There are no children in the Overlord series, except a few in Overlord: Dark Legend — that are conveniently invincible, and you're supposed to be helping anyway. When you're playing the Witch Boy before his Overlord days in Overlord II the children there are invincible, but in retribution for their bullying and tormenting you, you get to chase them down, harass and torment them and finally stranding them naked in a secret clubhouse while your minions use their clothes as a disguise.
In The Getaway Alex Hammond appears to be the only child whole of Greater London.
A level in God Of War features Athens burnt to the ground, with random civilians running around all over the place, whom you can kill if you so desire. No children are present. There is one child that appears in the game, the daughter of The Protagonist, Kratos. She is already dead before the game begins, because she was killed along with her mother by Kratos's own hand, and only appears in flashbacks. This is a vitally important part of Kratos's backstory as he is constantly haunted by the knowledge that he was personally responsible for the deaths of his wife and daughter.
Sword Of The Samurai 2 is Grand Theft Auto in Late Edo Japan... you can draw your katana on a busy market-street, and start cutting down innocent civilians left and right. Unlike GTA, however, there are children. They're just Made of Iron — your strongest attack will do little more than slow them down as they run towards the nearest exit. Even on "Extreme mode", where everyone in the game, including yourself and the final boss, dies from a single hit, the kids remain immortal.
In the console version of Spider Man 2, countless adults get injured and mugged and it's up to you to save them but the only scenario in which you have to help a child is when they let go of a helium balloon and you have to go and save it, in increasingly improbable places and times (like 2 AM in the morning in the middle of Queens).
Ultimate Spiderman: Ultimate Venom is allowed to eat these balloon-carrying children. Note that the games were made by the same development studio.
Justified in Half-Life 2. The Combine have suppressed human reproduction for many years (it varies between 10 and 20 years, depending on where you look), so City 17 is populated only by adults. The children all grew up. Lampshaded in the first chapter when Gordon comes across an empty playground—cue ghostly laughter of children. Also, in Episode One, Resistance members will occasionally say "I'm glad there aren't any children around to see this."
Despite several towns decimated by a zombie pandemic, there are no child zombies in Left 4 Dead. Taken to extremes in the "Dark Carnival" campaign in Left 4 Dead 2, which takes place in a Amusement Park of Doom without any children. Supposedly this is because the green flu everyone is infected with simply kills children, but this begs the question of why there aren't any corpses.
Played with in The Darkness. At one point in the game an orphanage is blown up as an act of revenge against the protagonist. Everything is relatively cleaned up by the time you enter it, but there's still the matter of the police-drawn chalk outlines of children's bodies strewn all over the floor.
In one level of Swat4 you are pitted against a cult and told to expect children inside. Naturally, it would be very problematic to have you deal with children as hostages, so the game seems to be in a irreconcilable position. The solution? As you proceed through the level you see cribs, childlike decorations, and stuffed animals - but no children.Finally, in the basement you find numerous tiny graves with farewell messages scrawled on the wall. The implication being that the cult members murdered their own children.
Players of City of Heroes have a running joke in that the entire city lacks any children save for one, who stands in the middle of a zone infested with hostile alien monstrosities with all the invincibility of a non-targetable NPC. There are also no educational facilities below university level, although school books are occasionally mentioned as a MacGuffin to save.
Children NPCs are invincible in World of Warcraft, even when you try to kill kids from opposing faction. There is even a holiday event in the game called Children's Week, where players can act as a "big brother/sister" to a child from an orphanage by allowing the child to accompany them while they go about their normal activities. Predictably, enemies that the player might battle while the child is present will never attack the child. Even if the player is hit by an area-of-effect attack, the child will not be affected.
Children do not appear in Age of Empires until the third game, and even then they only do as decoration cinematics in the "Home City" menu boards or in Native villages. The player can't attack these villages, only compete with other players to built trade outposts in them and get extra technologies and units from them, so the children can't be wounded either.
The Elder Scrolls II Daggerfall has two types of NPCs: those who were animated and could be attacked, and those who were fixed two-dimensional sprites which could not be used for anything other than conversation. This kind were found only in in-door environments and did include at least one child.
Fable was originally going to include children that could be killed (a widely-circulated pre-release picture showed the protagonist impaling a child on his blade), but this was scrapped at the last minute. Instead, children only appear in places in the game where you're not supposed to be able to kill anyone, at least not without glitches.
There are children all over the place in Fable II. You still can't kill them, but they quite distinctly notice you if you try. Specifically, you get some evil points, everyone gets very upset, and the guards will chase you down... to make you pay a fine.
In Neverwinter Nights, Players can destroy every guard and adult in the place, but there is a little child in one of the districts who cannot be killed. If you kill his parents, he even seeks vengeance. Protected by sheer invincibility, he will follow you anywhere in the game, pounding on you with his tiny fists. He will follow you into every room of the game.
Dubloon. The closest to the child you will get in this game is Riley.
Despite visiting many colonies and other places where families clearly live, no children are ever seen in the first two Mass Effect games. Partially excused by Shepard spending most of his/her time on military bases or small colonies and research facilities where families wouldn't be living anyway, but it is still a little odd to never see any on the Citadel or Illium... or Horizon, for that matter, especially because children are specifically mentioned in an e-mail received after the Horizon mission.
In Mass Effect 3, it is mentioned in the Ex-Cerberus Scientists mission that the defectors brought families and children with them into hiding—families and children who, naturally, are never seen; we just take Brynn's word for it. Also, in the Citadel's refugee camps, we see a teenage girl (who is obviously just a youngish-looking female NPC) asking a guard if her parents have arrived yet. When she worries over her parents being missing or possibly dead and having no one to look after her, the effect is somewhat lessened by the character model used.
One of the levels in Hitman: Blood Money has our hero carry out a hit on a mobster in witness relocation during a child's birthday party. The clown is there, the caterer is there, but the child is nowhere to be found.
Hitman: Absolution lampshades this. At the beginning of a level that involves a thug assault on an orphanage, there is a cutscene in which 47 overhears two nuns discussing how all the children are away on a field trip.
In Resident Evil 4, an entire town is infected by a parasite, which turns them into bloodthirsty zombie-like beings. No children are ever seen, of course. A montage during the credits gives a glimpse of how the parasites were introduced to the villagers, and children are seen. Thus, one way or another, a lot of kids died before the game began. There's a strong implication from that sequence that the children were murdered by the Plaga-infected parents.
Resident Evil 2 both plays this straight and averts this; the T-Virus-stricken town of Raccoon City has zombies galore, but there are no zombified children at all. However, there's a small portion of the game where you play as a young girl named Sherry (the daughter of the main antagonist of the game), and it's possible for her to get killed by zombies and dogs. Since the Game Over animation for 2 includes a brutal and gory scene of whatever killed you tearing you apart, it can be nerve-racking to see a twelve-year old girl getting eaten by zombies, moreso than if Leon (a rookie police officer) or Claire (a college-aged student) were to face the same fate.
The American release of Silent Hill 1 featured enemies that resembled gray skinned children with knives. These were absent from both Japanese and European releases, replaced by a less obviously human-shaped creature. The demo of the American version, meanwhile, had these gray child-things giggle like infants on spotting you; this was replaced in the finished game, of course.
Third Person Shooter
For reasons that make sense both in and out of game, there are no children anywhere in the Crusader series.
Wide Open Sandbox
The 3D Grand Theft Auto games do this a lot. Only one character under the age of fifteen or so has ever appeared in the series, in any capacity other than the radio; in Grand Theft Auto Vice City Stories, Vic's love interest Louise has a baby daughter named Mary-Beth, whom you have to help protect.
However on the radio several children have been heard and even killed, for instance a Jerk Ass gun safety mascot tricked a little girl into shooting herself in the head.
Lampshaded on Vice City Public Radio show "Pressing Issues" when the host asked secessionist John F. Hickory if he'd been born in Florida.
John Hickory: Of course not! No one's been born in Florida since 1877, but! I've been here five years which is a very long time.
GTA 3 was originally going to include kids, schools and yellow school-buses◊ however they were scrapped for an unknown reason; although many people speculate it was because of school shootings that happened around the time the game was to be released, that caused them to take kids out. In fact, there was a quite well known mission that was taken out, in which the objective was to blow up a bus full of elementary school kids, and another mission was to have the player go into a school and kill all the people inside. Both were taken out, for obvious reasons.
GTA Advance involved a mission in which you had too kidnap a school kid. This trope is still played however, when the protagonist gets pissed at his employer for hurting the girl.
In the Saints Row games, no children show up at all. Ever. This is lampshaded in 2 where a ban on children and animals in public is talked about in the Ultor Cathedral.
The only humans in the Destroy All Humans!! series are all middle-aged male and female suburbanites, hippies, and farmers, except for the occasional old crackpot scientist or mid-50's communist hating general. More likely, the same character will respawn in the same spot a few minutes later, implying that they reproduce Asexually, or some such.
Prototype plays with this trope. You can eat or slash through the whole of Manhattan without encountering a single child but the Web of Intrigue cutscenes not only feature children, they feature children who are dead, mutated or experimented on. One of the "memories" has the creepy, distorted cry of a baby. Have fun sleeping.
In Red Dead Redemption, we see two children in the entire game; a kid selling newspapers in the opening cutscene, and John's son. In Mexico, it's mentioned that kids have been taking up arms in the revolution, but we never see any, for obvious reasons.
Dead Rising 2 features one child, the PC's daughter Katey. She can be killed through the player not fulfilling certain tasks, but not directly and her death is never shown on screen. Note also there's one survivor who has an age of less than 18. Snowflake the tiger, who is three years old. Even this plays the trope straight as that is considered the age of maturity/adulthood for the average tigers.
The Postal series, especially Postal 2, lacks anyone under adult age, as Vince Desi and the rest of the RWS staff felt it would be crossing a line. Considering that the player can kill, maim, burn and/or urinate on(which means the character is walking around with his genitals exposed) anyone or anything, from civilians, store clerks, priests, police officers, Gary Coleman, Taliban members, Osama Bin Laden and even digital expies of the game company staff, as well as dogs, cattle and cats(of which cats can be used as makeshift pistol silencers!), the ability to kill children is considered one hell of a big line to cross. Some NPCs will mention that they have children if they're huddled down, begging not to bekille din the many random acts of violence that seem to infest Paradise. On the other hand, this trope is averted in the Uwe Boll movie adaptation, which features dozens of kids getting hit during a particular firefight, in an attempt to cross said line as far as possible.
Dragon's Dogma has children down to about the age of twelve, then stops; it's as if a decade ago, everyone decided to stop reproducing. This is due to characters construction using the same system that the player is allowed in Character Customization, and the youngest Arisen possible is that age. This also means that every young girl is post-pubescent, if ever so slightly, as there is no body for a completely breastless female; there is only a range from A to DD.
Non-video game examples:
Lampshaded in Five Hundred Years After, in which Lemony Narrator Paarfi points out that he's specifically avoided all mention of Dragaera City's children, babies, or pets in his account of the events leading up to Adron's Disaster, specifically so readers won't have to dwell on such defenseless innocents being wiped out.
In the direct-to-DVD Futurama movie "The Beast With A Billion Backs", the titular Beast has neck-sex with every single being in the universe. In the commentary track, the creators note that they very deliberately did not have any children appear in the episode.
Later in the track, Bender makes a deal with the Robot Devil - The Devil will give him an army to take over the world...in exchange for his firstborn son. We then see Bender pick up a small robot who says, "Daddy! I knew you'd come back!", take it to robot hell, and punt it into a smelter!
American Mc Gees Alice contains Insane Children. While you don't kill them directly (mostly, they get in the way), they are made into clockwork automatons that you do have to fight. However, one of them helps you in a later level.
In Terranigma, there are zombie children in Louran. Disturbingly, the girls cry when you hit them, right before they send their severed heads at you.
During the Venom tutorial of the Ultimate Spider Man game, your first order of business is to devour a darling little girl holding a balloon. She is spit back out, but doesn't seem to be moving after that. This is a parody of the above Spider-Man 2 missions.
In LEGO Indiana Jones, you can gleefully kill your partner Short Round whenever you like. He will simply respawn a few seconds later. In his review, Yahtzee notes that doing so a few dozen times helps deal with any lingering resentment you may have for the character.
Excluded in the game Harvester, where just about anyone can be killed, and whether this has game-ending disastrous consequences is generally random. You need to kill several children to complete the game, including a mob of small children you find feasting on their mother. Of course, this is a twisted horror game where interactivity is part of the horror.
Samurai Shodown has several children amid its roster. It also has moves that lets you slaughter the opponent messily. Aside from IV, where the programming to hit two characters with the finishing moves was left out due to time constraints, everyone can be killed in brutal fashion, age notwithstanding.
First Person Shooter
In Prey, there are children captured by the aliens. You never get to kill them, but you get to see two die messily, and one enemy type is a ghostly, possessed little girl. She was originally going to be a fleshy possessed girl, and have a male counterpart that was a child husk stretched over an insectoid wraith, but these were dropped from the final game, likely for much the same reasons that motivate the trope in general.
In Deus Ex Invisible War, you can easily go on a shooting spree in a school populated by twelve year old girls, though the place is protected by security turrets and guards.
The children in the original were killable, too but that's the game's setting, not its attitude - Deus Ex was and to some extent still is notable in encouraging the player not to plow through the game destroying everything in their path.
In BioShock, creepy little girls who collect genetic material from corpses and their massive armoured guardians are prominently featured. These "Little Sisters" are immune to damage as long as their "Big Daddies" live; if the player tries to shoot them or harm them in any other way, the ADAM in their bodies causes all damage to literally bounce off them. However, if the Big Daddy is dispatched, the little girl is completely helpless against The Protagonist. At this point you can do one of two things with them: either rip out the symbiote that controls the Sister and carries their supplies of ADAM, killing the Sister in the process, or use a special plasmid to "cure" the Sister, meaning she becomes a normal girl again, while the protagonist will not get as much ADAM he would have gotten if he had "harvested" her. Note both the harvesting and the curing are conveniently obscured ("harvest" by a black-green mist, "rescue" by a flash of white light). According to a pre-release review, this happened in plain sight in an earlier version of the game shown to journalists.
After saving a little sister, they become a plain young girl, thank you, then run to the nearest vent to escape. You can shoot them after saving them, but your bullets will still bounce off her and a stern message will appear:
Message: "You can only HARVEST or RESCUE Little Sisters."
It's possible to kill children in another way - the final level of the first game is an Escort Mission where you have to guide a Little Sister who can open doors that you can't. If she takes enough damage, she will die and Tenenbaum will berate you - then tell you to go get another sister.
There is also a single scene in which you find that a family of five committed suicide in their apartment by drinking poison. Oddly, the parents show sign of decay, but not the three identical daughters.
You can also find a family sitting down to dinner, which had apparently been turned into a semi-living statue by deranged artist Sander Cohen (and you actually have to help Cohen in order to continue on in the game). Of note is that, if you strike the parents, they make a squishy sound indicating they were/are alive. Hitting the girl produces a sound like hitting rock.
In Resistance 2, you don't face any human children... but some of the conversion cocoons and Chimera resulting from them are distinctly child-sized. You can break open the cocoons, killing the occupant, and the "child" Chimera will try to kill you just like any others — What Measure Is a Non-Human? probably applies.
Also averted in Doom 3, as cherubs look like a kind of mutated human infants, although they may be just demons.
The second game had a child (or childlike) character grow to giant size in a boss battle. No prizes for guessing what you have to do.] Arioch [[spoiler: will actively seek out and murder small children.
In Diablo, there is a peg-legged young boy in Tristram named Wirt with whom you can "gamble" to buy items. In Diablo II, you return to Tristram, which has been overrun by monsters, and you can find Wirt's remains (as well as his peg leg, which you can use as a weapon, and a stash of gold he likely conned off the player character in the last game). After defeating Diablo (and either starting a new game or moving on to the Lord of Destruction expansion) go back to the rogue camp from act 1 and combine it with a Tome of Town Portal and enter the infamous Cow Level!
Wirt is the exception to the rule, as no other children are seen in Tristram. However, this is justified, because the manual and NPC dialog indicate that all the other children have already been killed by the demons.
As a Mythology Gag in Warcraft III, you can acquire an artifact called "Wirt's Other Leg" that boosts your hero's attack power. In World of Warcraft, you can recover Wirt's Third Leg, a fairly rare and fairly powerful one-handed mace. As a Shout Out, you can retrieve "Wart's Peg Leg" in Hellgate: London, though Wart is a much less obnoxious character and he doesn't have to die for you to get it.
In Dantes Inferno, the game, there are Unbaptised Babies to kill freely...yikes.
Although there are children present in a few major cities in World of Warcraft, there is an event where you can pick up an orphan from your faction's capital and take them around questing (read: 'killing stuff') with you. They seem to enjoy it.
Overlaps with What Measure Is A Nonhuman in Northrend with a quest to kidnap Wolvar pups for the Tuskarr. The Tuskarr insist that they want to raise the Wolvar to be more peaceful than the vicious hunters they normally are, but the lack of any Wolvar in their village can lead to some nasty Fridge Horror implications. Also, to capture the pups they have to be targettable, which also makes them attackable; players that don't watch what they target, or use AoE abilities on the adults, can kill the pups as well.
In RuneScape there are some human children you can find but can't attack, but go to the Grand Tree can you can slay little gnome children galore.
Though you never see a child die in Guild Wars, the canon makes it very clear that children can and do die; as one character puts it: "There were no children left after the Searing. They either grew up fast, or they didn't grow up at all."
Heart of Darkness got away with death sequences that showed the kid player character crushed, devoured, incinerated and drowned in a variety of non-gory, yet non-discreet ways. Heart is one of the few realistic 2D platformers, along with Another World and the first Prince of Persia, so falling off the screen would look flagrantly out of place — and all of them are sadistic to begin with, at least in difficulty levels.
Real Time Strategy
In Warcraft III, you can actually kill children NPCs. Without any ill-effects. As a holy paladin. Who is also the prince of the kingdom. Yeah, seriously. And this can happen well before Arthas' corruption. Try it in the first Human mission, go nuts.
Dwarf Fortress. Not only do infants catch arrows and melee attacks initiated at the mother, the children will blithely follow their mothers into combat. Since soldiers tend to have the highest birth rates, unless you have a lot of traps outside your fort, you're not going to have a lot of children surviving into adulthood. And that's not even including the people who practice 'population control', and actively kill off the children that take up space in their fortress. This is just Fortress Mode. Play on Adventurer and you can easily liberate children from Goblin fortresses to be in your party (which is a good idea, as they are useful as shields since you can't hire drunks anymore). Sound bad? How about the fact that, should you decide to invade a human town, you'll find yourself catapulting children into walls as they try to kill you? Sound bad? How about invading an elven town, where you will frequently find yourself beset upon by entire waves of children, some as young as two?
Role Playing Game
You can murder children in the first two Fallout games, though the resulting penalty to your reputation makes the rest of the game nearly unplayable. The European version removed the children by turning them invisible, which makes the town full of pickpocketing urchins even more annoying then it was already.
A Fallout 3 which promptly makes use of the "present but invincible children" subclause by not allowing the children to die. You can shoot them, stab them, nuke them, burn them, etc. but you can't kill them or splatter their brains all over the pavement. Or maybe just use them as living shields...
Played literally in Phantasy Star IV, the entire population of a town has been turned to stone by the first major villain of the game; the player can bring the party around to see all the statues who were once residents, but most of the buildings are locked up— except one house. Inside, there are two adults, standing in front of the stairs leading into their basement. If you walk around them and go down, you'll find their two young children hiding, frightened but otherwise in perfect condition, and they'll tell you that their mother told them to hide down here and be quiet.
The first form of the last boss in Parasite Eve Is, in fact, a baby. Wich is the Ultimate Being. As such, it keeps developing, eventually becoming an adult, and a bizarre gelatinous skull thing.Also, Aya's dead sister; Maya, is a key character in the game, as well as being in the true final boss fight.
A big exception occurred in Ultima VIII, where it was possible to round up a bunch of children near the edge of the starting town and start hacking them to bits. Doing so resulted in a very powerful guardian coming to kill you in their defense, but especially nearer the ending of the game, that guardian was perfectly beatable.
Even bigger exception in Ultima V: there is a dungeon room full of children in jailcells. To proceed to the next area, one has to pull a lever which opens the cells, letting the children out. More precisely, letting them out with a very clear desire to kill. As you are the Avatar, the paragon of virtues (and acting virtuous IS monitored by the game), this creates an interesting moral dilemma. Some (if not most) players rather chose to flee.
Even outside the dungeons, children aren't necessarily faring well. The player will meet a child enslaved to extort information from her mother, another child subject to brutal punishment along with his father for a trivial offense, and another child in hiding and slowly starving since his father was unjustly imprisoned.
The dungeon room is even worse in the brilliant remake Ultima V Lazarus, where you hear the children laughing as you approach, and hear them screaming in pain as you and your companions mercilessly kill them.
In fact, rooms with children is a Running Gag in the later Ultima games—there's usually a dungeon room somewhere in each game that is populated with children with the generic monster AI, that will attack the player. There's been one in pretty much each game since IV.
In Ultima IX a boy highwayman demands gold from the Avatar and taunts him on being unable to fight a child. Whether the boy is given gold or not, he immediately flings powerful fireballs while laughing. Killing him results in a hefty karma penalty. Near the game's end, the Avatar comes across a girl who has been incurably poisoned with a toxin that will slowly, excruciatingly and inevitably kill her, and she begs the Avatar to end her suffering. Whatever choice the Avatar makes, the Guardian will beam a Breaking Speech into the Avatar's head over it.
The World Ends With You features various child NPCs — mostly just scenery, but one of them, Rhyme, is a major character. It's established fairly early on that anyone in Shibuya during the "Reapers' Game" is at risk of being Erased And you actually get to see it happen to Rhyme partway through the game.
Nevermind the fact that since everyone in the Game is dead, you get a brief blink-and-you'll-miss-it flashback of her and her brother about to be run down by a truck.
Chrono Cross features a nine-year-old girl. As a Boss Battle. Go ahead and beat the crap out of her. She even shows up again in another Boss Battle, with her co-workers, a big brawler and an axe swinger, and is considered at least equal in power to them.
In Avernum 1-3 there are children in towns (where they are unlikely to be harmed). However, the young of Always Chaotic Evil races like goblins and giants almost never never appear. The slithzeraki are an exception. In the first game, when they are universally evil, you can slaughter a tribe's young with no negative consequences. (In fact, to complete one quest it may be necessary.) In the second game, you can do the same thing in very similar circumstances, but now that many slithzeraki are friendly, it's heavily implied you shouldn't. In Avernum 4-5, where towns are more likely to be wiped out, children show up a lot less. However, Avernum 5 does give you the option to wipe out several baby giants.
In the original version of Exile II, destroying the enemy slithzeraki children is first described as fun, but when complete, your party feels Tears of Remorse because you shouldn't be killing children even if they are enemies.
If you're going for the evil-deity-good-creature combo, this is actually a good way to counterbalance all the nice things you have to do to train your Creature.
The Sims:Sim children can die from drowning and fire but they can't die of starvation. If you try, they'll be taken away by social services before they reach death. Most sims can use cartoony violence on each other, with the "slap" and "fight" interactions, but the worst an adult sim can do to a child is "argue" and "condescend". Child sims themselves can't do any negative interaction except "argue", even when talking to another child.
Stealth Based Game
The Thief games have 'child-like things' but there are far fewer children around than there logically should be; the game involves sneaking around houses in the middle of the night when children should be at least present, if asleep. However, you encounter the ghost of a child in Thief II and Thief III, and something that might be a child transformed by mad science in Thief II, as well as a couple of robotic children (sometimes very annoying and... yes, invulnerable). All these are used for their disturbing qualities.
While more than a few kids die in the game Rule of Rose, the game is noticeably shy about showing it happen, keeping the deaths off camera and featuring empty clothes in the place of bodies. Even though in this game, the children are the bad guys. Although the enemy Imps resemble children with either bizarrely distorted faces or the heads of animals, and it's not at all shy about showing them dying gruesome deaths.
Fatal Frame has the ghosts of children who will help you some of the time but other times they will attack you like the adult ghosts and have to be dispatched like adult ghosts. It probably helps that defeating a ghost once does not stop it popping up again at a later time — they'll usually keep hassling you until a suitably dramatic final battle — and your weapon is a magical camera.
Dead Rising Appears to play this straight at first glance, due to the fact that out of the 50,000+ zombies in the mall there is not one child. However, the reason that two of the human psychopaths (Adam and Cliff) are the way that they are (Read:Insane) is due to the fact that they had to watch children be killed by the zombies (even worse with Cliff as the kid killed was his granddaughter). Also, one of the survivors who can be rescued by Frank is a woman who was helpless to stop her baby from being devoured by zombies. There is also the Easter Egg on the title screen.
Turn Based Strategy
Averted in Fire Emblem The Sacred Stones, where there are two chapters where civilians, including children, are on the field. While you cannot harm civilians, enemy units often attack them, and generally kill them in one hit. While you can defend them, doing so is not strictly necessary, and you can still beat the level if one of them dies, although even one civilian death will prevent you from getting the rare items that civilians give you at the end of the chapter.
An exmaple that applies to most of the series: When visiting villages and noteworthy homes on a map, you might occasionally meet little kids there; if Bandits proceed to torch said house/village before you can get there in time, it's safe to assume the occupants are dead.
Turn Based Tactics
Averted in Jagged Alliance 2: children appear in most towns and, like other civilians, can get caught in the crossfire, or murdered for a huge hit in morale.
Wide Open Sandbox
In L.A. Noire, you come across a handful of kids in the entire game, usually during cutscenes and interrogations. But none of these times are even remotely pleasant for either you or them. In the final Arson case, you come across a 15 year-old almost-murder-victim who was drugged and raped after running away from home to become a super star. During Homicide, you get to tell a pre-teen girl that her mother has been raped and murdered by a serial killer. Then you get to interrogate her, and later end up hunting down and arresting her father in front of her. The same thing you later do to a father of two kindergarden-age girls, whom the father quickly ushers into the next room. Then, in Arson, you investigate in two houses that have been burnt down with everyone in it, including the children. The second house is particularly gruesome, as you find the charred corpses of the whole family in upright praying positions. Later, when you play as Kelso, you find a suspect in bed with a twelve-year old prostitute. The last children you see in the game are Cole's daughters, sitting in the first row at his funeral during the ending sequence.
No-one dies in Bully, but there are elementary-school kids. After one too many yelled out 'I'm telling!', it was too much, and they just had to be beaten until they disappeared. Granted, even touching one shoots your Wanted Meter to max, but sometimes they just deserve it...
Its even possible to deliberately humiliate the younger kids; by taunting them enough times until the context sensitive "Humiliate" option becomes available, the player can provoke one of the little kids into flinging himself at Jimmy, being held back by the head just out of punching range, before Jimmy crisply sidesteps and sticks out his leg, and puts the kid flat on his face via momentum... or, Jimmy grabs the kid by the nose and lifts him up onto his tiptoes, the kid moaning in pain the entire time.
Mafia averts this somewhat, with Frank's daughter Alice appearing ingame, where you have to rescue her and her mother at an airport. A pedestrian that bears resemblance to Alice appears in the opening video, but other than that, no child besides her ever shows up ingame.
Even Spore averts this. In creature stage, you can kill baby animals of another species, which makes sense considering how real life carnivores often go for the young. (Note that doing this will make that species hate you forever- you'll pretty much have no choice but to extinct them.) But it's a bit more morbid in tribal stage, when attacking another village allows you to kill their babies as well. Civilization and Space stages play the trope straight, though, unless you enter a Galactic Adventure that allows it.
Children in the Zoo Tycoon games, although never actually attacked by zoo animals, will run away in a panic if an escaped predator comes near them.
Minecraft lets the player kill not just villagers, but villager children and baby animals as well. You can even sic zombies on villager children so that they become children zombies!