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* ''VideoGame/ConquerorsBlade'' features several types of poisoned weapons:
** The Shortbow hero weapon can shoot poisoned arrows with its Poison Arrow and Angry Hornets skills.
** Dual-Blade heroes can throw Bo-Shurikens (poisoned daggers).
** All units from the Rattan Army have poisoned weapons (usually arrows) or can obtain them through mastery upgrades.
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* ''VideoGame/NobodySavesTheWorld'': The Rat form's basic attack builds poison in enemies, as does any attack while the Ranger's Poison Tipped passive ability is equipped. Once enough poison is built into an enemy, they gain the poisoned status and take constant damage while it lasts. Some enemies also have attacks that build poison into Nobody in the same manner.
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** Some jurisdictions have entirely banned lead ammunition for hunting. The motivation here is not to prevent poisoning of the animal being shot, but to prevent poisoning of whatever eats that animal - be it a human, a scavenger eating remains left by a hunter, or a predator that eventually eats an animal that is shot but escapes.

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** Some jurisdictions have entirely banned lead ammunition for hunting. The motivation here is not to prevent poisoning of the animal being shot, but to prevent [[PoisonousPerson poisoning of whatever eats that animal animal]] - be it a human, a scavenger eating remains left by a hunter, or a predator that eventually eats an animal that is shot but escapes.
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* ''Fanfic/VowOfNudity'': After getting a venomous snake for a familiar, Kay'la begins milking it to coat her blades and deal extra damage.

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* Early bullets were usually made entirely out of lead, which is a toxic metal. Assuming that a gunshot victim lived long enough, secondary poisoning from the bullet lodged in their body may become an issue. It is for this that "lead poisoning" became a common euphemism for getting shot. Modern bullets are generally made out of lead as well, but coated with copper (which tends to be less toxic).
* Depleted uranium, a byproduct of enriching uranium for weapons or nuclear reactors, is used by a number of countries for military purposes. The density of uranium (which is much higher than steel or lead), along with its propensity for spontaneous ignition and self-sharpening on impact, are all ideal qualities for armor-piercing ammunition. Depleted uranium is chemically toxic and (very ''very'') mildly radioactive; while the residue from a single round is unlikely to do lasting harm, firing thousands of them across the battlefield can leave enough toxic dust to cause long-term health problems in those exposed to it.

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* Early bullets were usually made entirely out of lead, which is a toxic metal. Assuming that a gunshot victim lived long enough, secondary poisoning from the bullet lodged in their body may become an issue. It is for this that "lead poisoning" became a common euphemism for getting shot. Modern bullets are generally made out of lead as well, but are fully or mostly coated with copper alloy (which tends to be make them less toxic).
** Some jurisdictions have entirely banned lead ammunition for hunting. The motivation here is not to prevent poisoning of the animal being shot, but to prevent poisoning of whatever eats that animal - be it a human, a scavenger eating remains left by a hunter, or a predator that eventually eats an animal that is shot but escapes.
* Depleted uranium, a byproduct of enriching uranium for weapons or nuclear reactors, is used by a number of countries for military purposes. The density of uranium (which is much higher than steel or lead), along with its propensity for spontaneous ignition and self-sharpening on impact, are all ideal qualities for armor-piercing ammunition. Depleted uranium is chemically toxic and (very ''very'') mildly radioactive; while the residue from a single round is unlikely to do lasting harm, firing thousands of them across the battlefield can leave enough toxic uranium oxide dust to cause long-term health problems in those exposed to it.
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* ''Fanfic/TheAccidentalWarlordAndHisPack'': Agata attempts to murder Jaskier with a poisoned dagger but Eskel gets in the way and is cut instead. His mutagens ensure his survival.
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** In ''VideoGame/FireEmblemThreeHouses'', Venin weapons can be forged at the smithy using Venomstones. The minor antagonist Metodey favors using a Venin Edge, and in a late chapter of ''VideoGame/FireEmblemWarriorsThreeHopes'', he stabs one of your allies with a poisoned dagger (Leonie or Dorothea, depending on the route), requiring you to rush them to your home base before the poison kills them so they can be recruited.
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* ''Film/OurManFlint''. Gila uses a poisoned dart propelled by a harp to try to assassinate Flint, and Flint uses a curare-tipped dart to take out a fly.

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* ''Film/OurManFlint''. Gila uses a poisoned dart propelled by a harp to try to assassinate Flint, and Flint. When Flint uses is offered a silenced Walther PPK by his boss for the mission, he rejects it and demonstrates his blowgun which fires a curare-tipped dart to [[SuperFlyReflexes take out a fly.fly]].
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** ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'', in a more traditional use of the trope, lets you apply poisons to your weapons which will deliver the poison's effects on the next enemy it strikes. Poisons can be found or purchased, and you can also create them yourself through the [[AlchemyIsMagic Alchemy]] PotionBrewingMechanic. This causes [[FridgeLogic some confusion]] as to how a [[DropTheHammer warhammer]] -- [[CarryABigStick or other blunt weapon,]] which [[MindScrew has no method of actually transmitting the poison into the host's body]] -- can be poisoned in the same manner as, say, [[HeroesPreferSwords a sword]] or an axe. (It can also be applied to a ''bow'', although it's implied that you're actually applying to the next arrow fired.) Further, "poisons" can have effects beyond simply dealing damage. Poisons can drain [[{{Mana}} Magicka]] and Stamina, or inflict "weakness to" [[ElementalPowers certain elements]], or [[StatusInflictionAttack inflict other status effects]] such as Silence or Paralysis.

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** ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'', in a more traditional use of the trope, lets you apply poisons to your weapons which will deliver the poison's effects on the next enemy it strikes. Poisons can be found or purchased, and you can also create them yourself through the [[AlchemyIsMagic Alchemy]] PotionBrewingMechanic. This causes [[FridgeLogic some confusion]] as to how a [[DropTheHammer [[CarryABigStick warhammer]] -- [[CarryABigStick or other blunt weapon,]] which [[MindScrew has no method of actually transmitting the poison into the host's body]] -- can be poisoned in the same manner as, say, [[HeroesPreferSwords a sword]] or an axe. (It can also be applied to a ''bow'', although it's implied that you're actually applying to the next arrow fired.) Further, "poisons" can have effects beyond simply dealing damage. Poisons can drain [[{{Mana}} Magicka]] and Stamina, or inflict "weakness to" [[ElementalPowers certain elements]], or [[StatusInflictionAttack inflict other status effects]] such as Silence or Paralysis.

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* ''Literature/TheBelgariad'': [[MasterPoisoner Sadi]], one of the heroic party members in ''The Mallorean'', carries a variety of poisons, and his major weapon in battle is a poisoned dagger. When [[MentorArchetype Belgarath]] asks the group to minimize casualties during a fight with {{Mooks}}, he's responsible for two of the three deaths at its close -- "It's a little hard to unpoison a knife." (The third was [[CombatPragmatist Silk]] taking out an ambusher.)



* ''[[Literature/TheBelgariad Mallorean]]'': [[MasterPoisoner Sadi]], one of the heroic party members carries a variety of poisons, and his major weapon in battle is a poisoned dagger. When [[TheMentor Belgarath]] asks the group to minimize casualties during a fight with {{Mooks}}, he's responsible for two of the three deaths at its close -- "It's a little hard to unpoison a knife." (The third was [[CombatPragmatist Silk]] taking out an ambusher.)

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* Generally speaking, poisoned weapons were not very commonly used in warfare, as they were an unreliable and overly complicated way of killing a person. Any injury inflicted with a poisoned weapon is more than likely to bleed out faster than the poison could be absorbed; even if were to be absorbed in sufficient amounts, it would take some time before the effects actually come into play. Typically, poisoned weapons were mainly used for hunting, in which case the poison can be given enough time to take hold and debilitate an animal so that a hunter can catch up and deliver the final blow. For obvious reasons, this requires a poison that is relatively benign and/or destroyed by the heat of cooking.

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* Generally speaking, poisoned weapons were not very commonly used in warfare, as they were an unreliable and overly complicated way of killing a person. Any injury inflicted with a poisoned weapon is more than likely to bleed out faster than the poison could be absorbed; even if were to be absorbed in sufficient amounts, it would take some time before the effects actually come into play. Typically, poisoned weapons were mainly used for hunting, in which case the poison can be given enough time to take hold and debilitate an animal so that a hunter can catch up and deliver the final blow. For obvious reasons, this requires a poison that is relatively benign and/or destroyed by the heat of cooking. For example, Curare, mentioned below, can't be absorbed through the digestive system - it needs to hit the bloodstream directly through a wound to have an effect.
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[[folder:Puppet Shows]]
* ''Series/FraggleRock'': Downplayed. In "The Cavern of Lost Dreams", Gobo and Cotterpin meet two ancient Doozers named Crusty and Yeaster. The spears they carry are covered with sap that causes an uncontrollable itch.
-->'''Cotterpin:''' One drop of that sap on your skin, and you'll never stop itching!
[[/folder]]
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** In ''VideoGame/FireEmblemEngage'' all daggers are poisoned by default. The poison itself, its {{Universal|Poison}} nature aside, is surprisingly gentle. Instead of the usual DamageOverTime it merely makes poisoned units take a single point more damage for every successful knife attack against them, capping at three. It still can be useful thanks to the [[CombinationAttack Chain Attack]] mechanic.
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Moving to new namespace.


* ''WebOriginal/{{Serina}}'': In their second battle against the warmongers, the gravediggers give their daydreamer allies spears tipped with paralytic poison derived from the fireslime lumpus, a terrestrial tribbet, which means the sea-dwelling warmongers have no resistance to it. This also leads to a CruelAndUnusualDeath for these warmongers, as their large size and ability to hold their breath for extended periods means that they sink to the bottom and slowly drown while [[AndIMustScream remaining fully cognizant the entire time]], something that traumatizes the daydreamers doing the stabbing.

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* ''WebOriginal/{{Serina}}'': ''Website/{{Serina}}'': In their second battle against the warmongers, the gravediggers give their daydreamer allies spears tipped with paralytic poison derived from the fireslime lumpus, a terrestrial tribbet, which means the sea-dwelling warmongers have no resistance to it. This also leads to a CruelAndUnusualDeath for these warmongers, as their large size and ability to hold their breath for extended periods means that they sink to the bottom and slowly drown while [[AndIMustScream remaining fully cognizant the entire time]], something that traumatizes the daydreamers doing the stabbing.
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* ''Literature/TheChroniclesOfDorsa'': Some assassins in the books make use of poison darts.
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* ''LightNovel/TheFamiliarOfZero'': Jeanette's dagger is coated with a paralyzing potion.

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* ''LightNovel/TheFamiliarOfZero'': ''Literature/TheFamiliarOfZero'': Jeanette's dagger is coated with a paralyzing potion.



* ''LightNovel/GoblinSlayer'': Goblins are fond of poisoning their weapons, which results in Wizard of the Greenhorn Team having to have a MercyKill performed on her when the poison spreads too far for an antidote to be effective. The poison used is a mixture of the goblins' own spittle and excrement, along with herbs they find in the wild.

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* ''LightNovel/GoblinSlayer'': ''Literature/GoblinSlayer'': Goblins are fond of poisoning their weapons, which results in Wizard of the Greenhorn Team having to have a MercyKill performed on her when the poison spreads too far for an antidote to be effective. The poison used is a mixture of the goblins' own spittle and excrement, along with herbs they find in the wild.
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->''"Gingerly he drew the sword, and from it dripped a greenish liquid exactly like that which slavered from the scimitar-fangs of the reptile. The blade was steeped in the poison of the snake's own kind, and the obtaining of that venom from the fiend-haunted swamps of Zingara would have made a saga in itself."''
-->-- '''Creator/RobertEHoward''', ''Literature/BlackColossus''

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->''"Gingerly ->''Gingerly he drew the sword, and from it dripped a greenish liquid exactly like that which slavered from the scimitar-fangs of the reptile. The blade was steeped in the poison of the snake's own kind, and the obtaining of that venom from the fiend-haunted swamps of Zingara would have made a saga in itself."''
''
-->-- '''Creator/RobertEHoward''', ''Literature/BlackColossus''



** Players in ''VideoGame/RuneScape'' can create poisons to use on daggers, arrows, spears, and a few throwing weapons using the Herblore skill. There are three poisons, each stronger than the previous, and they're made from a herb and a dragon scale, a cactus spine and spider eggs, and poison ivy berries and belladonna respectively, from weakest to strongest. Belladonna is potent enough to strongly damage the player just when it's touched with bare hands.

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** Players in ''VideoGame/RuneScape'' can create poisons to use on daggers, arrows, spears, and a few throwing weapons using the Herblore skill. There are three poisons, each stronger than the previous, and they're made from a herb and a dragon scale, a cactus spine and spider eggs, and poison ivy berries and belladonna respectively, from weakest to strongest. Belladonna is potent enough to strongly damage the player just when it's touched with bare hands.



* In ''VideoGame/SyphonFilterTheOmegaStrain'', Lian Xing gets to use poisoned shurikens while on a ninja-style stealth mission disguised as a Sherpa.
* There's Bruno from ''Quest for Glory I'' and [[spoiler: the same Bruno's]] in ''VideoGame/QuestForGloryV''. The poisoned daggers were a plot point in the second. The hero could obtain and even use one. Not recommended if you're playing a [[LawfulGood paladin]].

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* In ''VideoGame/SyphonFilterTheOmegaStrain'', ''VideoGame/SyphonFilter: The Omega Strain'', Lian Xing gets to use poisoned shurikens while on a ninja-style stealth mission disguised as a Sherpa.
* There's Bruno from ''Quest for Glory I'' ''VideoGame/QuestForGloryI'' and [[spoiler: the [[spoiler:the same Bruno's]] Bruno]] in ''VideoGame/QuestForGloryV''. The poisoned daggers were a plot point in the second. The hero could obtain and even use one. Not recommended if you're playing a [[LawfulGood paladin]].



* ''VideoGame/WarcraftIII'' has two main kinds of poison: Envenomed Weapons does damage over time (but can only reduce HPTo1 if the target runs away) and Slow Poison slows the target's movements. The Undead's Disease Cloud also deals low damage for a long time without killing, the Night Elves' Orb of Venom gives the hero Envenomed Weapons (and an anti-air attack if melee) and the Warden's Shadow Strike hurls a poisoned dagger for massive damage, damage over time, ''and'' slow.

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* ''VideoGame/WarcraftIII'' ''VideoGame/{{Warcraft}} III'' has two main kinds of poison: Envenomed Weapons does damage over time (but can only reduce HPTo1 if the target runs away) and Slow Poison slows the target's movements. The Undead's Disease Cloud also deals low damage for a long time without killing, the Night Elves' Orb of Venom gives the hero Envenomed Weapons (and an anti-air attack if melee) and the Warden's Shadow Strike hurls a poisoned dagger for massive damage, damage over time, ''and'' slow.



** In Mists of Pandaria, [[spoiler:Vol'jin]] gets stabbed with a weapon that interferes with his regeneration capabilities. It's up to you to find the herbs necessary to heal him.

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** In Mists ''Mists of Pandaria, Pandaria'', [[spoiler:Vol'jin]] gets stabbed with a weapon that interferes with his regeneration capabilities. It's up to you to find the herbs necessary to heal him.
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* Depleted uranium, a byproduct of enriching uranium for weapons or nuclear reactors, is used by a number of countries for military purposes. The density of uranium (which is much higher than steel or lead), along with its propensity for spontaneous ignition and self-sharpening on impact, are all ideal qualities for armor-piercing ammunition. Depleted uranium is chemically toxic and mildly radioactive; while the residue from a single round is unlikely to do lasting harm, firing thousands of them across the battlefield can leave enough toxic dust to cause long-term health problems in those exposed to it.

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* Depleted uranium, a byproduct of enriching uranium for weapons or nuclear reactors, is used by a number of countries for military purposes. The density of uranium (which is much higher than steel or lead), along with its propensity for spontaneous ignition and self-sharpening on impact, are all ideal qualities for armor-piercing ammunition. Depleted uranium is chemically toxic and (very ''very'') mildly radioactive; while the residue from a single round is unlikely to do lasting harm, firing thousands of them across the battlefield can leave enough toxic dust to cause long-term health problems in those exposed to it.
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* ''Anime/BloodPlus'': Saya's sword has a little groove in it for her blood, which is fatal to most chiropterans.

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* ''Anime/BloodPlus'': Saya's sword has a little groove in it for [[BloodyMurder her blood, blood]], which is fatal to most chiropterans.
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->''Gingerly he drew the sword, and from it dripped a greenish liquid exactly like that which slavered from the scimitar-fangs of the reptile. The blade was steeped in the poison of the snake's own kind, and the obtaining of that venom from the fiend-haunted swamps of Zingara would have made a saga in itself.''
-->-- "Literature/BlackColossus"

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->''Gingerly ->''"Gingerly he drew the sword, and from it dripped a greenish liquid exactly like that which slavered from the scimitar-fangs of the reptile. The blade was steeped in the poison of the snake's own kind, and the obtaining of that venom from the fiend-haunted swamps of Zingara would have made a saga in itself.''
"''
-->-- "Literature/BlackColossus"
'''Creator/RobertEHoward''', ''Literature/BlackColossus''
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* In ''Literature/LegendsOfTheRedSun'', the conservatively religious [[SuperSoldier Night Guard]] Nelum buys from a cultist (that setting's term for a MadScientist) a knife made out of the solidified toxin of the botullism bacteria. He intends to use it to kill his commander Brynd when he learns Brynd is a homosexual, but accidentally cuts himself instead. The concentrated botullism is so poisonous that even his Night Guard enhancements can't protect him and Nelum dies shortly after.
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* In ''Literature/WayOfTheTiger'', Avenger can spit out needles that have been poisoned with spiderfish venom if he has that skill. Avenger also carries a dose of the supernatural toxin, the Blood of Nil which is the most potent poison in the setting.
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