyes have flatter irises and less light than the other characters.
- In Another World with My Smartphone: Ellen, the wife of the Duke of Belfast, had been blind ever since contracting an illness five years in the past. Her eyes are dull and non-reflective at first, until the protagonist uses magic to restore her vision, and they gradually return to normal.
- Asura Cryin': Rikka Kurasawa loses her vision in one eye near the end of the series, and it becomes dull-colored and non-reflective.
- Jayfeather from Warrior Cats has reflectionless blue eyes. He was born blind.
- A Game Of Chance: Matthias Cline's eyes are blank and unmoving.
- Toph from Avatar The Last Air Bender has these eyes to show she's blind.
Inhuman and Nonhuman:
Anime & Manga
- Assassination Classroom
- Looking closely, Blood Knight Karma's eyes lack the shine his classmates have. Also, his eyes are drawn a little wider, making him appear just a bit... off compared to the others.
- Asano Sr. and Jr. lack any glimmer in their eyes, presumably to make them look more focused and ruthless.
- Vestals from Bakugan are different from humans by their eyes, because they have a colored pupil and no shine.
- Black Jack: When a patient notices that doctors, nurses and his mother are acting strangely, he starts seeing them as having these eyes. Instead of alien possession as he's convinced, it turns out his disease is so serious that everyone is hiding this information from him. Ironically, the attempted aversion of Lethal Diagnosis makes him become paranoid, almost killing him. Once the secret is disclosed, their eyes return to normal.
- Jeri Katou in Digimon Tamers has these while she is behaving oddly. However, this "Jeri" is actually a clone constructed from data.
- El Cazador de la Bruja
- Ellis whenever she manifests her powers.
- L.A. on several occasions as Mind-Control Eyes.
- Freezing: Nova eyes, if they have humanoid eyes at all, glow so much that they overwhelm the light reflection. Pandoras get the same eyes if the Nova tissue in their body affects them too much.
- InuYasha: Half of the Big Bad Naraku's incarnations have glazed eyes.
- Majin Tantei Nougami Neuro: When Neuro, a demon, takes human form his swirly eyes have no highlights; though he frequently pretends he's an ordinary man with ordinary eyes.
- Mahoraba: The Occult Research Club President's irises are entirely black.
- Mahou Sensei Negima!: The demonic eyes of Zazie Rainyday and her sister.
- Mobile Suit Gundam SEED: People surpassing their physical and mental limits ("SEED mode") exhibit dull, expanded irises and constricted pupils.
- Morita-san Wa Mukuchi: Mayu Morita, the titular Quiet One, has "the eyes of frozen squid".
- In Phi Brain: Puzzle of God, the Friendly Enemy Rook frequently lacks highlights in his eyes. The Mood Whiplash comes after he and the hero spend an episode hanging out together, when he thanks his friend for the day with the highlights fading as the sun sets, and challenges him to the final battle. Averted after his Heel–Face Turn.
- Pani Poni Dash!: It's as if Ichijou's flat brown eyes let nothing in or out; she is always emotionless about everything happening around her, and we don't get to see what's happening inside her Chaotic Stupid mind.
- The Prince of Tennis: When doubles players "synchronize" with each other and play as one, their eyes turn gold with no pupils.
- The Buff Clan in Space Runaway Ideon look identical to humans, with the exception of their eyes.
- Several Tengen Toppa Gurren Lagann characters get spiral-shaped eyes at various points when they're utilizing massive amounts of Spiral Power.
- Turn A Gundam: The Moonrace's eye reflects light less often than the Earthrace's. This serves as a way for the audience to distinguish Dianna and Kihel when they switch places.
- Yondemasu Yo Azazelsan: Akutabe, a devil summoner with cold eyes who even devils are afraid of.
- Pokémon Black and White: N is truly good-intentioned, but his non-reflective eyes are a sign that something isn't quite right. Indeed his world view is heavily distorted, because he has a strange personality and his father has been misleading him with biased information. In a trailer for Black and White 2 after he is freed from the latter, his eyes have sparkle—still, the former reason alone is enough for him to retain these eyes ingame.
- In Pokémon X and Y, Hex Maniacs have, well, maniacal eyes.
- Monsuno: Master Ey has flat green eyes, indicating his otherworldly knowledge.