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Anime and Manga
- Shiki Ryougi from Kara no Kyoukai—at least, until a car accident kills off her male personality. Also, her entire bloodline is capable of developing this if a specific ritual is performed when they're infants, and she's the heir of the family rather than her older brother because he was unable to manifest his second personality.
- Hato, the Wholesome Crossdresser of Genshiken is male but has a female inside voice/spirit/personality/whatever, teasing him each time he is with Madarame, much to his annoyance.
- The former spirit detective Shinobu Sensui from YuYu Hakusho has developed no less than 7 identities, one of which is a girl called Naru, who represents the last remnants of his innocence.
- Kotonoha Nanase from Gun×Clover has seven different personalities which protect her primary personality, who has been targeted since childhood because of a unique ability to read dead languages. Her fifth personality is a Hot-Blooded male martial artist named Itsuba.
- Invoked in Love Stage!!. The protagonist Izumi, an otaku from a prominent family of actors and music talents, is cast in a TV Drama as the main character, a rich young master with three personalities, one of which is a girl. This difficult role shows off Izumi's prodigious but heretofore unseen acting abilities, causing feelings of inadequacy in his senior co-star and boyfriend, Ryouma.
- Mari from Inside Mari is implied to have three personalities: The female "Mari", the female "Fumiko", and the male "Isao". Fumiko is her natural personality however Mari developed due to childhood traumas and her mother forcibly changing her name. Isao is the newest personality and developed due to her interest in the real Isao. The Isao personality is the main character of the manga and believes he is the 'real' Isao stuck inside Mari's body.
- Linnéa in We Are All Pokémon Trainers shares a body with her male split personality, Ray, who was formed out of her desire for a protector from her abusive mother.
- A sub-plot in Session 9 revolves around a psychiatric patient named Mary Hobbes, who suffered from dissociative identity disorder and had three "alters" named The Princess, Billy and Simon. Billy and Simon sound very masculine and have masculine names while The Princess sounds more feminine. The film leaves it deliberately ambiguous whether this is actually a case of dissociative identity disorder or Demonic Possession.
- The main character from Doctor Jekyll and Sister Hyde is a man whose Hyde is a woman.
- In the famous twist ending from Psycho it turns out that Norman Bates' mother is long since dead, but Norman has a split personality who he thinks of as his mother. Even more creepily, we actually hear Norman talk in her voice near the end of the film.
- In Identity, the ending reveals that all of the ten main characters, consisting of seven males and three women, are alternate personalities of Malcolm Rivers.
- An in-universe example in Adaptation., in which Donald's inane psychological thriller screenplay The Thr3e ends with the reveal that the cop protagonist, the killer he is chasing after and the female victim the cop falls in love with are all the same person. Donald chooses to cheerfully ignore all of the Fridge Logic and Plot Holes created by this plot twist.
- Carter in Raising Cain has several split personalities, who are leftovers from the research he went through as a child. One of them is a quiet, intimidating woman named Margo, who takes over to make him escape the police, and go after the real villain of the story.
- The Truth introduces Altogether Andrews, a beggar with no less than 8 different personalities, one of which - named Lady Hermione - is female. They activate at random, and can apparently communicate with one another. And none of them respond to "Andrews".
- When Rabbit Howls, the autobiography of Truddi Chase and her Troops, matter-of-factly describes both male and female selves, different ages and races. One of the powerful protective selves was Mean Joe Greene, a huge black man. Chase was physically a white woman.
- United States of Tara is about a woman with DID named Tara Gregson and her multiple personalities, one of whom is a man named Buck who claims to have lost his "member" in 'Nam.
- In a first season episode of Shawn and Gus are hired by a client who turns out to have multiple personalities. One of them is a woman who has been trying to arrange a sex change behind the (male) primary's back, another is a murderous psychopath who kills the doctors the female alter has been going to.
- In another episode, Gus falls for an extremely attractive woman... at a mental hospital. Eventually, he learns that she is sharing a body with another personality named "Frank".
- In a House episode, a girl develops an alternate personality whom she considers her "boyfriend". Oddly enough, she tests positive for pregnancy and the doctors think he got her pregnant, which doesn't turn out to be true.
- In an episode of The X-Files there was a woman who claimed to have a Split Personality; one of the personalities was male.
- Bates Motel, as a TV prequel to Psycho, has Vera Farmiga playing both the real Norma Bates and Norman's manipulative secondary personality "Mother".
- One Law & Order episode revolved around a woman with an apparent case of this; she had formed a male personality to protect her from the person abusing her, but she would black out after becoming the other personality and couldn't remember what "he" did; the episode hinged on how much proof of the diagnosis there was and whether she could make an Insanity Defense.
- In killer7, KAEDE is one of the many split personalities of Harman Smith and the only female one. The appearance and physical characteristics change to match that of the personality in charge though, and it's never made totally clear how these personalities came about in the first place as the game is one big Mind Screw.
- Umineko: When They Cry has a variant of this, since Kanon and Shannon are actually alter egos of Sayo Yasuda (although Sayo's original gender is left ambiguous, and so which one's the OGSP is left to speculation). There were hints of this throughout the entire novel, but it's pretty much spelled out by the seventh Episode. This is the largest clue to solving the entire story; figuring this out blows most of the closed rooms open.
- Uendo Toneido from Phoenix Wright: Ace Attorney – Spirit of Justice suffers from multiple personality disorder. Most of his personalities are male, but one of them, Kisegawa, is a female courtesan (the game even switches to the higher-pitched text blips used for female characters when said personality takes over).