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Films — Live-Action
- Abbott and Costello Meet Dr. Jekyll and Mr. Hyde.
- Friz Freleng really liked this trope: he directed the Looney Tunes cartoons "Hyde and Hare" (with Bugs and the real Dr. Jekyll), "Hyde and Go Tweet" (with Tweety and Sylvester), and "Dr. Jerkyl's Hide" (with Sylvester and a pair of dogs). When he later went to work on Pink Panther cartoons, the same plot was recycled in an episode of "The Inspector" ("Sicque! Sicque! Sicque!") and again with the Pink Panther himself, where the monster was Dr. Jekyll's old car he bought used ("Pink Lightning").
- The Huckleberry Hound Show: Huckleberry Hound is faced with a pastiche of Dr. Jekyll in the cartoon "Picadilly Dilly".
- Tom and Jerry did it in 1947 with "Dr. Jekyll and Mr. Mouse", and in 1975 with "See Dr. Jackal and Hyde!".
- One of the Dragonlance short stories had a Kender stumble upon (i.e. steal) a magic dragon figurine. It turns him into a dragon at various times.
- Dexter's Laboratory had an episode such as this, in which Dee Dee was the monster.
- Mr. Meaty has an episode of this.