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- Any aspirin commercial from the 1960s or earlier. Interestingly enough, most of the medicinal effect of aspirin occurs at the site of injury, the drug prevents inflammation (which causes futher pain) and the release of pain-signalling molecules. But any claims that a non-conscious drug molecule can actively seek out sites of pain is just silly.
- Similarly, avertisements for Nurofen, which are still shown regularly today. They've even gone from implying to outright stating that the painkiller "goes straight to the source of pain" as the little animated target rondel homes in on the affected body part. God knows how they got that past advertising standards.
- The "Before You Can Say Anbesol" commercial, for a mouth-sore relief medication. (That said, you do directly apply the medication to the affected area; it's a local anesthetic.)
- "Lanacane's great for itching—all kinds of itching. It quiets itch nerves fast!" (emphasis added)
- Although, dedicated itch receptors are strewn throughout the skin, the same way pain receptors are.
- Cortizone 5 and Cortizone 10 used to do the same thing. The commercial talked about it calming "the itch nerves that cause every itch" and had an animation along with it.
- The little firemen in adverts for Gaviscon Cool heartburn relief, who will hose down your pain centre with Gaviscon.
- Lest we forget: Head-On, apply directly to the forehead (to relieve a headache by, no joke, numbing your forehead, which is about as effective as you're thinking right now).
- You can even get the same effect rubbing a candle on your forehead. Head-On is mostly paraffin, by virtue of the homeopathic theory that the less of the active ingredient there is, the more effective it is.
- Worth noting, to prevent the commercials from being instantly pulled off the air, they make no claims whatsoever. They only implied it's for headache relief.
- Pepto-Bismol ads used a variation of this trope for a long time, using an animation demonstrating its "protective coating action" on the stomach and esophagus. They stopped doing this after it was determined that bismuth salicylate doesn't work that way — it's actually a mild antibiotic with some antacid capability.
- Earth: Final Conflict included a gizmo which somehow turned all the nerves in your body into pain receptors. Just what was going to process these pain signals was not discussed.
- In The Simpsons episode where Homer and Barney visit the Duff brewery they see an old Duff ad that has a pleasure center directly targeted by Duff beer.
- On Rocko's Modern Life, Doctor Hutchison refers to this trope both visually and literally when she describes she merely has to remove the lightning bolts of pain from Rocko's body and install the wavy lines of relief for his appendicitis.
- Cracked.com have made an advert spoofing this. The advert is for a medicine against "constantly being struck by lightning". Customers are reminded that it treats actual lightning bolts, not just pain, and also does not treat "suddenly glowing red areas" or "anthropomorphized mucus filling your lungs with furniture".