"I will rebuild what the many have lost. I will create a future with limitless possibilities.This character has been hit with a Viral Transformation, Emergency Transformation, become a cyborg, demon, magical creature, alien or discovers they were never human at all. Despite this, and regardless of any angst over What Have I Become?, they decide that rather than go down the path of Transhuman Treachery and be a Smug Super, Black Shirt, or The Quisling, they will do everything in their power to stay a part of humanity. And if their new species/transhuman fellows are anti-human, they will vow to protect humanity in a pseudo Faustian Rebellion. This can also include transhumans who cast themselves in a shepherd-like role for mankind. This doesn't include forcibly applying What Measure Is a Non-Super? to bootstrap humanity up, though. That's more of a Visionary Villain who believes Utopia Justifies the Means. Many Friendly Neighborhood Vampires fall in this category. If the transformation is due to The Virus, this requires copious Heroic Willpower. These characters can usually pull off a Sheep in Wolf's Clothing gambit. See also Monster Adventurers. Related to My Species Doth Protest Too Much, which refers to creatures that aren't former humans. Opposite Trope to Super Supremacist, a superpowered individual who regards the non-superpowered as beneath them. Super Trope to Vampire Refugee and Phlebotinum Rebel. Contrast Transhuman Treachery. See also/compare A God I Am Not.
I will protect and sustain. I will act as guardian for the many.
And throughout it all, I will never forget.
I will remember the ones who sacrificed themselves so that the many could survive.
And I will watch over the ones who live on. Those who carry the memory of the man I once was.
The man who gave up his life to become the one who could save the many."
I will protect and sustain. I will act as guardian for the many.
And throughout it all, I will never forget.
I will remember the ones who sacrificed themselves so that the many could survive.
And I will watch over the ones who live on. Those who carry the memory of the man I once was.
The man who gave up his life to become the one who could save the many."
— Commander Shepard, Mass Effect 3 note
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Anime and Manga
- In Attack on Titan, Eren is a human who can transform into a Titan. He is firmly on the side of humanity unlike the other Titan Shifters, who are either The Mole, or, in case of Ymir, a Heel–Face Revolving Door.
- In Claymore, the eponymous warriors are Half human half demons who choose to fight for humanity's sake. Just about every one who finds out that the organization which transformed them does not have the best interests of the citizenry at heart ends up going rogue.
- In Silent Möbius, some Type 4 Lucifer Hawks ( Rally and Katsumi!) raised as humans decide to serve humanity.
- The protagonist in Blue Gender has a "disease" called B Cells which are a form of Gaia's Vengeance. It's intended to cause humans to rebel against their peers and go kill crazy (which it does spectacularly to two other characters). He manages to stay sane despite the various hardships Gaia and humanity throw at him.
- Ayato in RahXephon is part Mullian (basically a human subspecies with blue blood) and when his Mullian blood manifests, there's concern he'll pull a Face–Heel Turn and join the Mullians, but he remains a nice guy on the side of his friends.
- Schwartz Bruder in Mobile Fighter G Gundam is this. He is a dead body occupied by the DG (Devil Gundam) Cells to live. Despite being made up by the cells of the Big Bad, he is the Devil Gundam host Kyoji Kasshu's physical manifestation, driven to save his brother and stop the Devil Gundam.
- In Hellsing:
- While most vampires revel in their non-humanity even if they fight for humans, Seras does everything in her power to remain as human as possible without neglecting her duties to the organization... which involve drinking blood so that she can use her vampiric powers to kill vampires that threaten humanity.
- Alucard's a weird case. He'll gleefully slaughter ordinary humans just for being ordered to attack him, but he also believes that monsters like himself are, in truth, weak because they could not bear to live mortal lives. He believes firmly that humans are the only ones who could ever truly defeat him, the way Abraham Van Helsing and his companions did in the past. Thus he has a loathing for humans who choose to become monsters for the sake of power, especially the power to defeat him.
- In Nightwalker, Shido, a vampire, defends humans from the nightbreed. He apparently has been a vampire for a long time and at first he was not so friendly to humans, but later changed his mind.
- In Trinity Blood, Abel Nightroad is a Cruznik, a being that feeds upon vampires (and is thus two steps above humans in the food chain). That doesn't stop him from devoting his life to defending humanity, and using his relatively harmless default form to masquerade as a normal human. He is an interesting example of a Pro-Human Transhuman in that he was a Designer Baby and thus born a transhuman. He was also originally quite anti-human.
- Kira in Mobile Suit Gundam SEED is accidentally this, being a Coordinator fighting for an army consisting entirely of Naturals (in a war started to exterminate his kind!). Not really his intention: he only fights to protect his friends. When it's revealed that both sides have genocidal intentions, he and his girlfriend, Lacus, form the Three Ships' Alliance, which includes deserters from both the Natural and Coordinator armies, and want an end to the war. Naturally enough, several other Pro-Human Transhumans, including Lacus, Athrun, Dearka, and the Desert Tiger, end up in this faction.
- Amuro Rey of Mobile Suit Gundam upon discovery and confirmation that he is in fact a Newtype argues that this does not make him special or any better than anyone else on the White Base crew. Even later on in Mobile Suit Gundam: Char's Counterattack he outright says he is not going to force humanity to change and has faith that humanity can improve on its own.
- This is invoked in Tiger & Bunny as all of the Heroes are trans-humans called NEXTs with extraordinary powers which they use to save people and stop crimes, all of which are recorded by Hero TV for people's entertainment.
- Most of the characters in GUNNM / Battle Angel Alita, largely justified by the fact that, because the percentage of Hollywood Cyborgs in the setting is roughly equal to the percentage of the Americans owning cars, the question of What Measure Is a Non-Human? simply doesn't come up. It is still played straight in cases of Caerula Sanguis and the protagonist, though. In fact, even Aga Mbadi is in it just for the world domination.
- The sequel to Tokyo Ghoul has the members of the Quinx Squad, all experimental Half Human Hybrids created as a new potential weapon for CCG to use against Ghouls. Their existence and usage is controversial, with many other investigators expressing unease about the organization performing human experimentation and blurring the line between humans and Ghouls. In particular, team leader Haise Sasaki was transformed into a Half-Ghoul against his will and made the decision to use his new-found powers to protect humanity. Or rather, after Ken Kaneki was fatally wounded and lost his memory, CCG took him in and studied him before putting him to work as a potential trump card. As such, it isn't clear how genuinely "pro-human" he is.
- Blade chooses to use his vampiric abilities as a Dhampyr and daywalker to hunt vampires.
- In the original 30 Days of Night, sheriff Eben purposefully infects himself with vampirism and manages to save the survivors with his newfound strength. He then kills himself since he can feel the bloodlust coming on and knows he can't maintain his original self for much longer.
- The second comic series, Dark Days, has an originally less-than-nice vamp pulling a gradual Heel–Face Turn (at first helping Stella out purely for revenge against the Big Bad, but later on out of genuine feelings for her); by the end of the story, he doesn't even try to feed on her, despite having the perfect opportunity, which is saying something as vampires in that 'verse are pretty much all bloodthirsty (in both senses) Always Chaotic Evil sociopaths from the moment they're turned, even if they were dedicated vampire killers just before. Unfortunately, after his resurrection, vampire!Eben is not quite so inclined...
- Hellboy is a half demon fighting demons for humanity.
- The X-Men are a whole organization of mutants who behave this way.
- DC Comics hero Metamorpho.
- Michael Costner and Sasha Bordeax, two of the OMACs in the post Infinite Crisis continuity.
- Sasha Bordeaux, formerly a Batman companion and then part of Checkmate, was infected with the O.M.A.C. nanovirus to become a more advanced O.M.A.C., with enough free will to coordinate and command the other units. That enables Sasha to rebel, destroy Brother Eye and later reclaim a less advanced, but more useful and human-like cyborg form for herself.
- Michael Costner, a young thief and grifter is activated as a regular powered O.M.A.C. unit to help rebuilding a thrashed Brother Eye. A peculiar combination of guilt for his past as a common burglar, lack of self worth, his earlier bout with drug addiction and The Power of Love enable Michael to shake off his programming and fight against Brother Eye for the sake of the world and his girl. In the end, while his pregnant girlfriend Vienna acquires his very same powers and rushes to his help, she dies and with Brother Eye deactivated, Michael loses access to his powers. In a bittersweet ending, Clark Kent manages to have Michael and Vienna revered as heroes and saviors of the human race.
- The Thing of Fantastic Four.
- Dr. Manhattan in the beginning of Watchmen. Though this is actually his main character arc— he becomes less and less so as the story goes on, eventually getting to "Why would I save a world I no longer have any stake in?". By the end, Silk Spectre II must convince Dr. Manhattan that humans lives are worth protecting. It's the revelation that her father is The Comedian that does it - realizing the sheer improbability of human life is enough to restore his interest in protecting it.
- Just about every superhero ever, or at least the ones that aren't space aliens or Badass Normals.
- Gunn in Angel: After The Fall (a direct sequel to the Angel series). He is determined not to become a monster and continue being a hero, though he's really trying to prove he's better than Angel, who he blames for letting him get turned.
- The Confessor in Astro City is a Batman-like hero who is secretly a vampire. He wears a cross as his Chest Insignia so the constant pain will help distract him from his thirst. After he's destroyed, his sidekick is surprised to find the Cross Breed, a local Christian super hero team, mourning him; they assert that as far as they're concerned, he was always doing the Lord's work.
- Shinichi of Experiment is turned into a cyborg by Ai, but because he's the only one around, he has to do the masquerade and try to be as human as possible.
- The shinigami of Vathara's Project Tatterdemalion are Super Soldiers made this way through a live virus vaccine against a superbug, giving them Combat Tentacles, venom, Absurdly Sharp Claws, an EMP-based Starfish Language, Super Strength, Flash Step, destructive psychokinesis, a loneliness that can only be alleviated by staying near the pack, a Healing Factor that works fast and a bad case of Cuddle Bug. Because The Republic does not allow Bio-Augmentation, they are UnPersoned.
- Adam Jensen in Mass Effect: Human Revolution is this trope even more than he was in Deus Ex: Human Revolution, to the point where Hein means to use him to force humanity as a whole into a Heel–Face Turn
- "I'm going to turn Jensen into the most powerful human being in the Galaxy. I'm going to make the rest of mankind turn green with envy and stew in their jealousy as Jensen comes to their rescue, again and again and again, and go mad when he fails to turn into the monster they all expect him to become. "
- Even though literally all humans in the Pokeumans universe are sleeper agents for Pokextinction, the members of the Pokeumans organisation are still determined to protect them from people who have no scruples with using the new powers of their transformation freely and dangerously. It doesn't help that Pokextinction's plans towards their said sleeper agents are callous at best and Kill 'em All at worst.
- David Bowman in 2010: The Year We Make Contact. Transformed into a demigod by the Monolith, one of his first acts after awakening in his new form is to say goodbye to his wife and mother, as well as sending a warning to the crew of the Discovery for them to evacuate the area around Jupiter immediately before the Monoliths turn it into a star.
- Juxtaposed with Transhuman Treachery in Captain America: The First Avenger: Johann Schmitt believes that Erskine's Super Serum has elevated him above humanity, while Steve Rogers takes Erskine's understanding of the serum to heart - as it enhances everything a person is, Rogers states that the Serum simply made a monster such as Schmitt more monstrous, while he sees his enhancement solely as a greater responsibility towards his fellow man.
- Lucy: Protagonist Lucy is exposed to a Super Serum which vastly expands her mental powers, but which will surely kill her. She searches for a way to record her new-found knowledge for the common good before she dies. Features more shooting and shouting than you might think from that summary.
- Defied in Ultraviolet, where a human tries to reason with the not-vampire heroine, saying she was human once, too. She dismisses it, saying that humans were who made her that way and then wanted her dead, so she owes them no loyalty.
- The Brotherhood is presented this way in Perfect Creature. They are an all-male order of vampire monks that are perceived as superior to humans in every way (stronger, faster, smarter and long-lived) therefore closer to God, but are nominally sworn to guide and protect them and have managed to live in peace and prosperity with humans for centuries, surviving on willingly donated blood by church goers, and they consider abhorrent to drink directly from the body. However, its revealed that they are corrupt in many ways, such as subtly keeping mankind dependent on their rule by outlawing scientific research, and being indirectly responsible for the main villain's actions by practicing it in secret: in a effort to produce more vampires after no new ones being born in decades, they commission the Big Bad to perform experiments on the virus that ends up infecting him and driving him insane.
- Terry Pratchett's Discworld:
- In Thief of Time, the character Myria LeJean is an Auditor, an enemy of humanity, but upon taking human form she realises what it is she seeks to destroy and becomes opposed to her own people, in defence of humanity.
- In Snuff, the Dwarvish demonic entity The Summoning Dark, vanquished by Sam Vimes, becomes his ally in the cause of law and order.
- Also, DEATH himself is fond of people, and on more than one occasion actively defends them. His granddaughter, Susan Sto Helit, is a straighter example since she actually IS human, but inherited some of her grandfather's traits and abilities. She's also his most reliable ally in protecting the people of the Disc from the Auditors of Reality.
- In Fred Saberhagen's Berserker stories, Hilary Gage, an artificial intelligence designed to mimic every aspect of the human thought process, continues to think of "himself" as human, at least with respect to interstellar politics, despite being very much aware of the fact that "he" has no biological body parts. Later, he downloads himself into a berserker warship's central AI, and has to make sure he maintains enough control to prevent the warship from continuing its fight against humanity.
- In Old Man's War, the CDF consists almost entirely of elderly men and women downloaded into genetically enhanced pseudo-clones (the rest is even less human). During boot camp one guy asks why they're bothering to defend baseline humanity when their new bodies are the next step in human evolution. Sergeant Ruiz tells him he couldn't be more wrong, all the alien DNA in their genomes makes them sterile and thus an evolutionary "dead end". In fact one of the reasons for the advanced enlistment age is so most of the recruits would have grandkids back home they would want to protect from baby-eating aliens.
- In Karen E. Taylor's Vampire Legacy series, Vampire Detective Dierdre prefers working with humans to other vampires, despite the Fantastic Racism that carries.
- In Larry Niven's Known Space Pak Protectors evolved to be this, they are hardwired to protect their descendants no matter what, however they will attempt to exterminate any other sapients including other Paks (except for the rare few whose descendants are all dead and have dealt with it by protecting the whole species), and will even kill their descendants who have mutations. Humans evolved from a Lost Colony of Pak Breeders and have differentiated so far that Pak Protectors will destroy them if given the chance, however humans can become Protectors and are intelligent enough to rationalize that they should protect all of humanity. Unfortunately this includes using the virus that causes Protector transformation on an entire planet to kill off everyone too young or too old to become a Protector and create an army of childless Protectors to fight off the coming Pak invasion fleet.
- In the Revelation Space Series, the Conjoiners are a faction of Transhumans who use advanced nanotech to enhance their minds and physiology. When they learn of the Inhibitors coming to destroy humanity they make preparations to flee, leaving the "baseline" humans to their fate. However, their nominal leader, Clavain, defects in an attempt to warn human space of what's coming. Captain John Armstrong Brannigan also became a pro-human transhuman after he becomes one with his starship and got over his repeated attempts to kill himself, cooperating with Ilia Volyova to try and save as many people from Resurgam as possible before the Inhibitors blast it with a directed solar flare.
- The Great Ones in Belisarius Series embody this trope, being all for freedom, diversity and free adaptation of the human race to the new circumstances, while their archrivals the New Gods are Politically Incorrect Villains bent on racial purity and conformism.
- This is the case in stories written by Greg Egan, thereby justifying how transhumanism led to utopia rather than some sort of crapsack Feudal Future— apparently the process causes those who undergo it to become more empathetic than baseline humans, meaning that the first transhumans worked selflessly to peacefully uplift everyone else to their level instead of exploiting or subjugating them.
- The trope is downplayed in Diaspora in the treatment of the statics, people who remain baseline humans rather than accept any Bio-Augmentation, cybernetics, or Brain Uploading. Their choice is respected and their communities protected, but most individuals disregard them as being backwards, short-lived, and absurdly limited in their capacity for experience. When the Earth is scoured by a gamma ray burst, a few AIs try to save them by forcibly uploading as many as possible, others offer assistance on the statics' terms, and many have no qualms about standing back to watch the organics' self-righteous principles come back to bite them in the rear.
- Mira of The Accidental Superheroine, chooses to side with humanity rather than Orlov, although she has the occasional second thought about it when government organizations attempt to capture her for experimentation.
Live Action TV
- In Being Human the three main characters are a vampire, a werewolf, and a ghost who still care about humans and are trying to live as normally as they can.
- This happens a couple of times in the new Doctor Who:
- This happens a lot with Cybermen who haven't been 100% perfectly converted.
- Similarly, Oswin Oswald and Tasha Lem resisted Dalek conversion and helped save the day.
- In "The Pandorica Opens", Rory Williams' Unexplained Recovery as a Roman soldier despite being erased from history is discovered to be because he was really an Auton duplicate and Manchurian Agent implanted with Rory's memories. Despite being forced to shoot Amy when his programming briefly took over, his genuine love for her allowed him to break his programming and he vowed to spend the next 2000 years protecting the Pandorica with Amy inside until she could be safely revived. And he did.
- Kamen Rider series does this as a tradition. For instance, the original show (also named Kamen Rider) involves the main character becoming a Shocker cyborg monster, but he didn't lose his humanity and used the same transformation to fight the Shocker creations.
- In Kamen Rider 555, Orphenochs are supposedly the next evolution of mankind, and the evil organization forces them to attack normal humans (in hopes of siring more Orphenochs. However, about one in a hundred can be transformed; most just turn to dust.) Some just go nuts on their own. However, there's a trio of renegade Orphenochs living together Being Human-style. The Rider suits were created by the bad guys, but are not themselves part of the transformation, though for the main Rider, it turns out there's a very good reason he can use a Transformation Trinket that isn't supposed to work for humans.
- Pretty much all the series more or less follow the same idea of their ability to transform being related to the villain of the show.
- Teen Wolf does this. Scott. He cares deeply for humans and innocents, even trying to protect the Argents when possible. In contrast Derek is fine offering the "gift" of Lycanthropy to those who crave it, outcasts, the ones who are emotionally damaged and with health problems. Scott is particularly upset at this because of the active hunting werewolves face, making that much more likely the new converts die... Assuming they don't kill someone first.
- The Vampire Diaries has Stefan. Even though he is a vampire, he still tries to retain his humanity as much as possible.
- Elena as a vampire. She still retains her compassion and empathy even after she turned.
- Supernatural has Sam when he was temporarily soulless, he still dedicated his life to hunting (though a bit differently) and still seemed to care about pleasing his brother.
- MasterBook RPG The World of Species, based on the film Species. Humans are injected with some of Sil's DNA, causing them to gain some of her abilities. This allows them to hunt down and destroy Sil's progeny, but they have alien thoughts and personality traits generated by the DNA in their systems.
- Dungeons & Dragons supplement Knight of the Living Dead. A lich brings a paladin of Torm back from death as an undead creature. The lich orders him to gather magic items to help the lich conquer the city of Waterdeep, but instead he decides to fight against the lich's forces and protect the inhabitants of the city.
- Especially in the d20 fork, there are a lot of transhuman options (of varying degrees of alteration from the base norm) available for good characters (good, of course, being by its nature opposed to a lot of the classic symptoms of a Super Supremacist).
- In Warhammer 40,000, every Space Marine is a bioengineered Transhuman, yet they serve humanity with zealous ferocity. It helps that the transformation, and the very reason they exist, is explicitly to protect humanity better. Of course their methods of protecting humanity include ruthlessly exterminating anything that isn't human. note
- It does actually vary by Chapter to Chapter on whether they're the protectors of humanity or the executioners of the Emperor's enemies. Some of the nicer Chapters including the Ultramarines (who run a Lawful Good and comparatively pleasant sector of the Imperium), the Space Wolves (who pulled an epic What the Hell, Hero? on the Inquisition and actually had a small war with them at one point over it), the Raven Guard (who will save everyone or die trying due to their Tear Jerker past), and the Salamanders (who are the only chapter who actively protect civilians, making them something of an Ensemble Darkhorse in the fandom) count especially as this trope. The Flesh Tearers and Marines Malevolent, and especially the Chaos Space Marines, however...
- Virtually everyone who's not a "flat" (unaugmented human) is some shade of this by default in Eclipse Phase. Not much of a choice since the vast majority of those who survived the hard-takeoff Singularity were transhumans (and the harsh realities of the setting will ensure that they stay the majority no matter what anyone has to say about it); in fact, the setting refers to transhumanity. Though there are exceptions such as the Exhumans (in particular the Predator sub-faction) and the Ultimates.
- The Carthian Movement from Vampire: The Requiem aren't exactly advocates for humanity - some of their plans for alternative models of vampiric government rely on a steady supply of "cattle" - but of the various Covenants, they're the ones most likely to advocate for human ingenuity, believing that human models of civilization will point to a grand replacement for the standing model of praxis. One of their more radical factions, the Anti-Obstructionist Army, actually takes action against anyone who tries to Embrace a human, claiming that human thought is hampered by the somewhat cooling effect of becoming a vampire.
- The God Eater series features this trope more subtly in the form of the titular God Eaters. In order to use their God Arcs and defend humanity, they need to be injected with Oracle Cells that effectively turn them part Aragami. Otherwise, they would not only lack the strength and endurance needed to fight said Aragami, but would also literally be eaten alive by their own weapons. The use of a powerful drug called Bias Factor is the only thing keeping them from transforming fully into the same monsters they fight.
- Sergeant Tarkus from Warhammer 40K: Dawn Of War II, to the point where he has the Fan Nick Name of "Grim Dark Kenshiro" by 1d4chan.
- In BioForge the Mad Scientist hoped that you would succumb to Transhuman Treachery after he upgraded (and deformed) you, but instead made you into a vengeful Phlebotinum Rebel.
- In Sid Meier’s Alpha Centauri, eventually you gain the technology to turn your people into transhuman "transcendii," who are basically energy beings via Brain Uploading. They're still loyal citizens, each and every one.
- If one plays through Deus Ex: Human Revolution with a pacifist slant, this is how protagonist Adam Jensen identifies himself in any of the four endings. After all, he never asked for this. He does, however, admit that augmentation can be very beneficial.
- In the original Deus Ex, this advocacy is exactly why the Helios AI wants to fuse with J.C. Denton instead of Bob Page. Page is a power-crazed tyrant bent on world domination who would oppress and subjugate. JC has been a staunch proponent of the people, and Daedalus, an aspect of Helios, had been watching the entire time. The "Pro-Human" aspect of JC is what Helios wants, to understand the human condition so it can better function as a benevolent machine god ruler. Helios knows enough about humans to know Bob Page is emphatically not a good choice for this. One of the three endings for the game involves JC volunteering and doing just that.
- In Mass Effect 3, if Commander Shepard chooses to control the Reapers in the ending, Reaper!Shepard - especially a Paragon one - vows to use them as a force for good.
- Technically, Paragon Shepard became Transhuman during the second game, having been resurrected with cybernetic implants, as well as undergoing extensive genetic modification that not only gives them increased speed and stamina, but resistance to small arms fire and strong enough to wield weapons that when fired, would normally shatter every bone in a normal person's arm. Shepard is a Pro-Human Transhuman in either case; paragon Shepard is a hero who protects all sentient life in the galaxy, while renegade Shepard helps humans and nobody else.
- In Dragon Age: Origins, part of the Joining Ritual to become a Grey Warden involves ritually drinking Darkspawn blood, where the Wardens willingly submit themselves to the Taint, becoming immune to it's effects (for thirty years), gaining the ability to sense the Darkspawn and rendering them the only ones capable of truly slaying an Archdemon, thus ending the latest Blight.
- The Architect in Dragon Age: Origins – Awakening qualifies, although technically he's a Token Heroic Orc who is not so much concerned with preventing further Blights to help humanity as much as he desires to free the Darkspawn from the influence of the Old Gods. However, he's not been particularly successful so far, since the last time he tried to help he ended up accidentally causing the Fifth Blight.
- On the other hand, the reason the Circles of Magi exist is because the Chantry, as well as a good chunk of the population, do not believe that mages can be reliably Pro Humans. This is mainly because of the Tevinter Imperium, which is ruled by powerful mages, and controlled much of Thedas centuries before. In fact, according to Chantry teachings, the Tevinter mages are responsible for creating the Darkspawn. There's also the little fact that every mage is a potential conduit for evil spirits of the Fade to enter the world.
- A good example of a Pro-Human mage would be the father of Hawke who taught his mage children to use their powers responsibly and had his own Badass Creed where he reminded himself that his magic would "serve that which is best in (him), not that which is most base." Mage player characters can be this as well... or not.
- In The Elder Scrolls V: Skyrim, the Dragonborn is a mortal with the soul of a Dragon, prophesied to protect Mankind by hunting down and consuming the souls of Dragons.
- The player characters Vent and Aile in Mega Man ZX are, like most people in this period, crosses of human- and Reploidkind, and fight to protect everyone. In the earlier series, Dr. Light is this, having become an infomorph and continues protecting humanity through aiding his "son" X.
- All of demigods in Asura's Wrath are transhuman cyborgs, but Asura is the only one after 12,000 years that stands up against them for humans after they start slaughtering them to obtain their souls for more power.
- In Warcraft III, Night Elf warlock Illidan Stormrage seeks demonic powers to prove himself to his skeptical brother and sister-in-law and ultimately fights against the genocidal undead Scourge. By the time of World of Warcraft he's turned evil.
- To be fair, his track record includes being subjected to rejection, distrust, betrayal, ten thousand years of incarceration, distrust and rejection... And even at that point, it was because he had no one to turn to when meeting Kil'Jaeden, that he at long last started his descent into darkness. It took meeting Big Bad while being systematically deprived of freedom, support and hope by the woman he loved and by the brother he trusted to get him to turn. Despair Event Horizon and Darkest Hour at their worst. And even then the task he accepted was arguably beneficial to the world of Azeroth - to destroy The Lich King, and he specifically attempted to turn away from Kil'Jaeden and create a place for himself after his first attempt failed.
- In Crysis 2, humanity's best chance at fighting off an alien invasion is a Dead Man Walking, kept alive by a semi-intelligent suit of Powered Armor based on Ceph nanotechnology.
- Taken even further in Crysis 3, where a protracted nanotech Fusion Dance has you playing as an amalgam one dead guy's body, another dead guy's personality, and both of their memories, with an artificially intelligent suit of Powered Armor holding it all together. You're about as transhuman as it gets, but still firmly on the side of humanity and more badass than ever.
- In Infinity Blade, the Deathless are revealed later in the series to be normal humans from a bygone era, who technologically altered their Q.I.P.'s and bodies to make them immortal, permanently at their physical peak, and grant them superhuman power. In the second game, it's revealed that Siris, the main character, is actually the Deathless Ausar the Vile, who lost his memories and lived on amongst normal humanity, but this fact doesn't stop him from fighting for humanity's freedom.
- Keine Kamishirasawa of Touhou is a were-hakutaku who's described as the safest person for a human to be around.
- Mr. House in Fallout: New Vegas is this in spades. While he claims to be “flesh and blood, not silicon,” he projects his will through a brain-computer interface into an army of robots, all of which are functional extensions of his body when they’re close enough to the Lucky 38, and any Courier who turns against him will probably see the extent of his cybernetics. And his stated raison d'être? Nothing less than “[Give me] 100 years, and my colony ships will be heading for the stars, to search for planets unpolluted by the wrath and folly of a bygone generation.” He’s as cold as you like, but he does want to save humanity (though he doesn’t respect most of it, much less trust it to govern itself).
- Gilgamesh of Fate/stay night was created by the gods of his time to tie them to humans, ensuring the continued existence of the gods. Gilgamesh eventually came to love humans more than the gods and rejected his role in the gods' plan, choosing to rule over Uruk because it was worth ruling. Even Gilgamesh's attempts to unleash Angra Mainyu on humanity is driven by his belief that the best humans will survive and be worth ruling.
- People in Crimson Dark with lots of augs, despite often being less than 20% flesh, still act just like normal humans.
- The Kingfisher: Vampirism doesn't make one inherently evil, but the pro-human vampires are few: mainly Helen, Vitus, Jack, Tristan, and Darren. Notably, some of the least powerful characters in the story.
- Genocide Man: Genocide Men believe that they are such, except maybe for Joey, using their ceramic skeletons, artificial glands, and suitcases full of ebola to hunt down and exterminate genetic deviants for the good of humanity. Though there are signs that their philosophy is flawed, and they turned most of the planet into deviants themselves in an attempt to make people immune to designer plagues and less violent, with a virus that killed over a billion people.
- The Sephirotic Archailects and their ancestors, the early pro-human transapients, from Orion's Arm are this. The Archai are not specifically pro-human as such (humans are but a fraction of the 10th millennium terragen populace), but generally benevolent towards lower toposophic lifeforms and promoters of sophont rights regardless of singularity level. This is as opposed to the solipsist AIs, who just don't care about anyone else positively or negatively, or the ahuman AIs who will, at best, kick lower beings off of their turf, or, for the less fortunate, Mind Rape them to death or worse.
- In Justice League, Gorilla Grodd intends to publicly kill the League because they are Transhumans fighting to protect humans, which, according to him, is contrary to natural selection.
- The female lead hero Cyber Six from the animated show of the same name. While pretending to be a "normal" human by day and "becoming" the hero Cybersix and fighting monsters by night.
- Casper the Friendly Ghost is Exactly What It Says on the Tin. Most other ghosts in the franchise are mean and just want to scare people.