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Anime and Manga
- Deconstructed in Kotoura-san's Downer Beginning. Neither Kumiko nor her daughter Haruka are aware of the latter's inadvertent Telepathy, and the school told Kumiko that Haruka is being "a compulsive liar" even though she's really revealing everyone else's lies. After several hospital visits note , none of the doctors could find anything truly wrong with Haruka enough to take her in because Psychic Powers are not recognized by the setting's mainstream science and Haruka wasn't sick nor delusional in any sense. This failure drives Kumiko into alcoholism, and Kumiko eventually disowns Haruka altogether since Kumiko could not understand Haruka at all.
- It doesn't deal directly with spirits, but Fujino Asagami of Kara no Kyoukai was medicated since she was a small child to seal her psychic power to bend things, which had the side effect of making her unable to feel pain. When she starts getting her sense of pain back in fits it also unlocks her powers and then you understand why they were sealed in the first place when she goes after a gang that sexually abused her and bloodily rips them apart.
- Slayer, Interrupted is all about this in this Buffy the Vampire Slayer comic installment set between the Buffy movie and the TV show.
- Not exactly this but close, Cade Skywalker from the comic book series Star Wars: Legacy medicates himself with death sticks (a narcotic drug) to prevent himself from seeing spirits of his ancestors.
- Anderson: Psi-Division: On what would later become Deadworld, having dreams was derided, because to become an adult one must learn to crush their dreams. Children with psi-abilities were locked up and sedated.
- Bird: Many patients at Alchemilla are not actually insane, and are medicated to deal with dangerous, indiscriminate, or uncontrolled powers. It's repeatedly lampshaded that one of the reasons some parahumans are difficult to control is because thier brain chemistry can differ from baseline humans, thus reducing the effectiveness of medication.
- Constantine: The title character and Isabel and Angela Dodson all first displayed their psychic abilities as children. Unfortunately, these abilities helped them to see the half-demons infesting the Earth, resulting in one of them being forced to undergo psychiatric treatment and later committing suicide.
- In Dark Shadows, the little boy, David, sees his mother's ghost, has a personal psychiatrist living in the house, and could be on meds. These measures help none. Victoria had it worse: she sees her earlier incarnation and was abandoned by her parents on the grounds of being too embarrassing to keep, and thrown into a barbaric mental asylum with featureless, padded rooms, habitual straitjacketing and nasty treatments. And they helped none.
- The setup of The Sixth Sense.
- This trope actually gets people killed in A Nightmare on Elm Street 3: Dream Warriors, in which Kristen's disbelieving shrink has her sedated to force her to get some rest. Several of her friends die in their attempt to protect Kristen from Freddy.
- By the time of Freddy vs. Jason, however, people know enough about Freddy and what he can do that experiments on drugs that put people to sleep but keep them from achieving REM state (which is where science says "dreams" occur, and thus where Freddy strikes) are being done. Unfortunately, Freddy destroys said experimental drugs before any of the protagonists can obtain them... and they also discover that the experiment's staff has overdosed multiple people, putting them on permanent comas.
- Jem, the heroine of Numbers, has a psychic ability to look into a person's eyes and know their date of death. She discloses this ability and ends up committed to a mental hospital for treatment. Unusually for this trope, not only is Jem's psychic ability completely eradicated by the drugs she's administered, she's happy to lose it.
- In Shards of Honor, Cordelia got a rare non-supernatural version of this, since she couldn't tell the whole story about her involvement in the Barrayar-Escobar war and the part she could tell was dismissed as obvious Barrayaran brainwashing.
- Zhegorz in the Circle of Magic series spontaneously developed at a very young age the ability to scry the winds, hearing and seeing events that the winds had touched earlier in their travel. Unfortunately, this ability not only tends to drive people crazy on its own, but it's so rare that nobody realized he had it, so he wound up getting put in a lunatic asylum and drugged to within an inch of really going mad. Luckily, he eventually bumped into someone who had taught herself the same ability, and teaches him to use and control it.
- Katie in the Enchanted, Inc. series can temporarily lose her magical immunity when dosed with anti-depressants.
- In Amy Tan's The Hundred Secret Senses, this happens to Kwan, Olivia's half-sister. She's confessed to Olivia that I See Dead People with her "yin eyes". At night, she talks to them for hours and tells Olivia long stories of her Past-Life Memories. Olivia is terrified, so tells her parents. They promptly have Kwan incarcerated in a nuthouse and given countless shock treatments. Instead of stopping the ghosts, this lets evil ones in and makes her unable to stop talking about them. She never blames Olivia.
- In Marion G. Harmon's Wearing the Cape novel Villains Inc., Dr. Cornelius was heavily using drugs to tone down and cope with his powers
- In Lives of the Mayfair Witches, Carlotta has this done with Deidre to prevent her from invoking the spirit Lasher. It fails to have the desired effect however, as Lasher is, if anything, able to materialize more often because Deidre has no conscious control over her summoning of him.
Live Action Television
- In Twin Peaks, taking the medium off his medication was part of the process of solving the murder of Laura Palmer.
- Buffy the Vampire Slayer spent some time in an asylum after she saw her first vampires and made the mistake of telling her parents about it.
- In the episode "Normal, Again" Buffy is almost convinced that the entire Slayer world she is living in is actually her delusion. The episode leaves open the possibility that this is actually true (and, by extension, Angel as well).
- In Ghost Whisperer, Melinda's half-brother was put through rough treatment in medical facilities because of his powers. Melinda escaped this fate because she lived with her grandmother who also had the sight. This key difference in the reactions to their powers defines who they become in life.
- In Bedlam, Jeb spends time in a mental hospital due to seeing ghosts, and his family think he's crazy. In the second season, Ellie refuses to take meds or get help with what her fiance thinks is a mental issue.*
- On Millennium Frank takes part in a drug trial that he thinks may suppress visions like his own. Not for himself, but for his daughter Jordan. It doesn't work out, but the trouble he gets into does bring some things to light.
- In the first season of Iron Fist (2017), Danny Rand is thrown in a Bedlam House by the heirs to his parents' company — who are enjoying his money too much to admit his identity. Once he wakes up strapped to a bed, the first thing he realizes is that the drugs interfere with his Ki Manipulation abilities. After a few days he's able to convince one of the therapists he actually is a disenfranchised heir, but because false belief in superpowers is a known phenomenon and he can't demonstrate them is still considered delusional... and kept on the drugs. Danny eventually focuses hard enough to purge the drugs from his system and punches his way to freedom — through a two-foot steel door.
- Wynonna of Wynonna Earp was institutionalized, medicated and subjected to electroconvulsive therapy when she was young because she insisted that demons attacking her home led to the death of her father and older sister. It didn't help her case that, in the attack, she was the one who accidentally shot her father. By the time she returns to her hometown as an adult in the series pilot, even she believes she was probably just crazy all along.
- Zandalee from Demon Hunter Kain spent four years in a mental institution, until the spirits either left her alone for a while or the medication dulled her ability to sense them.
- A variant in Homestuck: it's suggested that Roxy Lalonde's perpetual drunken near-stupor is keeping her from manifesting her powers as the Rogue of Void to their fullest. The Alpha session's "blackouts" grow more frequent as she sobers up.
- The heroines of Cheshire Crossing have spent most of their childhood hopping from asylum to asylum and initially believe the institute is just another one.
- The Perry Bible Fellowship has "Return of the Ghost".
- An important point in The Salvation War.
- A Russian joke: Beware of haloperidol, it doesn't cure anything! It blocks chakras and blinds the third eye!
- Unfortunately, the Russian joke isn't that funny once you know that haloperidol is often given to people with dementia who experience hallucinations. In some cases it helps, in others, not so much. In at least one type of dementia, the hallucinations have a different cause and the haloperidol makes the hallucinations worse instead of better. There has been at least one real life case in which a doctor failed to recognize this.
- A little known fact about modern psychiatry is that much of it began in the Spooky Sťance room as medical doctors and scholars tried to ascertain if spirits and spirit communication could be real, and how to distinguish between mediumship and mental illness. These doctors were some of the first to research how hypnosis could be used to benefit clients, and the first to describe and name dissociation and multiple personalities in their modern context as psychological conditions.