But couldn't give a rat's ass about his (and her) son.
Well, YMMV about that. It is implied that he made Shinji hate him in order for him to focus affection on Yui and thus synchronize with her better, that he was afraid of Shinji, or wanted to build a better world so as to not cause him pain. His final line in End of Evangelion echoes this: When I'm with Shinji, all I do is cause him pain. It'd be better if I wasn't around. Forgive me, Shinji.
Horrifying enough, his wife was not technically dead, so much as her own "Soul and Body" being absorbed into the Eva-01 mecha... Part of Gendo's Plan to 'reunite with her' involved getting his son to "ride inside her cockpit" unknowingly. No, he is not a very sane individual, why do you ask?
Pegasus' motivation in Yu-Gi-Oh! was to resurrect his dead fiancée/wife through a combination of ancient magic and the "Solid Vision" holographic technology.
Featured heavily in Fullmetal Alchemist. Attempting to bring back a dead person with alchemy is not only strictly forbidden, but is almost guaranteed to go horribly awry, scar your body, kill an innocent, create a monster, etc. People (including the protagonists) try it anyway. Different than the villainous examples as all the people who try this are painted in a sympathetic light.
While attempting human transmutation causes you to merely lose a body part (and find out later that bringing back the dead is flat-out impossible), in the 2003 anime version, things are somewhat different: human transmutation causes you to lose part of your body, and the corpse becomes a nigh-immortal monster.
The 2003 anime version also hints that the homunculus is the person who was supposed to be brought back. By the end, Lust is thoroughly convinced of this while Sloth is scared to death of the possibility; it's why she wants to kill the Elrics so much: no mother would do such a thing, thus differentiating herself from Trisha.
In Naruto, Obito Uchiha's motivation for siding with Madara and his Moon's Eye Plan, which involves casting a worldwide genjutsu in order to create a dream world, is essentially this. In Obito's case, this would allow him to live together with his deceased love interest and teammate (whom was killed at the hands of his former best friend no less) once more, and he's willing to set monsters loose upon villages and wage war to achieve it.
Featured in Chrono Crusade. Azmaria's foster father adopted her in the hope that he could use her HealingVoice to bring his wife's soul back to a body he reconstructed for her after she died in World War I.
Precia Testarossa of the first season of Magical Girl Lyrical Nanoha was attempting to resurrect her daughter. She tried creating a clone named Fate, but Fate having her own personality enraged her.
A story arc in Slayers NEXT features a wizard making a pact with mazoku in order to resurrect his lover. He succeeds, but she awakens in a zombie-like state begging to be sent back. Needless to say, things do not end well.
Lucifer of the Divine Design arc of Get Backers. He kidnapped and brainwashed children, played sick mind games with everyone, and seemed to enjoy doing it, but in the end it was revealed that he really just wanted to bring his daughter back from the dead.
Sinner, an antagonist from the first Scrapped Princesslight novel, carried around the long-past-decayed corpse of his daughter Lynthia in hopes that he would be able to bring her back to life after she succumbed to a curse. Unfortunately, he's also Ax-Crazy, and refuses to believe that she's even dead (until Shannon beats seven shades of hell out of him).
Faust VIII, a former villain from Shaman King, was a perfectly ordinary, handsome, cheerful young doctor before the death of his wife in a botched robbery. Now his ultimate goal is to use his necromancy to achieve his goal of reviving his wife's spirit, using corpses (including his wife's and their dog's) as weapons.
Although, for a sort of subversion, his goal is not seen as horribly evil as it usually would and it really isn't. It is just his mind and personality that got really crushed with her death i.e. he's a bit snooker-loopy and amoral at times, but that has nothing to do with his necromantic powers. The act of resurrecting someone is even called "True Necromancy". The only problem is that on his own, he's not capable of resurrecting her. He eventually quits and decides to die for good to join up with her. At least in the Manga.
In the anime, if I recall properly, he did get her back. But Anna resurrected her, not him.
In D.Gray-Man, the Millennium Earl gets people who are grieving for the recent death of a loved one to allow him to resurrect the dead person. Although the mourner is not the necromantic per se, the person nevertheless allows the dead loved person to be twisted into a demon-servant just so they can live again.
In Pokémon, the guy who made Mewtwo was a Necromantic. In order for Giovanni to fund his efforts to clone his dead daughter, he had to make him a Super Soldier as well.
In Umineko no Naku Koro ni, at first it appears that the entire plot apparently revolves around Kinzo trying to revive his dead mistress... who also happens to be a 1000 year-old Sealed Evil in a Can. Kill 'em All ensues. But then it's revealed that Kinzo has been dead for over a year before the story begins, meaning he wasn't involved in any of the murders. And although he did have a dead mistress whom he loved dearly, she was not 1000 years old nor Sealed Evil in a Can.
After Yuki's parents die in Future Diary, he decides to win the power of God in the survival game and bring them back to life.
It should be noted that, unlike most examples, he is told this is perfectly possible, and what's more is that he also intends to bring everyone back to life, not just his parents. Well, everyone who died in Royale at least.
Oh, and it turns out Dues was lying, it isn't possible to bring someone back to life, only their body. Though if you are dead set on it, you can always go back in time and try to save them.
Subverted in One Piece with Doctor Hogback. After going through something of a motive rant that looks like he's using this as an excuse for his start of darkness, he reveals he doesn't actually care about Cindry's personality and just liked her pretty face anyway. He prefers her in her new zombie form, completely subservient to his every command.
Though not for the same romantic overtones, Mikado of Hayate the Combat Butler was hinted at wanting the Power of the Gods to bring back the daughter he loved. except that, when he'd first made the attempt, she was alive.
One of the ultimate goals of comic book supervillainDr. Doom, along with the destruction of nemesis Reed Richards and the conquest of Earth, was the resurrection of his beloved mother (or at least, saving her from hell). Ultimately, he was able to do so, but only by forcing his mother to renounce her love for him. No wonder he's always so pissed.
Cicada from The Flash was killing people the titular hero had saved to gather enough energy to bring his wife (whom he had murdered, only to feel remorse) back from death.
Mr. Freeze's attempts to bring his wife back from the dead succeeded when he put her in a Lazarus Pit... until she Came Back Wrong with eternal pain, insanity, and fire-manipulation powers. Now, she is Lazera, constantly hating Freeze for bringing her back.
When X-Men villain Quentin Quire came back to life the first time, the first and only thing he did was dig up the body of his crush, Sophie Cuckoo, and seek out the Phoenix to bring her back as well. She woke up, took one look at him, and immediately dropped dead again out of spite, while her sisters telepathically mocked him.
Gillian's insistence on trying to resurrect her accidentally poisoned boyfriend in the 1998 film Practical Magic is the catalyst for a lot of later trouble for both her and her sister Sally.
Of course, this is less about wanting her beloved back and more about trying to avoid a murder charge; Sally accidentally killed him by giving him a dose of belladonna to keep him from trying to kill Gillian.
The plot of The Mummy revolves around the Big Bad trying to resurrect his lover, an ancient Egyptian queen. Interestingly, his own resurrection was a lot easier than hers.
For the simple fact that he didn't die and go to the afterlife like her, he was cursed with undeath. Meaning his soul remained in that dried-up piece of jerky that passed for a body, bound to protect the Book of the Dead. Which those Americans stole. Also, he was eaten alive by scarabs. You try to rest in peace with that going on.
The trope is touched upon in the 1994 adaptation of Mary Shelley's Frankenstein. Frankenstein resurrects his dead bride, to horrific effect, as she is a stumbling, barely-aware reanimated corpse. And about the only thing she does notice is that she's an abomination and so sets the place on fire.
The eponymous Biollante from Godzilla vs. Biollante is an interesting variant on the end result, as the Necromantic character was intentionally trying to resurrect his loved one as a strange creature. By combining his daughter's DNA with that of a rose with psychic abilities and Godzilla, he was hoping to create a plant that contained her spirit and protected it with Godzilla's super-regeneration and near-indestructibility, making the new her virtually impossible to kill. It still ended up not being quite what he intended, though, as the Godzilla DNA made it a giant monster rather than merely Nigh Invulnerable.
In The Abominable Dr. Phibes, the title character is trying to avenge his wife's death. In Dr. Phibes Rises Again, he's done that, and is now trying to bring her back using Ancient Egyptian magic (with the added bonus of getting eternal life for the pair of them). At the end of the film, he explains to his nemesis why they're not only Not So Different, but Phibes actually holds the moral high ground.
The Mad Scientist in The Brain That Wouldn't Die isn't trying to resurrect his decapitated fiancée (as her head is still living), but he does some pretty villainous things while trying to "secure" her a body, all the while ignoring her piteous demands to be killed. (Of course, said body has to come from a freshly killed victim...)
One of the earlier film examples is probably Metropolis, in which the prototypical Mad Scientist Dr. Rotwang tries to bring his dead wife back in the form of a machine-woman (said wife also cheated on him while she was alive and died giving birth to another man's son, doubling the tragedy). Unfortunately the end result turned out a tad more evil than he probably hoped. This motivation is explained in far more detail in the novel, and is cut out in most versions of the film, leaving the viewer to assume he just likes to build evil-lady robots because EVIL.
In "The Monkey's Paw" (by W. W. Jacobs) a series of Literal Genie moments culminate with the protagonist's child being wished back from the dead after an earlier wish (for a sum of cash) resulted in his death (for which the parents received the exact sum wished for as an insurance payout). The mom is in denial that their son may come back wrong, but the dad is Genre Savvy enough to use the last wish to put him back in his grave before he even makes it back to the house.
An episode of Buffy did same thing essentially, with Dawn trying to bring Joyce back after she died. Buffy gets to Dawn moments too late, the ritual complete, and argues with her to undo the spell before it's too late and someone gets hurt. Their argument reveals how much Buffy was hurting too (she had been putting on a brave face for her sister's sake) and the two end up switching positions on the matter: Buffy is in tears and rushes to the door hopefully when the unseen "Joyce Thing" knocks, but Dawn undoes the spell at the last second and nobody is there when Buffy opens the door.
Dr. Mordenheim, the Frankenstein Expy in the Ravenloft novel of the same name. Despite the fact he lives in a Dungeons & Dragons setting (albeit a Gothic Horror one) where it should be easy to bring his wife back from the dead, he goes the Things Man Was Not Meant To Know route, because he doesn't trust magic.
Given that resurrection magic in Ravenloft has a high probability of the intended resurrectee coming back wrong, can you really blame the guy for not trusting it? In addition, before he was brought to Ravenloft, he lived in a world where magic was largely unknown and was replaced by technology.
An interesting twist occurs in the Edgar Allan Poe story Ligeia, in which a morose nobleman is pining over the loss of his first wife. The twist is that he does nothing, while the spirit of his first wife poisons and takes over the body of his still-living second wife.
In the original Frankenstein book, it's strongly suggested that Victor Frankenstein was doing all his research in the hopes of bringing back his dead mother. Instead, of course, he makes a monster who ends up killing off most of the rest of his family.
The Last Incantation by Clark Ashton Smith plays with this: the ancient necromancer thinks the lover he resurrected was brought back wrong somehow, as she's somehow less beautiful than he remembers, but as it turns out, the spell went off without a hitch. He has just grown too old and twisted to love her the way he did when he was young.
There's also The Chain of Aforgomon. Calaspa could have had his beloved's body reanimated or her spirit called back by magic easily enough...but that wasn't good enough, was it? He just had to actually turn back time for an hour to when she was still alive...yeah. That didn't end so well.
Okay, bear with me. Can Heterosexual Life-Partners count? I'll grant you, Necroplatonic hasn't got the same ring to it. And are you sitting comfortably? But, anyway, in the Doctor Who Expanded UniverseEighth Doctor Adventures novel Interference, the Doctor discovers that after he misplaced Fitz, he ended up falling in with a group of people who are cloned after their deaths. Clone Degeneration is an intentional part of the process — the people basically become increasingly Flanderized, which is supposed to make them more their true selves, etc. — sort of like how Bugs Bunny hasn't got an awful lot of depth, but everyone knows who he is. The Doctor is not terribly keen on this whole thing and thinks that Fitz has pretty much been boiled down to his worst traits plus a couple brand new flaws, so he turns the copy (named Kode) back into the Fitz he knew with the help of the TARDIS. Basically, this means he tells an eighteen-year-old boy, which is what Fitz has been turned into, that he's pretty awful and should just die so he can turn into someone more worthwhile, and, for added creepiness, Sam leaves shortly before the Doctor carries this out, and he all but lies to her, as he evidently knows he's doing something wrong. Of course, from a Doylist perspective, it's hard to disapprove of this plot development, as it brought back an Ensemble Dark Horse and gave him more reason to be The Woobie, but... honestly, Doctor. You killed a guy because you liked someone else better. We all agreed with your preference, yes, but you killed a kid.
In Isis, by Douglas Clegg, the titular character, (Real name: Iris Claviger Villiers), loses her beloved brother Harvey in a fall. Eventually, she slowly goes mad, and raises Harvey from the dead, only to find that he would rather stay dead. Parallels between her and Harvey, and Isis and Osiris are drawn frequently, leading her to take the name Isis.
In Galaxy of Fear: City of the Dead, Zak Arranda is consumed with regret and Survivors Guilt over his parents, obsessing over the fact that he Never Got to Say Goodbye and feeling like he abandoned them to die. When visiting Necropolis, he's told the legend of a dead Necromancer named Sycorax who some locals prayed to in the hopes that she would bring back their loved ones; even though Sycorax is also believed to be very strict about the respect Due to the Dead and doesn't want people messing around in her graveyard lest something bad happen, he goes in to try to ask for the spirit's help. He doesn't get a response from a spirit; instead he finds zombies. Necropolitans blame the hapless Zak, saying his disrespect triggered Sycorax's curse. Really it's a Mad Scientistraising a zombie army. No biggie.
Shows up in the backstory of the Resurrection Stone in the last Harry Potter book.
Karl Kreutzfeld in The Lost Room wasn't out to destroy the world and didn't think it would actually happen as a result of his plan. Nevertheless, he might have unmade all of reality in his attempt to bring back his dead son had not the protagonist intervened.
Done repeatedly in (wait for it) Buffy the Vampire Slayer, such as the would-be Dr. Frankenstein who rebuilds his dead older brother, only to have him demand a mate.
And Dawn's attempt to bring back Joyce.
Shows up in a season 2 episode of Supernatural by way of an ancient Greek resurrection spell.
The main character of Pushing Daisies disconnected himself from normal social interaction partly for fear of becoming this trope - he was worried that if someone he loved were to die, he would, in his grief, bring them back at the cost of taking someone else's life, so he largely avoided forming relationships for most of his life.
Nevertheless, it's happened more than once- as a child, Ned brought back his mother, and the cost of the father of Chuck, his true love. Years later, when Chuck was murdered, Ned brought her back, knowing, and accepting, someone would die in her place. Then, Chuck tricks Ned into bringing back her father permanently.
Inverted in Charmed. There's a dead Necromancer who wants to bring himself back to life to be with the woman he loves.
In Kamen Rider Wizard, it is eventually revealed that the White Wizard, Sou Fueki performed the Sabbath and manipulated the events which followed in an attempt to resurrect his daughter, Koyomi.
In Kamen Rider Ryuki, one of the Riders' wish is to revive their sister who was killed by another Rider. In fact, the entire war had this as its primary goal, as the person holding it has it rigged so that his Rider can steal the prize and save his sister.
Dr. Whale (aka Dr. Victor Frankenstein) wants to revive his brother, and does so with tragic effects, and Regina wants to revive her lost love, and Dr. Frankenstein does so, with tragic effects in Once Upon a Time.
Deep be the mud on the fresh dug graves - on yours, I recite
An ancient spell I know so well, success is guaranteed
I'll bring you back from where you've gone
On All Hallows Eve
This is a fairly common theme in Native American legends, though it is generally the hero doing it. (Still never seems to work out well, though.) Expect An Aesop about how we're supposed to accept death, mourn, then move on.
In Egyptian Mythology Isis tries unsuccessfully to bring her husband Osiris back to life, but fails to because his brother Set ripped his dead body apart and a fish eats the penis. Isis is by no means a villain though.
Isis then conceived Horus with her dead husband (yes, after he was dead, and without his original penis), who avenges his murdered father.
In the Armenian folktale of Ara the Handsome, Ara is the king of Armenia and the most handsome man in the land. The Queen of Assyria, Semiramis, hears about how handsome he is and asks him to marry her, but he refuses because he already has a wife. Angry, Semiramis declares war on Armenia and orders her soldiers to bring Ara back alive. However, Ara dies in battle. Semiramis attempts to resurrect him by calling upon wolf spirits to lick his wounds and heal him, but the sorcery is unsuccessful.
In Norse mythology Loki has Baldr, the most well loved of the gods, killed. Frigg, Baldr's mother, then sends an emissary to Hel, the goddess of the Underworld, begging her to bring him back to life. Hel says that they can have him if they have everything in the world cry for him. Earth, sky and everything in between - in other words: it's not going to happen! The gods try though, and fail as the last person in the world they have not asked, an old giantess, refuses to cry. The tale is about the inevitability and finality of Death, whom even the gods can not fully control.
A cast of TSR employees at GenCon 1999 performed a Ravenloft-themed dialogue skit, "One Piece At A Time", that employed this trope. A female Mad Scientist attempted to resurrect her dead fiancee by keeping his disembodied head alive, murdering people, and surgically reassembling him from their salvaged body parts. Being a Ravenloft story, It Got Worse.
The storyline for Transformers: Kiss Players feat—no, wait!Comeback! Ahem. In addition to its more (in)famous elements, the Kiss Players storyline features a woman who has this as her motivation—her daughter was killed in an accident involving a Transformer, so she, having apparently watched too much Neon Genesis Evangelion, starts doing all kinds of nasty things in hopes of bringing her back while putting on a show of protecting Earth from horrible monsters.
Ironically subverted in Wild ARMs 3 where the villain eventually succeeds...but in the process had become non-human. His resurrected mother runs away from him in horror and dies.
The Shadow Hearts series uses this trope in just about every game, thanks to the recurring plot element known as the Emigre Manuscript, a book with instructions for raising the dead.
The main plot of the first game, Koudelka, revolved around the game's villain trying to resurrect a loved one. It does not turn out well.
Jack in Shadow Hearts was trying to resurrect his mother... and conducted experiments on orphans to work out how. The end result: a vicious monster with her face, which killed him. In many ways his section of the game is a Shout-Out to Koudelka.
The hero tries this in Shadow Hearts: Covenant, despite being well aware of the above two examples. The best thing you can say about the result is that it doesn't try to kill him at least.
In Shadow Hearts: From The New World, the entire plot turns out to have been set in motion by someone attempting this and actually succeeding for once, if only partially.
In Breath of Fire III, the director of the Plant, Palet, is revealed to have worked with Momo's father Retsol on a method to raise the dead; Retsol wanted to bring back his wife, while Palet wanted to resurrect his mother. Retsol eventually backed out of the project in disgust; Palet continued it, and when the party (Momo included) confronts him, he uses some of what he's found to become a giant mushroom beast. Afterwards, the party finds a tormented creation in the plant's reactor, the results of Palet's attempt to raise his mother from the dead; they shut the machine off and let her rest in peace.
Count Bleck from Super Paper Mario almost has this as his motivation. However, even with all his power he can't bring his lover back, so he just decides to do the next best thing: Destroy all worlds. Sadly, he doesn't know until it's far too late that she came back already, and is helping Mario defeat him.
The Second Chapter of La Pucelle: Tactics involves a man-turned-monster who is that he can bring his dead wife if he finds a heart just like hers... by ripping out those of the living.
This is the protagonist's motivation for slaying the Colossi in Shadow of the Colossus. In the process, he nearly unleashes a surprisingly honest ancient evil being on the world in a Deal with the Devil (said "Devil" more or less keeps Their word, and even warned the protagonist of the consequences several times), and is turned into an infant.
Shadow of the Colossus is pretty gray, really. Dormin (the aforementioned ancient evil) is really more bitter than actually evil, whereas the knights who reseal Them at the end are implied to have caused this whole mess in the first place by killing the woman the protagonist spends the game trying to resurrect.
Mithos Yggdrasil from Tales of Symphonia spent four thousand years trying to revive his dead sister Martel. He succeeded. Only to have her reject his actions for the past four millennia and be sent back to the dead five minutes later. He didn't take that well.
The tradition continued in Tales of the Abyss. As a child, Jade accidentally killed his beloved schoolteacher, Professor Nebilim. He tried to revive her by making a perfect copy of her body, but the Replica Nebilim ended up as an insane, bloodthirsty monster. Subverted in that this particular Necromantic is a good guy, even if his loyalty to the party can be ambiguous sometimes. Dist, on the other hand...
Fairly early in Bullet Witch, you discover that the events leading up to the game — disastrous plague, demonic invasion, etc. — were caused by such a character attempting to revive their loved one. A bit farther in, you discover that it was his daughter, not a lover. Towards the end... You find out that it was Alicia's father, resurrecting her after a plane crash — she seems to be Walking Techbane for aircraft. She came back to life as a super-powered witch with a mysterious demonic Exposition Fairy... and he's spent the entire time since alive but in agony from being impaled, as the physical embodiment of the contract opening the demonic portal. She's been spending the time since fighting the demons to make up for her resurrection bringing them about in the first place... and has to kill him to finally close the portal and allow any chance of ending the demonic invasion once and for all.
Lezard Valeth of Valkyrie Profile is one of the more demented villains out there even before he discovers that valkyries are only active when the humans serving as their Soul Jar are killed. So he kills a few dozen female humans and elves to make homunculi for Lenneth Valkyrie to be incarnated into (it's never made clear how many, but at least a dozen homunculi are shown, and it's suggested it takes a few of both species to make just one), all so he can woo her. By the end of the game, he gets away with it, too.
This happens in one of the endings to Silent Hill 2 to James, who, throughout, the game gathers several artifacts as part of a ritual to return his wife, Mary, back to life.
The antagonist to Silent Hill 4 isn't so much attempting to resurrect a loved one, as transform an apartment into what he thinks of as his mother.
Fable II'sBig Bad, Lord Lucien, begins researching the Spire to bring back his dead wife and daughter, but over the ten-year time skip after the introduction, he becomes much more power-hungry. The game also features a side-quest where a man is tracking down the body parts of Lady Grey (from the last Fable game) in order to resurrect her because he's fallen in love with her.
In the Lego Battles game for Nintendo DS, one of the story modes involves playing as an Evil Wizard in control of an army of skeletal mooks... who turns out to be just after the pieces to a magic staff that can resurrect his dead girlfriend. In a partial subversion, he actually manages it at the end, although she Came Back Wrong repeatedly, including coming back as a crab, a robot and an angry pirate.
Quentin of Dragon Age II is a Serial Killer with this fixation, who murders women so that their parts can be used in a blood-magic ritual to bring back his dead wife. The killer's final victim is Hawke's mother.
Similarly, Windhelm in The Elder Scrolls V: Skyrim is being terrorized by Calixto Corium, a Serial Killer known only as "The Butcher", who is murdering women in order to use their parts to create a new body for his dearly departed sister.
Lady Vayle, the Necromantress of DragonFable and AdventureQuest Worlds, was into necromancy to try to bring her brother Back from the Dead. It didn't end well, in no small part because of Noxus, her master at the time, and because Artix destroyed the crystal containing his Spirit Orb. She's still not happy with him on that score.
Rue (a heroic example) in Threads of Fate spends his path looking for a legendary artifact which may have the power to bring his dead guardian back to life. In his route, he succeeds with no negative effects (Though it wasn't easy).
In the iOs game The Quest, one early-mid quest involves a noblewoman who's determined to propagate her branch of the Donnen family. Thing is, she's also determined to make sure the heir in question is absolutely pure Donnen blood. Her solution? Conjure back the spirit of her dead father for just long enough to impregnateher. No wonder Anton abjured his birthright...
Vampire: The Masquerade – Bloodlines has a quest named Necromantic, but it's just for the pun. However, the trip through Alistair Grout's mansion shows that his rather bizarre research was intended to save his wife, who he has preserved in a sealed glass cylinder, though it's unclear if she technically died.
Malistaire, the former teacher of the death school, from Wizard 101 plays this to a T. After his wife dies he leaps off the slope. Even when the ghost of his wife begs him to let her go, he believes she's just an illusion. He also takes the nice step of that his way of resurrecting her has the possible side effect of destroying the goddamn world. After he dies he apologizes to her and the two of them go to rest in peace together.
Liara T'Soni of Mass Effect is (if you romanced her) a rare heroic example; she goes to great lengths to recover her dead lover's corpse and give him/her to an N.G.O. Superpower with the technology (and absurdly extensive funding) to bring him/her back as a cyborg.
Josef Capek's loved one in Shikkoku No Sharnoth died during a seance and he's trying to bring her back to life with magic.
In Jack, this happened the first part of the arc Two for You, though the male protagonist isn't shown as being especially evil for doing it.
In Mutant Ninja Turtles Gaiden, Donatello fits this role as he performs unpleasant experiments in hopes of bringing Splinter back to life.
Trace's backstory in TwoKinds. he goes insane from the Black Magic required to even try the spell, and begins to slaughter people left, right, and down the middle. He gets so evil that it takes a god to stop him (the beastman god, incidentally. trace going mad was all part of the human god's plan).
In Quentyn Quinn, Space Ranger this turned out to be the cause of the attempted killer's motivation in the "Murder on the Sapphire Star" arc. Sebak was trying to replicate his dead wife Anippe from 50-year old medical scans and then overwrite the clone's brain with a 30-year old brainscan taken just before her death. Unfortunately Anippe's digital copy freed her biological copy and she attacked him.
In The Gamer's Alliance, the elven necromancer Thanatos Barca wishes to bring his deceased wife back to life by using an eldritch ritual and is willing to go to almost any lengths to achieve that goal.
Mr. Freeze from B:TAS (and later the comics), who turned to crime for funds to cure his sick, cryogenically frozen wife.