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Films — Animated
- In Disney's Hercules, Hades has his minions Pain and Panic kidnap an infant Hercules to feed him a potion that will turn him mortal so he can be killed, but because they miss the last drop Herc loses only part of his powers. Hercules becomes a full god again at the end of the movie, but chooses to go back to being "just" a demigod (and thus mortal) to live with his Love Interest.
Films — Live-Action
- In The Mummy, it turns out that the companion book to the Book of the Dead doesn't kill the Big Bad when read from. What it does is remove his immortality, allowing him to be killed like a mortal. Imhotep, however, didn't know this and simply walks into a sword, assuming he'll be fine.
- Pirates of the Caribbean: The Curse of the Black Pearl has this happen to Barbossa at the worst possible time; Will drops the final gold piece into the cursed treasure chest just after Sparrow blows a fatal hole in Barbossa's chest with a pistol, removing the curse and causing Barbossa to bleed out.
Barbossa: Ten years you carry that pistol, and now ya waste your shot?Will: He didn't waste it. (drops coins)
- Part of The Prize in Highlander is the option to live as a normal human, which Connor states is his intention at the end of the original film.
- In Wrath of the Titans, the level of prayers to the gods has dwindled so much that the gods have lost their immortality and many have died before the movie even started. The gods who are left still have their powers, but they are fading and they are vulnerable to being killed.
- And Another Thing...: Wowbagger the Infinitly Prolonged wants to die, but can't because he's been made immortal against his will. At the end he become de-immortalized, so he will eventually die. Close Enough.
- The plot of Harry Potter and the Deathly Hallows was Harry and company searching for and destroying the Horcruxes in order to remove Voldemort's immortality.
- In J. R. R. Tolkien's Middle-earth, the members of the Half-elven family descended from Lúthien get the cosmic choice to which kind they want to belong, leading to (im)mortality and a different fate after death. Arwen from The Lord of the Rings, and before her her uncle Elros, choose humanity and mortality. Their ancestor Lúthien was Elven, but got a once-only cosmic exception to have a mortal fate to be with her human lover Beren, before and after death.
- In Skin Game, Uriel lends his Grace to Michael to use for a day, resulting in him becoming temporarily mortal. It is revealed when Harry punches him in the face and sees him actually bleed, which a being who can unmake galaxies should not do.
- In the same book, Nicodemus temporarily takes off Judas' Noose which makes him invincible to anything but being strangled with itself, for a ploy.
Live Action TV
- Star Trek: The Next Generation: In an episode Q had his omnipotence taken away as a punishment by the Q continuum, thus becoming mortal. The Enterprise crew are saddled with him until he regains his immortality—in fact, he specifically chose them because he knew that they are idealistic enough that in spite of their own dislike of Q, they would still protect him from other creatures who might desire revenge on Q for his past torments.
- Star Trek: Voyager:
- 7 of 9 hurt her hand while working and was upset with the fact that supressing the Borg nanotechnology removed her Healing Factor.
- Q once made his son q (yes, lower-case) mortal and dumps him on Voyager. It's less of a punishment and more of a disguised lesson.
- On Angel according to the Shanshu Prophesy, the Vampire with a Soul will eventually be rewarded by dying - which is to say, he'll be rewarded by becoming human, and thus being allowed to die as a human.
- Nathan from Misfits sells his immortality on the black market.
- The clone of David Tennant's Doctor, grown from his severed hand, was cleansed of Time Lord DNA and will have a normal human lifespan, living with Rose in a parallel universe.
- The final episode of Lost implies that Richard Alpert has lost his immortality, which he considers a very good thing.
- In Torchwood: Miracle Day, Captain Jack Harkness loses his immortality.
- At the end of the series, this happens to everyone, except Jack and Rex.
- In his best ending in SoulCalibur 3, Zasalamel succeeds in becoming mortal and spends the rest of his life as a scholar, chronicling everything he experienced.
- In Final Fantasy III, the great sage Noah awards each of his three students with a gift. Doga is bestowed with great magical power while Unei was given control over the world of dreams while she slept, and both go on to become renowned sages in their own right. Xande? He receives the "gift" of mortality. He doesn't take well to this perceived snubbing. In fact, he's so bent on avoiding death that he's willing to "live" forever by freezing time for himself and everyone around him.
- The Big Bad of Final Fantasy V, as well as the previous wielder or the Void, both lost their immortality when they acquired this power.
- In the finale of World of Warcraft Cataclysm the Dragon Aspects lose their immortality (and possibly more of their powers) after focusing their power through the Dragon Soul to slay Deathwing for good.
- This is the goal of the Nameless One in Planescape: Torment, in part due to the Immortality Immorality he's unwittingly using — whenever he dies, somebody else in The Multiverse gets the life sucked from them to restore him, causing them to linger as vengeful undead shadows.
- The Elder Scrolls provides several examples:
- This was the goal of the Underking in The Elder Scrolls II: Daggerfall, as a necessary component of being able to finally die — which puts him as one of the endings of the game, as to die he needs the Mantella (which will be destroyed by this), the thing everyone else is searching for to either power Numidium or become a god. Whether he pulled it off is uncertain, but trending 'yes' — indications are that the end of Daggerfall broke time and all endings happened as much as was possible without directly contradicting another in anything but cause, and the Underking's death would have been easy to slot in for Akatosh' servants.
- The Elder Scrolls III: Morrowind has the Tribunal, a trio of flesh and blood gods who ascended to that status by tapping into the heart ("divine center") of the dead creator god Lorkhan. The main quest of the game features the Nerevarine severing their ties to the heart in order to defeat the Big Bad Dagoth Ur, who also draws his power from the heart. Once those ties are severed, the Tribunal revert to mortal forms, which only happens, per Vivec (one of those deities), due to the faith of their followers.