[[quoteright:320:[[Film/TheLordOfTheRings http://static.tvtropes.org/pmwiki/pub/images/rsz_tumblr_mgkc4w79hg1s3p6mwo1_1280_7830.jpg]]]]
[[caption-width-right:320:[[ElvesVersusDwarves Elves and dwarves are enemies]], you say? Not this time. [[VitriolicBestBuds Won't stop 'em from]] [[BodyCountCompetition competing]], though.]]

->''"I don't mind having a demon friend."''
-->-- '''Fuka Kazamatsuri''', ''VideoGame/Disgaea4APromiseUnforgotten''

In everyday life you're unlikely to know anyone of a different species to yourself, besides pets, and however much you might love your furry/scaly/feathered friends, the relationship probably isn't quite the same as the one you have with your bipedal ones. Animals in question also have a tendency to fight each other over food and territory.

In fiction, this restriction is ''way'' more lax, especially in the realms of of Fantasy and Science Ficton. Those worlds are populated by a whole host of fantastic aliens, elves, werewolves, robots, vampires, and who ''knows'' what else. It's incredibly common for people of completely different species to become close friends. Since the majority of these creatures tend to have an intelligence on par with--if not greater than--that of humans, it might be stranger if people of various species didn't develop some sort of kinship. Even for species that are AlwaysChaoticEvil, you can expect at least one individual to [[PlanetOfHats throw off his hat]] and say MySpeciesDothProtestTooMuch, thus joining the good guys.

Sometimes, in universes where the existence of other magical/advanced races are part of TheMasquerade, or there's a lot of FantasticRacism going on, these friendships might be more limited. This will usually allow people to comment how strange the hero(e)s' friendship is.

See InterspeciesRomance, when the relationship is less platonic than this. Sometimes overlaps with OddFriendship.
If they are not supposed to be friends, see ForbiddenFriendship.

LoyalAnimalCompanion is a Subtrope. See also AndroclesLion, ABoyAndHisX, and PredatorPreyFriendship. One of these may lead to a MayflyDecemberFriendship.



* [[https://www.youtube.com/watch?v=vnVuqfXohxc This]] Android commercial, which very fittingly uses the song "Oo De Lally" from Disney's ''Disney/RobinHood'', whose main characters were an anthropomorphic fox and bear.

[[folder:Anime & Manga]]
* The bond between humans and their partner ''Anime/{{Digimon}}''.
* ''Anime/{{Pokemon}}'':
** Ash Ketchum and series mascot, Pikachu.
** Friendship, trust, and understanding between trainers and their Pokémon are recurring themes on the show.
** Jesse and James with Meowth. This is different than any of the other examples from this show because Meowth is treated more like a equal than a {{Mon}} or pet. This is probably because he is one of the few Pokémon that speak human.
* Rem ({{Shinigami}}) and Misa (human) of ''Manga/DeathNote''. Rem develops a platonic love for Misa and is even willing to die for her. Light (human) and Ryuk ({{Shinigami}}) also fall under this having a few VillainsOutShopping moments together, though they are of a more {{vitriolic|BestBuds}} type.
* ''Manga/{{Hellsing}}'' has Integra and Pip (humans) with Alucard and Ceres (vampires).
* ''Anime/WolfsRain'' had a pack of wolves and a genetically engineered flower-human hybrid.
* Kimba and Roger Ranger from ''Manga/KimbaTheWhiteLion''.
* ''Manga/BlackJack'':
** Used with a human scientist who's a friend of Manga/BlackJack adopting his last experiment (a super-intelligent deer) and treating him like a brother. It soon went FromBadToWorse.
** Also between a young fisherman and a whale. Again, it got worse when the whale was blamed for the death of some fishermen. [[spoiler: Unlike the scientist and the deer, they get better.]]
* ''Manga/DragonBall'': Goku and most of his friends. But a more prominent example is Gohan (Saiyan/Human hybrid) and Piccolo (Namekian), which looks more like an IntergenerationalFriendship, but Piccolo is [[YoungerThanTheyLook only four years older.]]
* ''Manga/OnePiece'':
** The most notable being Tony Tony Chopper, a reindeer who is a member of the Straw Hat Pirates and a [[TrueCompanions dear friend]] to the other 8 Straw Hats, who are all human.
** Luffy and Jinbe, who is a fishman. Later, during the Fishman Island arc, the other Straw Hats become friends with him, too, and all of them befriend a few of the other mermaids and fishmen on the island as well.
** In the Zou arc, we get the Minks, a race whose appearances range from animal-human hybrids to straight-up talking animals. They are very friendly to the Straw Hats, and have [[spoiler:apparently been friends with the human Kogetsu clan, a samurai clan from Wano, for a very long time]].
*** One particular, previously established human-Mink friendship is that of Trafalgar Law and his polar-bear-Mink navigator, Bepo, who have been friends for ten years.
* ''Webcomic/AxisPowersHetalia'':
** America and Tony, his alien friend. They've been shown hanging out and playing video games, and America goes to Tony for help regarding the Pict invaders in the movie.
** England has several magical creatures such as fairies and unicorns that he is friends with. However, with the exception of Norway, no one else can see them.
** Like England, Norway has fairies and a troll friend that are invisible to almost everyone else.
* ''Manga/{{Bleach}}'':
** Tousen and later his lieutenant Hisagi with the anthropomorphic wolf Komamura. Komamura is eventually confirmed to be a member of a clan of werewolves. They're not supposed to consort with others not of their own kind and it took Komamura a long time to build up the friendships he now has in the Gotei 13.
** Ichigo's group befriend Nel and her companions Pesche and Dondochakka. Humans and Hollows do not get on because Hollows typically kill and consume Humans. Ichigo is also a "substitute Shinigami", and Shinigami have been warring with Hollows for a thousand years.
** Humans and Shinigami do not typically have the ability to befriend each other. When Ukitake and Hisagi discuss the friendship between Rukia and Orihime, Hisagi finds it weird. Ukitake reprimands Hisagi, pointing out that any friendship should be treasured even if the friends are walking slightly different paths in life.
** Shinigami and Quincies have been bitter enemies for a thousand years. This does not stop Ichigo (a Shinigami representative) and Uryuu (a Quincy) transforming from enemies to FireForgedFriends. Their mutual friends eventually point out they're really VitriolicBestBuds, much to the horror of both. They actually [[GenerationXerox take after their fathers]], as [[CrouchingMoronHiddenBadass Isshin]] (a Shinigami) and [[HeroicNeutral Ryuuken]] (a Quincy) have been friends for over twenty years. The reason their friendship has survived for so long is because both men [[MysteriousPast appear to be exiles]] from their own kind, living in the human world and keeping some enormous secrets from even their own sons.
* ''Manga/ChronoCrusade'': The demon Chrono bonds with his human allies; most notably Rosette.
* ''Anime/PrincessMononoke'': The eponymous heroine was literally RaisedByWolves, whom she considers her family. So much so, that when Ashitaka tried to tell her she was human, she vehemently denied it and said she was a wolf.
* Natsume and most of his spirit/Youkai friends in ''Manga/NatsumesBookOfFriends'', including an inukami (a wolf-like spirit) and a kitsune-kodomo (a child fox spirit).
* From ''Manga/YuYuHakusho'', there is Yusuke and Kuwabara (humans) and Kurama and Hiei (demons).
* Any friendship Mamoru in ''Anime/GaoGaiGar'' develops, as he is an [[HumanAliens alien.]]
* The titular ''Manga/InuYasha'', who is a half-demon, half-human, with Miroku and Sango, both humans, and Shippou and Kirara, both youkai.
* ''Anime/YuGiOhGX'': Any human and duel spirit friendship, such as Juudai and Hane Kuriboh, Manjoume and Ojama Yellow, or Hayato and Death Koala.
* The premise of ''Literature/ArashiNoYoruNi'' revolves around this idea. Though whether this crosses over to {{Bromance}} or InterspeciesRomance territory is up for interpretation, especially in the anime when they change Mei's gender.
* ''Anime/SummerDaysWithCoo'' is about a human boy who befriends a {{Kappa}}.
* Hiyori (human) and Yato and Yukine (god/spirit) in ''Manga/{{Noragami}}''.
* In ''Anime/BravePoliceJDecker'', Yuuta, a ten-year-old human boy, is friends with Deckerd, a HumongousMecha with a complex [=AI=].
* ''Manga/MissKobayashisDragonMaid'' has Makoto (human) and Fafnir (dragon), along with Saikawa (human) and Kanna (dragon), though the latter one dips into InterspeciesRomance. Both also qualify as a MayflyDecemberFriendship.
* ''Anime/UnicronTrilogy''
** ''Anime/TransformersArmada'': There's Rad, Alexis, Carlos, and eventually the bullies turned friends, Billy and Fred. The kids even manage to befriend the Decepticon Starscream [[spoiler:when he changes sides. Even though he later returns to the Decepticons, Alexis remains friends with him]].
** ''Anime/TransformersEnergon'': A multitude of humans working alongside the Transformers, notably the Jones family, Misha Miramond, and the now-adult Rad, Carlos, and Alexis.
** ''Anime/TransformersCybertron'': There are the brothers Coby and Bud Hansen, their friend Lori, scientist Lucy Suzuki, and Colonel Mike Franklin.
* ''Manga/Naruto1997'' has Naruto, a {{kitsune}} child, befriending two adult humans named Takashi and Kuroda. They are his first friends. Naruto grew up not trusting humans because [[FantasticRacism they look down upon him for being a demon]].

[[folder:Comic Books]]
* ComicBook/MickeyMouseComicUniverse. Disney/MickeyMouse and WesternAnimation/{{Goofy}}.
* In the ComicBook/XMen there is ComicBook/KittyPryde and Lockheed the Dragon, who is her friend, not her pet.
** Also in the X-Men there is ComicBook/{{Cyclops}}' father Corsair and the other Starjammers (except [[InterspeciesRomance Hepzibah, who is his lover]]), each of whom belongs to a different race (except for Sikorski, who is a robot).
** Longshot and Shatterstar - both from Mojoworld - and their teammates (except for lovers) on various X-teams.
** Warlock and the other ComicBook/NewMutants.
* Human Rick Jones and the Kree [[ComicBook/CaptainMarVell Captain Marvel]] (Mar-Vell as well as Genis-Vell).
* ComicBook/SheHulk and Jazinda the Skrull.
* Most of Franchise/{{Superman}}'s friendships qualify, though not necessarily Clark Kent's.
* The Wolfrider elves and their wolves in ''ComicBook/ElfQuest'', partly because they can exchange feelings telepathically, and partly because they're [[ItMakesSenseInContext related by blood]].
* ''ComicBook/{{Nextwave}}'' has a human, two superhumans, a mutant, and a robot.
* ComicBook/TomPoes: Tom Poes, a cat, and Olivier B. Bommel, a bear.
* ComicBook/JanJansEnDeKinderen: The cats and the dog of the family are friends with each other. Similarly Eucalypta the Witch is best friends with Krakras, a featherless baby chick.
* ''ComicBook/{{Cubitus}}'': Cubitus the dog and Sémaphore, a human.
* ''ComicBook/{{Urbanus}}'': Urbanus' best friends are a fly, Amedee, and Nabuko Donosor, an alien dog species.

[[folder:Comic Strips]]
* ''ComicStrip/PaulusDeBoskabouter'': Paulus, a wood gnome, is friends with Oehoeboeroe the owl, Salomo the raven and Gregorius the badger.

[[folder:Eastern Animation]]
* ''Animation/GogonaDaTovlisGunda'': Snowball, [[CaptainObvious a snow boy]], makes friends with a human girl.

[[folder:Fairy Tales]]
* From the Grimms' collection:
** "Literature/TheBremenTownMusicians": A donkey, a dog, a cat and a rooster form a happy company.
** "Literature/PussInBoots": A boy and his cat.
** "Old Sultan": An old dog, a wolf and a three-legged cat.
** "Dog and Sparrow": A tale of [[RoaringRampageOfRevenge vengeance (and how!)]] for a friend's death.
** "Literature/TheGooseGirl" and her horse Falada.
** "Snow White and Rose Red" and a bear. Subverted, as he turns out to be an enchanted prince and marries Snow White, while [[PairTheSpares Rose Red marries his brother]].

[[folder:Fan Works]]
* In ''Fanfic/TheParselmouthOfGryffindor'', Hermione, being most of all a defender of the rights of nonhumans, has many nonhuman friends of her own. They include the Boggart Maximilian, several snakes (most notably the Basilisk, Apophis, Nettle and Tsh), and the [[PhantomZonePicture magical portrait]] Minerva.
* Empath Smurf and Polaris Psyche in ''Fanfic/EmpathTheLuckiestSmurf''.
* Pretty much the plot of ''[[http://www.100megspop2.com/kayasps/main/mikehero.html Scar The Unsung Hero]]'' as the plot is [[Disney/TheLionKing Scar]] befriending a teenage human.
* "Human in Equestria" stories are a ''very'' common theme in ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfictions. FishOutOfWater comedy or [[InterspeciesRomance romance]] stories are most common, but stories involving time travel, alien invasions, and just about everything have been done.
* Because she grew up in a different country in ''FanFic/BadFutureCrusaders'', Apple Bloom was raised by and friends with a group of zebras and a gryphon. She is also implied to have been romantically involved with a zebra named Peppercorn.
* In the Super Mario World/Lucky Star crossover ''FanFic/{{Super Miyuki World}}'', Miyuki Takara befriends Yoshi after freeing him from a question mark block.
* In ''Fanfic/HopeForTheHeartless'', which takes place after the events of Disney's ''Disney/TheBlackCauldron'', [[NiceGirl Avalina]] (a human) befriends not only the [[ResurrectedForAJob resurrected]] [[VillainProtagonist Horned King]] ([[OurLichesAreDifferent a lich]]), but also his lackey Creeper ([[OurGoblinsAreDifferent a goblin]]) and the remaining [[GiantFlyer gwythaint]] she names Taranau Adeon (or Addie in short). She's also quite close to Mitternacht, her CoolHorse. Also, Mitternacht and Addie become close playmates through the races they have with Avalina riding Mitternacht and Creeper riding Addie. The circle later gets an addition in the form of Gethin, Addie's baby. The circle includes also the four Invisibles, [[ExactlyWhatItSaysOnTheTin invisible]] creations of [[CosmicEntities the Fates]] themselves. They're certainly fond of Avalina (she also likes them), but they lean more towards VitriolicBestBuds territory with the Horned King and Creeper.
* Many ''Film/JurassicWorld'' fanfictions display the idea of Rexy (a ''TyrannosaurusRex'') and Blue ([[RaptorAttack what the film calls]] a "''Velociraptor''") becoming friends after the film's climax (certainly helped by the look they give each other at the end). Some fics like to add the ''[[SeaMonster Mosasaurus]]'' to the mix too.
* In ''FanFic/ThisBites'', once Su gets her voice as a LittleMissSnarker, she and [[TheGadfly Soundbite]] get along like a house on fire.
** Likewise for Boss and Franky, due to similar attitudes.
* ''Fanfic/Persona3MomentoUmbrae'' has Hamuko Takahashi and Kana, a Shadow who originally took on the former's appearance when they were both children to help her escape from the research facility she was locked up in. They eventually start to see each other more as genuine sisters though, with Kana referring to Hamuko as "Oneesama" and Hamuko showing concern for her like any older sister would.
* In ''Fanfic/AdorableMurderbeasts'', Superboy quickly bonds with Red's Chesnaught after the mission to Santa Prisca. At first, it seems to be because their similar strength and toughness means they work well together in a fight, but it quickly develops further than that. Of course, given his ability to befriend Wolf and the Super-Cycle in canon, this isn't that surprising.

[[folder:Films -- Animation]]
* This is common in Creator/{{Disney}} and Creator/{{Pixar}} films:
** Mickey Mouse, Donald Duck and Goofy (dog?) going back to before World War II.
** Genie [[ExactlyWhatItSaysOnTheTin (a genie)]] and Aladdin (human) in ''Disney/{{Aladdin}}''. Before meeting Genie, Aladdin's best friend is Abu ([[EverythingIsBetterWithMonkeys a monkey]]).
** In ''Disney/TheLionKing'', Zazu (bird) and Mufasa (lion). Also Timon (meerkat) and Pumbaa (warthog), close friends who later befriend Simba (lion).
** In ''Disney/{{Hercules}}'', Herc, who is a demigod, has Pegasus, a flying horse, for a companion, and his mentor, Phil, is a satyr.
** ''Disney/TheFoxAndTheHound''. Between, well, a fox and a hound.
** ''Disney/LiloAndStitch'', a human and a genetically-engineered alien monster. This is emphasized more in the rest of [[Franchise/LiloAndStitch its franchise]], in which more genetically-engineered aliens befriend the human.
** ''Disney/BrotherBear'': Kenai (a human turned into a bear) to Koda (a bear cub). Alternatively, two bears and Rutt and Tuke (two moose brothers).
** In ''WesternAnimation/FindingNemo'', not only do different kinds of fish get along, but they also befriend sea turtles, and [[CarnivoreConfusion species that otherwise prey on fish]], such as sharks and pelicans.
** ''Disney/TheJungleBook'' has Mowgli the human (who was raised by wolves) befriending Baloo the bear. They also friends with Bagheera the black panther.
** ''Disney/OliverAndCompany'' has Oliver the cat befriend Fagin's dogs.
** ''Disney/TheRescuers'', along with its sequel, involves mice talking to and befriending humans. The first even has a cat talking to and befriending both humans [[ItMakesSenseInContext AND mice]]. The sequel also has Cody feeling very attached to Marahoute the eagle, though they can't communicate with each other.
** ''Disney/{{Bolt}}'' has a trio of three different species: Bolt (a dog), Mittens (a cat) and Rhino (a hamster).
** ''WesternAnimation/ToyStory'': While Andy does not know his toys are alive, they do care a lot about him. Woody in particular gos to great lengths to return to him when separated. Said toys are also TrueCompanions with each other.
** The title character of ''Disney/{{Tarzan}}'' is friends with a gorilla and an elephant.
** ''WesternAnimation/ABugsLife'' has several different insects and arthropods as friends.
** In ''Disney/{{Mulan}}'' Mushu the dragon is friends with Mulan (human), Crikee (cricket) and Khan (horse). Villain Shan Yu has his falcon.
** ''WesternAnimation/{{Ratatouille}}'' has Remy (rat) and Linguini (human).
** ''Disney/{{Frozen}}'' has a few. Kristoff and Sven the reindeer, who, though [[SpeechImpairedAnimal he doesn't talk]], shows a degree of intelligence and sentience; Kristoff and the trolls; Anna and Olaf the snowman.
** ''Disney/{{Zootopia}}'' has Nick Wilde (a fox) and Judy Hopps (a rabbit) becoming best friends. Although there are some serious hints this may lead to an InterspeciesRomance later.
* In ''WesternAnimation/AnAmericanTail'', Fievel Mousekewitz ([[CaptainObvious mouse]]) makes friends with Tiger (cat). They even have [[http://www.youtube.com/watch?v=dQeBcnNQys0 a song together]].
* In ''WesternAnimation/TheLandBeforeTime,'' a long-neck ([[YouKeepUsingThatWord "Brontosaurus"]]), three-horn (Triceratops), swimmer (Saurolophus), flier (Pteranodon) and spike-tail (Stegosaurus) overcome their parents' generations-long [[FantasticRacism racism]] and become TrueCompanions. A sequel adds a sharp-tooth (TyrannosaurusRex) to the gang and the TV series adds a fast-runner (Oviraptor).
* ''WesternAnimation/IceAge'': Manny (mammoth) and Diego (saber-tooth tiger) and Sid (sloth) form one of this type of friendship with each other by the end of the first film and it continues into the second film and third film. (The unusual nature of this "herd" is duly lampshaded.)
* WesternAnimation/{{Shrek}}, [[OurOgresAreHungrier (an ogre)]] Donkey and eventually Literature/PussInBoots become friends in the ''WesternAnimation/{{Shrek}}'' films.
* The wolf-dog ''WesternAnimation/{{Balto}}'' is friends with a Russian goose and two polar bears.
* The title character of ''WesternAnimation/SpiritStallionOfTheCimarron Spirit'' (a horse) appears to be friends with an unnamed bald eagle and he later befriends a human.
* Hiccup and [[OurDragonsAreDifferent Toothless]] in ''WesternAnimation/HowToTrainYourDragon''.
* In ''WesternAnimation/{{Home}}'', Oh (male Boov) eventually forms an unbreakable bond with Tip (female human).

[[folder:Films -- Live-Action]]
* ''Film/{{Maleficent}}'': The title character is a fairy. She befriends a human at the beginning of the plot, and is also friends with beings that don't look like they're the same species of fairy.
* ''Franchise/{{Blade}}'' ({{Dhampyr}}) and Whistler (human)
* ''Film/{{Dragonheart}}'': Draco (the world's last dragon) and Bowen (a knight-turned-dragonslayer) form an unlikely friendship, which is seen as unusual since dragons and humans consider each other their greatest enemy.
* The original ''Franchise/StarWars'' trilogy had Han Solo and Chewbacca, the Wookie, as friends and partners.
* As with the books, in ''Film/TheHobbit'', a friendship was struck up between Bilbo (a hobbit) and Gandalf (disguised as more or less human), not to mention Bilbo's friendship with the dwarves.
* ''Film/LordOfTheRings'':
** The Fellowship is composed of hobbits, men, an elf, a dwarf and a Maia. There was already a strong friendship between Aragorn (a human) and Legolas (an elf) and one would develop between Legolas and Gimli (a dwarf), the ones pictured above.
-->'''Gimli:''' Never thought I'd die side-by-side with an elf.
-->'''Legolas:''' What about side-by-side with a friend?
-->'''Gimli:''' Aye, I could do that.
** Merry and Éowyn, and Pippin and Faramir, hobbits and humans respectively, also become quite close.
* Being a FriendToAllLivingThings that she was, Giselle from ''Film/{{Enchanted}}'' was close to all her animal friends, particularly Pip the chipmunk.
* ''Film/StarTrek'':
** It takes most of the film, but one develops between Kirk (human) and Spock (half-Vulcan, half human).
** Also, Scotty and Keenser. A human and a... [[BuffySpeak cute alien thing]]...
* Sam and Bumblebee in ''Film/{{Transformers}}'', as well as Captain Lennox and the rest of NEST with the other Autobots.
* Kevin Flynn and the program ''Film/{{TRON}}''.
* In ''Film/{{District9}}'', Wikus and Christopher, a human [[spoiler:(in the beginning, at least)]] and an alien respectively.
* Any relationship with Thor in ''Franchise/MarvelCinematicUniverse''.
* Everyone in ''Film/GuardiansOfTheGalaxy'' since none of them share the same species.

* In the ''Literature/{{Hurog}}'' duology, Ward befriends ... some people who are only part human. [[spoiler: Axiel, a half-dwarf, and Oreg, a part-dragon. Though Ward himself has dragonblood, too.]]
* ''Literature/TheJungleBook'', ''The Second Jungle Book'', and the ''Just So Stories'' by Creator/RudyardKipling are full of friendships between humans and animals - Mowgli, the adopted wolf and friend of Baloo the bear, Bagheera the panther, and Kaa the python is only one example of many - and between different species of animals.
* ''Literature/WinnieThePooh'': Features a human boy and his friends, who are [[strike:toys]] a bear, pig, tiger, rabbit, donkey, owl, and two kangaroos. The animated series adds a gopher.
* In both of Nalini Singh's series this is a recurring theme, along with InterspeciesRomance:
** ''Literature/GuildHunter'' features a number of [[OurAngelsAreDifferent angel]]-[[OurVampiresAreDifferent vampire]], [[OurVampiresAreDifferent vampire]]-human and human-[[OurAngelsAreDifferent angel]] friendships.
** ''Literature/PsyChangeling'' features a number of [[PsychicPowers psy]]-[[OurWerebeastsAreDifferent changeling]], [[OurWerebeastsAreDifferent changeling]]-human and human-[[PsychicPowers psy]] friendship.
* In ''Literature/TheSorceresssOrc'', the human student Amethyst and the orcish bodyguard Kiki become close friends.
* The Literature/{{Twilight}} books and films, which feature friendships and [[InterspeciesRomance romance]] between humans and vampires, werewolves (technically shape shifters) and humans, and friendships between werewolves and vampires.
* In the book ''Literature/FireWorld'', Rosa (A human) and Alleron (A Firebird) are friends.
* In ''Literature/TheLordOfTheRings'', the Fellowship consists of representatives of five species and races (Elves, Humans, Dwarves and Hobbits, plus Gandalf the Maia). Hobbits Pippin and Merry also later become friends with the Ent Fangorn, while Gandalf numbers Gwaihir the Wind-Lord (an intelligent eagle) among his friends.
* A number of examples from the ''Literature/{{Discworld}}'' novels, notably in the Ankh-Morpork Night Watch, starting with Detritus the Troll, Cuddy the Dwarf, and Angua the Werewolf in ''Men at Arms''.
* ''Literature/GoodOmens'' has Aziraphale (an angel) and Crowley (a demon).
* ''Literature/TheBookOfNightWithMoon'' has Arhu (a cat) and Ith (a t-rex).
* ''Literature/DragonridersOfPern'' in which humans form lifelong bonds with intelligent dragons.
* ''Literature/{{Animorphs}}'' has Ax, an Andalite, and the five human characters. Or four human characters and one red-tailed-hawk/human/Andalite (Tobias). The team also count Hork-Bajir and Chee among their friends and allies. Cassie even befriended a Yeerk.
* The core premise of ''{{Literature/Dinotopia}}'' is human/saurian friendship. And human/prehistoric mammal friendship, and etc. When they're close enough, they are called "nestfriends", bringing to mind a common sight in the books: babies and children of different species being raised together, sometimes literally with time spent in nests.
* ''Literature/IfYouGiveAMouseACookie'' has a friendship between the eponymous mouse and the nameless protagonist.
* ''Literature/HarryPotter'':
** Harry is friends with Dobby, a house-elf, which is considered odd because most wizards treat them as [[FantasticRacism inferior slaves]]. Before him, [[spoiler: Regulus Black had a similar relationship with his house-elf Kreacher]].
** Harry, Hermione, Ron and a fairly large number of the Hogwarts staff are also friends with [[spoiler: Hagrid, a half-giant. The slightly strained relationship with Hagrid's full giant brother, Grawp, might fit this trope better, though]].
** In ''[[Literature/HarryPotterAndTheOrderOfThePhoenix Order of the Phoenix]]'' the murderous giant Golgomath is friends, or at least friendly with, the Death Eater Walden Macnair. They apparently bond over their shared passion for violence and it probably helps that Macnair supported Golgomath in usurping the previous Gurg of the giants who wanted to ally with Dumbledore and then hunt down and kill those giants who opposed him taking over.
** Depending on whether or not you count [[OurWerewolvesAreDifferent werewolves]] as a [[FantasticRacism different species]], all of Remus Lupin's friendships could count as this.
* ''Literature/TheHorseAndHisBoy'', about the friendship between...[[CaptainObvious well...]]
* Lyra Belaqua (human) in ''Literature/HisDarkMaterials'' becomes close friends with Iorek Byrnison and Serafina Pekkala, an armoured polar bear and a witch respectively.
* In the ''[[Literature/InheritanceCycle Inheritance]]'' quadrilogy you have riders and their dragons. You also have friendships between humans, dragons (outside their riders), elves, dwarves and werecats. Eragon (a human) in particular has several friends from other races, including Arya (an elf), Orik (dwarf) and Solembum (a werecat).
* The ''Literature/MalazanBookOfTheFallen'' includes quite a bit of this. Sometimes it's odd, others times it's not:
** Trull, a Tiste Edur develops a deep friendship with the undead T'lan Imass Onrack in ''Literature/HouseOfChains''.
** Spinnock Durav, a Tiste Andii upholds a friendship with the human Seerdomin in ''Literature/TollTheHounds''. It is also remarked that Spinnock is among the very, very few Andii who mingle with the human population of Black Coral.
* In ''Literature/{{Temeraire}}'' the bonds between dragons and their captains probably go beyond even friendship. However, even if you're not that dragon's captain, close friendships exist. One of the things that marks the Aviators apart from everybody else is that they see dragons as equals, while practically everyone else think they're just talking beasts of burden.
* The ''Literature/ArtemisFowl'' series contains quite a lot of this, especially between human Artemis Fowl and high-tech fairy Holly Short.
* The Second-Stage Lensmen of E.E. "Doc" Smith's ''{{Literature/Lensmen}}'' series are all good friends: Kinnison of Tellus (human), Worsel of Velentia ([[OurDragonsAreDifferent Dragon]] with multiple eyes on stalks, multiple hands and arms, and a multi-compartment mind), Tregonsee of Rigel IV (Oil-drum body with four legs, four branching tentacle-arms, and no eyes or ears - uses a "sense of perception" instead), and Nadrick of Palain VII (Whose appearance cannot be described because his species has a metabolic extension into the fourth dimension). And it's hinted that these sorts of friendships are not all that unusual among Lensmen or in the Galactic Patrol in general.
* In ''Literature/DonQuixote'', it is mentioned that Don Quixote's horse Rocinante and Sancho's donkey Dapple develop a close bond of friendship throughout their adventures.
* C. S. Lewis ''Literature/SpaceTrilogy'':
** In ''Out of the Silent Planet'', [[TheProtagonist Ransom]] befriends Hyoi, hross (otterlike Martian).
** In ''That Hideous Strength'', friendship between she-cat and bear (rather normal ones) is shown.
* In ''Literature/VampireAcademy'', Rose Hathaway is a dhampir, Sydney Sage is a human. They are reluctant friends, though their species rarely interact. The Alchemists, Sydney's organization, think all vampires and dhampirs are evil. So the friendship between them is rare.
* Multiple examples exist in the [[PettingZooPeople anthropomorphic]] setting of {{Eludoran}} between Zephyr and Arulaine, Lorelei and Pendarynn and [[FriendsWithBenefits Malachi and Marissa]]
* Paul the [[SiliconBasedLife silicon-based]] alien and Indira in ''Literature/AlienInASmallTown.''
* In ''Literature/TheTraitorSonCycle'', human archer Cully becomes best friends with [[BeePeople boglin]] archer Urk of Mogon after the former is amazed by the latter's skill during a competition.

[[folder:Live-Action TV]]
* In ''Series/{{Smallville}}'', any friendship involving [[HumanAlien Clark]], obviously.
* ''Series/{{Supernatural}}'':
** Dean (a human) and Castiel (an angel). Begins as a ForbiddenFriendship, as Castiel is not supposed to develop an emotional connection with his charge, on the grounds that it could impair his judgment. The forbidden aspect becomes moot when [[spoiler:Castiel rebels against Heaven, which is ''also'' forbidden.]]
** Also, Dean's brother Sam and Castiel after they grow closer over the seasons (although, to quote Castiel, he and Dean do share a more profound bond).
** Sam, as a child, became friends with Amy, a kitsune who goes on to save Sam's life. Dean, however, saw her solely as a supernatural threat that needed to be eliminated [[spoiler: and ultimately kills her (right in front of her son, no less) in season 7,]] triggering a breach of trust in the brothers' relationship. Ironically, Sam was later expected to accept Dean's friendship with Benny (a vampire who helped Dean get out of Purgatory), to which Sam responds by pointing out the hypocrisy of it all after Dean's hostility and actions towards Amy.
* In ''Series/DoctorWho'', all of the Doctor's companions aside from his granddaughter Susan, as well as Romana, fall under this.
** A few of the companions also have had an InterspeciesFriendship with ''one another'', e.g. Tegan and Nyssa, Bill and Nardole, K-9 and pretty much everyone the tin dog ever met.
* It's hard to imagine ''Franchise/StarTrek'' without this.
** ''Series/StarTrekTheOriginalSeries'' has [[TheCaptain James T. Kirk]], [[TheMcCoy Dr. Leonard McCoy]], and [[HalfHumanHybrid Spock]]
** ''Series/StarTrekTheNextGeneration'' has several, including [[TinMan Data]] and Geordi, [[HalfHumanHybrid Deanna]] and Beverly, Guinan (El-Aurian) and Ro (Bajoran), etc.
** ''Series/StarTrekDeepSpaceNine'' has Sisko (a human), [[TheNthDoctor Dax]] (Joined Trill), along with Kira's (a Bajoran) friendship with the aforementioned and Odo (a Changeling) [[spoiler: who is secretly in love with her, and they (eventually) get together]].
** ''Series/StarTrekEnterprise'' Captain Archer and T'pol (eventually),
* In ''Series/BabylonFive'', there's a particularly [[OddFriendship odd]] one between Londo (Centauri) and G'kar (Narn), who are the ambassadors of two warring species--one of which (the Centauri) had previously conquered and enslaved the other--and started out hating each other. [[FireForgedFriends Circumstances force them to tolerate and eventually like each other]], if a bit [[VitriolicBestBuds snarkily]].
** The more amiable case is between G'kar and Garibaldy, the head of security and human.
* ''Series/BuffyTheVampireSlayer'' and the spin-off ''Series/{{Angel}}'' had several friendships between humans, vampires, werewolves, and demons.
* ''Series/{{Lexx}}'' had a human, [[HalfHumanHybrid a half-human lizard girl]], an undead assassin, a robot head, and a living spaceship.
* ''Series/{{Farscape}}'' had a human, HumanAliens, and StarfishAliens.
* ''Series/StargateSG1'':
** The Stargate team (humans) with Teal'c (a Jaffa).
** As the series progresses, it also becomes evident that Thor ''really likes'' SG-1, particularly O'Neill. They even named the first of their new line of Starships "The O'Neill". They had to blow it up 5 minutes later, but the thought was there. The feelings are mutual though, and SG-1 makes it rather clear that they ''much'' prefer the company of Thor compared to the other Asgard.
* Series/{{Tracker}} Mel and Cole-Although Mel is a HalfHumanHybrid, that only came out in the next to last ep of the series, so it was viewed as human and alien for most of it.
* The ''Franchise/PlanetOfTheApes'' series had two humans (Virdon and Burke) and an ape (Galen).
* ''Series/{{Roswell}}'', with its human and alien teens.
* In ''Series/{{Grimm}}'', Nick (a human/Grimm) and Monroe (a Wesen/Blutbad).
* ''Series/TeenWolf'':
** Stiles and Scott remain best friends despite the latter being turned into a werewolf in the pilot episode. Also, Scott's girlfriend Allison Argent, who's human, and Lydia Martin, [[spoiler: a banshee.]]
** Kali and [[spoiler:Jennifer]] were pretty close in the past despite belonging to different species (the former a werewolf, the latter a druid), although they were torn apart when Kali massacred her entire pack to become an Alpha and join Deucalion, marking the druid's StartOfDarkness.
* ''Series/MysteryScienceTheater3000'' puts the human host's relationship with the 'bots right in the opening theme song:
-->''He'll try to keep his sanity''
-->''With the help of his robot friends''

[[folder:Other Sites]]
* ''Wiki/SCPFoundation'', [[Characters/SCPFoundation [=Characters/SCPFoundation=]]], [[http://scp-wiki.net/scp-530 SCP-530 ("Carl The Variable Dog")]]. Carl gets along with [[http://www.scp-wiki.net/scp-529 SCP-529 Josie]] the Half Cat.

[[folder:Video Games]]
* ''Franchise/TheLegendOfZelda'':
** ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' had the friendship between Saria (a Kokiri) and Link (a Hylian/Human), sans ShipTease. He was also friends with Navi, a fairy. The plot of [[VideoGame/TheLegendOfZeldaMajorasMask its sequel]] starts with him trying to find Navi after she left him.
** ''VideoGame/TheLegendOfZeldaTheWindWaker'' sees Link becoming friends with Medli of the [[BirdPeople Rito]] and Makar of the [[PlantPerson Koroks]]. There's also his friendship with his talking ship the King of Red Lions, [[spoiler:though the latter turns out to actually be an alter ego for King Daphnes Nohansen Hyrule, a fellow Hylian]].
** ''VideoGame/TheLegendOfZeldaTwilightPrincess'' has Link growing a friendship with [[TheImp the imp-like]] Midna, a Twili. This one also comes with some good amounts of ShipTease. Midna also develops a friendship with Princess Zelda.
** ''VideoGame/TheLegendOfZeldaSkywardSword'' sees Link becoming friends with the robot-like sword spirit Fi, though [[WhatIsThisThingYouCallLove it takes the latter until the end to realize it]].
** While all the GuestStarPartyMember characters of the various races in ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' come to respect Link for helping them save their people from the Divine Beasts, Prince Sidon of the [[FishPeople Zora]] is the only one who openly declares Link to be a close friend. [[spoiler:The fact that his sister Mipha was in love with Link, which could have resulted in the two guys [[BestFriendsInLaw becoming brothers-in-law]] if she hadn't been killed, is also a major factor.]]
* Early in ''VideoGame/SuikodenII'', the player is given the opportunity to recruit Kinnison and his dog companion (who's actually a wolf), named Shiro.
* ''VideoGame/TalesOfVesperia'':
** Yuri Lowell and Repede. Bonus points since Repede earns two titles specifically regarding his friendship with Yuri:
** "Sinful Sidekick", which is earned after [[spoiler: he witnesses Ragoh's death at Yuri's hands.]]
** "Considerate Sidekick", earned after [[spoiler: he leads Karol and the others to Yuri, for trying to strike off on his own]].
* Pretty much all of ''Franchise/SonicTheHedgehog's'' friendships fall into this. For example, there's his long-timed friendship between him, a blue hedgehog that can run at mach speeds, and Miles "Tails" Prower, a twin tailed fox... who can fly.
* ''Franchise/MassEffect'', where [[PlayerCharacter Commander Shepard]] can develop close, non-romantic friendships with several different kinds of aliens, and, of course, develop {{Interspecies Romance}}s as well. Not to mention the ones between [=NCPs=]. Notably, of Shepard's consistently closest friends on the Normandy, only one of them is a human (Joker). The others are a turian (Garrus), a quarian (Tali'Zorah), and an asari (Liara).
* In ''Franchise/DragonAge'', no matter your race, you can befriend elves, dwarves, humans, [[OurGiantsAreBigger Qunari]] and the odd Fade spirit.
* In ''VideoGame/CaveStory'', the group of survivors who band together to get off the island includes three humans, two humans-turned-[[PettingZooPeople Mimiga]], the remnants of the island's Mimiga village, the two robotic main characters, and in the GoldenEnding a witch of unspecified race and...whatever Balrog is.
* ''Franchise/{{Metroid}}'':
** In ''VideoGame/SuperMetroid'', Samus can befriend creatures who teach her to WallJump and use the speed booster. They survive [[EarthShatteringKaboom through the ending]], and show up again in ''VideoGame/MetroidFusion''.
** In ''VideoGame/MetroidPrime3Corruption'' Samus can count among her friends Rundas, a [[AnIcePerson Phyrigisian]] and [[{{Shapeshifting}} Gandrayda]], whose species is unknown, though Gandrayda seems to love piling on the LesYay.
* ''Franchise/SuperMarioBros'':
** Considering humans, dinosaurs, mushrooms, [[LoadsAndLoadsOfRaces and what not]] live all in the same kingdom it's only natural this'd show up. For a specific example, Mario and Yoshi are best friends.
** The ''VideoGame/PaperMario'' series is even more obvious about this, with its focus on storyline and the huge amount of partners Mario has, many of them being friendly versions of {{Mook}} species like Goombas, Koopas, Lakitus, Boos, Bob-ombs and many others.
* ''VideoGame/{{Okami}}'' has Amaterasu, a sun goddess in wolf form, and Issun, a [[{{Lilliputians}} Poncle.]]
* The entire Creator/NipponIchi verse is full of these, since regular humans live side by side with angels, demons, robots, aliens, talking animals, and bipeds with animal aspects. For example: Flonne with Laharl and Etna in ''VideoGame/DisgaeaHourOfDarkness''.
* ''Franchise/{{Pokemon}}'':
** An important {{Aesop}} in all of the games, but especially ''VideoGame/PokemonGoldAndSilver'' and the remakes, is that Pokémon should be friends and partners to their trainers, instead of just tools.
** The ''VideoGame/PokemonMysteryDungeon'' series has the PlayerCharacter and their partner. Not only are both different especies of Pokémon, but the PlayerCharacter is also a human turned Pokémon by some circumstance.
* In ''VideoGame/BlazBlue'', we have the trio of Noel Vermillion, Tsubaki Yayoi (two humans) and Makoto Nanaya (squirrel girl). This has such a great effect that the formerly prejudiced-for-her-race Makoto is incredibly loyal to those two and makes it her mission to ensure no harms come between them, and anyone who does get horribly killed by her hands (Or so she says for the latter), and the mere thought of her friendship to them is the one thing that enables her to survive the Boundary like Hakumen, and be immune to Terumi's infamous {{Troll}}ing. [[spoiler: Unfortunately, while getting [[MindRape mind raped]] in her bad ending, it's revealed that deep down, Makoto doesn't trust Noel and Tsubaki either, and she's just waiting for them to reject her like everyone else. We'll see if this comes into play in future games.]]
* The vast majority of ''VideoGame/{{Kirby}}'s'' friendships are of the interspecies variety, due to living in a world inhabited by many different sapient species but very few of his own kind.
* ''VideoGame/{{Xenoblade}}'' has several examples of this all around the world. Amongst the main party, both Riki (a [[RidiculouslyCuteCritter Nopon]]) and Melia (a [[OurElvesAreBetter High Entia]]) have a good friendship between them, and also develop some close bonds with their [[HumanAliens Homs]] partners as the game goes on; in one case even growing into unrequited InterspeciesRomance.
* ''Franchise/KingdomHearts'': Most notably, Sora's friendship with Donald and Goofy, and Riku's friendship with Mickey.
* In ''VideoGame/FireEmblemAwakening'', any friendship that involves either Panne (Taguel), Yarne (half-Taguel), Nowi (Manakete), Nah (half-Manakete), Tiki (also a Manakete), a female Morgan (if any of the aforementioned women is her mother) and a male Morgan (only if he's fathered by Yarne).
* In ''VideoGame/FireEmblemFates'', any friendship that involves the PlayerCharacter (half-dragon), Kaden and Selkie (Kitsune aka fox spirits), Keaton and Velouria (Wolfskin aka sort-of werewolves) or any child of the Avatar (one-quarter Dragon, might have Kitsune or Wolfskin blood).
* ''VideoGame/Splatoon2'' features a duo of musicians branded as Off The Hook. One is Pearl, an Inkling, just like the protagonists of the series. Marina, on the other hand, is an Octoling, the enemy of Inklings. Since the first game featured no friendly Octolings whatsoever, this came as a surprise to many players. [[spoiler: Marina witnessed the final battle of the first game, and moved to Inkopolis soon after, where she likely became a duo with Pearl and ascended to stardom]].

* ''VisualNovel/TheLastBirdling'' is about the friendship between two children, a human named Tayo and a Birdling named Bimonia. Humans and Birdlings have long hated and fought each other, but neither Tayo nor Bimonia care about that; they just want to be friends. It ends up causing disastrous consequences. As Bimonia's mother puts it: "History can't be changed by a couple of kids."

[[folder:Web Comics]]
* Pretty much every FurryComic ever.
* Florence ({{Uplifted|Animal}} wolf) and Sam ([[StarfishAlien Alien Sqid]]) in ''Webcomic/{{Freefall}}''.
* ''Webcomic/TheInexplicableAdventuresOfBob:'' Bob is friends with [[DragonsAreDinosaurs dragons,]] [[{{Unicorn}} unicorns,]] [[BigfootSasquatchAndYeti bigfeet,]] [[AlienTropes aliens,]] [[RobotBuddy robots,]] [[StockNessMonster mutants,]] [[OurGiantsAreBigger giants,]] and [[CuteMonsterGirl furry lab accidents.]]
* ''Webcomic/TheMansionOfE'' has the repair-team of Sprocket and Flange (Gnoll and Helipath), and the idlers Tuft and Dap (Gobule and Gnoll).
* In ''Webcomic/OffWhite:'' [[{{Hellhound}} Hati]] the wolf and the two ravens. One raven even [[spoiler: sacrifices himself for Hati.]]
* The title character of ''Webcomic/{{Digger}}'' is a wombat who befriends a human, a shrew in business as a Troll, several hyenas, and a juvenile demon. And then there are her acquaintances...
* In ''Webcomic/{{Homestuck}}'', between the kids, carapacians, and some of the trolls. The post-scratch kids and Calliope are also friends, though Calliope's abusive brother makes it strained at times.
* ''Webcomic/{{Nebula}}'': Between Mercury, [[RockMonster a planet]], and Sun, [[WreathedInFlames a star]]. They get along surprisingly well despite their [[OddFriendship vastly different personalities]] and the fact that Sun's biology makes it impossible for anyone who isn't a star to even stand too close to him without being burned.

[[folder:Web Original]]
* ''Website/ChatoyantCollege'': Corrie/Dawn and [[spoiler: Professor Lal]], the gang and [[spoiler: Troy]], and [[spoiler: Dawn and Tom]]
* ''WebAnimation/RatboyGenius'' has Happyman and Green Monster. [[ExactlyWhatItSaysOnTheTin Happyman appears to be human and Green Monster is a ... Monster. Who is green.]]
* In ''Literature/AfterlifeLabirynth'', Vryg the bred (male, Polish ''bred Wryg'') and Waom the wohu (female, Polish ''uowujka Uaom'') are [[TheProtagonist Joseph]]'s friends.
* In ''WebAnimation/{{RWBY}}'', any friendship with a Faunus is this. Most notable is Blake (cat faunus) with her human teammates and Velvet (rabbit faunus) with her human teammates.

[[folder:Western Animation]]
* ''WesternAnimation/AdventuresFromTheBookOfVirtues'' has two human kids, a bison, a red-tailed hawk, a bobcat, and a prairie dog.
* ''WesternAnimation/AvatarTheLastAirbender'' also has this with Aang and his sky bison, Appa. Later, he befriends Momo (his pet flying lemur) as well; which isn't surprising since Aang's a FriendToAllLivingThings.
** SequelSeries ''WesternAnimation/TheLegendOfKorra'' has Naga (Korra's polar bear dog) and Pabu (Bolin's fire ferret) being friends...just after the former tried hunting the latter.
* ''WesternAnimation/Ben10Omniverse'' has Ben with Rook, a Revonnahgander.
* In ''WesternAnimation/{{Futurama}}'' there is Bender and Fry, and to a lesser extent the other members of the Planet Express crew. Also Zoidberg.
* ''WesternAnimation/GeorgeOfTheJungle'' comes to mind.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
** The unicorn Twilight Sparkle is friends with her assistant Spike, a baby dragon. [[FriendToAllLivingThings Fluttershy]] is friendly with most non-pony animals and beasts (which seem to be more intelligent than real-world animals), and goes on to become the first friend [[MadGod Discord]] has ever had and [[ReformedButNotTamed reform him to boot]].
** Pony characters have also developed friendships with buffaloes, zebras and gryphons (all of which are sapient species equal to ponies).
** This is a major plot point in "[[Recap/MyLittlePonyFriendshipIsMagicS8E1SchoolDazePart1 School Daze]]", where Twilight opens a school to foster friendship between different species. While the leaders of the various nations quite clearly do not get along with each other, six students of different species -- Sandbar the earth pony, Gallus the griffon, Silverstream the hippogriff, Ocellus the changeling, Yona the yak and Smolder the dragon -- quickly bond and become fast friends.
** In the first ''WesternAnimation/MyLittlePonyEquestriaGirls'' movie, Twilight Sparkle makes friends with the human counterparts of her friends in an AlternateUniverse. Her friendship with Flash Sentry even gets ''this'' close to being an InterspeciesRomance.
* ''Franchise/{{Transformers}}'':
** Starting it was Spike, his father Sparkplug and Carly in ''Franchise/TransformersGeneration1''.
** In ''WesternAnimation/TransformersAnimated'', there was Sari, although [[spoiler: she turns out to be half-Cybertronian]].
** ''WesternAnimation/TransformersPrime'' has Jack, Miko, and Raf. The latter two are in some ways closer to their Autobot partners than their biological family, especially Miko.
* ''WesternAnimation/AdventureTime'' has the two main characters, Jake the dog and Finn the human. There's also Marceline the Vampire Queen and Princess Bubblegum (the anthropomorphic candy). Really though, almost every relationship in the land of Ooo could count as this on account of the world being made up almost entirely of anthropomorphic everything (animals, food, land etc).
* In ''WesternAnimation/ThreeTwoOnePenguins'', Jason and Michelle, two humans, are friends with Zidgel, Midgel, Fidgel, and Kevin, four penguins.
* ''WesternAnimation/TheSilverBrumby'', an Australian animated series based off of the titular books, has Thowra (the titular silver Brumby), Storm and boon Boon (two other horses) hang around with Benni (an old male grey kangaroo). They also get along well with other animals like a grumpy wombat, two gossiping emus, a rhyming owl, and a mother dingo.
* Several WesternAnimation/LooneyTunes shorts feature these, including:
** ''Birds of a Father'' shows {{Sylvester|TheCatAndTweetyBird}}, Jr., befriending [[OneSceneWonder a bluebird named Spike]], much to the chagrin of Sylvester, Sr.
** ''WesternAnimation/FeedTheKitty'' has a small kitten named Pussyfoot winning over the heart of an initially brutish bulldog named Marc Anthony. This friendship is seen through all five shorts they appear in together, as Mark Anthony will do ''anything'' within his power to make sure Pussyfoot is both happy and safe--even bearing with her claws kneading into his back before she goes to sleep.
** ''Go Fly a Kit'' starts with an eagle with an overactive mother complex adopting an orphaned kitten as her very own offspring. It's such a strong bond that the eagle mother cries when her young kitten [[HeliCritter flies away]] by himself--[[NotMakingThisUpDisclaimer literally]].
** This trope applies, sparingly, in shorts where WesternAnimation/DaffyDuck appears together with either WesternAnimation/BugsBunny or WesternAnimation/PorkyPig.
* ''WesternAnimation/{{Animaniacs}}'' has [[FemaleFelineMaleMutt Rita and Runt]], respectively, a cat and a dog. However, Runt doesn't like cats, so his friendship with Rita only exists because he doesn't know--or refuses to acknowledge--that Rita is feline.
* Brian and Stewie Griffin in WesternAnimation/FamilyGuy.
* From ''WesternAnimation/RockyAndBullwinkle'':
** The title characters are a (flying) squirrel and a moose, respectively.
** [[ABoyAndHisX Mr. Peabody and Sherman]].
* A handful of the later Creator/HannaBarbera ''WesternAnimation/TomAndJerry'' shorts depict the title cat and mouse as more friendly to each other than they usually are.
* Star and Marco from ''WesternAnimation/StarVsTheForcesOfEvil'' may both look like humans, but the former is actually a [[HumanAliens Mewman]], a species that looks like a human, but are from the dimension Mewni.
* Seen a lot in ''WesternAnimation/{{Chaotic}}'', as part of the show's main theme is humans getting to travel to a world inhabited by non-human creatures of vastly varied shapes, sizes and looks. The four main characters, all human teens, befriend a good number of creatures throughout the series run.

[[folder:Real Life]]
* They say a man's best friend is his dog. Cats, birds, and horses are also common companions.
** Really, just about any solid pet/owner friendship. Most domesticated animals quite enjoy human company.
** And that of ''other'' domesticated animals, regardless of species. Even dogs and cats will get along just fine as long as at least one of them is young or submissive enough.
* Koko the gorilla used to have a pet kitten, and she received two new ones for her 44th birthday.
* [[http://www.msnbc.msn.com/id/10903211/ns/world_news-weird_news/t/hamster-snake-best-friends-tokyo-zoo/#.Tzw8eVHC5v8 This news story]] tells of Gohan and Aochan - a dwarf hamster and rat snake, respectively - who peacefully share an enclosure at a zoo in Japan (or ''shared,'' most likely, due to the average lifespan of hamsters and the article being written in 2006). [[MeaningfulName Gohan]] was intended to be Aochan's lunch when the snake refused to eat frozen rodents, but Aochan never showed any hostility, eventually taking to frozen food. They got along so well that Gohan could safely climb onto the snake's back to take naps.
* [[http://youtu.be/0czs_OtqrLA An old man named Dominic and a goose]] known by locals as "[[http://en.wikipedia.org/wiki/Maria_(goose) Maria]]"[[note]]now known as "Mario" after [[UnsettlingGenderReveal they discovered that the goose was in fact a male]][[/note]] from Echo Park suddenly started following him and has been doing so ever since. The goose would even scare away people and other animals whenever they get anywhere near the old man.
* There is a show on the channel Creator/AnimalPlanet called ''Series/UnlikelyAnimalFriends'' that has many examples of this trope. Warthog and baby rhino, boar and cows, baboon and bush baby, etc.
* Happens a lot on ''Series/TooCute'', particularly between kittens and dogs.
* The French racehorse Allez France shared its box with a sheep. It turns out that horses and goats or sheep make very good friends. This is actually where the term "Getting your goat" came from: owners of racing horses would give them goats as stable companions, and sometimes before a race someone would kidnap the goat to make the horse perform poorly.
* This [[https://www.youtube.com/watch?v=vL8x7LcA-Y4 grizzly bear and wolf cub]], even after six year they were still together!
* It seems it's not just grizzlies, [[http://channel.nationalgeographic.com/wild/unlikely-animal-friends/videos/polar-bears-heart-wolf-dogs/?cmp=user_post polar bears and wolves]] also make fast friends.
* At Noah's Ark animal sanctuary in Georgia, an African lion, a Bengal tiger, and an American black bear all share the same enclosure. The three were rescued from a drug dealer's house as cubs, and they have lived together as the best of friends for over a decade, even acting out and getting distressed when sanctuary personnel temporarily remove any one of the "brothers" for medical treatment. What makes the arrangement even more unusual is that black bears and Bengal tigers in the wild are solitary creatures who rarely associate even with their own kind. Also, wild Bengal tigers ''eat'' bears that size.
* Some sheep ranchers will include a llama in the herd, because the llama will protect the sheep from coyotes and even ''wolves''. Llamas are badass.
* [[http://wolfandravens.blogspot.com/ Wolves and ravens]] have a propensity for this in Real Life, ranging from sharing kills to playing together.
* Solo was an African Wild Dog who lost her pack. She was eventually accepted by a clan of hyenas and then a family of jackals. What's amazing is that all three species are mortal enemies.
* It's common practice at zoos and wildlife parks, when a young big cat or bear is orphaned or rejected by its mother, to bring it up in the company of a domestic dog. The dog provides a playmate from which the motherless cub can learn social cues, and also demonstrates that their human caretakers are trustworthy by being friendly to people too.
* There's at least one example in ''fish'': reef-dwelling groupers will sometimes form hunting partnerships with large moray eels. The grouper leads the moray to the prey - something which the grouper's acute senses are better-equipped to locate - and the eel can wriggle into crevices when the small reef-fish they're pursuing try to hide away in the coral.
* People who keep pet mice can't allow males to live with one another, as they fight when confined together. Nor can they be housed long-term with female mice unless neutered, which is risky surgery for such tiny pets. Rather than leave a male alone, it's increasingly common to house them with female African soft-fur rats (''Mastomys natalensis''), which are gerbil-sized and get along well with true mice, grooming and snuggling together, yet can't interbreed.