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Immune to Drugs
Drugs Are Bad, mmmkay?

Except when terrible addictions to horrible drugs are Played for Laughs, often using a character who is Immune To Drugs.

These characters should be long since dead due to the vast amount of drugs and/or alcohol they take, but since their wacky antics must go on they rarely suffer any serious or lasting medical problems from them, aside from being insane, and quickly recover from them. It's almost like a superpower in some cases.

Aside from the physical effects, the character will rarely encounter any financial difficulties in supporting their habit, except as a plot point, even if they have no apparent job or other source of wealth.

Sometimes used when the character in question is poisoned, in which they show no ill effects. Because it's funny. Often used in this manner to break the Drama or establish the character as Immune to Drugs.

There is also a second variety where characters from Sci-Fi and fantasy media are literally immune due to their race or some kind of Green Rocks. That overlaps with Never Gets Drunk.

Can easily become a Charles Atlas Superpower due to Rule of Funny.

Examples

    open/close all folders 

First Kind: Inexplicably Immune

    Comic Books 
  • Spider Jerusalem from Transmetropolitan, though he gets a rather horrible neurological ailment that makes him even more unpredictable, and is eventually likely to turn him into a vegetable — but that is caused by the one "drug" that he didn't take voluntarily.
    • He lives in a future where you can change your species and smoking won't kill you as long as you take the appropriate medication. It should be relatively easy to repair any damage caused by drugs and alcohol.
    • Even then, regenerative medicines don't reduce drug effects; his editor Royce recalls the one time he found Spider in a bathtub bound with healing tape and desperately trying to find a vein because all the other ones had collapsed.
  • On more than one occasion, Zippy The Pinhead inadvertently ingests a many-times-over-lethal amount of drugs, and though he may be wildly hallucinating, it's apparently no different than everyday life for him.
  • Sociopathic drug addict FBI agent Red Ketchup started taking drugs for the job. Then casually. Then to keep going. Then to keep his drug-fuelled metabolism from shutting down. By the time the sleazeball movie director boss of his sister tries to poison him with cyanide, he merely does a Heroic BSOD instead. An emergency room doctor is amazed at the content of his blood, which reads more like the description of Otto's urine below, with some trace amounts of actual blood.
    Doctor: 10cc of this would kill an elephant.
    • It's unsurprising poison would fail to kill a guy who starts the day with a gallon of Prestone the same way most people drink coffee. His metabolism could make Ozzy himself back down from a drinking contest.

    Fan Works 

    Films — Live-Action 
  • In Thank You For Smoking, a group of anti-tobacco activists kidnap tobacco industry spokesperson Nick Naylor and attempt to kill him with a lethal dose of nicotine (by covering him from head to foot in nicotine patches). Later, his doctor tells him that he only survived because of his years of smoking, but if he ever smokes again, he could die because of the damage from the overdose.
  • One character in The Men Who Stare at Goats claims to have built up a tolerance to a number of narcotics. Considering how he acts when dosed with LSD (along with a military base) this may not be true, or that may just be how he acts all the time now...
  • According to the Other Wiki, "Withnail is shown drinking roughly nine and a half glasses of red wine, half a pint of cider, one shot of lighter fluid [emphasis added]..., two and a half shots of gin, six glasses of sherry, thirteen glasses of whisky and half a pint of ale" throughout the movie. And he also does pot. There's a supposed Drinking Game where the player drinks everything Withnail drinks when he drinks it, with something else substituted for the lighter fluid. It's unlikely that anyone who has even attempted the game has actually completed it.
    • In an earlier scene, he is offered a drug whose street name is "The Embalmer." His response? "Balls. I'll swallow it and run a mile."
  • Get Him to the Greek: Aldous Snow, as demonstrated especially by the infamous "Jeffrey" scene.

    Literature 
  • Raoul Duke and Dr. Gonzo in Fear and Loathing in Las Vegas. Seeing as Duke is a self-insert of author Hunter S. Thompson (see Real Life below).
  • If you try to drink along with any character in any work by Ernest Hemingway, you will die.
  • According to the medical report in Thunderball when James Bond is not engaged in strenuous duty, he consumes half a bottle of spirits between 60 and 70 proof a day. And he smokes 60 cigarettes a day (of a higher nicotine content than standard cigarettes). In fact, a medical journal analyzed Bond's alcohol consumption and found that "The level of functioning as displayed in the books is inconsistent with the physical, mental, and indeed sexual functioning expected from someone drinking this much alcohol."
  • While we're on the subject of nicotine and cocaine, Sherlock Holmes, anyone?
  • In Barbara Tate's memoir, West End Girls, she writes about a prostitute who claims to be virtually immune to drugs, at one point taking an entire inhaler of benzedrine. Averted painfully - it becomes very clear over the course of the book that she vastly overestimates her immunity, and the aforementioned inhaler nearly kills her.

    Live-Action TV 
  • Father Jack Hackett from Father Ted who is always drinking but never dies — even after drinking floor polish, toilet cleaner (once drank a bottle of Toilet Duck), and a whole bottle of illegal sleep medication. He is apparently only sober every twelve years.
    • Subverted: "I suppose sobriety for Father Jack must be like taking some sort of mad hallucinogenic." Whilst sober he can't see properly with single-vision. Usually able to spot a Nun, he has to be told a Nun is standing right in front of him.
    • Subverted again, when we discover one of the few things Jack can't stomach:
      Fr. Ted: No, Father! Don't drink that it's—
      (Jack takes a sip)
      Fr. Jack: FECKIN' WATER!!
  • Karen from Will and Grace. She seems to border on Immune to Everything, as she's admitted to taking things that aren't designed for humans ("an eye dropper of cat tranquilizer") and who knows what else (I seem to recall her mentioning that she once took a random pill she found under her kitchen sink.)
  • Reverend Jim Ignatowski, on Taxi.
  • Gregory House pops way too many pills, mostly Vicodin. His colleagues, as doctors, are not terribly comfortable with this. He, as a doctor, even as a paragon of Dr. Jerk, isn't always comfortable with this.
  • During one episode of WKRP in Cincinnati, it's revealed that Johnny Fever has developed such a massive tolerance to alcohol, his reaction time actually improves with every drink he takes. (Fellow DJ Venus Flytrap, on the other hand, gets plastered.)
  • Bottom: Edward Elizabeth Hitler – a man who has only ever been drunk once. note  Managed to get blind—drunk note  on ₤1·75 note , leading him to be unable to find the front door or the floor after falling over, finally finishing—up with a nightcap consisting of a bottle of bleach. He always carries a hip―flask which contains brandy, meths, Pernod, paint stripper, Mister Sheen, brake fluid and Drambuie.
  • Patsy Stone from Absolutely Fabulous. Although she's had her stomach pumped many times, she's never experienced long-term side effects. Along with her rampant drug and alcohol abuse, she is almost never seen without a cigarette. When she attempted to quit smoking, she apparently began recharging the multiple patches on her body!
  • Subverted by Charlie in It's Always Sunny in Philadelphia. The hard-drinking, glue-sniffing loon scarfs down some home-made brownies that he himself spiked with downers, saying, "I can handle my sedatives." To the amazement of his friends, he's still standing hours later, but he's in a drugged-out fog, muttering gibberish. By the end of the episode, he's passed out and drooling.
  • Super Hans on Peep Show. In one episode, he takes four grams of cocaine in one go "to relax himself".

    Music 
  • Murdoc of Gorillaz has been almost constantly drunk for several months, as of current canon, on top of all the drinking and drug-taking he did before this. 2D, meanwhile, is addicted to prescription painkillers. Neither of them seem to have suffered any permanent harm from their habits.

    Pro Wrestling 
  • André the Giant: "It usually takes two liters of vodka just to make me feel warm inside." Weighing somewhere between 475 and 540 pounds was almost certainly a factor.
  • While Jake "The Snake" Roberts isn't exactly in a good place in terms of health, finances or professional standing, the fact that he should, by rights, be dead by now might count.
  • Rob Van Dam. Despite being the most obvious space cadet in the wrestling business (and that's up against some very stiff competition), complete with periodic interviews with High Times magazine, he's still well regarded professionally, gets plenty of job offers and is a three time world champion.
  • Jeff Hardy. A total of four Wellness violations with WWE; a drug raid on his home produced a laundry list of narcotics, leading to his ongoing drug trial (including one charge of opium trafficking) and was the subject a humiliating on-screen feud with CM Punk over his drug habits. Still has legions of fans and gets loads of offers of work. A notable exception was Victory Road 2011 where he turned up drugged as fuck, and got his ass kicked by Sting in under 90 seconds.

    Tabletop Games 
  • This trope is one of the reasons the Noise Marines in Warhammer 40,000 are so messed up, except replace "drugs" with "all sensation". After thousands of years in worship of the god/ess of decadence, they get to the stage where they need to invent new drugs and listen to concussive blasts of pressure to get their kicks.

    Video Games 
  • Joshua Graham in Fallout: New Vegas. His strange immunity to drugs has let him survive assassination attempts, but his immunity comes to bite him every single day since he was burned on every inch of his body (and thrown off a cliff), and forced to strip and reapply his bandages every day for sanitary reasons, without any hope of painkillers or healing chems.
    • The Player Character can be a downplayed example in the first two games through the Chem Resistant trait, which reduces the chance of getting addicted to a drug by 50%, but also means that the effect of the drug only lasts for half as long. There's also an inverse trait, "Chem Reliant", where drugs affect you for twice as long, but you are twice as likely to be addicted as well. Taking both traits is a fun way of accomplishing absolutely nothing with maximum effort. The latter games in the series, however, turns Chem Resistant into a perk, removing the downside (with "Chemist" be the perk equivalent of "Chem Reliant").
    • The Old World Blues add-on adds the Logan's Loophole trait, which makes you immune to chem addiction, but caps your level at 30. As with other traits, you can change it with the upgraded Sink Auto Doc, and you get another perk anyway in the add-on which boosts your addiction resistance, stacking with Chem Resistant.
  • Deus Ex: Alcohol will heal you, although it will mess up your screen for a short period of time, and zyme, a rather addictive drug of the future, will just blur your screen as well. Cigarettes will harm you though. Averted in Deus Ex: Invisible War however, in which alcohol will harm the character. In Human Revolution, alcohol will again health you (though with Regenerating Health it's mostly for temporarily boosting health beyond the regular maximum) and make you drunk, and while they're not an item it's stated Adam's aug's cancel out any negative effects of smoking (he muses that he's not even capable of a little self-destruction anymore).
  • Godot in Phoenix Wright: Ace Attorney: Trials and Tribulations drinks up to 17 cups of coffee in court (and who knows how many more during the rest of the day) with no ill effects. It doesn't seem to be making him jittery or anything (rarely even scalded!). At one point, the judge admonishes him that he is going to ruin his health, but the situation is that his health is already ruined thanks to a deadly poison that didn't kill him, and he apparently needs the coffee to keep him going the rest of his short remaining lifespan....
  • The members of Love Fist, the Fake Band from Grand Theft Auto: Vice City, are implied to be Immune To Drugs: their favorite drink is a lethal Gargle Blaster, and they can drink "boomshine" without much problem.
    • Just to explain how serious boomshine is, in a separate scene Tommy gets critically drunk from the fumes it gives off. At one point, a portion of Boomshine explodes violently enough to instagib a guy's entire arm. It makes jet fuel look like mineral water.
  • Cody from Final Fight: Streetwise is forcefully fed some drugs. There are some effects, but none of them are permanent. Actually, wait... there is a permanent condition. The drugs have healed his previously injured knees! Drugs are awesome!
  • The protagonist in System Shock 2 can use alcohol to regain health at the cost of psychic energy. Subverted in that smoking just drains your health with no benefit. Since psychic abilities aren't a requirement in any way (many perfectly viable character builds won't even touch them), downing bottles and BOTTLES and BOTTLES of hard alcohol not only won't even make your vision blurry, but can save you from death!
  • In Left 4 Dead and its sequel, you can take pain pills and adrenaline with no negative side effects.
  • In Saints Row 2, you can drink and smoke pot to an insane degree, but all it will do is make your screen go wobbly.
  • Alcohol in BioShock allows Jack to regain health, and drinking a lot makes your vision blurry. So if you're low on health and find a lot of wine....
    • It also reduces the level of available EVE you have...unless you have the appropriate gene tonic, in which case it produces extra EVE instead, meaning that with Boozehound you are well and truly this trope.
  • Drinking vodka in S.T.A.L.K.E.R. will cure your radiation poisoning. It'll also make your screen sway a bit, but that passes after a few minutes.
  • Averted in Soulbringer, with ale and wine. Ale comes in mugs, and heals you...two or three hit points apiece. And lest you think you can stack these, around four or five mugs is when the vomiting (and health loss) starts. Thardolin red wine is even worse; probably because you chug the entire bottle, a single serving makes the screen wobble and your movement wonky (with no health gain), and a second will have you throwing up.
  • In Alpha Protocol, the arrest report for Konstantine Brayko (provided you left him alive) mentions he had enough cocaine in his system to, quote: "Make a baleen whale see Jesus". He shows absolutely no negative effects of this, and you can have the resident Heroic Comedic Sociopath spike his coke with rat poison and all it will do is make his drug-fuelled rampages slightly less imposing.
  • Between the amount of painkillers he throws back in the course of normal gameplay and the fact he somehow survived getting forcibly overdosed with Valkyrie, a drug best described as the retarded dumpster-baby of LSD and crystal meth, Max Payne has to count.

    Web Comics 

    Web Original 
  • PPCers tend to go through Bleeproducts, alcohol, and painkillers at a fair rate and never suffer any longterm effects. they can draw on medical treatment from any continuum ever created, so the ill-effects could be mended if they start to become a problem. To quote one agent when told he shouldn't try marijuana, "If Dr Fitzgerald can sew limbs and genitals back on he can rebuild the inside of my lungs if necessary, and I fail to see what it could do to my brain that this job has not already done."
  • Michael Swaim from Agents Of Cracked is stated to be "immune to pills," from taking too many of them at one point.

    Western Animation 
  • The Simpsons
    • Barney. It's been lampshaded, including several references to a failing liver (including a gag on "The Joy of Sect," in which Barney sees a discarded liver on the floor of an airport bar and thinks that his liver tried to escape—again), and no appearances in the "future" episodes.
    • Krusty, by his own description, has become so jaded and world-weary that the only drug that affects him anymore is freebased ground-up moon rocks (and all that does is get him to normal).
    • The real walking pharmacy on the show, though, is Otto. Aside from being a run-of-the-mill pot smoker, he's also shown in "Father Knows Worst" buying model kits and glue, then dumping the kits as soon as he's out of the store, he walked out of a kitchen cutlery store called "Stoner's Pot Palace" due to "flagrant false advertising," his urine is so full of traces of illegal drugs that it barely has any actual urine in it and looks like a scene from Yellow Submarine. The "best" part in all of this: he drives the schoolbus!!
      • The episode where Otto loses his license and Skinner takes over driver duty quickly shows that in order to not go utterly insane, he needs to be high as a kite all the time!
    • The full list of what was found in Otto's urine sample:
  • Pickles on Metalocalypse, due to his frequent use of (all) drugs in the past, and having been on "government weed" since the age of six (for his "kiddie glaucoma"), is immune to "Totally Awesome Sweet Alabama Liquid Snake", the mind-destroying drug created to reprogram the minds of Pickles' old band, Snakes-n-Barrels, in a plan to use them to get to Dethklok.
    • Doctor Rockso is powered by cocaine. C-C-C-C-COCAINE!!!
  • Pickles on The Oblongs. All that drinking and smoking (and living in a polluted town) should have killed her years ago. The second episode where Milo gets a pet dog had her accidentally drink gopher poison with no adverse effects (she was supposed to bury the gopher poison).
  • Replace drugs with sugar and Pinkie Pie should have long ago succumbed to diabetes. Instead, she's just a somewhat weird and hyper.
  • Pam from Archer. In The Papal Chase, Woodhouse accidentally injects two syringes full of heroin into her neck, with no noticeable effect at all. She's recently taken to using enough cocaine and amphetamines to keep a medium-sized city high for several days, and aside from a brief cardiac arrest (that also doesn't faze her), it hasn't affected her behavior in the least.
    • To a lesser extent, Archer, himself.
    Archer: Luke, you're not thinking straight. You wildly underestimated my liver's ability to metabolize toxins.

    Real Life 
  • Ur Example: In many cases, the drug users can develop a tolerance, and they need progressively larger doses to get the same effect. Death due to overdoses or drug-induced diseases comes when the person can't live without his or her usual "high" and intentionally takes the drug in insane amounts. Being "immune" to the mental effects of a drug is not the same as being immune to the physical effects. Like death.
    • Overdoses are overwhelmingly cause by the variable strength of street drugs - see the occasional fentanyl sold as heroin overdose "epidemics" and such. Actually trying to commit suicide by overdose would be difficult and or expensive with either street or prescription drugs.
  • Furthermore, different people produce different amounts of drug metabolizing enzymes such as cytochorme P450s. Some people produce so much of these enzymes that they are able to inactivate an otherwise lethal dose of drug before they have the chance to do too much damage.
  • Hunter S. Thompson.
    • Here's a page from his personal journal, which lead to Fear and Loathing in Las Vegas being published after sent it to his boss (who sent it to a publisher).
    "The sporting editors had also given me $300 in cash, most of which was already spent on extremely dangerous drugs. The trunk of the car looked like a mobile police narcotics lab. We had two bags of grass, 75 pellets of mescaline, five sheets of high-powered blotter acid, a saltshaker half-full of cocaine, and a whole galaxy of multi-colored uppers, downers, screamers, laughers . . . and also a quart of tequila, a quart of rum, a case of Budweiser, a pint of raw ether and two dozen amyls."
  • Keith Richards cannot be killed by conventional weapons. As Robin Williams said about him:
    I know there's a cure for bio terrorism or whatever it is, and I know it lies within Keith Richards. He is the only man on the planet who can go "Anthrax? (snort) Alright! Doesn't go with my e-coli, but fuck..." Keith is the only man who can make the Osbornes look fucking Amish. He's insane! I've seen him go up to a drug dealer and the drug dealer's like, "I'm out man, I'm sorry; I have nothing left!" Supposedly, he goes to Switzerland and changes his blood...not one or two pints, but like a fucking Chevrolet—all of it. Now what I wanna know is who gets his blood? Some old Swiss man, going, "HEIDI! We gotta go on tour, you bitch! We gotta pay for Mick's babies!" I know we will all be dead and gone, but Keith will still be there with five cockroaches. He'll be going, "You know, I smoked your uncle, did ya know that? Fucking crazy..."
    • According to Robin, Jack Nicholson has done every drug known to man and is the only one who will have Keith Richards say, "I have to go home now, Jack".
    • In Good Will Hunting, Robin Williams ad-libbed a line about how Sigmund Freud "did enough cocaine to kill a small horse."
  • Lemmy Kilmister.
  • William S. Burroughs.
  • Slash.
  • John A. Macdonald.
  • Graham Chapman. According to the other Pythons, he would sit around during their writing sessions sipping what everyone thought at the time was a large glass of water. It was gin.
    • According to the documentary Python, a significant part of the problem was that he acted exactly the same when drunk as he did when he was sober — so they couldn't tell the difference between when he was completely sloshed and when he was just doing Pythonesque things.
  • Ozzy Osbourne. Apparently now he's just on coffee, but at this point he probably doesn't need them anymore.
    • According to his autobiography, when he went for a colonoscopy, he had to be given four times the regular dosage of sedative before he was knocked out. The doctor insisted that it wasn't possible and that Ozzy wasn't human.
      • This is a minor Crowning Moment of Funny in his autobiography. Regular Dose of Anesthetic: "Ooh, there's the good stuff!" Twice the Dose: Doctor: "Blink once if you can hear me." Ozzy: "Why would I do that? I can talk to you just fine." Three Times the Dose: Doctor: "Jesus Christ, you're not human!"
    • Ozzy's actually having his genome mapped, so scientists can figure out why he and others like him can survive what they do themselves. Really!
    • Turns out he's a mutant. It explains a lot, doesn't it?
  • Pretty much everyone in X Japan. While alcohol and drugs contributed to the deaths of hide Note  and Taiji both, it took something other than the drugs themselves to kill both (a Noodle Incident involving asphyxiation for hide, likely murder for Taiji) and to this day, Yoshiki Hayashi and especially Pata seem to be genuinely immune. (In fact, there is a Running Gag that Pata doesn't have alcohol in his bloodstream, he has blood in his alcohol stream.)
  • Charlie Sheen. Or so he claims.
    • He is a warlock with tiger blood and adonis DNA. Those things overpower everything else, except the winning.
  • David Crosby.
  • Kurt Vonnegut wrote the following in A Man Without A Country:
    ...I am going to sue the Brown and Williamson Tobacco Company, manufacturers of Pall Mall cigarettes, for a billion bucks! Starting when I was only twelve years old, I have never chain-smoked anything but unfiltered Pall Malls. And for many years now, right on the package, Brown and Williamson have promised to kill me. But I am now eighty-two. Thanks a lot, you dirty rats. The last thing I ever wanted was to be alive when the three most powerful people on the planet were named Bush, Dick and Colon.
  • Jeanne Calment, who currently holds the world record for oldest person of all time, smoked for 96 years starting at the age of 21, and lived to be 122. She reportedly only smoked one or two cigarettes a day in her later years, but it's still very impressive.

Second Kind: Immune with Justification

    Anime & Manga 
  • In Ah! My Goddess, Belldandy packs away shot after shot of liquor without even getting tipsy, but drinking a single can of ordinary soda gets her plastered. Her sister Urd can only get drunk on sake.
  • Lum and other Oni characters from Urusei Yatsura are immune to alcohol (and probably most poisons too, as seen with some badly-prepared fugu in a manga story arc) thanks to their alien metabolism. However, eating plums will make them drunk.
  • Ryoko from Tenchi Muyo! is immune to all forms of toxins, including alcohol. She can shut this immunity off if she wants to get drunk (which is a common occurrence), but doing so requires a sustained conscious effort. Which means that if she gets too drunk to maintain her concentration on suppressing the immunity, she'll instantly sober up again.
  • Cyborgs in Ghost in the Shell (Makoto's a full body cyborg, essentially a Brain in a Jar in a Fem Bot body, but presumably partial cyborgs can have the same sort of thing built in) can filter alcohol straight out of their system to sober up. In the first movie, The Major switches this off so she can actually get drunk on beer though.
  • Some girls from Claymore are once shown to go drinking. When one starts getting tipsy, somebody (either a young Claymore or a human, can't recall) asks if they weren't supposed to be immune to alcohol. Another one then explains that they are actually in control of their metabolism, so they CAN get drunk, if they want.

    Comic Books 
  • Wolverine from X-Men and The Thing from Fantastic Four are both smokers who cannot contract cancer. Wolverine once drank 25 beers and didn't even get a decent buzz.
    • Wolvie's not technically immune to alcohol, he just sobers up a lot faster. He's become absolutely smashed on the really hard stuff, but beer? He's over the first one before the second one gets cracked open.
    • This is also why the cigarettes he smokes don't hurt him much. (When his regeneration factor was briefly suppressed after Magneto yanked the adamantium out of him, he started coughing and getting sick from them, and in one issue, threw them away in disgust. Fortunately, that problem got better quickly.)
    • Quicksilver can also get drunk, if he drinks a lot really fast. Then he sobers up in 30 seconds and gets a 30 seconds hangover. He might as well not bother.
  • Due to his advanced metabolism, Captain America cannot get drunk.
  • Subverted by Aaron Stack, Machine Man, in Nextwave, who personally rewired his robot body to be affected by alcohol consumption. He's since become dependent on the stuff.
  • Hyperion in Supreme Power is unaffected by any drugs whatsoever, due (probably) to his impossibly dense musculature and alien physiology. After several bottles of tequila, he isn't even buzzed.
  • The various Doctors from The Authority, not to be confused with Doctor Who, have had problems with this. At least one of them went on a murderous rage that ended with drinking every bottle of Dom Perignon in existence (leaving him so drunk he couldn't fight back). The first Doctor in the series was a heroin addict, something that was a continuing problem for him. This is despite their ability to alter reality at will which normally puts this trope in effect.
  • I am Snowflame! Every cell of my being burns with white-hot ecstasy. Cocaine is my God, and I am the human instrument of its will! Courtesy of the 'New Guardians' run of books. Thanks, DC.

    Fan Works 
  • John in With Strings Attached is immune to alcohol because of his metamorphosis. It's only really an issue once, when he first discovers it while the others are getting completely smashed.

    Films — Live-Action 
  • Aversion: In Dogma, not only were angels vulnerable to alcohol, but God forbade them from drinking after a drunken Loki told God off after carrying out the ten plagues described in Exodus. Early on, we see the Metatron order tequila "and an empty glass" — he can drink it for the taste but then has to spit it out.
  • Legolas in The Lord of the Rings claims to only feel a "slight tingling in [his] fingers" after drinking enough ale to make Gimli, a dwarf, pass out.
  • The Newcomers from Alien Nation process alcohol harmlessly, but get drunk off of spoiled milk.
  • As mentioned in the Comics section above, Captain America can't get drunk because his sped-up metabolism metabolizes the alcohol before it has time to take effect.
  • In X2: X-Men United, Wolverine gets shot with Instant Sedation darts and doesn't stop charging. A moment later he yanks the darts out and shakes his head as if to clear it, but continues on like nothing happened.
  • The vampires in We Are the Night can consume and feel the effects of drugs, as demonstrated during the party montage scenes, but they are said to be immune to unpleasant side effects such as overdoses or addiction.

    Literature 
  • Bilbo the Hobbit mentions that elves (unlike the D&D ones) are quite difficult to get drunk. They are shown to get drunk on really large mugs of very strong wine (the exact amount needed is not specified), but then, Legolas is of somewhat higher blood than a mere warden.
  • Case from the classic cyberpunk novel Neuromancer, has his pancreas and parts of his liver replaced (against his will) with one that, to his chagrin, renders him immune to stimulants. One of his efforts in the novel is to find a way to still get high. Yep, he's that kind of hero.
  • Hope Hubris, protagonist of Piers Anthony's Bio of a Space Tyrant series, has a hyperactive immune system that lets him shake off the effects of most drugs while immunizing him to future doses. Subverted at the end of the series, when relying on this talent after recovering from food poisoning lets the damage to his kidneys become irreversible - while causing the failure of all but the most primitive forms of dialysis, with even that option doomed to stop working in the near future.
  • In one of Mercedes Lackey's Serrated Edge novels, an organization trying to kidnap a psychic finds one and puts something in his drink which should incapacitate him and would kill him if the antidote wasn't given within about ten hours. However, he is an elf, immune to anything but Cold Iron and caffeine, and he saw them do it, so he drinks and goes on his way, not thinking much of it. The head operative, thinking that either her subordinates had betrayed her or the drug was a dud, feeds it to them. Since it works on them exactly as advertised, she puts it down to treachery.
  • Good Omens uses the "angels" (and demons) being immune to alcohol but with a slight twist: as is seen at one point, Aziraphale and Crowley can (and do) get roaring drunk, but can instantly make themselves sober again.
  • Homo drakensis from Drakon have extremely fast metabolisms, one side effect of which is that they metabolize alcohol so quickly it's almost impossible for them to get drunk. The protagonist is shown downing several double brandies one after the other, which apparently has the same effect on her that one glass of wine would on a human.
  • It takes an enormous amount of pot to get the Duumvirate even mildly buzzed.
  • Most militaries in the Honor Harrington vaccinate their members against various drugs to prevent enhanced interrogation.

    Live-Action TV 
  • Claire Bennet from Heroes is immune to alcohol due to her ability to heal.
  • The Doctor in Doctor Who is mostly immune to drugs. Most drugs — he mentions "shrooms as an example at one point — do nothing to him, but he's once seen tipsy from drinking ginger beer, and once hallucinated after taking antihistamines.
    • Not to mention curing himself of cyanide poisoning in one episode of the new series.
    • Also, aspirin can kill him.
  • The Gua hybrids in First Wave are built to be stronger than regular humans and immune to our diseases and, presumably, our drugs. But they get completely stoned on table salt.
  • In the final season of Angel Spike moans about how hard it is for vampires to get drunk. He and Angel are next seen drunk, several hours later having drunk all the alcohol on the private jet they're on.
    • Spike is seen very drunk in the Buffy the Vampire Slayer season 3 episode "Lovers Walk", though. Probably must have consumed a ton of hard liquor for that.
  • In the Supernatural episode "99 Problems", the angel Castiel remains alive, conscious and mostly ambulatory after drinking an entire liquor store.

    Tabletop Games 
  • The werewolves of Werewolf: The Forsaken are said to be all but Immune to Drugs as an extension of their Healing Factor. Due to the extremely harsh nature of their lives many grow quite frustrated by the inability to get drunk or high for the sake of escapism (though it can be overcome by imbibing massive quantities, or occasionally with the aid of spirits).
  • Novas in Aberrant usually metabolize drugs too fast to experience the effects, although weaker individuals can make up for it with volume. There are also super-powerful synthetic drugs available that would generally kill a normal human, including an extract from the brains of slain Novas.
  • Space Marines of Warhammer 40,000 are generally immune to normal drugs due to their modifications, Fenrisian mead might be an exception though considering a Space Wolf once claimed it would give you a hangover "like continents colliding."
    • This one is actually explained in one of William King's Space Wolf novels: there's actually a chemical in Fenrisian mead (at least the variety served in the Fang) that shuts off the organ that grants Space Marines their immunity to drugs. It's specifically so they can get drunk.
  • In Dungeons & Dragons 3.0 and later, a character with enough ranks in the Monk class becomes effectively immune to toxins, which means that they are effectively immune to any intoxicating substances like alcohol or recreational drugs.
    • Same with the druid class and possible numerous other non-core ones.
    • Note that the Drunken Master prestige class has as prerequisites both Monk-specific class features and nights of drunken revelry with a mentor Drunken Master. Your character must be a monk still capable of getting drunk to become a Drunken Master.

    Video Games 
  • The SOP nanomachines in Metal Gear Solid 4: Guns of the Patriots break down any alcohol their users drink before it can intoxicate them. This is only one of their dehumanizing effects. Arms dealer Drebin has taken to drinking cola as a substitute. After the SOP is taken down he breaks out the booze.
  • Grim Fandango, true to its Film Noir roots, has everyone chain smoking. But since everyone is already dead...
    • Humorously lampshaded in the manual, possibly to pre-empt any Moral Guardian complaints about all the smoking: "Sure, everyone in the game smokes, but please note that they're all dead."
    • One puzzle also involves drinking some liquor with gold flakes in it in order to trip a metal detector. It does have some... effects on Manny, but apart from that puzzle making him drunk is pretty useless (though still somewhat amusing).
  • After getting rebuilt by Cerberus in Mass Effect 2, Commander Shepard exhibits some drug immunity. While Shepard can still get drunk, it takes a lot more than usual to knock him/her out (as in: krogan liquor), and sedatives have very little effect, as the researchers in The Arrival found out the hard way. At one point, Shepard can (accidentally) drink poison that is generally lethal, but wakes up a couple hours later with a bad headache as the only side effect.
    • Krogans are highly resistant to most forms of poison and drugs, due to their resilient biology. To get drunk, they resort to a mixture called ryncol, which has been known to cause those who drink it to set off radiation alarms for up to a week afterward. It has also been compared to drinking paint thinner.
      Grunt: Don't try to act tough... that stuff goes through humans like broken glass.
      • In the Citadel DLC, Grunt has been arrested for stealing a police car and crashing it into a noodle house. When he tells you what happened he explains that he threw his (nearly full) bottle of ryncol at the car and it spontaneously combusted. Grunt was also so drunk (from only a small amount of ryncol) that he thought stealing the burning car was a good idea. This drink (read: poison) is one of the few ways that Shepard can get intoxicated after his reconstruction.

    Web Comics 
  • Cry Havoc, with werewolf mercenaries:
    Skoll: (with several empty glasses in front of her) Guys... I don't think I can get drunk anymore...
    Hati: Well you've had six pints and four shots, so for your liver's sake I'd hope not.
  • Given a morbid twist in The Order of the Stick installment Start of Darkness, when newly-liched Xykon discovers that one of the side effects of being a walking skeleton is the lack of any way to drink coffee. He takes this badly.
  • Also from S.S.D.D are Tessa Edwards and her fellow augmented CORE marines, who need enough alcohol to poison a small elephant to get drunk. The bars they frequent serve "cider" that is legally considered paint thinner.

    Western Animation 
  • Bender from Futurama who, as a robot, is actually fueled by booze. In a "what if?" episode, where he is turned into a human, his habits become worse and he dies of massive overindulgence.
    • Bender develops the typical symptoms of a wino when he doesn't drink.
    • In older episodes, he's seen getting drunk on alcohol, but this is no longer canon. Apparently, he can also power himself with nice, clean, mineral oil, similar to becoming a vegetarian. Lampshaded by Fry.
      Fry: Bender, you've been drinking too much. Or not enough. I can't remember how it works with you. The point is, you haven't been drinking the exact right amount.
  • American Dad!: Roger. If any drug on the show is mentioned, Roger has either tried it or is on it, with barely any side effects at all.

    Real Life 
  • Mileage tends to vary from person but several people with ADHD can consume caffeine and not have an sort of effects of it, that is not being hyper or otherwise intoxicated from it, this being justified by the fact that A) caffeine is a stimulant and B) ADHD is a condition commonly treated with stimulants and tends to have the opposite of the unexpected effect.

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