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- Antiviral rather than antibiotic, but in Outbreak, Robbie contracts the Motaba virus and is on the brink of death before they administer the virus' antiserum. She is almost completely recovered after only a day. In reality, this is far too soon to recover from a hemorrhagic fever, which causes massive internal bleeding and organ failure.
- In the last section of The Stand, Stu Redman comes down with the flu. Tom Cullen, on the advice of his dead friend, finds some antibiotics and cures him. While Tom saving Stu's life is a Crowning Momentof Heartwarming, antibiotics don't cure the flu (a viral infection), and the antibiotics would be several months out of date, as it's after The Endof The World As We Know It.
Live Action TV
- Played with on House: first prescribe the most widely useful antibiotics, then find out what they actually have before the patient's kidneys shut down because of the antibiotics.
- This trope also applies to cancer treatments. While in reality there are dozens of families of antineoplastic drugs, any of which is only effective and used on a handful of specific cancers, House's team is fond of using one-size-fits-all chemotherapy.
- House is one of those rare examples in fiction that acknowledges the existence of separate treatments for fungal and parasitic infections.
- Averted in a Jon Pertwee Doctor Who story which has a major subplot about a deadly plague being released by the story's antagonists. The Doctor and Liz Shaw eventually find a cure by literally going through every single available antibiotic drug to see if it works in lab conditions. In the meantime the best they can do is use high doses of broad-spectrum antibiotics which are just effective enough to delay the plague's symptoms, and a character notes that this policy is causing severe side effects.
- Averted in Combat Hospital. In the second episode, the antibiotics the hospital staff keep doling out have no effect on a local strain of bacteria.
- Sadly prevalent in real life medicine, as providers frequently don't want to wait to culture an organism before attempting to treat it. A major cause of the explosion in the rates and severity of multidrug-resistant bacterial infections. However, since a culture & sensitivity requires anywhere from one to five days to result and it looks kind of bad if your patient dies of his infection before the C&S report comes back, "empiric therapy" - prescribing a broad-spectrum antibiotic "cocktail" and narrowing it down when the C&S results - is common. This treatment is always prescribed in conjunction with a "pan culture" - culturing samples of the patient's blood, urine, stool, sputum, occasionally cerebrospinal fluid, and any wounds they might have, in order to pinpoint a source of infection. The classic example of this scenario is when someone is dragged into an ER unconscious, running a high fever and in apparent septic shock. They're dying, and you need to treat bacteremia immediately. What do you do? Bomb the infection with as broad-spectrum a cocktail as is reasonable, and hope the drugs kill the bugs before fatal damage results.
- Choosing antibiotic therapy for as-yet unidentified infections poses yet another wealth of traps for the physician. For example, vancomycin, commonly used as a one-stop bug bomb for skin and soft tissue infections, is deadly to practically all Gram-positive organisms but practically no Gram-negatives. The choice of antibiotics for pneumonia changes quite a bit depending on whether the patient has recently spent time in a hospital or nursing home. Gastrointestinal organisms behave very differently in skin and soft tissue versus their home tract. The general wisdom is to treat with the most effective and narrowest spectrum antibiotic you can; when you don't know the specific infection's resistance, you make an educated guess as to which antibiotics should cover the most common causative organisms. (Hospitals are Genre Savvy to this, and one of the jobs of the hospital's infection control department is to create and publish an "antibiogram" - a comprehensive chart of the most common bugs in the community and which drugs they're sensitive and resistant to.)
- It's worth pointing out that antibiotic resistance is complicated. It's not like all bacteria resist the same things. Penicillin is often useless against Staphylococcus aureus but great for Streptococcus pyogenes pharyngitis (a/k/a "strep throat")... but useless again for S. mitis. Tigecycline is rarely resisted but won't work against any Pseudomonas due to quirks of the bacteria's biology; cefepime is quite commonly resisted by many bacteria but works great against Pseudomonas. Giving clindamycin to a patient can actually increase the risk of Clostridium difficile infection. You treat C. difficile with metronidazole, and metronidazole is used for Candida vaginosis (yeast infection) as well... and may cause Mobiluncus vaginosis. And so on. Treatment isn't easy or obvious.
- Many people will demand antibiotics from doctors for common ailments like colds or influenza. Although those are viral and antibiotics are completely useless, doctors often give in.
- Dr. Drew Pinsky noted on an episode of Loveline that azithromycin (known best under the brand name Zithromax) is frequently given as a catch-all treatment, and estimated that it was the appropriate treatment for maybe 10% of those cases in which he's seen it prescribed.
- The 1918 influenza pandemic. At least in the US, doctors tended to jab untested or marginally tested "vaccines" into as many arms as they could manage in the hopes that this time, they had it right. (Given that medical science of the early 1900s assumed that influenza was a bacterial disease, any cures would have been accidental.)
- Related are anti-bacterial soaps or cleaning agents. They are claimed to wipe out infectious bacteria, but the only way to guarantee killing bacteria is to maintain 20 minutes of exposure. Washing your hands or 30 seconds only destroys bacteria with the weakest resistance, and later generations of bacteria will evolve with better resistance to them.
- Note: This doesn't apply to hand sanitizer. The active ingredient in most hand sanitizers is alcohol; your typical sanitizer is basically 80 proof vodka turned into a gel. Almost needless to say, we've been using alcohol to kill microbes for millennia (without realizing it for most of that time), and none of the critters has ever developed a resistance to that. The same goes for bleach, ammonia, peroxide, and acid (none of which you should get on your hands!).
- In some parts of the world, some doctors really do prescribe antibiotics for everything. Typically these are older doctors in developing countries, from a time when indiscriminate prescription of antibiotics was seen as harmless-resistant bacteria hadn't popped up yet. However, even though doctors their age in the rich world have stopped this practice, they haven't—largely because wealthy countries tend to impose fairly rigorous continuing medical education (CME) requirements to ensure that doctors keep up with the state of medicine, while poorer countries either don't have CME requirements or cannot enforce them. So the doctor keeps handing out antibiotics like it's candy, not realizing that this has been a terrible idea for at least the last 30 years.
- There is a legend about some grave robbers during The Black Death. Despite robbing, you know, plague victims, they never got sick. When they were finally caught, they were asked to reveal their secret. It turns out that one of the grave robbers was a doctor or herbalist, and had fixed up some type of protection using herbs and spices that were later found to have antibiotic properties. (They didn't know that, but they did know that using these plant parts tended to result in less sickness.) It isn't known whether or not this was an actual event (hence its placement here), but the story did inspire (and/or has been used to promote) an essential oil blend called "Thieves."