-> '''Galvatron:''' The Autobots are acting like madmen!\\
'''Rodimus Prime:''' It's a madness plague, Galvatron. If one of those Transformers touches you, you're infected.\\
'''Galvatron:''' You're lying!\\
'''Rodimus Prime:''' Fine. Whatever makes you a happy Decepticon. Just [[GettingCrapPastTheRadar watch your rear]] [[HoldYourHippogriffs thruster]].
-->-- ''WesternAnimation/TheTransformers'', "[[Recap/TheTransformersTheReturnOfOptimusPrimePartOne The Return Of Optimus Prime: Part One]]".

A plot wherein the characters are affected by a force unknown to them and become increasingly snappish and disagreeable to each other, sometimes escalating to outright murderousness. This is often a subtle plan by the {{villain}} of the show who figures that it's easier to let the heroes kill each other off. Naturally, the heroes realize it just in time. This is sometimes a way for characters to vent hitherto unmentioned grievances. Ironically, despite the use of AppliedPhlebotinum, this is a more believable version of ToiletSeatDivorce and JerkassBall, since everyone is NotHimself.

In video games with StandardStatusEffects, this can show up as an actual game mechanic, usually "Confusion" or "Berserk."

The TropeNamer is the plot of ''WesternAnimation/TheTransformers'' cartoon storyline "The Return of Optimus Prime", a red glowy virus transmitted by touch that affects human and robot alike.

Subtrope of EmotionBomb. Contrast with LoveIsInTheAir. Compare AppleOfDiscord. See also MindVirus and ArtifactOfAttraction.


[[folder:Anime & Manga]]
* One of the ''Anime/LupinIII'' television films, [[Anime/LupinIIIDragonOfDoom Dragon of Doom]], has the main villain attempt to finish off Lupin and his cohorts this way, by exposing them to a gas that makes anyone who breathes it a psychopathic murderer. Jigen, Fujiko, and Goemon all become AxCrazy and LaughingMad, but Lupin holds his breath long enough to find a way to vent the gas and restore everyone to normal.
* In ''Anime/MacrossDelta'', the Brisingr Globular Cluster is swept by a mysterious disease called Var Syndrome, which causes people to behave violently, even making them commit acts of terrorism. [[spoiler:It also renders them susceptible to the Wind Singer's mind control, whose homeworld of Windermere has been deliberately spreading Var Syndrome for this very purpose.]]
* In ''Anime/RODTheTV'', one VillainOfTheWeek uses two kinds of sounds to protect his base as the heroines try to infiltrate it, both of them out of the range of normal hearing: one is a subsonic hum that enhances depression and melancholy in people who are already disposed to it, and the other is a supersonic hum that makes more excitable people angrier and more irritable.
* In the first ''Series/StarTrek'' manga, a man and a woman who were once lovers (and who had a bit of a falling out) come on board the ship. They end up making all the men and women on board turn against each other merely from their presence.
* Yubel uses this in duels to great effect in ''Anime/YuGiOhGX''. While she's on the field as a monster, she can force monsters to attack her; she takes no battle damage, and inflicts the same damage to her opponent in retribution. She calls this effect "Nightmare Pain." Shortly after Yubel reveals herself in Season 3, Judai's cloest friends are also infected with a Hate Plague against him, which was quite effective in bringing out his SuperpoweredEvilSide, especially when followed by their apparent deaths.

[[folder:Audio Plays]]
* In ''AudioPlay/PassageToMoauv'', a ''Franchise/StarTrek'' audioplay from 1975, the ''Enterprise'' is transporting a sort of alien cat called a waul to its owner. When it (inevitably) escapes their custody, its frightened yowling has the crew hissing and snarling at each other like angry cats until Lt. M'ress comes along. It takes to her immediately and begins purring.

[[folder:Comic Books]]
* Also ''Franchise/{{Transformers}}''-related, one issue of Marvel's ''ComicBook/TransformersGeneration2'' comics featured black energy goo beings that induced and lived on other creatures' aggression.
* {{Inverted}} in the ''ComicBook/{{Hellblazer}}'' arc "The Red Right Hand", in which the plague makes its victims incredibly empathic. Unfortunately it takes hold in [[ViolentGlaswegian Glasgow]] and so everyone begins to share one another's guilt and misery, culminating in mass suicides.
* An alternate version of the ''ComicBook/NewXMen'', set in the House of M universe, dealt with Wallflower, a mutant with pheromone powers, causing Sooraya to engulf her best friend Jubilee in a sandstorm that likely would have shredded her body to its bones if given time.
* In ''ComicBook/TheSavageDragon'' #55, a massively powerful mind-controller [[PowerIncontinence unintentionally]] sends everyone in Chicago into a murderous rage the moment he steps out of his bunker.
* During the ComicBook/BlackestNight, [[EmotionEater Psycho-Pirate]] used these on Smallville. Horror ensued as his mask's abilities to influence any nearby target to near-suicidal hatred, uncontrollable fear or demented avarice ensued, heightening minor feelings to killing urges.
* The main shtick of the villain Hate-Monger from the MarvelUniverse. (Who is actually UsefulNotes/AdolfHitler. )
** And Psycho-Man, a ComicBook/FantasticFour villain.
** A new (non-Hitler) Hate Monger appears in a {{Punisher}} story as the leader of a racist organization. The Punisher infiltrates the group, but discovers that his final initiation is to beat a Hispanic reporter investigating the group to death. Unfortunately, by then he's succumbed to the Hate Monger's Hate Plague and he goes through with it. Doubly unfortunately she was the girlfriend of the Punisher's current tech guy. Needless to say, there was a falling out and a rare bout of guilt for Frank Castle.
* In ''ComicBook/{{Asterix}} and the Roman Agent'', Tortuous Convolvulus has the ability to sow mistrust (indicated by SpeechBubbles gaining a green background) that quickly escalates into shouting and fistfights.
** He complemented the power of causing mistrust and discord by his presence alone (he didn't have to say or do a thing to start a fight between Caesar's advisers) with a good amount of mundane skill in psychological warfare and sowing mistrust and fear. He also had been sentenced to death at the Colosseum, and was alive at the beginning of the book due to [[CrowningMomentOfAwesome making the beasts attack one another]].
* ''ComicBook/JudgeDredd'':
** East Meg One used a literal Rage Virus as a precursor to invading Mega City One.
** Later, the remnants of East Meg One (which was mostly wiped out after the aforementioned invasion attempt) had another go with the Chaos Plague, which also caused eventual death. This one worked slightly better, relatively speaking, killing about 350 million (!) in the end.
* In ''Franchise/ArchieComics'', a flower putting off purple "bad vibe lines" caused nearby people to start acting meanly and selfishly. It, naturally, got passed around town for a while during the course of the story, making as many people as possible get into shouting matches. Probably not the only time such a story happened in that series.
* The eponymous ''ComicBook/BlackGas'' of Warren Ellis' ZombieApocalypse -style comic operates via progressive brain damage, eating away at the parts of the brain responsible for people's inhibitions.
* The Franchise/WonderWoman villainess Genocide has powerful energy blasts. Anyone lucky enough to survive the explosion gets consumed by rage and paranoia.
** Ares tends to incite rage in order to start wars.
* ''Franchise/{{Batman}}: Jekyll and Hyde'' had a drug that was described as unifying the conflicting halves of a person's identity. Apparently everyone secretly wants to murder, torture, and/or cannibalize the nearest primate. Huh.
* In ''Comicbook/AstroCity'', when Black Velvet is mortally wounded by Jitterjack, her body releases black energy that infects the populace and starts a riot.
* In the earlier ''ComicBook/SonicTheHedgehog'' comics, evil wizard Ixis Naugus can amplify peoples' emotions. This is hinted to be the driving point for the Great War between the Mobians and human-esque Overlanders, and then the Mobian/Robian civil war.
** More recently, he used that same magic on the citizens of New Mobotropolis, magnifying their mistrust of NICOLE - following her stint being [[BrainwashedAndCrazy brainwashed]] by the Iron Dominion - into full-blown paranoia, so that they will view her as a threat, and him as their "[[DarkMessiah savior]]".
* The plot of ''ComicBook/{{Crossed}}'' is centered on a virus that causes its victims to turn into predatory psychopaths.
* In ''ComicBook/DarkwingDuck'', the Phantom Blot has created an inky mind-altering substance to create new rogues in St. Canard which is also used to control the populace briefly.
* In the grand finale of Creator/GrantMorrison's run on ''{{JLA}}'', this turns out to be the nature of [[DoomsdayDevice Mageddon]]: a hate plague on a global scale that eventually causes all sentient life on a given planet to wipe itself out.
* The Franchise/SpiderMan storyline ''ComicBook/MaximumCarnage'' has Carnage's partner Shriek increase the hatred in everyone in New York to start mass riots throughout the city.
* In the first ''[[ComicBook/TeenTitans Titans]]'' series, the Gargoyle slowly began to spread his influence on the Fab Five to the point that Nightwing sealed himself off in a cave because he was sick of being compared to Batman. After being trapped in a LotusEaterMachine dimension and reverted to their teenage forms, they assumed apologizing would get them out, until Roy Harper realized they were going in circles and admitted that real friendship is about being honest with your friends when they're acting like assholes and glorifying everything your friend does is not helping. Roy got the point across by punching Nightwing in the face, who seemed to be the focus point due to the Gargoyle's immense hatred of him.
* The DC Comics miniseries ''[[ComicBook/LegendsDC Legends]]'' has Glorious Godrey use his powers of persuasion to manipulate the average citizens of the DC Universe to fear and hate the world's superheroes.
* The 2014 Marvel event ''ComicBook/{{AXIS}}'' starts with ComicBook/RedSkull using [[Comicbook/XMen Professor X]]'s brain to spread one of these across the globe. Not even the heroes are immune. In the ''Comicbook/LokiAgentOfAsgard'' issues the "heroes" (as much as Loki, Verity, and Valeria Richards can be called that) use Doom's science equipment and Gram the Sword of Truth to create a "Truth Wave" to counter it. It works.
* ''ComicBook/SpirouAndFantasio'' has the mosquito from the Valley of the Banished: Those it stings become murderously insane and turn on their friends.
* ''ComicBook/ZombiesChristmasCarol'' combines this with a zombie apocalypse, as Scrooge's bitterness and callousness towards others, particularly those he cared for, caused and spread the infections. Conversely, after he reforms his kindness towards those he spurned heals the zombies.

[[folder:Films -- Animation]]
* ''WesternAnimation/MyLittlePonyEquestriaGirlsRainbowRocks'': The Dazzlings trio use their magic and music to turn the students of Canterlot High against each other. The heroes are immune because of their innate magic, but the Dazzlings are eventually able to turn them against each other the old-fashioned way, leading to a NearVillainVictory.
* In ''WesternAnimation/BatmanVsTwoFace'' Two Face uses a gas to turn most of Gotham City's citizens into AxCrazy TwoFaced maniacs.

[[folder:Films -- Live-Action]]
* ''Film/TwentyEightDaysLater'' and its sequel revolve around a [[TechnicallyLivingZombie sort of]] ZombieApocalypse caused by a literal Hate [[ThePlague Plague]], the Rage Virus.
* Ditto ''Film/TheCrazies'' and ''Film/{{REC}}''. ''The Crazies'' is a somewhat different variant, as the infected often retain coherence and elements of their personality, unlike the mindless fury of the ''28'' movies and ''Film/{{REC}}''.
* German zombie movie ''Rammbock'' a.k.a. ''Film/SiegeOfTheDead'' also has the same basic premise, it even looks like a German remake of ''Film/TwentyEightDaysLater'' or a movie set in same universe.
* In the movie ''Return in Red'', a government agency uses sound waves to induce insanity and homicidal urges in the people of a small town.
* In the movie ''Film/GhostbustersII'', the sewers of New York City become filled with an ectoplasmic sludge that absorbs emotions. The Ghostbusters discover it while it's been negatively charged, and after they end up covered in it, they briefly end up going at each other's throats. Egon discovers the malleable nature of the slime, however, and in order to break through a barrier of negatively-charged slime, the Ghostbusters positively charge some of it through [[CrowningMomentOfAwesome a combination of the song "Higher and Higher", and the most inspiring thing they can find in Manhattan: The Statue of Liberty.]]
* One of the "non-lethal" weapons employed by the good guys at the end of ''Film/MysteryMen'' is a ray (the Blame Thrower) that can cause angry arguments amongst whomever gets hit with it. A rare case of the protagonists employing such a tactic as psychological warfare.
* ''Film/{{Serenity}}'': The Reavers (murdering, raping madmen who terrorize the fringes of ''Series/{{Firefly}}'''s Verse) are revealed to be [[spoiler:the victims of a government-sponsored mind-drug experiment on an entire planet's population GoneHorriblyWrong. The Pax, as the drug was called, was meant to weed out aggression in the population. Instead it made the majority of the population so passive that they couldn't even be bothered to take basic measures to continue living, while it became a Hate Plague for a fraction of a percent of the population. They proceeded to wipe out whoever was left, and then start ''recruiting''.]]
* This is the alien threat in the film ''Film/AlienCargo''.
* Utilized by Loki through his scepter in ''Film/{{The Avengers|2012}}'' to make the already volatile team turn on each other so as to distract them from his assault and [[spoiler:unleash the [[ComicBook/IncredibleHulk Hulk]] upon S.H.I.E.L.D.'s helicarrier.]]
* In ''Film/{{Apollo 13}}'', the astronauts getting increasingly snappish with each other is discovered to be induced from the high carbon dioxide levels in their cabin. They then have to work together to prevent the [=CO2=] from getting any higher. (Doesn't count as a Real Life example, because the real astronauts confirmed the arguments were made up by the film for RuleOfDrama.)
* The [[Literature/TheColourOutOfSpace color-infected]] livestock and people from ''Film/TheCurse''.
* In ''Film/KingsmanTheSecretService'', Valentine's weaponized SIM cards are this, emitting a signal which drives up aggression while removing inhibition.
* ''Film/ThirteenThirteenThirteen'' has people losing their inhibitions and having their aggression ramped up. They generally find some sort of a narrative to make sense of it, but it results in a lot of killing.
* The K[[spoiler:nell]] segment of ''Film/ABCsOfDeath2'' involves a woman watching an apartment across from hers have its inhabitants go into a violent frenzy by an EldritchAbomination... before it goes after her.
* The infection in Korean film ''Film/TrainToBusan'' causes blind homicidal rage to the infected.

* The Cunning Man from ''Discworld/IShallWearMidnight'' is an ''embodiment'' of this. He's the ghost of a witch hunter whose hatred for witches is so great, wherever he goes people become more suspicious and angry with witches.
* ''Literature/{{Xanth}}'' features the Goblinate of the Golden Horde: ''the'' most hated and hateful goblins in the land, so much they make Goblin Mountain (''pre''-reform) look genteel in comparison. The centerpiece of their village is a rare Hate Spring that inflicts the trope on anyone who steps in it. The Goblinate get their kicks throwing victims into it and watching them kill each other in blind hatred.
* In David Moody's ''Literature/{{Hater}}'' and its sequels, a virus causes people to murder their loved ones and anyone else in their path. The local media even calls the infected people "haters."
* Played with in ''Literature/StarTrekATimeTo''. It sort of happens on the planet Delta Sigma IV, in ''A Time to Love'' and ''A Time to Hate'', only with a twist. [[spoiler: The plague isn't really causing the hate and violence--in fact, it's curing the populace of a mind-altering drug that kept them peaceful. Suddenly confronting emotions such as hate and rage for the first time, the Delta Sigma inhabitants can't cope, and old racial tensions erupt into violence. Riots soon spread across the planet.]]
** The entity from "Day of the Dove" (as outlined in "Television" below) figures in the destruction of the Tkon Empire in ''The Q Continuum'' trilogy, mainly by inciting war between the outer planets and youths and the elders and the home planet.
* Used in Creator/DavidEddings' ''[[Literature/TheElenium Elenium]]'' arc--the negative influence of the MacGuffin / SealedEvilInACan, the Bhelliom, causes the heroic FiveManBand to start getting mutinous...
** The Bhelliom got far nicer in the ''Tamuli'', though. You'd be nasty, too, if you'd been used and abused and tortured by blood-stained jewels for thousands of years. [[spoiler:When Bhelliom was actually addressed properly, like a person, a lot of misunderstandings got put to rest.]]
** Countess Bellina afflicts the minstrel with such a plague.
* ''Literature/HarryPotter'', in ''[[Literature/HarryPotterAndTheDeathlyHallows Deathly Hallows]]'' [[spoiler:the Slytherin Locket Horcrux has this effect and leads to Ron leaving the group for a while]].
* ''Literature/TheChroniclesOfAncientDarkness'' have a few hate plague-inducing things, including the Fire Opal and soul-sickness.
* In James Tiptree Jr.'s short story "The Screwfly Solution", a mysterious plague spreads outward from the equator, turning male sexual urges into murderous violence against women.
* In ''Literature/{{Cell}}'' (the 2006 horror novel by Stephen King) a signal (possibly sent by terrorists) broadcast over cell phones strips away the higher functions of the brain, leaving just a state of murderous rage. [[spoiler:The infected then progressively evolve into an organized, non-raged Hive Mind and develop psychic powers.]]
** Another Creator/StephenKing example, 1987 novel ''Literature/TheTommyknockers''. A crashed spaceship begins to effect the area around it, causing the inhabitants of the nearby town of Haven to start changing, mentally and physically, into aliens like the spaceship's inhabitants, the "Tommyknockers". Tommyknockers have incredible technical skills, but also [[HairTriggerTemper quick tempers]] and [[ViolationOfCommonSense no common sense]]. Anyone who crosses a Tommyknocker, even in the smallest of ways (say, stealing pennies by cheating at poker), invites [[DisproportionateRetribution harsh punishment]] (like being sent to a distant, nearly-airless planet).
** Stephen King also used the idea in ''Literature/NeedfulThings'', where the BigBad, Mr. Gaunt (a demon, if not the devil himself) manipulates the town into destroying itself through a series of escalating "pranks". Evidently Mr King likes this trope.
* The novel ''One Rainy Night'' by Richard Laymon is about a bizarre black rain that causes [[AxCrazy Ax Craziness]] in everyone who gets wet.
* Creator/BrianKeene:
** The short story "Purple Reign" features purple rain that causes [[AxCrazy Ax Craziness]] in everyone who gets wet; it affects animals as well as humans.
** ''Jack's Magic Beans'' takes place in the same universe as "Purple Reign", but this time, the Hate Plague has no detectable cause and doesn't appear to affect animals or people who take Prozac.
* In ''The Long Last Call'' by John Skipp, the Devil goes to a strip club, where his tainted fifty dollar bills inspire murderous rage in the employees. Yes, even the girls. ''Especially'' the girls.
* The One Ring in ''Literature/TheLordOfTheRings'' has this effect, turning people against one another by playing on their lust to use its power, particularly on Bilbo and Boromir. This was shown well in the [[Film/TheLordOfTheRings film adaptation]] in a shot which showed the arguing Council of Elrond reflected in the Ring as fire blazed within it.
** Also the flashback to Deágol and Sméagol finding the Ring while fishing. Within minutes Sméagol (Gollum) has killed his relative in order to possess the Ring.
** Sam proved resistant when he used it to rescue Frodo, since he had no desire for power whatsoever.
** [[spoiler: Faramir]] was also resistant. Well, in the original text, anyway.
*** Even in their cases it still took a fair bit of willpower.
*** [[spoiler: Boromir]] was exposed to the ring far longer than his brother; Tolkien may portray one as a "better" man, but [[FridgeLogic the younger brother]] had been exposed for only hours, not days and days.
*** [[spoiler: Boromir showed hints of being tempted during the council scene, immediately upon being faced with the ring.]]
*** [[spoiler: The Ring works on ambition as well as hate. Faramir just wanted to live his life, and if he happened to be some sort of hero it would only be because he had to. Boromir wanted to be a big famous hero, cast down Mordor, restore Gondor and Arnor to their former glory. Certainly not a bad ambition, but the Ring can latch on to that to start its Hate Plague after taking hold.]]
*** [[spoiler: The One Ring is so purely evil and so powerful in its corrupting influence that it can twist even the noblest desires into arrogance and narcissism and gradually makes the Wearer feel better and greater than all the others which is the first step to isolate him.]]
*** [[spoiler: One reason Faramir escaped the Ring's lures was he was smart enough to avoid ever even seeing it, telling Frodo to not even show it to him. Boromir wasn't so smart.]]
** Morgoth in ''Literature/TheSilmarillion'' was capable of sending these off with his will eventually, although he was just as good at using rumor and misdirection to accomplish the same end without sorcery.
* ''[[Literature/AbleTeam Able Team #8: Army of Devils]]''. A drug capable of creating instant rage in the user is smuggled into Los Angeles, in an attempt to create a race war in the United States.
* One of the ''Literature/{{Dinotopia}}'' companion novels (''The Maze'') includes a heavier-than-air Hate Plague-inducing gas as one of the obstacles en route to the center of the titular maze. [[spoiler: The raptor of the trio is driven out of the group first and decides to go up the walls, clearing his head. He then manages to take advantage of the gas' effects to dare the other two to stay together and not kill each other until they get out of the hazard zone.]]
* In ''Literature/TheWheelOfTime'', the dagger from Shadar Logoth is so tainted with evil that his carrier becomes paranoid and hateful, and then starts to infect other people.
** Padan Fain, a recurring villain partially possessed by the spirit who ''created'' Shadar Logoth, also has this effect- people who spend too much time in his company become increasingly paranoid, ill-tempered, and generally corrupt. When he gets the dagger back (another character carries it for a good chunk of the early books) his powers are increased dramatically.
* Creator/KirBulychev's book ''The Purple Sphere'' (also known as ''Literature/LilacSphere'') is about an artificial virus (stored in the titular container) which causes unnatural hatred in anyone infected. The developers got infected. They killed each other off, the rest of their planet's biosphere evolved into a {{Deathworld}} over the millennia. What's worse, they've left such time bomb on Earth and the heroes only have two weeks until it breaks open.
* ''Literature/TheFog'' is about the titular mist--it's [[SealedEvilInACan a bio-weapon]] that turns half of England insane and depraved in a manner very reminiscent of ''Film/TheCrazies''.
** ''The Dark'' by the same author uses a more supernatural version of the same trope, with similar results.
* The god of war Ares in Literature/PercyJacksonAndTheOlympians radiates an aura that makes people around him more susceptible to violent impulses. It's not quite a weapon, but it means the characters have to be more careful around him since he is always looking for an excuse to start a fight.
* Milder example in ''Literature/GalaxyOfFear: The Planet Plague''. Tash's illness makes her more irritable and impulsive, and gets her to dwell more on thoughts of {{Revenge}} - and negative emotions make it progress faster [[spoiler: and will speed her [[TheVirus transformation]]]]. Calming herself and focusing on positive emotions helps with the symptoms, but doesn't cure her.
--> "Your body has a certain temperature, and usually it creates certain kinds of chemicals in your blood, your brain, and all the different parts of your body. But when your body changes - as when you are angry, or sad, or when you are sick - your body temperature changes, and your brain sends signals to produce different chemicals. Somehow this virus affects those signals and feeds off of them."
* The antagonist of the ''Literature/PastDoctorAdventures'' book ''The Hollow Men'' utilized one of these in the climax.
* [[SyntheticPlague H7D3]] in the ''Literature/BlackTideRising'' series ultimately turns the infected into feral, non-sapient cannibalistic animals who are human only in a biological sense and will attack anything that draws their attention.
* The SpiderMan novels ''Literature/CarnageInNewYork'' and ''Goblin's Revenge'' feature Spider-Man fighting to prevent a PsychoSerum that causes anyone exposed to it to fall into a murderous frenzy from being unleashed on the public, first by Carnage, and then [[VillainTeamUp both Carnage and a new Green Goblin]] [[spoiler: who's actually the Chameleon in disguise.]]
* ''Franchise/ANightmareOnElmStreet: Perchance to Dream'' has the main character use his powers to suppress the dreams of the townspeople, in order to protect them from Freddy. Unfortunately, this has the unintended side effect of gradually causing everyone to become violently unstable, and begin lashing out at random. A few incidents mentioned by the police include a student stabbing a teacher in the eye with a pencil over a bad grade, and a man shooting his wife because she was "vacuuming in a really irritating way".
* Creator/WalterJonWilliams' ''Implied Spaces'' features 'Zombie plagues', nanotechnological infections that drive victims into a murderous rage, and rewrite their brains so they can't be in any other state.
* In ''Literature/BeautifulChaos'', the spell Ridley casts on everyone during [[AlphaBitch Savannah Snow's]] party amounts to basically this, and it causes everyone in the party to start screaming at each other.
* In the second ''Literature/{{Uplift}}'' trilogy the Rothen tried to use a psi-emitter to stir up conflict among the six races of Jijo.
* In ''Literature/TwilightSparkleAndTheCrystalHeartSpell'', Prismia caused one for an earth pony village nearby.
* This is the ultimate weapon of the ArmsDealer in the ''Franchise/DoctorWhoExpandedUniverse'' novel ''Silhouette''. The Doctor manages to counteract it by first creating a pocket of resistance with a circus, and then getting the {{empath}}ic LivingWeapon the villain used to collect the anger to collect the happiness from the circus audience and releasing it into the rest of the city.
* In ''Literature/{{Worm}}'', a more subtle form of this is present. [[spoiler: It turns out that the thing that gives the super heroes their powers is a nigh-omnipotent being that uses its influence on said powers to psychologically [[TheChessmaster Chessmaster]] every single parahuman into subconsciously desiring, seeking and creating conflict. Every. Single. One.]]
* Played with in Creator/JamesPatterson's ''Zoo'', in which a HatePlague that affects all mammals except humans appears to be triggering an escalating global epidemic of animal attacks. [[spoiler: It turns out that, while animals' behavior is indeed being altered, it's more of a ''Hate Me'' Plague: thanks to pollution plus radiation from cell phones, humans have begun emitting pheromones which incite other mammals to attack them.]]
* In ''Literature/TheMazeRunner'', the Flare has those infected show symptoms of paranoia, hallucinations and extreme, unwanted violence before eventually descending into madness and gruesomely attacking anything that moves, even resorting to cannibalism.
* In the ''Literature/StarDarlings'' franchise, starting with the second book, ''Libby and the Class Election'', something in Starland has been causing the girls to argue amongst themselves. The exact cause isn't discovered in the book, but is implied to be the flowers in the girls' rooms.
* In the ''Literature/TheGolgothaSeries'', one of the evil artifacts kept secured in Golgotha is the Skull of the First Murderer. If it were to be broken, it would unleash a hate plague that would cause everyone in the world to murder one another.
* Literature/TheAvenger story ''The Hate Master'' uses a serum that can be injected or ingested to create this effect. A politician takes advantage of the fact that he has the antidote to create trouble that he can then smooth over, proving his diplomatic skills.
* The first book in ''The Familiars'' series has a cursed location called the Bridge of Betrayal. As the name suggests, anyone who crosses the bridge with others will betray their companions.

[[folder:Live-Action TV]]
* ''Series/StarTrekTheOriginalSeries'', "[[{{Recap/StarTrekS3E7DayOfTheDove}} Day of the Dove]]": An {{Energy Being|s}} that feeds on hate brings the Federation and the Klingons, who are trying to abide by the peace treaty, into conflict. It goes as far as implanting FalseMemories so that the manipulated will have an extra source of conflict. An interesting part of this trope in Star Trek is that those who are killed are somehow brought back to life with their fatal wounds healed to fight again. Once they all figure it out the creature is repelled from the ship by laughter. Lots and lots of laughter.
** In "[[{{Recap/StarTrekS3E9TheTholianWeb}} The Tholian Web]]", a NegativeSpaceWedgie drove the crew of one starship to kill each other, and then begins to drive the Enterprise crew to outbursts of anger.
** In " [[{{Recap/StarTrekS1E24ThisSideOfParadise}} This Side of Paradise]]", an anger-inducing sonic broadcast is used to counteract the effects of tranquility-inducing spores.
* ''Series/StarTrekTheNextGeneration'' also dealt with this a couple of times.
** In "[[{{Recap/StarTrekTheNextGenerationS3E23Sarek}} Sarek]]", where it was caused by an aging Vulcan telepathically "leaking" his suppressed emotions into the minds of the crew. [[spoiler: Said aged Vulcan is ''Spock's father,'' and he has, basically, Vulcan Alzheimer's Disease.]] Picard puts his mind at risk by letting him "absorb" some of his willpower because if anyone finds out, the treaty he has been working on for ''years, if not decades'' could be at risk. [[https://www.youtube.com/watch?v=EOm1dKSOq1g By the by, the effects on Picard really gave his actor, Patrick Stewart, a chance to shine.]]
** Season 4 episode "Night Terrors" saw the ''Enterprise'' trapped in a NegativeSpaceWedgie that drained power away from the ship's reactor and left them stranded, and the crew began to experience increased irritability, paranoia and eventually hallucinations. [[spoiler: It turned out that the crew of another ship trapped in the same way was trying to contact them telepathically to propose a means of escape, but their method was preventing most of the crew from entering REM sleep; the HatePlague in this case was simple sleep-deprivation.]] Despite the relatively mundane explanation this episode had some of the most genuinely creepy moments in the series.
* ''Series/StarTrekEnterprise'':
** In one episode, the closer the ship got to an undetected [[NegativeSpaceWedgie singularity]], the more the crew started to freak out, basically giving them a nuclear version of SuperOCD.
** This is also one of the possible effects of [[GreenSkinnedSpaceBabe Orion]] pheromones on other women.
* ''Series/{{Crusade}}'', the sequel to ''Series/BabylonFive'', had an episode where the crew visited a planet that was boobytrapped with a means of driving visitors into murderous rages. Afterwards, they would have no memory of the event and instead remember seeing a shadowy figure performing the act, leaving the victim unaware they were the actual attacker. Of course, it wasn't really a plague but [[spoiler:Technomage nanites]].
* The Croatoan virus from ''Series/{{Supernatural}}'', which was later part of [[HorsemenOfTheApocalypse Pestilence's]] plan to release it nationwide as part of [[{{Satan}} Lucifer's]] endgame.
** Pestilence's older brothers War and Famine got in on this action, too. War was a MasterOfIllusion who could, with a twist of his ring, cause paranoia and hallucinations in people until they divided into factions and started killing each other. Famine had a variation: his very presence drove up people's natural hungers (for food, sex, money, etc.) to a point where they lost all control and started doing anything to get a fix, even if it meant literally killing themselves (i.e., a pair of lovers start going at it on a diner table while the waitress cleans out the register and the short-order cook, apparently addicted to fatty food, ''plunges himself into the fryer'' to get to it). Even the heroes suffered the effects: Castiel (or, more accurately, his host body) craved red meat to such an extent that he ate hundreds of burgers and was rendered powerless by a tempting tray of raw steak, while Sam's addiction to demon blood reared up and had him killing monsters left and right. Only Dean was immune, but as Famine cruelly pointed out, that wasn't any sort of HeroicWillpower: rather, he was so depressed and listless after his [[BackFromTheDead trip to Hell]] that he was unable to fill the void inside himself with anything; as the Horseman put it, "You're already ''dead.''"
* Not quite a hate plague but a spiritual sister to the trope would be the depression toxin from the ''Series/RedDwarf'' episode "Back To Reality".
* ''Series/TheXFiles'':
** In episode "[[Recap/TheXFilesS01E08Ice Ice]]", an extraterrestrial parasite causes an Arctic research team, and later the investigating team, to turn on each other by increasing their paranoia.
** In "[[Recap/TheXFilesS02E10RedMuseum Red Museum]]", where as part of a GovernmentConspiracy the children of a town are infected with alien DNA which causes increased violent behaviour.
** Used for humorous effect in "[[Recap/TheXFilesS03E13Syzygy Syzygy]]", in which a rare planetary alignment causes strange behavior in a small town, and even Mulder and Scully begin to snipe at each other.
* ''Series/{{Angel}}'' had a variant: Billy Blim, a vicious misogynist, caused any man he touched to hate and attack any woman they came near. Angel was immune, since even as [[SuperpoweredEvilSide Angelus]], he never felt hate toward his enemies.
** In another episode, the bizarreness of the week causes people to bleed from their eyes and go into a murderous rage about whatever they feel.
* One episode of ''Series/TheFortyFourHundred'' concerned an attack by a 4400 who was able to stimulate aggression in men, resulting in a breakdown of discipline at NTAC headquarters.
* ''Franchise/PowerRangers''
** The Hate Master, one of the many MonstersOfTheWeek that the original ''Series/MightyMorphinPowerRangers'' had to deal with, has this as its primary ability.
** ''A Season to Remember'', the Christmas episode of ''Series/PowerRangersZeo'' had this as a plot. The villains beamed the rangers and their Jewish friend with a hate ray, causing them to squabble and fight about which cultural holiday is better. Ultimately, the day is saved by a little girl singing sappy Christmas songs about love and friendship, causing the effects of the ray to wear off.
** One of Divatox's plans in ''Series/PowerRangersTurbo'' involved releasing a brand of jackets that increased the anger of whomever wore them and turned them into a huge jerk.
* Multiple monsters in ''Franchise/SuperSentai'' possess the ability to sever bonds of friendship and/or love. Most of them are based on, or use sharp bladed objects to metaphorically cut these bonds. Naturally, destroying the monster instantly repairs all the damage it caused.
** Both ''Series/NinpuuSentaiHurricaneger'' and ''Series/ZyudenSentaiKyoryuger'' had a scissor based MonsterOfTheWeek, who could sever bonds of friendship by cutting them with their scissors.
** ''Series/MahouSentaiMagiranger'' had a Samurai based MonsterOfTheWeek possessing a sword that could, according to him, cut through anything. This included the bond of family the rangers had, causing them to severely dislike each other.
* An early episode of ''Series/StargateSG1'' subjected the team to subsonic frequencies that made some of them very irritable, resulting in a shouting match and a delightfully awkward non-apology apology afterward.
** A minor one was caused by withdrawal symptoms from some creepy Goa'uld light in the episode with the same name. Similarly, Daniel's withdrawal from the sarcophagus in ''Need'' had him almost shooting Jack in one scene.
* ''Series/TheSarahJaneAdventures'' had a single-target variation, where anyone who heard or read the name "Clyde Langer" turned against Clyde.
* An episode ('Sense and Antisense") of ''Series/{{Millennium}}'' (the TV series produced by Chris Carter) has Frank Black tracking down a man supposedly infected by a hate virus. At the end we see a photograph of the man posing with military personnel marked "Kigali, Rwanda, 1994".
* An episode of ''Series/TheManFromUncle.'' ("The Suburbia Affair") centered around a plot like this-- the electric lights in a suburban neighborhood vibrated on a frequency that caused the people living there, including our undercover heroes, to become irritable, suffer headaches, and fight amongst themselves. A mob scene was narrowly averted at the town meeting.
* The ''Series/{{Farscape}}'' episode "Crackers Don't Matter" has a highly amusing Hate Plague, causing several characters to become obsessed with ensuring their fair share of crackers, to the point of barricades and gun battles.
* One of the Gelliant Gutfright sketches from ''Series/ABitOfFryAndLaurie'' features the "Fighting Buttercup," a flower which causes anger and aggression [[spoiler: for about five minutes. And then explodes.]]
* ''Series/{{Eureka}}'' - "All the Rage": A device designed to ''calm people down'' [[GoneHorriblyWrong instead]] turns GD into [[ShoutOut "a Romero]] [[Film/NightOfTheLivingDead1968 movie"]].
* ''Series/UltraSeven'' episode 8 has aliens lace cigarettes with a toxic seed that made humans violent. It was all a plan to repopulate the Earth after humans wiped each other out.
* In ''Series/{{Alphas}}'', Matthew Hurly, a VillainOfTheWeek, has the ability to release pheromones that causes the people around him explode in homicidal rage.
* ''Series/DoctorWho'':
** In the episode "[[Recap/DoctorWhoS30E10Midnight Midnight]]", the MonsterOfTheWeek manipulates a group of ordinary humans into coming within a hair's breadth of [[spoiler: killing the Doctor]] by amplifying their fear, suspicion and irritation with his ego into a willingness to commit murder. One of the [[NothingIsScarier many unanswered questions]] from that episode is whether the creature was telepathically manipulating them or whether it was able to do it through mundane psychological methods; it clearly has psychic powers of some kind, but at the point of its near victory it hasn't provoked any reaction from the people that couldn't be achieved simply by playing on the escalating mob mentality.
** In "[[Recap/DoctorWhoS21E2TheAwakening The Awakening]]", a sentient alien WMD that is both the cause of and empowered by Hate Plagues is awakened in a British village.
* In ''Series/TheTwilightZone'' episode "The Encounter", a racist World War II veteran and a young Japanese-American man who came over to do housework are trapped in the veteran's attic by a samurai sword that belonged to a Japanese soldier the veteran killed. The sword bears an inscription "the sword will avenge me". And it does, as it brings out the darker sides of both men, culminating in a violent struggle that ends with the veteran accidentally impaled on the sword and the younger man throwing himself out the window in a fit of suicidal guilt.
* During the ''Disney/{{Frozen}}'' arc in ''Series/OnceUponATime'', the Snow Queen's "Spell of Shattered Sight" is evidently meant to function in this manner. In a flashback scene set in Arendelle, it's proven to be powerful enough [[spoiler: to briefly turn Anna against her sister Elsa]].
* In the ''Series/{{Sherlock}}'' episode "[[Recap/SherlockS02E02TheHoundsOfBaskerville The Hound of Baskerville]]", the CIA was researching on a hallucinogenic drug that also functioned as this, giving those it was forced upon images of horrible monsters... and then making them want to murder them.
* In ''Series/AgentCarter'' it turns out Howard Stark accidentally created a gas form of this. When the villains get a hold of it do a few tests, all hell breaks lose.
* Series/TheFlash2014 episode "Flash vs Arrow" had a Meta Human whose power was this. It only worked if you looked him in the eyes though, and the effects only lasted a couple minutes.
* In one episode of the 60's ''Series/{{Batman}}'' TV series, the Riddler spikes the lemonade at a fancy party with "Temper Tonic" which causes the party guests to have an all-out brawl with each other.
* The Yellow Fever in ''Series/{{Grimm}}'' has this effect on Wesens.
* A ''Series/{{NightVisions}} episode had an odd variation; a timid man is cursed by an angry Russian ([[DisproportionateRetribution for bumping into him and spilling his coffee!]]) to uncontrollably inspire homicidal hatred in others. This gets him fired, assaulted, and forced to kill his girlfriend in self-defense. Also, shot dead by the police. Turns out some novelist's book was coming to life, and picked this poor chap as a victim. Yeah, Night Visions was weird.
* One episode of ''Series/{{Charmed}}'' got as "realistic" as you can with this trope. A demon was killing [[DreamWalker Sandmen]] to collect their magical sand; as the Sandmen's numbers dwindled, they were unable to spread positive dreams throughout San Francisco. As time passed, the citizens became angry and short-tempered with one another, and one of the surviving Sandmen explained that humans need to dream to work out their problems and aggression subconsciously; if the demon succeeded in wiping out his kind, humanity would destroy itself in unchecked rage.
** A more concentrated example happens in "Sin Francisco," which focused on the SevenDeadlySins in the form of seven small crystal orbs. The person infected with the Wrath orb became violent and uncontrollable.

[[folder:Music Videos]]
* In the music video for "Follow You" by Music/BringMeTheHorizon, it is implied that a HatePlague has turned everyone in Oli's neighborhood (and possibly beyond) into cackling, murderous psychopaths except for maybe three people (Oli, an elderly woman who may be his grandmother, and a woman trapped in her car as a pack of psychos hammer on it and ultimately blow it up). A man in a hazmat suit is visible during the final sequence.

[[folder:Tabletop Games]]
* In ''TabletopGame/MagicTheGathering'' Red is the color of passions and emotions, which while it does have its positive sides like creativity and love it also includes hatred and warfare, which is what ends up being portrayed the most in cards (it is a battle game, after all). [[https://magic.wizards.com/en/articles/archive/feature/seers-parables-2008-08-05 Canonically]], the Nobilis of War induces this to feed itself, [[CrapsackWorld which is why Shadowmoor will never know peace]].
* Dracorage in ''TabletopGame/ForgottenRealms'' was murderous madness periodically magically induced in dragons world-wide. Designed by ancient elves to break dragons' control over the world, later magical device was hijacked and used [[spoiler:by Sammaster to convince evil dragons that becoming {{Undead}} with his help is their only option to avoid insanity and then ignominious death.]]
* Mindflayers are given magical stones that could potentially have this result in the [[TabletopGame/DungeonsAndDragons D&D]] 3.5 supplement ''Lords of Madness''.
* The [[TabletopGame/SecretsOfTheSynodHorrenda Secrets of the Synod Horrenda]] introduces an undead monster called the Nightrager, which drives nearby creatures into a homicidal frenzy.
* ''TabletopGame/PrometheanTheCreated'' has Disquiet, an instinctual reaction by ''all'' living things towards the titular creatures that makes them gradually desire to destroy them-even if that isn't normally in a person's nature (several times, the book features humans going into [[HumansAreBastards jerk-mode]] towards Prometheans, [[MyGodWhatHaveIDone then wondering exactly why they were doing that a moment later]]). Is it any wonder that a Prommie's quest ToBecomeHuman [[BlessedWithSuck makes perfect sense]]? There are two things that don't instinctively hate Prometheans: TabletopGame/{{Vampire|TheRequiem}}s, and TabletopGame/{{Werewol|fTheForsaken}}ves. Instead, Vampires and Werewolves find Prometheans so unsettling that it actually becomes harder for them to resist their UnstoppableRage--meaning that they'll quite likely end up killing the Promethean anyway, along with any other allies or innocents that are unfortunate enough to be there at the time.
* One of the horrors described in the ''TabletopGame/{{GURPS}}'' sourcebook ''Creatures of the Night'' is the Dread Blossom, a flower that makes people exposed to its scent paranoid and xenophobic.
* Also from ''TabletopGame/{{GURPS}}'', one of the scenarios in the Horror/Space adventure book Flight 13.
* Wraiths in ''TabletopGame/{{Shadowrun}}'' can cause uncontrollable aggression in those near them.
* Skarbrand in TabletopGame/{{Warhammer}} and TabletopGame/{{Warhammer 40000}} has a special rule which causes EVERYONE around him to reroll misses in close combat due to amplifies hate.
* Some Apostates in ''TabletopGame/BlackCrusade'' can 'Inspire Wrath' in people against specific targets, with just a few words. It makes PlayerCharacters more determined, and so more likely to, hit the subjects. [=NPCs=] are a little less predictable.
* Classic ''TabletopGame/{{Traveller}}'' Adventure 6 ''Leviathan''. When the {{PC}}'s explore the world Pa'an, the natives will use their psionic powers to inflict telepathically induced aggression toward other party members. The crew will begin by feeling antagonistic and short-tempered with each other, and within one to six hours will be actively engaged in trying to finish each other off.
* ''TabletopGame/VillainsAndVigilantes'' adventure ''Devil's Domain''. When the {{PC}}'s are fighting at the Stonehenge tower, killing a demon will cause it to explode in a cloud of demon ichor, which becomes a toxic brown smoke. After the battle is over, if the {{PC}}'s didn't destroy the smoke when it was created it will cause inhabitants of the nearby town to converge on Stonehenge in a killing frenzy directed at anyone who isn't infected.

* In ''Toys/{{BIONICLE}}'', the Dreaming Plague's first symptoms included irritability, which then grew to hatred and violent behaviour, finally leading to complete insanity followed by death. This is one way Kurahk can use its power.

[[folder:Video Games]]
* The entire ''VideoGame/MegaManX'' series started because of Zero's body spreading a computer variant of this, causing robots to turn Maverick.
* Although not necessarily a plague in it's own right, Mia Yung's blowpipe and poisoned darts can wreak havoc on unsuspecting enemies en masse in the video game ''VideoGame/{{Desperados}}''- one tiny dart will send them into paranoid homicidal rage, opening fire on anything that is caught in their path, usually causing multiple deaths before the infected will either pass out or be gunned down by their former comrades.
* Video game example (sort of): in ''VideoGame/{{Nethack}}'', there is a "ring of conflict" that, when worn, makes every creature (including peaceful creatures and the player's own pets) start attacking the player and each other.
* In ''VideoGame/{{Postal}} 2'', [[spoiler:when you complete all of your tasks on Friday, you suddenly get a newspaper highlighting how a Hate Plague has instantly affected the whole town. Now you have to make it back home amidst the chaos, which includes raining dervish cats. At least everyone's usually focused on killing each other instead of you in particular.]]
* In ''Blood Omen: VideoGame/LegacyOfKain'', the player can generate this effect with the 'Inspire Hate' spell, causing all nearby Mooks to ignore the player and attack each other. The description of the spell specifically states Kain's sadistic amusement with the effect this has on the survivors...
** Kain gains the same ability in ''Defiance''. In both cases it's related to the [[CosmicKeystone pillar of conflict]].
* This is the main goal of Dr. Regal in ''VideoGame/MegaManBattleNetwork 5'': Combine the Soul Net (unifying all hearts) with the power of the Dark Chip (makes people evil). We see a little bit of the effects during the cutscene before the FinalBoss.
** Gemini Spark's chapter's evil plan in ''VideoGame/MegaManStarForce'' is to attach a virtual plus or minus to each person, invariably attaching the same sign to two friends, lovers, spouses, etc. so that they'd argue with each other. The game never explored the effect of two people with opposite signs...
** It's pulled again at the end of the second game. The villain gets away with it for a while, too, and this time without the awkward positive/negative questions.
*** The BonusDungeon of the same game is a twisted BadFuture in which the villan's plan actually succeeded and humanity was completely wiped out. The result is a rather depressing dungeon where you wander around a world without life or hope, and kill insane versions of your allies from the normal time line and eventually confront a BonusBoss who's sole intention is to escape to your world and wreak havoc on it as well.
* The infectious "kombat rage" spreading from [[OriginalGeneration Dark Kahn's]] ''mere existence'' in ''VideoGame/MortalKombatVsDCUniverse'' is a straight example, though this is also subverted when Superman and Raiden eventually realize that they can focus their rage towards what they see as the invaders rather than each other. During gameplay, it also serves as a literally UnstoppableRage.
* In the video game ''VideoGame/{{Majesty}}: The Fantasy Kingdom Sim'', one temple provides the spell "Rage of Krolm" which promptly fills your heroes with an unstoppable rage that gives them bonuses to fighting ability.
* The violence of ''VideoGame/CondemnedCriminalOrigins'' centers on this.
* Used in spell form in ''VideoGame/SuikodenIII'', during the attack on [[spoiler:Karaya Village, which results in Chris killing Hugo's friend Lulu, and Boris going berserk on unarmed civilians]]. Naturally, the bad guys did this to sour relations between the Grasslanders and the Zexens, so as to be able to conquer them both later on without any troubles.
* Used in ''VideoGame/CommandAndConquer 3: Kane's Wrath''. The Brotherhood of Nod's HumongousMecha the Redeemer can cause enemy units to go into a rage; attacking anything within sight (including their allies); but only after they finish off their current target first.
** Black Hand Confessors in the same game can throw hallucinogenic grenades, which cause any infantry caught in their area of effect (including friendlies) to attack their own allies. Unfortunately, it doesn't affect vehicles.
** Similarly, in ''RedAlert 2: Yuri's Revenge,'' Yuri's faction has the Chaos Drone, which emits [[MushroomSamba a psychedelic gas with a similar effect]]. Or to be more exact, the gas causes units affected by it to prioritize targeting friendlies over targeting foes, with an [[UnstoppableRage extra helping of doubled rate of fire]].
* ''VideoGame/{{Fallout 3}}'':
** Vault 108, a social experiment where the interior was pumped full of hallucinogenic gases to see how the inhabitants would react. Result: everyone had gone insane and killed each other.
** Vault 92 as well. Using the internal PA system, everyone was subjected to low-frequency white noise with combat suggestions hidden in it. After a while, everyone who heard it gone berserk and brutally killed the nearest person.
* ''VideoGame/{{Fallout 4}}'': Entering the [=HalluciGen=] building finds a group of Gunners going nuts and shooting at each other in a thick fog while alarms and warnings of a chemical leak sound. Turns out the Gunners accidentally activated one of the company's products, an experimental pacifism drug. It also turns out that [=HalluciGen=] was ''really'' [[IncompetenceInc bad at their job]], which is why said drug is has caused the Gunners to go berserk and kill each other.
* ''VideoGame/Left4Dead'' doesn't actually feature the undead, but rather "infected" humans, in the vein of ''28 Days Later'', which [[WordOfGod the developers]] cite as an inspiration. Taking them further from the zombie stereotype is that they don't eat human flesh, or anything, for that matter, if a certain piece of safe room graffiti is to be believed.
* ''VideoGame/ResidentEvil4'' has this introduced instead of the zombie plague in all the other games in the form of Las Plagas, which (in their normal form) are only able to make their victims more aggressive, albeit controlled. Experiments show how much [[BodyHorror worse]] this can actually be for its victims.
* In ''VideoGame/TraumaTeam'', almost all of the case solved by Naomi involves the victim being infected with the [[spoiler:Rosalia]] virus.
** Though it isn't straight up hate, but rather a result of frontal lobe tumors causing dementia among with other symptoms. One of the cases involves [[spoiler:the murderer being infected with the virus and thought she was trying to save her family from a FateWorseThanDeath due to the hallucinations she was having]].
* In ''VideoGame/{{BioShock|1}}'', the Enrage plasmid causes splicers to go crazy (well, crazier than usual) and attack anyone-- you, their fellow splicers, or even Big Daddies.
** The sequel gives us a potential origin story for the Enrage plasmid and why the splicers in the first game are too angry to come up with any kind of plan against a juggernaut: the ADAM slugs love to eat a deep-sea plant that secretes red chemicals. This could be considered a passive-defensive mechanic, as anyone who consumes the chemicals from the flowers becomes really, really violent, and addicted to the stuff. You find one of Lamb's science staff, Gilbert Alexander, violently insane and addicted to the scent of the flowers in the area.
* This happens in ''VideoGame/PokemonColosseum'' and its sequel ''Pokémon XD''. Pokemon's hearts are closed, so that they have no sense of compassion, and only their primal bloodlust. They'll attack anything, and they sometimes go into uncontrollable rage fits.
* The Pox of [=LeChuck=] in ''VideoGame/TalesOfMonkeyIsland''.
* The Delphinus Parasite in ''VideoGame/ShinMegamiTenseiStrangeJourney'' is effectively this, though they have difficulty even finding out a physical vector for the disease. [[ParanoiaFuel Because it does]] [[EnergyBeings not have one]]--[[spoiler: it's effectively an avatar of Asura]].
* Features in ''VideoGame/DeadlyPremonition''. [[spoiler:A purple gas produced from the Red Seeds that drives people into a murderous rage was responsible for the Original Raincoat Killer incident.]]
** And it happens again [[spoiler: during the last mission of the game. Killing the FinalBoss puts a stop to it though.]]
* ''VideoGame/KingdomOfLoathing'': Almost everything that increases monster leveling has a description to that effect. The Annoy-o-Tron, the badly tuned radio, the Canadian Mind Control Device which takes it UpToEleven... even, as a ShoutOut to ''Nethack'', a ring of conflict. Most infamous is the hockey stick of furious angry rage, which is imbued with everything that makes hockey hockey.
* One of Omega's powers in ''VideoGame/MegaManZero'' is his ability to turn normally sane reploids into murderous psychopaths. This power combined with his bloodthirsty desire to kill is ultimately what caused the deaths of 90% of reploids and 60% of humans in the Elf Wars. [[spoiler: Not surprising, considering it's the Maverick Virus from ''VideoGame/MegaManX'' taken to its logical conclusion.]] Imagine a robotic Skarbrand and you have Omega in a nutshell.
* The [[ChekhovsGun Spice]] from ''VideoGame/Sly2BandOfThieves'' causes insanity and unbound hatred, the BigBad [[spoiler: Constaple Neyla/Clockla]] intends to use this worldwide hatred to fuel [[spoiler: her]] immortality.
* According to most ''VideoGame/{{Touhou}}'' fanon, this is how [[GreenEyedMonster Parsee's]] "power of jealousy" works. Well, that and BulletHell...
** Used in the first half of the game ''Double Dealing Character''. The power of the BigBad was causing usually calm youkai to become angry and seek a fight.
* In the first ''VideoGame/GrandTheftAutoIII'', there's a cheat that makes all of the citizens attack each other. There's also a cheat that ''arms all of them''. Use both cheats, find a good place to hide, and PassThePopcorn.
* In ''VideoGame/TwilightHeroes'', some items that raise foe toughness have descriptions of this flavor. In some cases, your equipment makes you look like such a smug jackass that your opponents become stronger just from the desire to beat the smugness out of you.
* In ''VideoGame/WorldOfWarcraft'''s fifth expansion, the Sha are creatures born of negative emotions that take possession of their victims and make them living avatars of the power they represent, which include anger, doubt and hatred among others.
* In ''VideoGame/TheTestamentOfSherlockHolmes'', the early stages of the game introduce a nasty poison that causes the victim to go literally insane with rage.
* In ''VideoGame/CaveStory'', Mimigas which eat a certain type of red flower instantly turn into gigantic, mindless killing machines. [[spoiler: They did this in their past, on purpose, to prevent killer robots from annihilating them - and the Doctor plans to use this trait to turn them into an unstoppable army.]]
* In ''Franchise/DeadSpace'', this is the usual effect that Markers have on humans: they drive humans violently insane through hallucinations and induced paranoia. All the better to cause humans to slaughter each other and gain dead bodies which can then become Necromorphs. Certain smarter humans can resist the effects to some degree (with a very rare few completely immune to them), but the Markers can instead manipulate these individuals into performing other useful tasks for them.
* The Infected of ''VideoGame/DeadIsland'' react to the outbreak as such. Unlike the standard zombie Walkers or painfully self aware Suiciders they are locked in a permanent BerserkerRage a la ''Film/TwentyEightDaysLater'', intent to kill everyone and everything they possibly can.
* ''VideoGame/DragonAgeII'' and ''[[VideoGame/DragonAgeInquisition Inquisition]]'' feature Red Lyrium, which is basically regular lyrium on steroids [[spoiler:or rather, the Blight]] and induces paranoia and delusions of power in those who come into contact with or even remain in close proximity to it for too long.
* The "Mist" in ''VideoGame/FinalFantasyIX'' causes this effect on the entire world. It's mild and most people have moved to places where the Mist doesn't lie, but it's nonetheless lead to increased wars over history, which is actually part of the BigBad's plans.
* In ''VideoGame/FinalFantasyX2'', the Den of Woe consists of a large cluster of pyreflies that were infected by [[spoiler: Shuyin's]] spirit and corrupted with his hatred. They will possess anyone who goes near them and cause them to slaughter everyone in sight. [[spoiler: They wind up possessing Yuna, Rikku, and Paine late in the game, but Yuna is able to eventually fight off the possession and free both Rikku and Paine.]]
* In ''Third VideoGame/SuperRobotWarsZ: Tengoku-hen'', Barbiel's Sphere (the Resentful Scorpion) awakens the latent hatreds and resentment in other people, depriving them of their higher reason. When it is unleashed upon the people of [[spoiler:New Japan]] during [[spoiler: Sidereal's conquest]], Zero had to use his Geass to stop them in their tracks before things got too out of hand.
* ''Franchise/TheElderScrolls'':
** The series has long included the [[StandardStatusEffect status effect]] "Frenzy", which can be achieved by spells in the Illusion school. This effect causes the target to attack anything in sight, including members of his own faction. The results are even better when the spell has a large area of effect, enabling you to turn entire groups against each other.
** By [[VideoGame/TheElderScrollsVSkyrim Skyrim]], there is a version of the spell powerful to an affect an entire town, causing them to turn on each other.
* Vitiate, the one-time Sith Emperor in ''VideoGame/StarWarsTheOldRepublic'', has a deep, disturbing love affair with this trope -- possibly because he can ([[UnreliableExpositor we think]]) grow more powerful when people die, especially in painful and shocking ways. He first tested the technique on certain [[ManchurianAgent Children of the Emperor]], then had one of his disciples attempt to [[ApocalypseHow induce the entire population of the planet Voss to kill each other]]. (Then the Jedi Knight player character killed the Emperor [[DeathIsCheap and he had to take a few years off]].) Most recently he turned his attention to Ziost -- the capital world of ''[[OmnicidalManiac his own empire]]'' -- and systematically took over the population one by one, forcing them to kill each other. It's implied that he could have [[spoiler: unleashed the WorldWreckingWave he uses to simply ''kill the entire planet'']] much sooner but [[ForTheEvulz the wanton, piecemeal slaughter appeals to him]].
** His disciples, the Dread Masters, prefer to [[EmotionBomb inflict, well, dread]], but they're perfectly capable of pulling this, too. Unlike the Emperor's variant, they tend to plant hallucinations that cause their enemies to become paranoid and turn on each other.
* This is a major side effect of Joy from ''VideoGame/WeHappyFew''. Joy alters one's ability to comprehend and understand reality, locking them in a near-constant state of ignorant bliss and happiness. Some cannot take it at all, their bodies and minds reject it, resulting in permanent brain damage (leaving them as Wastrels). Unfortunately, these are the least of its devastating side-effects. Those who take Joy too often (aka Wellies) become completely dependent on it to function, and become dangerous psychotic messes that cannot tolerate unhappiness or even normal people who aren't taking their Joy (aka Downers). Rather than simply ignore what offends them, they will actively hunt down and destroy anything that upsets or brings them off their high.

[[folder:Visual Novels]]
* ''VisualNovel/HigurashiWhenTheyCry'' arguably [[DeconstructedTrope deconstructs]] this trope [[spoiler:since the main characters always suffer from it. Through most of the arcs, no one figures it out, and as a result, anywhere from more than half of to the entire cast winds up dead at the various ends]]. It's actually more of a Paranoia Plague than a Hate Plague, with a side order of hallucination, but it gets the job done. [[spoiler:Whether shown or not, most of the arcs ends with the entire town dead as the military rolls in and kills everyone, ostensibly to stop a sudden mass outbreak of Hinamizawa Syndrome.]] Further, one character does have it figured out in every arc (and a few more know about it but don't find out about specific instances until too late). [[spoiler: Unfortunately, by not fighting against it aggressively enough she produces the same effect as if she hadn't known about it at all, which is to say none, and still gets to watch her friends descend into violent madness.]]
** ''Kai'' turns it straight again when [[spoiler:the heroes learn about the plague in question and conquer it with ThePowerOfTrust.]]

[[folder:Web Comics]]
* ''Webcomic/BloodBank'' features a deadly perfume that causes all vampires in the vicinity to lose their minds and slaughter each other.
* ''Webcomic/TheChosenFour'' has the heroes going through one of these by the Plague Rat of Doom, Ness and Paula have a falling out, Jeff and Poo argue with each other.
* In ''Webcomic/{{Cloudscratcher}}'', the Sky Kingdom (the former name of [[TheEmpire the Margoth Empire]]) wiped out the Avian enclaves with a chemical weapon called Toxic Toast, which incites anyone affected by it to attack all others in a mindless rage, especially those who aren't affected. It's still present in the ruins, though fortunately it's degraded over time.
* Frenzy from [[http://www.daemonslayers.net/links.htm The Daemonslayers]]. According to his Website/DeviantArt [[http://drakhenliche.deviantart.com/gallery/?offset=120#/d1q5qa2 page]], the Dire Unicorn is constantly surrounded by a blood-red mist that makes any who breathe it overcome with violence and bloodlust that forces them to turn upon their fellows and tear each other apart. Those who survived and regained their senses often lost their minds anyway due to retaining the memories of what they saw and did under the effects of the rage. Despite his awful power, Frenzy is ironically one of the most peaceful of the dire unicorns and refuses to harm other mortals because he is still able to remember his name and former life as a noble unicorn, unlike his other brethren(such as Knightmare, who is currently the capricious mount to darkest AntiHero Blackjack) who were [[BeingTorturedMakesYouEvil tortured into becoming evil perverse beings]] by the Demon Queen Shine. However, because Frenzy lives in a {{Crapsack World}}, he has absolutely no control over his powers and the effects of the curse that travels with him has caused him to slowly lose his mind and has now become quite insane. All this makes Frenzy (and every other decent person in the Daemonslayer universe, including even Blackjack) complete {{Woobie}}s.
* ''Webcomic/SchlockMercenary'':
** The "Random Access Memorabilia" storyline uses a nanite-based version of this, corrupting genetic engineering done to add variety to some members of over 950 million wormhole gate clones (ItMakesSenseInContext) so that they [[spoiler:get turned into {{Super Soldier}}s serving an underhanded faction of the UNS after being killed.]]
** Played with to some extent in the "Barsoom Circus" story arc, involving elephant [[UpliftedAnimal sophonts]]. Musth is rather akin to a mating period, wherein the affected species become extremely violent and territorial. The cause of this is generally unknown, though some hesitant efforts have been made to identify it. In ''Schlock'', there are a set of elephants afflicted by something akin to it, [[spoiler:but it's caused by nanites instead.]]
* ''Webcomic/{{Spinnerette}}'' has something in the water at the Canadian headquarters...
* In ''Webcomic/TheOrderOfTheStick'', [[BigBad Xykon]] used this against [[TheOrder the Sapphire Guard]] by casting a Symbol of Insanity onto a bouncy ball and flinging it into the throneroom [[http://www.giantitp.com/comics/oots0448.html upon his entrance.]] Nearly all of the affected paladins [[InsaneEqualsViolent slaughtered each other in a fit of madness]], and, when the spell wore off, the last survivor committed {{seppuku}} out of grief.

[[folder:Web Original]]
* On ''WebVideo/AtopTheFourthWall'', the Gunslinger trapped the cast in their apartment and set up a device that lowered their inhibitions and increased their anger; between the tension of the situation and pre-existing conflicts in the group, the situation shortly got violent.
* The Wiki/SCPFoundation has a handful:
** [[http://www.scp-wiki.net/scp-923 SCP-923]], a KillSat which works by driving AxCrazy everyone at the targeted location. At it's most intense output level it ''permanently damages the fabric of reality'', as if it were driving reality itself insane.
** [[http://www.scp-wiki.net/scp-053 SCP-053]] is an apparently ordinary three-year-old girl, except that anyone who is around her for more than a few minutes at a time becomes hyper-aggressive and homicidal toward her. This phenomena began happening after an incident where she may have been brought back to life or did not die when she was supposed to. The one thing that didn't want to kill her and actually befriend her was none other than '''SCP-682.''' This is very confusing otherwise it is an OmnicidalManiac that tries to kill ''everything'' it sees. Some have speculated that the irrational hatred humanity has toward her is the same that 682 has toward humanity because both find something fundamentally wrong with the target's ''existence.''
** [[http://scp-wiki.wikidot.com/scp-114 SCP-114]] is somewhat similar to the above: she is an adult Afghani woman that fosters conflict in those around her. However, unlike 053, that conflict is aimed at each other rather than at the SCP, and has more reach and no defences against it, resulting in much steeper and isolating containment procedures.
** [[http://scp-wiki.wikidot.com/scp-2089 SCP-2089]] is John_████████_Is_Here, an Internet blogger which drives viewers of his content into prejudice towards him, posting hateful content about him (comments expressing dislike, fan art of him being harmed, encouraging him to kill himself). Combined with his inability to die, [[MundaneUtility his condition is exploited]] to provide entertainment for other users by self-harm or suicide.
* The Cure from ''Roleplay/RubyQuest'' initially caused violent outbursts in those who'd taken it. [[spoiler: Ruby, under the influence of the Cure, murdered her boyfriend Tom and gave Red a GlasgowGrin.]] Those who it has mutated enough also become violent, as seen in Stitches, Daisy, and [[spoiler: Filbert]], though this is reset once they die and resurrect.
* The ''Literature/VeilOfMadness'' causes this. It's a section of the galaxy that drives anyone who stays in it for enough time violently insane. Any race unfortunate enough to ''evolve'' in it (except humans, who are immune to the effect) gets a generous helping of InYourNatureToDestroyYourselves.
* The Red Horse virus in the ''[[Music/NineInchNails Year Zero]]'' ARG is a weaponised haemorrhagic virus that causes violent psychosis, encouraging the spread of a disease that would otherwise be self-limiting given its extreme virulence.

[[folder:Western Animation]]
* The TropeNamer is the Hate Plague in ''WesternAnimation/TheTransformers''. Also occurred as one of a small handful of {{Shout Out}}s in ''WesternAnimation/BeastMachines''.
** Despite the name, it doesn't really fit. The infected often initially become violent, but will then begin to work together with other infected. In the second of the two-parter that introduced the plague, Cyclonus commands the other Decepticons to retreat after coming under fire from the Autobots, and they follow his orders unquestioningly. It's more of a "Lack of inhibitions" plague than a "hate" plague.
*** One example of the afflicted cooperating are the combiners. In spite of fighting amongst themselves minutes earlier, the Aerialbots re-combine into Superion. They later infect Defensor. Defensor immediately collapses into the 5 Protectobots; the five fight amongst themselves. The same happens when Galvatron raids the lab containing the plague. Menasor and Bruticus are touched immediately by afflicted Autobots and immediately collapse into 10 brawling Transformers.
*** The Decepticons' cooperation could be FridgeBrilliance at work, as hatred had already been a part of their driving motivation, so wouldn't necessarily alter their behavior as much as it does, the non-villainous characters'. Doubly so for Menasor and the Stunticons, whose bios indicate that they operate on a level that barely makes it ''up'' to TeethClenchedTeamwork.
* In ''WesternAnimation/JusticeLeague'', supervillain Gorilla Grodd uses his mental abilities to give the team's minor issues with each other a little push, much to their embarrassment.
* Both the [[WesternAnimation/TheCareBearsMovie first]] and [[WesternAnimation/CareBearsMovieIIANewGeneration second]] ''Franchise/CareBears'' movies show the villains having a dark influence on surrounding people -- the kids at the amusement park where Nicholas and the evil book are become rotten little monsters, and so do the kids at the camp where Dark Heart sets up shop.
** One episode of the animated series featured a [[AppliedPhlebotinum mysterious meteorite]] infecting a small town, making the surroundings dull and gray and the citizens depressed and apathetic. Then it started affecting the Care Bears and their Cousins, but fortunately they were able to CareBearStare the meteor into a deep hole on the outskirts of town.
** The Thanksgiving episode involved an evil pie maker named Sour Sam, who bakes a bunch of "crabby apple pies," that causes anyone who eats them to act like grumpy jerks, and the only thing that snaps them all out of it is a young boy's speech about what Thanksgiving is all about.
** In another episode, a variation occurs: on a rainy day, a demon of boredom appears and hits Hugs and Tugs Bear with a magical dust that drains them of their enthusiasm, making them dull and whiny. AnAesop about all of the fun you can have with your imagination serves as a helpful antidote.
** And ''yet another'' episode (boy, did this show like this trope!) features No-Heart conjuring magical bubbles that can imprison living things and amp up their anger, turning them into bitter, destructive monsters. The only cure was a rare type of gem called Caring Crystals, which Grumpy Bear had to collect while the others held back the bubble onslaught with a force field.
* The SoBadItsGood ''WesternAnimation/{{Batfink}}'' program featured main recurring villain Hugo A-Go-Go creating "hoke", a combination of hate and smoke. After it was released, the eponymous hero and his sidekick began arguing, including [[LampshadeHanging placing a lampshade]] on the overuse of the hero's "[[LuckilyMyPowersWillProtectMe My wings of steel will protect me]]" catchphrase, with the henchman replying, "Yeah, yeah, why don't you get some new dialogue?"
* ''WesternAnimation/ThePowerpuffGirls'' had the episode "Tough Love," where [[{{Satan}} Him]] replaces everyone's love for the girls with hate, causing them to turn against the girls - even the {{narrator}} was affected. It really hits home at the scene when the girls went to see the Professor; imagine all the love a parent has for their children magically swapped with hate.
--> '''Professor Utonium:''' ''(groans)'' How many times do I have to tell you girls not to come barging into the lab like that? ''(turning to face them, face red with anger)'' '''IT'S NOT NICE!!'''
* A more family friendly version is see in ''WesternAnimation/TheodoreTugboat'', in the debut episode of Guysborough the Garbage barge. His grumpiness gets Theodore in a bad mood, which puts Emily & George in a bad mood, and so on until the entire harbour becomes snappy with each other.
* One episode of ''WesternAnimation/DungeonsAndDragons'', featuring the usual "get to the one-chance exit back home" set-up, forced the kids to go through a maze to reach a portal. One part of the maze made all the kids become very aggressive, tetchy and downright bloodthirsty, which almost resulted in a nasty fight. Fortunately, Hank was able to snap everyone out of it.
* The ''WesternAnimation/MyLittlePonyTheMovie'' had the Smooze, which, in addition to making everything putrid and covering the land in a thick layer of concrete-like substance, made characters touched by it aggressive, spiteful, and pessimistic.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'': In "[[Recap/MyLittlePonyFriendshipIsMagicS2E1TheReturnOfHarmonyPart1 The Return of Harmony]]", Discord inflicts most of the main characters with the opposite emotions from their respective [[PersonalityPowers Elements of Harmony]]. Honest Applejack becomes a liar, merry Pinkie Pie becomes serious and grouchy, generous Rarity becomes greedy, kind Fluttershy becomes a cruel bully, and loyal Rainbow Dash deserts her friends. Eventually Twilight Sparkle became affected, no longer caring about friendship.
** In the episode ''[[Recap/MyLittlePonyFriendshipIsMagicS7E2AllBottledUp All Bottled Up]]'', Starlight, who was angry at Trixie for using a spell that teleported the Cutie Map to who knows where and acting like she doesn't care that it could get them both in trouble with Twilight, uses a spell that bottles up all of her anger in a jar. But then the jar breaks, and all the anger infects Bulk Biceps, Granny Smith, and a pony who works at the jewelry store, who all go after Trixie and start yelling at her about all the stuff she did to make Starlight mad.
* The little pink dog [[WesternAnimation/CourageTheCowardlyDog Courage]] once faced a literal sweeping Hate Plague called the "Cruelty Curtain". This energy barrier caused anyone it touched to become ridiculously rude to the point where benevolence was considered a crime. Courage managed to re-wire the Curtain so that it turned people nice - [[HeelFaceTurn even its evil creator]], who was later elected mayor.
** [[JerkWithAHeartOfJerk Eustace]] is nasty enough that he wasn't affected by the Hate Plague, and when it turned into a Love Plague [[DisabilityImmunity he was still a big jerk]].
** A variation occurs in the two-parter "The Tower of Dr. Zolost." The titular doctor develops bombs that, when fired, cause anyone they hit to turn green and become deeply unhappy ("depressed" might be a better term, as they lose all motivation to do ''anything'' and simply slump to the ground, unmoving). Thankfully, Muriel's "Happy Plum" recipe proves an excellent cure.
* WesternAnimation/TheSmurfs: The Root Of Evil in the episode of the same name. The Yellow Hate Disease in "Hefty's Heart" would also count, as would Chlorhydris' black-heart arrows which Cupid accidentally fires in "Chlorhydris' Lost Love".
* In [[WesternAnimation/SpongeBobSquarePants SpongeBob's]] second Christmas special, ''WesternAnimation/ItsASpongeBobChristmas'', Plankton obtains a mineral called Jerktonium, and laced it on a loaf of fruitcake, so that whoever eats the cake become jerks. And so, everyone in Bikini Bottom (sans Squidward, he was already a [[{{Jerkass}} jerk]]) eat the fruitcake and become jerks. The only exception was [=SpongeBob=], eating the tainted cake doesn't affect him due to his [[TooDumbToFool tiny brain]] and [[IncorruptiblePurePureness pure heart]].
* In the ''[[WesternAnimation/TeenageMutantNinjaTurtles1987 Ninja Turtles]]'' episode "Splinter No More", Shredder secretly plants a device to increase a mutant's hostility to keep the Turtles from following him. When they eventually arrive where the device is planted, the Turtles' attitudes quickly degrade and they begin fighting each other until April is able to snap them back to their senses.
* In one episode of ''WesternAnimation/{{CyberChase}}'', [[BigBad The Hacker]] attempted to take over {{Cyberspace}} with the "Curse of the Mean Green", which can [[TheVirus turn entire worlds]] [[ExactlyWhatItSaysOnTheTin mean and green]]. First person to be infected? [[FisherKing Mother]][[OhCrap board]].
** This happens again in "Hackerized". The plague is pretty much limited to Sensible Flats...but works on ''Matt and Jackie!''
* In an episode of WesternAnimation/ToadPatrol, the toadlets enter a cave which is filled with red crystals that, once touched, begin turning the toadlets against each other by making them argue over the smallest of things.
* A recurring villain in ''WesternAnimation/AtomicPuppet'' is a giant slug-like monster with the ability to shoot slime from his body pores. The slime causes people hit by it to become angry at each other, and in one episode, it broke Joey and AP apart.
* In an episode of ''WesternAnimation/BuzzLightyearOfStarCommand'', some [[Film/{{Alien}} squishy, triangular]] [[BigCreepyCrawlies parasites]] possess the heroes by latching onto the back of their necks and manipulating the synapses between their host's primary emotions and impulsive, spontaneous action decisions. They increase their threat manifold by reproducing asexually and very, very quickly.
* The ''WesternAnimation/BikerMiceFromMars'' episode "Test of Friendship" featured a villain named Evil Eye Weevil, who was able to fire a hostility ray from his eye, which made people become temporarily angry and aggressive. The hostility ray was used on the Biker Mice, which caused them to split up after getting into a fight so that it would be easier for the main antagonist Lawrence Limburger to defeat them. Thanks to the hostility ray's temporary nature, however, the Biker Mice manage to patch things up and foil Limburger's schemes as usual.
* Happens in the ''WesternAnimation/{{Mysticons}}'' episode "Quest of the Vexed." Fed up with Arkayna's treatment of her, Emerald hides her frustration by using canisters that bottle up one's anger. She ends up losing a canister in Centaur Park and it soon mafunctions, spreading Em's anger to other citizens in Drake City.
* In ''WesternAnimation/TheFantasticFour1978'', the episode "The Frightful Four" at one point has the Wizard use a gas to make the Fantastic Four become hostile toward each other.

[[folder:Real Life]]
* Mob mentality can often resemble this.
** Historically, the Mob mentality revolving around Witch Trials seen in Salem, Massachusetts are said to have been amplified from ergot poisoning, caused by a bread mold found on rye bread with symptoms including mania and psychosis, making it a bit more literal.
** [[PropagandaMachine 'Propaganda machines']] have been known to pour fuel on the fires of hate, if genocides in recent history are anything to go by.
* In the right doses, the right drugs can induce a psychotic episode, which can lead to explosively violent outbursts. However, the victim is just as likely to pass out, have a heart attack, or go on a bad acid trip instead, so the effect can't be used reliably as a weapon.
* Methamphetamine abuse and production. Methamphetamine abuse tends to lead to aggressiveness coupled with anger and paranoia (and in some instances can create a psychotic syndrome called amphetamine psychosis, which is almost indistinguishable from paranoid schizophrenia ''except'' that violence is far more likely in response to perceived threats, whereas most paranoid schizophrenics would want to run from or cower in fear before an imagined threat rather than fight it). When you add in the paranoia induced by the illegal status of meth use/abuse, this creates a volatile situation where people (especially users and cooks) are willing to hurt anyone who angers them/whom they see as a threat to their business or freedom. ''Series/BreakingBad'' is often an ''understatement'' of how horrifying "meth culture" can be.
* Many illnesses, such as rabies or brain tumors, often result in mood swings and sometimes increased aggressiveness. Rabies is a real life Rage Plague, as it causes an aggressive, feral mentality in order to spread itself, through biting, and also causes the host to avoid basic survival instincts, in this case, drinking water, which leads to eventual death. Compare with the Rage Virus of ''Film/TwentyEightDaysLater'' and the occasional side effects of G-23 Paxilon in ''Film/{{Serenity}}''.
* Dogs (particularly English Springer and English Cocker Spaniels) can have something called "Rage Syndrome" which does resemble Hate Plague. Fortunately, it's rare and it only lasts a few minutes, and can, in most cases, be controlled with medication.
* AllPeriodsArePMS; only if a girl doesn't track her cycles like she should and know when "that time" is about to come up again (or if she's just hitting puberty and hasn't settled into a predictable cycle yet). Of course, the culprit will become clear pretty soon, but, "My hormones make me crazy" isn't always bought as an excuse.