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Anime and Manga
- In the Ah! My Goddess OAV, after Keiichi brings an unconscious Belldandy to the abandoned temple, he collapses from a fever and wakes up with his head in her lap.
- In the television series, while trying to create an antidote for the breasts Keiichi sprouted (courtesy of pudding made by Skuld), an explosion occurs, and Belldandy grows ill from inhaling the fumes. Keiichi spends the rest of the episode trying to take care of her.
- In Ai Yori Aoshi, Kaoru walks through the rain to get Aoi, who's just gotten lost for the second time on the Tokyo train system. After they get back to his apartment, he collapses from a fever and Aoi has to save him with some very Intimate Healing.
- Toei's Yu-Gi-Oh! (first anime series) had Yugi get a cold in episode 15, which threw him off his dueling game and helped Risa exploit him for her own gain.
- Verity in The Transformers: Sins of the Wreckers is suffering from some sort of illness that gives her intense stomach pains, coughing fits, and leaves her much less physically capable than usual. Disturbingly, it seems to flare up every time a Transformer comes near.
- Spider-Man tended to get sick whenever he needed to struggle against lesser villains or lose outright. A famous example is in The Night Gwen Stacy Died, where he suffers from a cold for the first half, partially leading to Gwen's death, but it goes away in the second issue.
- In Deewaar, Sumitra falls ill, forcing her son Vijay to decide whether to visit her and get arrested or turn his back on her. When he decides to do neither, she quickly gets well.
- In Moulin Rouge!, Satine's illness takes hold at the worst possible time, just as she and Christian reunite during the climax.
- In Harry Potter, the Weasley twins develop a range of sweets that make one ill and test them on fellow students in Order of the Phoenix. Hermione is unamused and shuts them down. Well, at least she manages to stop them from trying it on first-year students by threatening to write their mother. She can't really do anything about it when they test the candies on themselves and willing test subjects who are of age, and she can't stop the students from buying and using the sweets once they're perfected. Given that they're mostly used as a mode of rebellion against Umbridge, it's not that surprising she isn't doing more to stop it.
- Had the baby never been sick in Skellig, Michael likely wouldn't have felt so alienated from his family and therefore wouldn't have gone exploring by himself in dangerous places like the garage (or old shed in the movie adaptation) and discovered Skellig, or at the least would have been enlisted by his parents to help more around the house or with the baby - and then he just would not have had the free time.
- Invoked in The Adventures of Jimmy Neutron, when Jimmy invents a "sick patch" that make the wearer sick when applied, which the kids then use to stay home from school.
- Star vs. the Forces of Evil: In "Star On Wheels", Glossaryck spends the first half of the episode not contributing at all to save Star from the runaway bike, even though his magic would have solved the problem immediately. The moment Glossaryck does decide to help, he gets sick from some food he had eaten earlier and becomes incapacitated.