Newspaper Comics of the 2000s
- Baldo started its run in April 2000.
- Big Nate continued its run all through the decade.
- The Boondocks continued its run from 1999 until 2006.
- Cul de Sac began as a Sunday Strip in the Washington Post in 2004, went to daily nationwide syndication in 2007, and ran until 2012.
- Foxtrot continued its run all through the decade.
- Frazz was launched in April 2001.
- Pearls Before Swine was launched in 2001.
- Pooch Café is the first comic strip of this era, launching in January 2000.
- PreTeena launched at April 2001 and ended in May 2008.