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- Greys Anatomy gave some of its doctors nicknames starting with "Mc" (as well as a few parodic ones), most prominently McDreamy and McSteamy.
- Happy Days: Fonzie sometimes uses the suffix "-amundo" for emphasis: correctamundo, exactamundo, etc. When he was a Rogue Juror he even voted "not guiltyamundo."
- Saturday Night Live: Adam Sandler's Opera Man from the early 1990s would sing his commentary in an exaggerated Italian accent by adding "a" or "o" to the end of many of his words. (An example (from Wikipedia): About the LA Riots - "La Chiefa Policia, no dispatcha gendarme/ morono, no respondo/ no excusa, bagga doucha!")
- Kenan & Kel: Throughout most of the first season, and some of the second, Chris had the habit of adding an extra prefix to his preterites, usually a "be" or "buh" sound, such as:
"Kel, you be-bruised my bananas!"
"How could you buh-lose a lottery ticket?"
- In the Doctor Who episode "Utopia", we meet Chantho, an insectoid alien who begins her every sentence with "chan-" and ends it with "-tho." She can choose not to do it, but it's implied that it's her race's equivalent of swearing like a sailor.
- Blaine of Project Runway season 5 liked to add "-licious" to words.
- Snoop Dogg attaches '-izzle' to a lot of his words, although a fair bit of those words have half of them removed, e.g. "fo' shizzle" for "for sure".
- Final Fantasy X-2: According to Rikku's brother, Brother, she has a habit of doing this with Spiran words, and even chides her for it. Most notably, her inclusion of "iffic" to the word "disaster"; resulting in "disasteriffic".
- The King of Fighters: Yuri Sakazaki has a habit of ending nearly all of her sentences, and certain words, with "-tchi". It was originally a schtick devised by her voice actress, Kaori Horie, which stuck and has since become a regular part of her character's speech pattern.
- In Dwarf Fortress forums, it's fairly common for players to refer to their dwarves as "Urist Mc(adjective or profession)". As in "Urist McMiner", "Urist McSpeardwarf", or "Urist McCannonfodder".
- Total Drama Island Season 4: Revenge of the Island had Lightning, whose big thing was words starting with "Sha-" (including Shazam).
- In Captain N: The Game Master, Kid Icarus (who should have been named Pit) tended to tack "-icus" on the end of words.
- Due to the fact that he often speaks with a slight Speech Impediment (like that of a 5-year-old), Mr. Bogus will often use the word "mondo" before adding the letter 'o' at the end of a word used after it in his sentences: "Mondo coolo", "Mondo safe-o", etc.
- The Simpsons has two, by two different characters:
- Homeric ma-infixation is an interesting application of Hyperafffixation in that the particle "-ma-" is an infix (it is put in the middle of a word), producing words like saxomaphone and babamabushka. Homer, as you can guess, uses it a lot.
- Ned Flanders also adds "-diddly" to a few of his words.
- Similar to the Homer Simpson example, Yogi Bear frequently calls picnic baskets "pic-a-nic baskets".
- McDonald's is the Trope Codifier for this, with their menu of 'Mc' foods. Soon everyone started doing it, although it is seldom a compliment (e.g. 'McMansion' for a cheaply-made, soul-crushingly uniform house).
- Moscow on the Hudson character Vladimir does this when he works at McDonald's, to the point of making the parting statement to some customers, "Come back McSoon."
- Apple Computer's habit of putting an "i" in front of every new product is parodied enough to be its own trope.