- MOTHER, a series of video games
- MOTHER 1, the first game in the series, also known as EarthBound Zero and Earthbound Beginnings.
- Mother, a 1996 comedy film directed by Albert Brooks.
- Mother/Madeo, a 2009 drama film by South Korean director Bong-joon ho.
- Mother, a 2017 horror film directed by Darren Aronofsky.
- Various tropes involving mothers; see The Parent Trope index.
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