Silver Diamond has Chigusa: half-man, half-plant. Which apparently makes you damn near immortal. Apparently, it's a family trait of the Senroh clan, earning them the title of Immortal Monsters.
Seriously handled in Bagi, the Monster of Mighty Nature: Bagi is a human/cougar hybrid created in a lab (although she has pink fur). She's somewhat rare in being pretty much human behaviorally as well. She also has psychic powers of hypnosis. Then without any explanation, at the end of the plot, she inexplicably loses her intelligence and ability to speak and even stops being bipedal.
The series Otome Youkai Zakuro is set during the Westernization of an alternate Japan, where humans and spirits (youkai) coexist. To solve the problems that arise between the two, human lieutenants are partnered with half-spirit girls to form the Ministry of Spirit Affairs.
The manga and anime series Bleach gives us Ichigo Kurosaki. His mother was human. His father is a retired Soul Reaper, meaning that he's a human/ghost hybrid. Though not shown, his sisters may also be hybrids as well, if they could unlock their powers.
Then it's revealed, in Chapter 530, that their mother was a Hollowfied Quincy, meaning that their family was never going to be truly normal to begin with.
Ichigo himself provides a deconstruction. He's always identified himself as a Shinigami, even when his powers were much closer to those of a Vaizard. It certainly helped that the Gotei 13 restored his Shinigami reiatsu in the penultimate arc. However, when he gets a chance to train with Squad Zero, the strongest living Shinigami out there, he fails to pass. Instead, it's Renji, the perpetual Jobber, who passes. His trainer, Oetsu Nimaiya, explains that it's because Ichigo is not a full-fledged Shinigami that he couldn't pass. Not only can Ichigo not fix his Empathic Weapon - he's kicked out of the Soul Society. Reconstructed once he learns of his heritage. Aware of his true nature and the source of his powers, he takes Oetsu's test again. He goes above and beyond Oetsu's expectations when the Asauchi don't even try to fight Ichigo and simply bow down to him en masse as he chooses his inner Hollow from among them.
It's implied that Chrono and Aion, as well as possibly the other sinners are like this, since their mother was a human woman turned into a demon when she was still pregnant with the twin boys. On top of that, there's a cryptic scene that implies that Satella and her sister Florette are hybrids as well. Aion claims that he's a "distant relative" of their parents. This could just be speaking about his human heritage, but he also says later that Satella's father was "our senior" and had defected "like us"... implying he was a demon, as well.
There's Remington, who infused his body with demonic legion, making him about 40% demon.
In Tekkaman Blade, the Tekkaman are basically half Human, half Tekkaman. They are not half Radam because Radam are actually a brain washing parasite.
In the manga/anime Claymore, the heroes are a sect of all female half-human, half-youma who hunt full youma, although the main heroine Clare is actually only a quarter youma. A fallen Claymore warrior is called an "Awakened One" and is far more powerful than a pure-blooded youma.
A Claymore warrior is somewhat different from other hybrids in that they are born human and become half-youma by having youma flesh implanted into their body. Claire is a quarter youma because she requested to have a certain Claymore's flesh used instead. This turns out to be a critical plot point because quarter-youma are physically weaker but have a far greater degree of control over their abilities and are more likely to survive Power Incontinence.
The Crow special agents in D.Gray-Man are half-human and half-akuma - they're akuma enough to set off Allen's eye, but human enough to not actually be seen with it. Exactly how they got that way has yet to be revealed, but Black Religious Order experimentation by their Chief is a big part of it.
Gohan, Trunks, Goten and Bra from Dragon Ball Z were half-Saiyans, an alien race. Even though humans and Saiyans are not the same species and seem to share no relation, they are capable of producing fertile offspring: Gohan has a quarter-Saiyan daughter named Pan, and Pan has at least one child and one grandson. Furthermore, while humans are much weaker then saiyans, taking much longer to train up to the same power levels, and have a lower strength cap, Saiyan/Human bybrid are exceptionally strong for some reason. All of the male hybrid characters gained power extremely rapidly and attained the Super Saiyan forms as children, and Gohan was the first character ever to reach the level of Ascended Saiyan and by the end of the series was the most powerful (unfused) being in the universe by a long shot.
In the original Dragon Ball its implied many people on Earth are part monster, animal, and the like. Earth being a World of Weirdness at that point.
There's a strange version in Elfen Lied. All Diclonii, drones included, can infect humans with a virus that causes all future offspring to be Diclonii drones, incapable of reproducing sexually. These drones are also always female. However, there is one Diclonius, the queen, who can reproduce sexually, and if her mate were human, her offspring would probably be some kind of Half-Human Hybrid. There are a bunch of powerless male half-human Diclonii wandering around, probably a result of something of that nature happening up in the family tree.
In the manga version, the male Diclonii are revealed to be descended from a family of humans who merely have a weird skull defect.
In the anime Gall Force, the Hybrid between the all-female Solonoids and the monstrous Paranoids turned out to be a human male. The first one, at that.
In a cyberpunk, non-DNA variant, the original Ghost in the Shell movie ended with Kusanagi merging with the Puppet Master's formless entity to become something else entirely.
Inuyasha is half-dog-youkai and has a mixture of dog and human traits. He's human in appearance but has dog fangs, golden youkai eyes and claws. His sense of hearing and smell is very much sharper than a humans. However, he lacks his full-blooded youkai brother's strength and his senses are duller than his brother's as well. However, being the son of a daiyoukai means he's much stronger than ordinary (and strong) youkai even if he's not a physical match for his daiyoukai brother. He's also inherited some magical abilities from his father's side. However, along with this, he has one night a month when he's forced to transform into a human and if his life is in grave danger, a Super-Powered Evil Side takes over where his youkai blood takes dominance over his mind and body, although even in that state he doesn't transform into a dog the way a full-blooded dog youkai can.
Jinenji is also half-youkai, half-human, but the species of his youkai parent is unknown. Unlike Inuyasha, his appearance is much uglier and more beastial. However, he's inherited healing powers from his youkai side and is incredibly gentle: a sharp contrast to Inuyasha who, while much prettier to look at, is much more aggressive and violent in personality. Along with his healing abilities, Jinenji has also inherited phenomenal physical strength, but he almost never uses it due to being a pacifist.
Shiori is the daughter of a human woman and a bat-youkai. Like Inuyasha's father's species, Shiori's father's species can transform between a human form and an animal form (a monstrously sized humanoid bat-creature). Aside from her white hair, violet eyes and very dark skin, Shiori looks almost human. She has inherited her father's barrier-generating abilities, however, a power she freely gives up to Inuyasha's sword after he saves her life from her own (youkai) grandfather.
In the manga of Mahou Sensei Negima! it is revealed that Setsuna is half-tengu. This is hinted at in the last episode of the anime, but never said outright.
The manga also features Kotaro Inugami, a boy who is half-Dog Demon/Youkai.
In Kishin Houkou Demonbane the Big Bad is revealed to be the offspring of Nero and Yog-Sothoth. It's never explained how this happened, which, for the sake of our sanity, is probably for the better... and he burst out of Nero's body, fully grown. And that his birth happened several episodes after he was killed.
Kaworu Nagisa is strongly implied to be a result of an experiment where an unidentified human donor's DNA "dove" into Adam. (The technobabble almost sounds like a euphemism for insemination.) Whether he is actually a half-Angel/half-Lilin hybrid who for some reason looks human, or a straight-up clone of the genetic donor, is unknown.
Rei Ayanami has a connection to Lilith, as well, but printed sources only say that she is a clone of Yui and contains Lilith's soul. It is heavily implied in her case that her Angel donor was Lilith, and her human donor was Yui. In Rebuild, Kaworu addresses either a sample of Adam or Director Ikari himself as "Father," remaining deliberately vague.
In Please Teacher!, the female protagonist, along with her sister, are half-alien, half-human.
Both Averted & Justified in Osamu Tezuka's Phoenix series, where there is only one species capable of breeding with others, the Moopies, who are able to do this due to Voluntary Shapeshifting (which is a completely different scientific impossibility, but what the hey).
Rue from Princess Tutu has been raised on the Raven's blood, and it's implied that it's made her a sort of hybrid.
An arc exclusive to the Ranma ˝ manga the Musk Dynasty, men who are half various animals. This was only possible because their ancestors used the cursed springs to turn animals into women, but they somehow inherited incredibly useful traits of their mothers' true forms (such as an acute sense of smell, superhuman strength, and, in the half-dragon's case, flight.)
In the manga/anime Saiyuki, humans and demons may interbreed, but the offspring, known as "children of taboo", are discovered to be infertile.
Super Dimension Fortress Macross is certainly full of these, usually Zentraedi/Human hybrids. Justified in that the entire premise of the show is that Zentraedi and humans are two genetically modified offshoots of the same species.
In Macross 7, we meet Mylene, the series's Genki Girl, who is naturally also a hybrid (Komillia's little sister, at that). In fact, when they discover an ancient (yet remarkably still functional) ruin, it's Mylene's hybrid nature that unlocks the final chamber, allowing the ruin's computer to see that the different races had stopped fighting and had children together.
In The Movie to the same series, we meet Mylene's other older sister Emillia, though their relation is only confirmed by a few seconds of dialogue.
Official material has confirmed that there are actually four MORE sisters never seen in the series. Max and Miriya apparently REALLY hit it off.
By Macross Frontier, we have at least one character who is quarter Zentran, as enough time has passed for grandchildren of the original Zentraedi defectors to begin to reach maturity, and there are mixed-heritage folks running around all over the place.
Averted, however, by the Zolans. Despite the Protoculture also messing with their evolution in the distant past and looking very much like humans as a result, they are evolved from marsupials and their reproductive system is incompatible with humans and Zentraedi (which is the subject of some tension in an Interspecies Romance radio drama in-universe). Whether they are still marsupials is rather unclear: the only unclothed female we see does not have an obvious pouch, and had not entered puberty yet anyway.
Finally, the character of Ranka Lee (quarter-Zentran) is also revealed to have psychic Vajra bacteria in her digestive tract. This is what allows her to communicate with the Vajra, and causes them to see her as one of their own. Notably, other humans/Zentraedi have been infected with this bacteria, but Ranka is the only person to have ever achieved symbiosis with it, apparently due to contracting it in utero; everyone else was killed.
SHUFFLE! involves two extra humanoid races, the Gods and Demons... and hybrids will happen.
Asa Shigure looks fully human and lets everyone think so, but we eventually find out she's half Demon. Her mother was the first test subject of Project Yggdrasil.
Mayumi is also a half-Demon. She doesn't hide her parentage, but could if she wanted to.
And then there's Sia... kind of. Her father is a God and her mother a Demon, but apparently race works like gender in the divine realms — the child turns out either one or the other, not a mix of the two. Thus, while she is a hybrid, Sia is still all God biologically.
Everyone except the hero in Utawarerumono has a varying combination of wings, long furry ears, and tails. It is revealed in the end that they're all descendants of genetically engineered research experiments who escaped shortly before the end of mankind. Despite having only minimal animal features, they were on the level of lab rats and dissected for research.
Slayers has Zelgadis, an artificial example of this trope. He was born pure human, but was merged with a Blow Demon (a kind of Astral Goblin) and a stone Golem through the magic of Rezo, the Red Priest. This gives him pointed ears, blue skin, purple/lavender hair, patches of pebble-like "growths" all over his body, and either skin or flesh of solid rock.
Dragon Half has the heroine Mink, whose mother was a dragon and whose father was a (human) dragon hunter. And Princess Vina whose father was a king, and whose mother was a slime (similar to those in Dragon Quest).
Guu is a half human, half Humanoid Abomination. She's a mix between Merlin and Loki (but maybe that's just with Haré). To everyone else, she's just a Creepy Child, and they don't seem to mind. They just think she's a little odd, but nothing to worry about.
Being a D&Dexpy, Record of Lodoss War has a few of these, the most traditional of these being Leaf, the Shaman from the Chronicles of the Heroic Knight TV series. Being Half Human and Half Elven, she is correctly referred to as a Half-Elf.
This seems to happen a lot in One Piece. There are several variations between common species, including but not limited to; Humans, Mermen, Fishmen, and Giants. And since One Piece usually adheres to the Rule of Cool most hybrids get strengths of both parents' species with few, if any, of the relative weaknesses.
Rin from Blue Exorcist. It is a little played with though: although Rin gets the usual treatment hybrids get in fiction, it is later revealed that it isn't exactly because he is a half-blood — apparently, a lot of exorcists have mixed heritage — but because he is a son of Satan himself.
He is the only one. Midway through the series, Ao and the audience found out that his parents, Eureka and Renton (come on, it was obvious) had a girl before they had him. Sadly, the final episode reveals that she died at birth due to high trapar exposure reacting badly with hybrids.
In Wicked City, the human Renzaburou and the demon Makie not only become a Battle Couple, but conceive a child. This is actually a part of a Batman Gambit by their boss Giuseppe: theirs is the first half-human, half-demon kid, and his/her existence will be the living proof that humans and demons can live in peace.
In Devil May Cry: The Animated Series, this is blatantly stated by Bradley to Dante. This is highly uncommon because demons tend to enjoy tormenting and killing humans. However, Dante's father was a demon who rebelled against the demon emperor and sided with humans. Afterwards, he ruled the human world and had two twin sons, Dante and Vergil, before disappearing.
In Sekirei, it is revealed that Minato and the other Ashikabi are essentially this because their ancestors were Sekirei that mated with humans in ancient times. Their alien heritage is expressed to a degree that they've been described as something other than human, but lack a Sekirei's core or powers.
The Light NovelVamp! features a half-vampire, Watt, who is impervious to sunlight but is said to never be able to reach the same level of power as regular vampires.
In The Familiar of Zero, Tiffania had a human father and an elf mother. Other than inheriting the Power of the Void and Gag Boobs from her father's bloodline (both of these traits are unusual in an elf), she looks just like any other elf.
Ai, the protagonist of Kami-sama no Inai Nichiyoubi, is half-human, half-gravekeeper (humanoid beings who can grant true death to people). Unlike other gravekeepers, she has emotions and can't sense the presence of the deceased, but she can still bury them just as well.
Yuu Mishouzaki's Zelda manga was created back when we knew very little about Hyrule or Zelda lore. As such the concept of Hyrulians wasn't really a thing so the manga had them as "elves". The elves are discriminated against but the Queen had a romance with an elf. Link is the child born from said romance.
One of the three Diggers sisters, Brianna Diggers, is a half-werecheetah half-human. Any questions on how that could happen genetically are neatly bypassed by her being the combination of her two other sisters via a combination of a magic curse and mad science (the werecheetah and human siblings being sisters in the first place by the simpler mechanism of adoption).
Also the aforementioned Werecheetah sister marrying a feline humanoid alien and having a child. How did that work out?
It was revealed that the Diggers sisters' father is also a hybrid — his father was human, but his mother was a living alien (albeit of Terran origin) supercomputer with a humanoid body. Ah, love... Anyway, while the Diggers sisters' mother is unquestionably human, she is from another planet and her parents are also from two completely different cultures. One might theorize a strong genetic resistance against inbreeding...
In addition said feline humanoid (Kryn) is actually another type of humanoid entirely (Gaoblin) that ages ago killed off and replaced four separate races (Kryn, Elves, Trolls and Atlanteans) as a way of hiding from the universe who wanted them dead for their service to the Dynasty. AND he's been bonded with several highly powerful artifacts. So he's an alien with an outer shell of DNA from another race and who knows what else affecting his gene pool. The world's resident gene-expert says that the husband's DNA is probably the most complex he's ever seen.
Hellboy is half-human, the result of a union between the witch Sarah Hughes and a demon prince.
Jack of Hearts, a Marvel Comics superhero, was half-human, half-Contraxian (his powers had little or nothing to do with that, it was a Freak Lab Accident).
Raven of the Teen Titans is half-demon in both the comics and the cartoon. Many other Titans are half-human/half-non-human as well.
Phyla and Genis]] are the children of a Kree father and an Eternal mother, the Eternals being an offshoot of humanity.
Mar-Vell's other kid, Hulkling of the Young Avengers, is his son by a Skrull princess. As one can imagine, the news of this has not gone over well with the Kree.* The Kree most likely wanted to kill him (the Kree have been known to put people on death row just for sleeping with a Skrull); the Skrulls on the other hand see him as Messiah. Also, Captain Marvel never met any of his children: Hulkling was kept by the Skrulls, and Genis and Phyla were created using his DNA after his death.
The Wild CATS are mainly half-Kherubim, an immortal super-powered alien race. It's not until many years after they were created that this was justified by having Earth be a planet terraformed by the Kherubim billions of years ago for their own needs, basing our DNA on theirs.
In Preacher, Genesis is the offspring of an angel and a demon.
Many Superman stories show a future child with Lois Lane, up to and including a human/Kryptonian Superman Dynasty lasting tens of thousands of years. However, many post-Crisis stories portrayed a human/kryptonian hybrid as impossible. The existence of Superboy proves that at least artificially created hybrids are definitely possible, although the various health problems he's had over the years show that hybrids aren't the most stable.
Rosie from Elfquest: The Rebels is an artificially-generated blend of human and preserver.
The official ElfQuest AU story 'King's Cross' has a human/elf hybrid, and HUGE helpings of magic are involved. Normally, a human/elf hybrid in the ElfQuest verse is impossible. (Wolves have four more pairs of chromosomes then humans. Pure-blooded elves can intermarry with the wolf-blooded Wolfriders. Ergo, no human interbreeding.) The hybrid in question does wind up being a little more elf then human, though.
Tigra of The Avengers is a human woman turned half-tiger thanks to magic. And then she... went and got knocked up by a Skrull pretending to be Henry Pym. Which I suppose makes her child half-Skrull, one-quarter human and one-quarter magic tiger. The disguise was so good that the Skrull imposter only gave Hank Pym's DNA, so the child is three-quarters human, one-quarter magic tiger.
The hero and his half-brother in Invincible are both Viltrumite hybrids. Mark is human on his mother's side while Oliver is part sapient alien insect on his mother's side. Since Viltrumite reproductive DNA is just as aggressive and ruthless as the race, a Viltrumite hybrid usually turns out to be all but identical to a full blooded one. Mark is indistinguishable from other Viltrumites, and Oliver, despite being part sapient alien insect, only has purple skin and very fast physical maturation to distinguish him.
Parodied in Scott Pilgrim, where Roxanne is described as being "half-ninja."
Prior to the DC reboot, Cassie Sandsmark a.k.a. Wonder Girl was the half-human half-Olympian daughter of Zeus. After the DC reboot, this applies to Wonder Woman herself.
In ClanDestine, the Destines are the children of the genie Elalyth and Adam of Destine, a human who was granted immortality and invulnerability by said genie after he rescued her and they fell in love. The kids are all incredibly long-lived, but not immortal, and have superpowers of varying degrees of usefulness.
Rom Space Knight: Jimmy Marks a.k.a. Hybrid, the son of a human woman and a Dire Wraith. He appeared in Avengers Academy. Don't worry, he's not as bad as a typical member of his father's race. He's worse.
Fables: Bigby thinks of himself as a wolf, but he actually had a wolf for a mother and the North Wind for the father. Meanwhile, Snow White is a human-style Fable who has six (seven, really) kids with Bigby.
From The Sandman: Desire is revealed to be the grandfather of recurring character Rose Walker, having fathered her mother while her grandmother was in a coma. So more of a case of 3/4 human hybrid. Rose, her mother and younger brother don't seem to have any explicit powers from their supernatural heritage other than looking young for their ages and being considered a bit more attractive than the average person. Interestingly, the titular character isn't shown to have any half-human offspring, but given Desire's penchant for making him fall in love it wouldn't be surprising.
He has a son, Orpheus, but he is not half-human, since his mother was the Muse Calliope. Though curiously he still was a mortal until his tragic fate led to an unfortunate outcome.
Peter Quill/Star-Lord of the Guardians of the Galaxy is half-human (mother) and half-Spartoi (father). He is physically indistinguishable from regular humans; his only powers come from cybernetic enhancements.
In the Taleof Solaron the rogue Blake is revealed to be the offspring of a human and a halfling, though he only looks like a short human.
In the second Interlude of Uplifted: Intervention, which is part of the Uplifted series, Tali's mother casually mentions that the company Daedalus Industries has successfully hybridized Human/Quarian DNA using Asari genetics as a baseline. Of course she mentions it while a young Shepard and Tali are sitting at the table together... Justified in universe by the fact that Humans and Quarians have been part of the same government since 1943 in the Uplifted verse.
The Mega CrossoverHalloween World and various side stories thereof are awash with Half-Human Hybrids of one sort or another, some of them distinctly unlikely, plus numerous half-anything-but-human hybrids and outright Heinz Hybrids. Justified in that magic in this verse has a tendency to get out of hand and a few people rather foolishly cast love/lust/fertilty spells that got really out of control.
In Divine Blood the Demons and Gods actively modified their DNA so as to be more human and allow them to infiltrate and manipulate humanity against each other. This led to them not only being genetically compatible with humans, but also with each other.
Averted in Chocobo Nights: the baby Tifa gives bears is apparently a purebred chocobo. Its only mammal characteristic is that it attempts to suckle. Yeah, it's that kind of fic.
Deconstructed in Morphic, a Pokémon fanfic about this sort of thing.
In The Tainted Grimoire, there is the Feol Viera who are half-Hume and half-Viera. Kanin is one of them.
Speaking of My Little Pony: Friendship Is Magic, "Satyrs" have become somewhat popular on 4Chan's /mlp/ board and sites like Derpibooru. Essentially they are the theoretical offspring of Anonymous and one of the ponies, with the entire Mane 6 having Fanon satyr children all with generally agreed-upon appearances and personalities. Even a number of minor characters like Gilda and Chrysalis have been done as well, and even one of the Diamond Dogsnote Anonymous is a sick, sick person.
Soul Eater fanfic uses this trope to explain how Death the Kid appears human while his father does not, and gives him a human mother. The anime never fully explained what the shinigami were, whereas the manga jossed the 'half-human' theory by revealing Kid is a Humanoid Abomination with a Truly Single Parent.
Barf the Mawg from Spaceballs, played by John Candy. "I'm a Mawg. Half man, half dog. I'm my own best friend!" Even worse, the gangster Pizza the Hutt is described as half-man, half pizza. So that's how those Pizza Boy Special Delivery scenes really end...
In Roger Avary's film adaptation of Beowulf, Grendel is a Half-Human Hybrid. He may be sterile (given his apparent lack of reproductive organs), and though it may just be because he's a monster he gives a good impression of being sickly. He's hideously deformed, has what appears to be a nasty skin condition, and is sometimes heard whimpering as if in pain (though that's probably just because loud noises irritate his super-sensitive ear). The dragon at the end of the film is also a Half-Human Hybrid, born of a mating between Beowulf and Grendel's mother. This is also very much unlike the original poem, where no human ancestry was suggested for Grendel except that he was a distant descendant of Cain.
In Sturla Gunnarsson's Beowulf & Grendel (2005), Grendel is referred to as a troll but his mother is some sort of sea creature. His son with Selma is this trope played straight.
B-movie Arachnid has a gigantic alien spider giving birth to all kinds of other huge bugs. Sometimes it is required to lay the eggs inside a human. We never get any clue exactly what, if anything, it was mating with.
In Splice, two married scientists pioneer a new technology to 'plug and play' any number of different animal's DNA together to produce new unique organisms. They decide to take the next step and insert human DNA into the mix. That worked out about as well as you would expect.
In Dreamscape, Alex is trying to help a young boy whose nightmares take the shape of a half-man/half-snake creature. One of the villains also later assumes this form while in the dream world.
District 9: After he is brought in to MNU, a scientist states that Wikus's DNA is in perfect balance between human and alien. It's only for a very short amount of time though, because the alien DNA is quickly taking over the human.
An early modern version is the boy Jervase Cradock, who is part Fair Folk in The Three Imposters by Arthur Machen.
Averted in Poul Anderson's short story, The High Crusade,which includes an instance of the humans finding one or more green-haired, feathery-antennae'd space babes. In the words of the narrator, "Nor was there any possibility of issue between [the Space Babe's] species and our own." Nevertheless, he indicates that the complications didn't stand in the way of Interspecies Romance... though being a priest, he does worry that "the prohibitions of Leviticus might apply," i.e. that it counts as the sin of coupling with beasts.
In cases where the two species involved are otherwise physically... incompatible, love springs have an inherent magic that overrules the laws of biology, allowing for even more bizarre blendings. When the two species are simply too different to coexist in a single form, they become were-creatures, able to transform from the one species to the other.
Hagrid had a human father and a giant mother. Madame Maxime is also at least part-giant, but trying to pass as "pure human."
Fleur Delacour is a quarter Veela.
Marcus Flint is often speculated to have troll-blood in him, though that might just be an insult and not meant to be taken seriously.
Professor Flitwick is "human with a dash of goblin," according to Word of God. Though that's more like "remote goblin ancestor."
Shadow from American Godswas the son of Odin and a mortal woman. Similarly, Charlie and Spider from Anansi Boys are the sons of the spider god Anansi and a mortal mother.
Tobias from Animorphs. His parents are Elfangor, the Andalite prince who gave him and the other Animorphs their abilities, and his human companion, Loren. Tobias's birth was possible due to Elfangor's own shapeshifting abilities — he lived as a human until the Ellimist takes him away to become the hero he was meant to be. While this would seem to make him all human, in the book The Illusion, he is able to have a vision of his father, an utzum, which occurs to comfort an Andalite warrior on the verge of death. This could be explained as a side effect of having acquired Andalite DNA from his uncle, Aximili, previous to his near-death experience.
Marion Zimmer Bradley's The World Wreckers includes a romance and eventually a child between a human and an alien chieri (one of a race of space elves). It's explicit in a number of the books that the Chieri and humans have been interbreeding infrequently for a long time now. In fact, it was the breeding program that created powerful psychics as well as leaving the nobility inbred with a number of "lethal recessives" was brought about to strengthen the psychic gifts inherited from the Chieri. Also, a number of Chieri features show up now and then in the noble families, particularly the ruling Hastur, including abnormally long life, tall slim builds, six fingered hands, and low fertility rates, even compared to the already low norm.
In Patricia Briggs's Hurog novels, half the cast have a dragon ancestor several generations back. (Dragons can assume human form.)
John Carter of Mars, the hero of Edgar Rice Burroughs's A Princess of Mars and subsequent books, had two children with Dejah Thoris, a red Martian princess. Martians lay eggs. Go figure. Then again, John Carter may not be human; he says he is very old and can recall no childhood. There is no mention of the other human/Martian couple in the series (Ulysses Paxton/Valla Dia) having children. The whole thing's made even stranger because it's strongly implied the various Barsoomian Human Aliens can't even fully interbreed with each other; In The Gods Of Mars the White Martians try to expand their gene pool with outbreeding, and get a bunch of pitiful monstrosities that are kept hidden away.
Averted in C. J. Cherryh's Brothers of Earth. A human man is isolated amongst humanoid aliens, but finds a place with them and gets married. Nobody expects the marriage to produce children and it is agreed that he and his wife will try for children for a year and after that the head of the household will step in.
In David Eddings's The Dreamers series, That-Called-the-Vlagh (or just The Vlagh) is a giant female insect who creates thousands and thousands of eggs, and whenever she sees a characteristic she likes, she mixes and matches animals with the characteristics she likes... creating the craziest creatures ever. But very, very, deadly.
Damsel of Austin Grossman's Soon I Will Be Invincible is not the actual child, but the genetic combination of her father's DNA and that of the Green-Skinned Space Babe he fell in love with. This is actually addressed with Damsel confessing that the combination isn't stable and she is constantly sick because of it.
Saaski, the protagonist of the Newbery Medal-winning novel The Moorchild is born among the Folk, which are the traditional Northern European idea of fairies (i.e., pagan spirits of nature fond of music and games, and completely amoral as long as something looks to be fun). However, she is actually the hybrid child of a Folk woman and a human man who wandered into their domain. As she's unable to exercise all the powers of the Folk, and seen as a danger to them, the Prince declares she must be sent out among the humans as a changeling child. Naturally, she doesn't fit in there either, as the humans fear and hate her, and she retains a terror of everyday features of human life like crosses, yellow flowers, salt, and iron (particularly unfortunate as her "adoptive" father is a blacksmith).
In William Hope Hodgson's The Night Land, the Giants are an extremely unpleasant example, "fathered of bestial humans and mothered of monsters." While generally humanoid in form, they're hideous, squat, furry, warty, and bigger than elephants.
In The Three Worlds Cycle books by Ian Irvine there are four humanoid species: Charon, Faellem, Aachim and old human. Those with ancestry from two of the above are blendings, three makes a triune and four makes a tetrach. This may be slightly played with as the books state that many hybrids are sterile, have a short lifespan and various mental and physical problems, these worsening the more "mixed" the blood is.
Also, at least some of these human species are directly derived from others. While it's likely there'd been enough genetic drift to make separate species, it's possible that at least a couple of these races are in fact from the same species. There are other non-human species in the series, but no-one's particularly keen to mate with them to see what happens.
Justified in Dark Lord of Derkholm in which Derk is a magician specialising in genetics and creates griffin children using his and his wife's DNA as well as cat and eagle DNA. However, it is implied that Derk's griffin children will have no problem having children with the "real" griffins that turn up in the second book (well... their Dad can help them out).
In Deep Secret a couple of centaur characters have human fathers. It's pointed out that it has to be that way round because a hybrid foetus would be too big for a human woman to carry.
In House of Many Ways, the insectoid lubbocks reproduce by laying eggs in humans. If the victim is male and doesn't have the eggs surgically removed, he will die, and the resulting offspring is another lubbock. If the victim is female, the victim will usually die in childbirth, and the resulting offspring will be a lubbockin (a Half-Human Hybrid that can interbreed with humans).
The mysterious gualdians of A Sudden Wild Magic. It's not very clear how they're not human, but they consider humans to be a different species and prefer not to interbreed, although it's definitely possible and humans often consider it desirable (to the extent of having very nasty plans for a captured gualdian).
Showed up fairly often in the works of H.P. Lovecraft: The inhabitants of the eponymous town in "The Shadow Over Innsmouth" come to mind in particular, but there were also "The Dunwich Horror" and the Jermyn family in "Facts Concerning the Late Arthur Jermyn and His Family". There's a bit of subtext reflecting Lovecraft's famed racist views in how the interbreeding is portrayed as so extremely unnatural.note The problem is not that he presented breeding with a gorilla or a "frog-fish" to be unnatural, the problem is that there was an unspoken component (you know, Subtext) that breeding with a non-white race is also unnatural, because they are no more human than a gorilla.
Averted entirely in Anne McCaffrey's Freedom's Landing series. There's only one species humanoid enough to be attractive to humans, and it's outright stated that they can't have children together. The children the heroine and her love have are from affairs on her part and a previous marriage on his, both with their own species.
In Un Lun Dun by China Miéville, the character Hemi is half ghost, half human. It's implied that it's extremely rare, and frowned upon by ghosts and humans, for such a pairing to occur.
In Eric Nylund's A Pawn's Dream, all the Dreamers are half (or less) human, as a child born of two Dreamers is incredibly powerful and therefore forbidden, as it would disrupt the balance of power. In this case the intermarrying isn't very far fetched, as the only differences from regular humans are the existence in both worlds and the ability to use magic.
In Tamora Pierce's Wild Magic, Daine Sarrasri is the child of a human woman (Sarra — thus the name) and the god of the hunt (Weiryn). Her mother later becomes a goddess in her own right (The Green Lady). Aly and Nawat's baby from the Trickster books also counts, being half-human and half-crow.
Lampshaded in H. Beam Piper's short story "When in the Course". One human female character is reminded several times throughout the story that, even though the inhabitants of Freya appear human, the two races "started in two different puddles of living slime, seven hundred light-years apart." At the end of the story, she announces that she's pregnant by a Freyan.
Played with in Brian Ruckley's The Godless World Trilogy. The world in question contains 4 sentient species (previously 5, before the werewolf race got wiped out). Of these only two are humanoid, the Huanin (humans) and Kyrinin (elves, but not as long-lived, wise or peaceful as elves tend to be.). The two races can interbreed, but the offspring, called Na'Kyrim, are always sterile and generally conform to real-life hybridization in terms of appearance and shared traits. They also develop a form of magic, known as the "Shared", which given the primary way to become a powerful user of it, tends to cause a great deal of mistrust in the average person. By the way things are looking by the end of the second book, they are very, very justified.
In Christopher Stasheff's Warlock of Gramarye books, Gwendylon Gallowglass of Gramarye is one-quarter elven (and her children are one-eighth). This is weirder than usual, because on Gramarye elves were originally an alien fungus shaped by the beliefs of humans with Psychic Powers.
J. R. R. Tolkien's Middle-earth books (The Silmarillion, The Lord of the Rings, etc.) there are a few human/elf children. In one of his letters, Tolkien said that biologically, humans and elves are the same species (though they are spiritually different), which is why they can interbreed; since orcs are presumed to be degraded creatures originally bred from corrupted elves and/or humans, they would be able to interbreed with us as well.
Only one Half-Elven family (descending from two separate mixed marriages, whose members married each other) is actually confirmed (that descended from Lúthien, Beren, and Eärendil). The early members of that family each had to make a choice to be counted among either Elves or Men, because elves and humans have incompatible afterlives for cosmic reasons. Not all members of that family chose the same, causing a lot of grief for them whenever close relatives were separated by the afterlife for all time.
The Uruk-hai are implied to be bred by Saruman from orc-human matings.
At least one Man outside the Númenórean royal line mentioned above, Prince Imrahil, is speculated by characters within the book to have Elven blood. This suggests the possibility of more intermarriage between Men and Elves occurring than just the three specifically mentioned instances in the books.
The half-Elven unions and offsprings mentioned in The Silmarillion and The Lord of the Rings involve (on the elven side) descendants of Elu Thingol, a Sindarin elf and Melian, a Maiar giving them all some Divine Parentage. This might imply that normal elves could not have children with humans at all.
Early notes on the story indicate that Tolkien originally assumed that being half-elven was not unusual, but no other ever appeared in his work.
In David Weber's Bahzell stories , humans have split into 5 separate species. Humans, Elves, Dwarves, Hradani, and Halfings. It is possible for any of the species to interbreed although only Elf-Human hybrids (Half-Elves) are common—several of the other matches produce offspring that die young or are infertile, although most of the human population of the Axeman Empire have some Dwarf blood. Half-Elves consider themselves to be the fifth species (since they came about before Halflings); however while breeding with each other and with full Elves preserves both the Human and Elvish traits, the offspring of a Human and Half-Elf will show a significant reduction in the Elvish traits. Finally it is established that only Humans and Half-Humans can be wizards or magi.
Used early on but mostly averted in the Star Wars Expanded Universe. Two unconnected characters are said to be "hybrids", and it's never explained exactly what species they're hybrids of. Since a lot of different species are related—humanity, for instance, has a long list of "near-humans", offshoots that can in some cases look very unusual—these hybrids might well be more plausible than some of the others on this page. There are also enough mentions of bio-engineering that some species might well be able to make a hybrid. However, in the few examples of Interspecies Romance, it's generally proven true that "the parts match up just fine, but that's about it", as Gavin says of Asyr.
In the X-Wing Series, a minor villain named Zekka Thyne is described as a halfbreed. It's never said what he is besides human, but he's got several Red Right Hands, namely very mottled skin, pointed teeth, and Hellish Pupils that catch the light.
One of the early Star Wars Expanded Universe books has a crossbreed mechanic whose parentage is also never described, who admits to Han Solo that he's not wholly of either species and is relieved when Han is okay with that.
The Star Wars Expanded Universe is filled with hybrids, due to the large number of "Near-Human" races, which aren't so much alien species as subspecies of humanity that descended from early space explorers who were cut off from the original human homeworlds thousands of years earlier, only to be rediscovered later. How far they diverge from regular humans varies; some just have different skin colors, while others have more extreme differences (the Miraluka, for example, have no eyes and see using The Force instead). On the other hand, species that aren't Near-Humans explicitly cannot interbreed with humans, no matter how human-like they appear to be.
Recent additions to the lore rendered near-human argument moot as not only near-humans can interbreed with humans but also species like Zabrak and Twi'lek.
Hybrids ("breeds") are so common in Glen Cook's Garrett, P.I. fantasy series, they sometimes outnumber the human characters. Exempting non-humans from military conscription, then inviting them in to work while your human subjects are off fighting a hundred-year war, can have unintended consequences...
Human/fairy hybrids appear prominently in Goblin Moon and The Gnome's Engine. They are prone to psychological instability and have unique responses to emotional stress, a fact which is central to the plot. A mixed dwarf/human marriage is also mentioned, although it's unstated whether children are expected to follow.
Averted in Neil Gaiman's Stardust, as Tristran and Yvaine get married despite their inability to interbreed.
A straight example would be Tristran himself, as his father was mortal and his mother was a fairy.
The Film of the Book, however, ends with mention of Tristan (different spelling) and Yvaine's children and grandchildren.
In Iain M.Banks The Culture novels, Culture comprises a number of humanoid species who were genetically modified at the Culture's founding to be able to reproduce with each other. Humanoid species from outside the Culture who lack such modifications would not necessarily be able to do the same, sometimes find that the Culture humans look a little unattractive. As masters of genetic tinkering and straight up body re-engineering, there's very little to stop the average Culture citizen from seeking out exciting new alien races as the gender of their choice...
Isaac Asimov's 'Tweenies' short stories features Martian-Human hybrids. There most noticable features are large white mohican crests and high intelligence. They are outcasts of both species. In the stories a sympathetic human ends up looking after several Tweenies, later becoming a small commune. Once older, they leave Earth to have adventures colonising Venus.
Michael Crichton's Next has Dave, the son of a researcher who manipulated his DNA and a chimpanzee's donated cells. He displays both human and monkey aspects, especially in personality, where he flings poo. It's also implied, that, playing with the theme of genetic engineering gone insane and that people never expect problems with their newfangled tech, he's aging rapidly.
Caspian's tutor, Dr. Cornelius, in Prince Caspian is secretly part dwarf, and it's implied that Caspian's childhood nurse is also descended from dwarfs who'd avoided Telmarine pogroms by passing themselves off as short humans. Caspian's own son is half star, stars being glowing humanoid beings in the world of Narnia. Furthermore, The Magician's Nephew states that the children of Narnia's first human king and queen married wood-nymphs and river-spirits.
In The Magician's Nephew, we also learn that the White Witch—and indeed, all people of Charn—is part giant.
Subverted in Jadis/the White Witch's case, as she only pretended to be part human to assert her claim to the throne. Her non-giant blood is actually genie (jinn), not human.
Vestakia from Mercedes Lackey's The Obsidian Trilogy is, by definition, hellspawn. Around eighteen years before the start of the books, a powerful wildmage discovered she had been seduced and impregnated by a demon who styled himself a Prince of Shadow Mountain. Casting something halway between a prayer and a spell, she was given a choice between making sure the child would be born looking normal and hoping a mortal upbringing would counter the evil in its soul or making sure the kid's soul was free of demonic taint while dealing with the outward effects of its parentage. She chose option B, confided in her sister, and (with said sister's help) ran.
Also in The Dark Tower series, the Can-Toi, or the "low men" are half-human, half-taheen.
In Tehanu, Therru turns out to be half dragon at the end of the book. Which really makes no sense, since she was only previously indicated to be a poor girl who was raped and then burned alive by thugs.
She's not half-dragon, she's something closer to a dragon in human form, and she's not the only one. Dragons and humans in Earthsea are strongly implied to be descended from the same original species, and Tehanu and other "dragon-people" such as Irian and the Woman of Kemay are not actual hybrids, but rather some sort of mystical throwback.
The Half Blood Chronicles by Mercedes Lackey and Andre Norton focus mainly on characters who are the results of elven lords impregnating their human slaves. The half-bloods/wizards are implied to be infertile, though it's never directly stated. The wizards find and save new half-bloods in order to perpetuate themselves as a society; they are never seen to have children of their own loins.
The Dragonlance series of books started the original Chronicles Trilogy off with one of the main characters as a half-elf, the conflicting emotions he felt stemmed from the mixture of his two races and serves as the character's main plot for most of the books; his name Tanis Half-Elven.
Played doubly straight. "Among the Elves... I am Half-Man."
The Bedlam's Bard series by Mercedes Lackey (and varying co-authors) has half-human, half-elven characters, but also states that the species are not cross-fertile unless deliberate actions are taken to make them so. One plotline in one of the books is Beth and Kory searching for a means to accomplish this without resorting to the means used by Perenor to father Ria (Which involved forcibly draining other humans of magic - with frequently lethal consequences).
Humans in Black Dogs seem to be able to hybridize with almost anything, from the plausible elves, Fridge Logic dragons and demons that vary wildly and posess more random body parts in otherworldly dimensions than you can shake a stick at. A couple of these hybrids are even main characters.
Though hybrids have yet to appear prominently in Discworld, it's mentioned a couple of times that humans with dwarf or elf blood exist. Nanny Ogg is the most prominent human character with a trace of dwarf blood, which may explain her short stature and hard-headed ability to survive ballistic farmhouses. It's also mentioned that humans can interbreed with werewolves, with unpredictable results, and at least one major character is a demigod.
In Kit Whitfield's In Great Waters all the royal houses of Europe (except Switzerland which is landlocked) have Deepman blood. Any hybrid not of royal blood is termed a Bastard and summarily executed, usually by burning. All hybrids have small, needle like teeth, black eyes with no white, clawed and webbed fingers and "legs" that are actually bifurcated tails which force them to use canes to walk. Because of inbreeding royals sometimes exibit other Deepman traits like bioluminescent blue skin (rare even among Deepmen) like Anne or tails that are whole down to the knees like Philip.
"The youth they tortured was like the tall man who came?" he asked at last. "As like as son to father," she answered, and hesitantly: "If the mind could conceive of the offspring of a union of divinity with humanity, it would picture that youth. The gods of old times mated sometimes with mortal women, our legends tell us."
In "The Scarlet Citadel," the alleged Back Story of Tsotha-lanti
In L. Jagi Lamplighter's Prospero's Daughter, Miranda learns that her mother was not who she thought she was, and therefore the demon that addressed a "nephilim" in her presence might have meant her.
The Nephilim of Angelology who are descended from FallenAngels called Watchers. They look like tall, pale and beautiful humans,have lifespans measured in centuries and have wings like their fathers. They also have a warrior caste called Gibborim who are pure white with red eyes but red wings which they can use to create and incendiary wind.
In Jasper Fforde's Something Rotten, the Bradshaws explicitly avert this; they don't have any children because he's a man and she's a gorilla. For double irony — they are fictional characters within the story.
Meredith Gentry, in the series of the same name by Laurell K. Hamilton, is Unseelie Sidhe on her father's side and (I believe) human, brownie, and Seelie Sidhe on her mother's. In fact, about half the cast are hybrids, half-human or otherwise. This is to say nothing of her kids...
The D'Artigo sisters of Yasmine Galenorn's The Otherworld Series have a human mother and a fae father. Additionally, Delilah was born with the powers of a werecat, and Menolly was turned into a vampire. Camille is a Moon Witch, but that's not exactly a species designation. Additionally, it would seem that interbreeding is reasonably common since "ordinary" humans are referred to as FBH's. (Full Blood Humans)
Bruce Coville's book Half Human is a collection of short stories all about this trope. These half-human creatures range from the traditional to the unexpected, with just a few examples being a girl who discovers one morning that her hair has turned into snakes overnight and that her mother doesn't wear a turban all the time just for the Nice Hat factor, another girl who was conceived when her mother drank dragon blood and begins exhibiting dragon-like mannerisms and sprouting ridges on her back when she grows up, and a treetransformed into a man who must learn how to be human.
Also present in Lynn Flewelling's Nightrunner and Tamir series, wherein the Aurënfaie and humans can interbreed, and such interbreeding is the reason some humans possess the ability to use magic. Such mixed-race individuals are known as Ya'shel (they would be half-elves in almost any other universe). This is all made even more interesting by the fact that the Aurënfaie are themselves part-dragon.
The Dresden Files has a couple of variants on these. There are changelings, who are the scions of humans and one type or another of the Fae. Outwardly, they look human, but as they grow older they take on characteristics of their Fae side; for example, a scion of a human and a troll would become large and brutish and with odd-colored hair. Eventually, the changeling has to "Choose" whether to embrace their faerie heritage and become a full-blooded faerie, or to remain human and lose the faerie powers. There's also Kincaid, a centuries-old hitman who is the scion of a human and something from Down Below.
Thomas Raith, who's the son of the King of the White Court of Vampires and a human wizard called Margaret LeFay Dresden, making him Harry's older half-brother. It's implied that most if not all White Court vampires are the offspring of a human/White mating.
In Aleksandr Zarevin's The Lonely Gods of the Universe, many humans are descended from a mix of the original humans and Human Aliens from planet Oll (who pretended to be Greco-Roman gods). Unlike their non-human ancestors, the hybrids are not immortal (the immortality is not due to genetics, though, but due to consuming an alien plant named Ambrosia that gained different properties on Earth). The only thing that appears to be the result of these inter-breedings is humans having different hair colors (apparently, original humans all had dark hair), thanks to the Ollans being redheads.
In The Mortal Instruments: Warlocks are the progeny of couplings between humans and demons. They are themselves generally infertile.
Apparently, a human can produce viable offspring with anything in Jane Gaskell's Atlan series. The invader from the first novel, The Serpent, is the product of a reptile mother and a human father, and later impregnates the heroine, Cija. In the fourth installment, The City, a red ape breeds with Cija, but her mother urges her to abort the resulting fetus.
In The Griffin's Daughter Trilogy, half-human/half-elves - like the title character, Jelena - are known as hikui among the elves, and are treated as second-class citizens, at best. Which is still far better than half-elves are treated in the (human-ruled) Soldaran Empire, where the local religion says elves are demons looking to steal human souls and half-elves are creatures of evil.
John's daughters in Dirge for Prester John: Sefalet (half-blemmye) and Anglitora (half-crane). Anglitora is considered fairly lucky to be a human-looking woman with a crane's wing while Sefalet has no face, instead having eyes and mouths in her hands.
Played straight with Chud', Lyud' and Tat' who can interbreed with humans. The descendants are capable of using the respective Sources of both parents. While Chud' and Lyud' often shun such children, Tat' actively works on both safeguarding their own bloodlines and on raising the amount of human mages by deliberately introducing Chud' and Lyud' genes into the population.
Averted with Moryanas. While a Moryana can bear children with a human, Chud' or Lyud' husband, she will only have daughters who will without exception be Moryanas.
In V. Zykov's Way Home elves are cross-fertile with humans, and half-elves are somewhat bound to elven laws.
Played straight and averted in Katharine Kerr's Deverry series. Dwarves and elves are infertile with each other. However, both races are fertile with humans. And a half-dwarf is shown bearing twin daughters to a father of half-elven heritage.
What really messes with your head is when said half-elf is turned into a dragon... and has a son with another dragon.
Several aspects of the hybridization are played with. There are three half-elf/humans shown in the cast. One is a weak, unstable character and magic/dweomer user, one is a strong dweomer user, and the third is a powerful warrior (but he probably would have been such regardless of his heritage). It is hinted that the human mother of the strong dweomer user may have had some elf-blood in her makeup, as well.
A Thousand Words for Stranger, the first book (publishing-wise) in Julie E. Czerneda's The Clan Chronicles series, mentions rather offhandedly that there are three known species with which humans can have offspring. In all cases, medical intervention is required and the child is infertile. It is implied but never confirmed that the Human Alien protagonist and her human love interest may also be inter-fertile.
In Katherine Kurtz's Deryni works, some characters have one Deryni and one ordinary human parent. The arcane abilities are a dominant trait, so having only one Deryni parent is enough to make an offspring Deryni, and the power isn't additive (in other words, having two Deryni parents doesn't make one more powerful). Sadly, this doesn't prevent Half-Breed Discrimination.
In the J.W. Wells & Co. series, Mr. Tanner, one of the partners, is half-goblin. (His shapeshifting goblin mother works as a receptionist for the firm.)
In The Sky Village, Mei/Dragonfly and Rom/Breaker are tri-human hybrids because they carry the "kaimira gene", which gives them beast (animal), human, and "mek" (robot) DNA.
Paul Richard Corcoran in Mikhail Akhmanov's Retaliation is the son of Lieutenant Abigal McNeil, who was captured by the Faata in the first novel Invasion and impregnated with the genetic material of a high-caste Faata with Psychic Powers. To maintain the secrety, the child was officially recorded as the son of Abigail McNeil and her lover Lieutenant Richard Corcoran (who was killed aboard the alien ship). Paul grew up to hate his biological father and the entire Faata race. His latent Psychic Powers manifest themselves when he is 37, right when the humans are preparing a strike force to pay the Faata back for the millions of lives lost during the failed Alien Invasion. Strangely, the fleet higher-ups don't consider Paul to be a liability and give him command of a frigate sent with the strike force, figuring his abilities may allow him to infiltrate the enemy. The subsequent books feature Paul's descendants as protagonists, as his genes begin to spread through humanity, and some of them exhibit his Psychic Powers and the "Corcoran curse". One of the descendants, Sergey Valdez, even manages to telepathically sire a child with a Lo'ona Aeo female name Zantu. The resulting child is genetically Lo'ona Aeo, but exhibits some human personality traits, such as desire for adventure and an ability to handle being near aliens (Lo'ona Aeo are xenophobic pacifists).
Akhmanov's Trevelyan's Mission series takes place in the same 'verse but about 500 years after the last Arrivals book. The main character Ivar Trevelyan eventually discovers that he himeself is a distant (about 1000 years) descendant of Paul Richard Corcoran, around the time he begins to manifest Psychic Powers and even gains the ability to teleport from world to world.
Averted with the other Human Alien races. The Haptors aren't even sexually compatible with humans. Many other humanoid races aresexually compatible but can't produce offspring together.
Subverted (and deconstructed) by way of Body Horror in Mickey Zucker Reichert and Jennifer Wingert's Spirit Fox. The heroine is a usually-human woman possessed by the spirit of a now-dead fox; she sometimes shapeshifts involuntarily into fox form. During one of these shapeshifted blackouts, she's impregnated by a male fox. She later suffers a miscarriage because her grotesquely malformed half-human, half-fox twin fetuses are not viable.
In Richard Ellis Preston Jr.'s Chronicles Of The Pneumatic Zeppelin, Max and her brother are half human, half "Martian". (The aliens definitely come from much farther away than Mars, but the name stuck.)
Mostly averted in the Riftwar Cycle: humans, elves, dwarves, goblins, dragons, etc. are different species, generally from different worlds. They may be mechanically compatible, but they can't produce offspring. Calis, the offspring of the Queen of the Elves and a half-human, half-Valheru father, is the only exception, and the impossibility of his existence is mentioned from time to time. (His father is pure A Wizard Did It, no breeding involved.)
Star Trek is awful about this, having numerous half-Earthling half-aliens in the various series (as if we wouldn't be able to relate to the characters otherwise). Spock was half-Vulcan. Troi was Half-Betazoid. B'Elanna Torres was Half-Klingon.
That's not so the audience can relate to the characters, but so the writers can do episodes about racism, or the problems people have adapting to different cultures when they're torn between two worlds. B'Elanna rejected her own culture because she blamed it for her bad temper and lousy life.
Hybrids apparently have a much harder time dealing with their dual heritage than most of their friends and colleagues.
Sarek rejected Spock for choosing to join Starfleet rather than the Vulcan Science Academy. They make up later. (If Sarek had actually had issues with humans, he wouldn't have married Amanda or had Spock.)
In an episode of Star Trek, Kirk, in a successful attempt to provoke Spock to anger calls him a "mutinous, disloyal, computerized half-breed".
The book The Science of Star Trek revealed that a Vulcan-Human hybrid is a biological impossibility to begin with — copper (the base of Vulcan blood) and iron (the base of Human blood) are chemically incompatible, and wouldn't be able to carry oxygen if they were somehow combined. And yet some Expanded Universe species have both chemicals in their blood, in separate cells.
Eventually the writers tried to mitigate this by establishing that although interspecies reproduction does occur, the probability of success is very low. As well, one episode shows that all the Human Aliens and Rubber Forehead Alien races share similar genetic stock planted by Precursors, which makes the whole thing a little more believable.
The chances of hybrid children can also be increased through science. On Deep Space Nine, Jadzia Dax (a Trill) and Worf (a Klingon) decided to conceive a child and sought Dr. Bashir's help in overcoming their physiological incompatibilities. Bashir treated the would-be mother with "ovarian resequencing enzymes" and reported encouraging results, but Dax's death at the hands of Dukat prevented the pregnancy from actually happening.
The novel The Final Reflection describes Klingon 'fusions' with other races via genetic engineering; John M. Ford, who also wrote the Klingon supplement to FASA's Star Trek RPG, used this to explain the changes in the appearance of Klingons through the TV series and into the movies. The main character, Krenn, a guest at the first Babel conference, attends a presentation describing the genetic engineering process that was used to produce Spock (who is a teenager at the time; in one of the many shout outs in the book, Krenn and Spock run into each other and play a game of chess) and suspects that the fusion process was stolen from the Klingons.
Crewman Tarses (introduced as part-human, part-Vulcan) is the victim of a witch hunt on board the Enterprise. Hounded by the over-zealous investigator of a sabotage conspiracy, he ends up revealing that the secret he's hiding has nothing to do with the sabotage: his nonhuman ancestor was Romulan, not Vulcan. Ironically, he lied to Star Fleet about his heritage to avoid racial persecution.
This actually becomes a plot point in Star Trek: New Frontier: An enemy of the Federation is busy studying hybrids for hints as to how to make the perfect body so that one of their own can wear one and infiltrate And it turns out it works, as either Nechayev was a hybrid all along, or she was kidnapped and a hybrid made to look like her infiltrated Starfleet.
Star Trek: Enterprise has the Villain of the Week, a raging xenophobe, create one in vitro from Trip and T'Pol's DNA, using it to represent the genetic doom that humanity is bound to plunge into if they continue harbouring aliens. Due to complications, it passes away, but Dr. Phlox reveals that naturally conceived hybrids ought to have no such problems (i.e. Spock).
Doyle from Angel was half-demon. In fact, most of the demons seen in the Buffy/Angel universe actually had some degree of human blood. "True" demons —such as the one the Mayor turned into —are monstrous, primal creatures with more in common with Lovecraft's gods than humanity.
Aside from the Nazi-esque "pure demons" The Scourge, who claimed not to be hybrids, but weren't any more powerful or less humanoid than other demons.
They were probably willingly ignorant.
Connor is an interesting case. Both of his parents are vampires (who normally can't have kids, but there was magic involved), but he seems human at first, though it's later revealed that he's part demon.
Sam and Dean Winchester from Supernatural are the direct descendants of Cainand Abel as well as the Nephalim. Their parents were even genetically engineered by heaven itself to create the perfect vessels for Lucifer and Michael
There is some debate over whether the Doctor Who TV movie on FOX was canon, and if the Doctor is in fact half-human, half-Gallifreyan, as was stated outright in that movie.
There is also some debate over whether the statement was intended to be true, within the context of the movie...etc, etc....!
In the new series episode "The Doctor Dances", although no Half Human Hybrids appear, it's mentioned that by the 51st century humanity has spread out among the stars, and has apparently had interbred and mixed into with every intelligent species possible. In fact, in about 5 billion years, pure humans are extinct, leaving only hybrids, engineered variants, and so on.
Likewise, "Gridlock" included a cat man having children with a human woman. They looked exactly like normal kittens.
"Evolution of the Daleks" is probably the most extreme example. Not only does Dalek Sec fuse himself with Mr. Diagoras to become a Human/Dalek hybrid, the "new Daleks" in the same episode, while looking human, are in fact humans whose DNA was replaced with a mixture of Dalek and Time Lord DNA. The latter was "accidentally" added into the mixture due to the Doctor's intervention and a very convenient lightning strike.
"Journey's End" had not one, but two half human, half Time-Lords showing up. One had only one life and heart though and the other could only be an extremely temporary thing. This is because it's more or less stated that it was just impossible to properly work. This would also seem to officially make the movie's claim about the Doctor's heritage Canon Discontinuity.
King Peladon, ruler of the planet Peladon, in The Curse of Peladon was half-Pel and half-human. His mother was a human princess. He later had a daughter, Queen Thalira. It's unknown who her mother was.
Half-human hybrids were one of the threats in The X-Files. (most notably the alien hybrids and the Flukeman)
For the most part averted in Babylon 5, where human/alien pairings and pairings of different aliens are rare and can't produce children.
Two very special cases, Delenn and Jeffrey Sinclair, serve as the only demonstrated exceptions to the rule, both of which were courtesy of extremely sophisticated biotechnology effectively indistinguishable from magic (see Clarke's Third Law) and far beyond the biotech capabilities demonstrated elsewhere in the series.
G'Kar specifically mentions that a direct mating with human telepath, Lyta Alexander, could be used to reintroduce the telepath gene into the Narn species with the aid of genetic engineering.
The existence of Cylon/human hybrid children is a central plot point of the rebooted Battlestar Galactica: There has been only one recorded case of a Cylon-human hybrid, Hera Agathon. The other turned out to be a subversion, as although we were led to believe Nicholas Tyrol was one of these, turns out the mother had been with another man around the same time she got together with her eventual (Cylon) husband.
The Finale reveals that Hera is the Mitochondrial Eve, and thus a common ancestor of all modern humans. In addition, Baltar and Cottle discussed interbreeding with the natives of the second (our) Earth. This means that modern humans are actually a mix of Cylons and two types of human, while what the Colonials would call pure humanity is extinct.
In Farscape. Scorpius is a hybrid of two alien races, Scarrans and Sebaceans, but suffers from many physical difficulties as a result, the most notable being maintaining an unusually high body temperature while being unable to tolerate heat. Also unusual in that Scorpius's conception and birth both took place under lab conditions, and prior to him, there had been over ninety failed attempts at creating such hybrids—all of which had resulted in the death of both the mother and the hybrid offspring.
But also played perfectly straight as well, with D'Argo's son Jothee, and John and Aeryn's baby.
It should be pointed out that the spoiler above is explained by (one of) the big reveals in the Peacekeeper Wars—Jothee is still a mystery though. Sebaceans are actually genetically engineered offspring Humans taken from Earth 10,000 years ago.
It is revealed in the ongoing comic series (the D'Argo's Trial storyline) that Jothee's conception required assistance from an expert doctor.
It is rather ironic that Sebaceans, with their emphasis on genetic purity, were the only race that was shown to have hybrids with more than one species.
Well, why would a race care about genetic purity if they couldn't hybridize easily with other races?
Another straight example: John was the only one who could have a child with a Sebacean princess whose genes were poisoned.
And for the record, in the same episode it was revealed that Luxans (D'Argo) and Nebari (Chiana) are not compatible.
Sebaceans and Hynerians are also shown to be incompatible.
Aeryn also technically qualifies, due to a Mad Scientist's experiment she ended up gaining some Pilot DNA.
Talyn is stated to be a Peacekeeper-Leviathan hybrid. That in itself doesn't mean much, since the Peacekeepers are an organization, not a species. Their ranks are almost exclusively made up of Sebaceans, which are physically extremely similar to humans. Leviathans on the other hand, are a species of living biomechanical starships, several hundred meters long when fully grown. Try to wrap that around your brain.
One could infer they were merely using the term "Peacekeeper" synonymously with Sebacean. The goal of Talyn was to create a Leviathan bred for war and controlled by a Peacekeeper via a neural link, instead of the normal Leviathan which carry no weaponry and are forced to rely on control collars and compliant Pilots to function. The implication therefore, is that Talyn possesses some trace amount of Sebacean DNA to provide the necessary compatibility.
Smallville has a Kryptonian exile on Earth who fathers a child with a human woman. It's also implied that a Native American tribe of skinwalkers derives their power from a combination of part-Kryptonian ancestry and Green Rocks.
The Stargate SG-1 sixth season episode "Forsaken" and its season 7 follow-up "Space Race" introduced the Serrakin, a spacefaring race that drove the Goa'uld off the planet Hebridan and formed a mixed society with their human slaves. The Serrakin and Hebridians frequently interbreed, producing a variety of individuals with features of both species.
Stargate Atlantis had a species of these, the Wraith, who were apparently a hybrid between humans and a beetle-like insect that sucks the life out of you. It gets even more confusing with the introduction of Michael, who is half-human, half-Wraith, and seems to oscillate back and forth on a regular basis.
Actually, the wraith were caused by half a million years of the bugs feeding and connecting to humans, to the point where they started to become just one creature.
Michael is a case of Unstable Genetic Code resulting from the Atlantis team's experiment at suppressing the bug genes of a Wraith. He's not so much half-Wraith as Not So Wraithy.
Earth: Final Conflict has an odd example in Liam Kincaid more properly Liam Sandoval-Beckett but no one calls him that, ever. He has three parents, two human and one Kimera and ends up with a kind of triple stranded DNA helix and a few special abilities. The entire manner of it is convoluted but the Kimera race were extremely advanced and had a demonstratable skill in genetic manipulation.
In one episode, Sandoval is revealed to be dying and requiring a transplant from a close relative. Unfortunately, his parents are dead (supposedly, killed by Zo'or when he leveled Sandoval's home island), and he has no children (none that he knows of, at least). Liam secretly donates the required materials for his genetic father, which brings to question why the doctor who tested the sample never commented on the triple-helix DNA, and why a proper doctor would even inject that into a human.
Averted on Monsterquest, where believers in the Monster of the Week occasionally claim to have found bones, hair, or living examples of this trope. To date, genetic or medical analysis has always concluded these either come from humans with physical abnormalities, or from known misidentified animals.
Wataru Kurenai from Kamen Rider Kiva is later revealed to be the result of his human father winning over his Fangire mother, Maya, aka Pearlshell. Although Wataru's heritage was hinted early on whenever he transforms into the titular Rider by Kivat.
The alternate world Wataru from Kamen Rider Decade is the opposite hybrid: the result of consummation between the Beetle Fangire and a human woman.
The Fallen miniseries is all about the Nephilim, the offspring of fallen angels and human females. The main character is a special kind of Nephilim known as the Redeemer, who can send repentant fallen angels back to Heaven. All Nephilim are orphans, as their fathers either don't know about them or don't care, while their mothers die at childbirth. While there are female angels, it appears they cannot get pregnant from a human male. Nephilim have some of the powers of angels, including wings, ability to speak and understand any language (including animals), and pyrokinesis (such as throwing fireballs and creating flaming swords). Like the fallen angels, the Nephilim are being hunted by the Powers, a group of non-fallen angels, who see them as abominations. A small group of humans also knows of their existence and wishes to use the Redeemer to get to Heaven.
The titular character in the 1998 Merlin series is a half-human hybrid born from a human mother and fairy magic. This becomes an important plot point in the novelizations.
Mel in the series "Tracker" finds out she is part Cirronian in the series's next-to-last episode.
Charmed first had Cole who was half human and half demon. He had demonic powers but have the power to actually feel. Then, Paige who is half whitelighter and half human. She had a hard time using her powers at first and it took her years for her to learn how to heal all by herself.
An then, Piper (witch) and Leo's (whitelighter) kids.
It is strongly implied that Whitelighters are all "ascended" former humans who either lived a life of service and self-sacrifice or died saving someone, so it doesn't seem exceptionally unreasonable that a magically enhanced ex-human might be able to sire children with a magical "regular" human. Still doesn't explain Cole though.
The season nine comics and the "Where Are They Now?" Epilogue introduce another type of hybrid: Cupid-Witches, the mix between witch (Phoebe) and cupid (Coop).
The titular protagonist of Merlin, who is the son of a human mother and a Dragonlord father, thus making him technically a creature of the Old Religion.
A variation in Grimm with Captain Renard who is a bastard son of a Royal and a Hexenbiest. It's never made clear if the Royals are Wesen or something else entirely, since they appear human, don't woge, and can't be detected by a Grimm. They may even be normal humans who have managed to gain power over the Wesen.
For an added bonus, when Renard woges, only half of his face shows his Zauberbiest side.
Renard and Adalin's baby is 3/4 Hexenbiest.
It's usually more complicated with Wesen-human pairings. A child of a human and a Wesen will either be a Wesen or a Kehrseite-Genträger (a human who carries Wesen genes). A child of a Wesen and a Kehrseite-Genträger will always result in a Wesen.
The Mercedes Lackey song "Mis-Conception" is about a...somewhat drastic...instance of this.
In fact, this is Older Than Dirt. Half-human children of the gods go back almost 4500 years with the Sumerian (Mesopotamian) myth of Gilgamesh, who was supposedly one third man and two thirds god — a heritage which would require an infinite number of ancestors, according to modern biology.
Other mythologies such as Greek are filled with the half-human children of gods and monsters as well. Zeus being particularly infamous, with upwards of 30 noted hybrids by mortal women, several of his hybrids ascending to the pantheon, such as Heracles and Dionysus. Even Judeo-Christian legend has Lilith's demonic children and the nephilim, the result of "unauthorized" human/angel relations.
Presumably, if you were a god, you could use some miracle to make it work out between yourself an a mortal, meaning that as silly as it sounds, this might actually be justified.
Both Loki and Thor from Old Norse religion are half-Aesir half-Jotun hybrids - Loki on his father's side, Thor on his mother's.
Loki is full Jotun. His parents are the Jotuns Laufey and Farbauti. Odin himself is half-Jotun and half-Aesir...his father Bor was Aesir but his mother Bestla was a frost giant. Thus making Thor three quarters Jotun and one-quarter Aesir. Loki's children Narvi and Vali born of the Goddess Sigyn would qualify as half-Jotun and half-Aesir. Magni, Thor's son with the giantess Jarnsaxa would be seven eighths Jotun and one eighth Aesir.
Loki was willing to have sex with anything and he did. In various stories he both fathered and mothered a great number of children, several of which were extremely important in the cosmology. (For instance: Hel, Fenrir and Jormugand—children of Loki and his Jotun/Giant wife despite the latter two appearing like animal-monsters—and Odin's horse Sleipnir.) Since Loki is not human and is also a shapeshifter most of these technically don't count as half human hybrids, but they are hybrids of a sort.
Merlin is traditionally depicted as the son of a woman (sometimes a witch, occasionally a nun) and an incubus. Or, sometimes, a man and a succubus. This is often given as an explanation for his magical and prophetic abilities. Modern interpretations of the legends vary significantly on Merlin's parentage.
This was the result of the Christianization of the legend, to explain how Merlin could wield magic powers (which are always Satanic), but still be a good guy. The woman incidentally is nearly always a raped nun who dunks her newborn into holy water to wash evil away from him as soon as he is born, but he still grows up a horny bastard with a taste for young virgins—the modern tellings tend to forget that aspect of his character.
Pretty sure in both the Christian and non-Christianized versions of the Arthurian Tradition Merlin was depicted as something of a fey spirit. So, half fairy was more like it. See works like the Elfin Knight, which predates most of the Malory as we know today. In the History of the Kings of Britain Merlin was depicted as born from a rather consensual experience. Try not to think about that too much.
... And if you want to go back to the source material with the myth of Myrddin and his sister, it's implied that they both have 'magical' heritage. However, the emphasis is more on Myrddin's far-reaching Sight than anything else.
In Greek Mythology, the minotaur is one of these. The minotaur's origin is rather convoluted. The King of Crete asked Poseidon for something marvelous he would then sacrifice to the sea god; Poseidon sends a magnificent white bull. It's so awesome a bull that the king didn't want to actually sacrifice it, and instead offered one of his own bulls. Naturally, Poseidon was annoyed, so he caused the queen to fall in love with the bull, have sex with it, and get pregnant by it. The offspring? The Minotaur.
From Eastern Europe (especially, but not limited to, Roumania) there is the dhampir or dhampire, child of a vampire and a human. Dhampir are meant to be excellent vampire hunters, but have a nasty habit of becoming vampires themselves when they die in many of the stories. Most half-human half-vampire characters in fiction draw on the dhampir mythology to some degree.
Then we can go to Japan. Japanese folktales are rife with henge, usually Kitsune, taking the form of human women, marrying humans, and having children. Abe no Seimei, a surprisingly close parallel to Merlin, was reputed to be half Kitsune.
A minor figure in the mythology of The Church of the Sub-Genius is Saint Oliver the Humanzee, who even has his own feast day. There really was a chimp named Oliver who was suspected of being a Humanzee, but DNA tests eventually revealed he was just a funny looking chimp.
In some cultures in South America, there are tales of half-dolphin half-humans (the river dolphins, botos, can turn into people who almost always wear white hats) who end up with blow holes on their heads and pink-white skin.
The Bible is very hush-hush on what the Nephilim were, but the most common theory is human-angel hybrids.
"And the sons of God looked upon the daughters of men and saw that they were fair, and took wives of all that they chose— and there were giants in the land in those days."
Arguably the basis for the Nephilim in Hand of Mercy though interestingly the human-angel hybrids don't get any powers or advantages. Instead, they get horrific bone deformities, since the bones of angels are light as chalk in order to aid flight.
The new Moon Maid from Dick Tracy. She was originally Glenna Ermine, the daughter of villain Poise Ermine. She won second place in a look-alike contest for the original, long deceased Moon Maid, and subsequently was kidnapped, had the original Moon Maid's DNA superimposed over her own, had facial surgery, and was given the original Moon Maid's memories. The scientists involved were using her as part of a plot to steal Diet Smith's Space Coupe.
Alex Campbell from the Eighth Doctor Big Finish Doctor Who audio stories An Earthly Child, Relative Dimensions, Lucie Miller and To the Death was the son of Time Lady Susan Foreman (The Doctor's granddaugter and very first companion) and human David Campbell. Although, it was revealed that only 7% of his genes were Gallifreyan so the only signs of his heritage were a powerful immune system. Other than that, he was non-telepathic, non-regenerative and only had one heart. The bit about him being unable to regenerate later had tragic consequences in To The Death.
Also from the Whoniverse; ex-companion Bernice Summerfield conceived a son with a Kiloran (humanoid with canine overtones) called Adrian Wall while she was possessed by a soul sucker called Avril Fenman. The birth didn't go so well as he was too large to be deivered normally so Benny had to undergo a C-section while in a prison cell. After being saved, he was named Peter Guy Summerfield. Being half Kiloran he looked mostly humanoid but with a few furry patches, dog-ears and a wet nose. He was also stronger than all but the most augmented humans by the time he was eight. This became important when Braxiatelmanipulated/hypnotised him into killing Jason.
Mortasheen has a class of monsters based on this concept. But, given the nature of the series, you probably won't be surprised to learn that they're Brundlefly-style arthropod-human hybrids of about every notable insect one could think of.
Series in the fantasy genre descended from Tolkien usually just use "half-elves", with the occasional half-orc, half-dwarf, half-minotaur (minotaurs themselfs in mythology being an example, see above.), etc.
Dungeons & Dragons has taken this trope to nearly ridiculous levels, up to and including half-dragons. (This last has been explained by the fact that dragons often have the ability to polymorph, or change their shape.)
In addition, "Half-breed" could be both a race and a template. Half-Orc and Half-Elf were races, but Half-Dragon and Half-Fiend were templates that could be added on to any sentient race. Applying one to the other yields results like, "Half-Dragon-Half-Half-Orc". What would that family reunion be like?
Probably because dragons can take any humanoid form so it would depend on what form the dragon was in at the time of the breeding.
Another example would be the Muls from Dark Sun, who are obviously based off of mules. They're half-dwarves, and lack the ability to reproduce. They are usually purpose-bred, being stronger, and having far greater endurance (can work for days), than either parent species, but their chances of surviving to come to term, and of the mother surviving bearing them, are somewhat low. Still, their great value as slaves means that the casualties are worth it.
Dragonlance had the Gully Dwarves - half-gnome, half-dwarves who are borderline mentally retarded (for example, they're completely incapable of counting past 2). After seeing what they had begat, gnomes and dwarves vowed never to interbreed again, on pain of death; however, by this time, Gully Dwarves had become a viable race of their own.
Also in Dragonlance, the hero Tanis Half-Elven. He seems to have increased life-span, pointy ears, but no other benefits. Spends a fair amount of time sulking about how rejected he feels by both races (don't call him "Half-Man"!).
In the Eberron campaign setting, half-elves have graduated into being a full-blown "race" in their own right. Their earliest ancestors were human aristocrats and elven opportunists looking for an inheritance from the short-lived humans (not knowing at the time that their species were mutually-fertile). Born into the aristocracy, these half-elves had an easier time marrying their own kind since noble marriages are typically limited to other nobles. Eventually they went on to become a true-breeding race and most modern half-elves are born to half-elven parents, with only a small minority coming from human/elf pairings. They have even developed two Dragonmarks, which are generally unique to specific bloodlines within specific races, thus further cementing their perceived status as race unto themselves apart from elves and humans. Half-elves (or Khoravar as they like to call themselves) can still interbreed with humans and elves, as well as with the Kalashtar.
Averted by Ravenloft's "half-Vistani", as Vistani are simply a human ethnic minority, albeit with some unusual supernatural baggage. Averted differently by several Ravenloft monsters, including red widows and dread doppelgangers, which mate with humans but produce their own kind rather than hybrids.
In Al-Qadim (Arabian Adventures setting) locals consider marriages between different creatures pretty normal as long as they are interfertile. This includes half-elves and half-orcs, but also it's specifically said that a proper Magically-Binding Contract allows a demihuman and a genie to have children.
In 3rd edition, a fairly substantial chunk of the populace (and two player classes) was descended, at least remotely, from dragons.
2nd edition lampshades it with the Mongrelmen, a monster race that's said to be the result of centuries of cross-breeding and tend to have mismatched bits of fur, scales, hide, etc.
4th edition half-elves, gain bonuses that correspond to neither of their parents.
You'd think the above would be enough but there are also people who are 75% humans, 25% something else. These including planetouched (Aasimar, Tiefling-descended from angels and demons/devils/daemons) Genasi (descended from elementals- Air, Earth, Fire, Water) and Yuan-ti (part reptile). And that's before we hit heritage feats and bloodlines. You've got to wonder if there is such a thing as 'pure' humans in the D&D universe.
It's somewhat notable that, in Fourth Edition, Aasimar, Tieflings and Genasi were all retconned to remove the half-human background. Tieflings are the descendents of humans who made a corruptive pact with devils, Aasimar (now renamed Devas) are Angels that gave up their "angelhood" to become more like mortals and who continuously reincarnate/resurrect (Time Lord style) rather than breeding, and Genasi are humans infused with the energy of Earth, Air, Water, Fire, Storms, or any combination of the five.
Earlier editions also featured the unusual Cambion and Alu-fiend demons, who were the half-human children of incubi and succubi respectively. Interestingly, both had a slim chance of not having the ethics of being pure evil, which put them heads and shoulders (morally speaking) over most other fiends.
Perhaps most disturbingly, the Book of Erotic Fantasy includes a table of crossbreeds, which implies that humans and dragons are the only two species which can have sex with virtually anything and produce viable offspring.
At least two half-kenders (Tarli and Scrounger) appeared in the Dragonlance novels, so it's canonical that the two races can crossbreed — albeit for obvious reasons it isn't something that happens often. There's even stats for them in the game at both the Dragonlance Nexus and Kencyclopedia. They also happen to be the one race on Krynn with even more angst than half-elves, due to being torn between their human and kender instincts/desires (mainly the border-line kleptomanical curiosity of their kender side and the fact their human side actually gives them the ability to understand such concepts as "ownership" and "private property") and the fact that no other race on Krynn trusts them. The average human, elf, etc considers a half-kender to be a "stealth kender" you can't even realise is a kender and so realise you need to protect your stuff from them—and thusly folks are quick to turn on half-kender when they realise their origin.
In the third book of The Cloakmaster Cycle one joins the crew and, of course, Hilarity Ensues. She "picked up" stuff out of curiosity as kenders do, but wasn't too distracted to remember where and put it back after examining. All this was pulled so well that instead of being a Sue Bomb she ended up praised as one of the best sidekicks ever and fan-preferred Love Interest. Later she was able to concentrate long enough to learn psionics (which in AD&D era implied above-average Intelligence and impressive Wisdom score, whether the teacher is an ancient supra-genius slug or not).
That said, this trope is averted in Classic D&D, which has races as classes. An elf and a human can certainly start a family with each other if they wish, but the result of their union will be either an elf or a human.
And then, Pathfinder, where Sorcerors (innate magic users) gain their powers from various supernatural forces breeding into their bloodline. The following is a current (early 2012) list of things which have created bloodlines for sorcerers: Aberrant (think Cthulhu Mythos like monsters), Abyssal (Demons or worse), Accursed (Hags), Proteans (chaos spirits), Aquatic (anything from sea elves to deep ones), Arcane (plain ol' A Wizard Did It - and how!), Boreal (giant & troll kin ala Norse Myth), Celestial (heavenly creatures), Deep Earth (earth spirits), several different kinds of genies and all four Western elemental types, Draconic, Fey, Infernal (Devils), Maestro (some musical monster from trumpet-wielding angels to shoggoths), Orc, Rakshasa (evil spirits of Buddhist myth), Serpentine (your friendly reptoids), Shadow (another dimension), Starsoul (spacefarers), Storm (unknown elemental spirits), Undead, and Verdant (plants). It's probably better not to ask how some of those happened. There are even more bloodlines available from third party developers or for characters with unusual archetypes.
There's no rule that says such a sorcerer can't also belong to a race which is already a half-human hybrid. A dhampir (half human, half vampire) sorcerer could have an Abyssal bloodline and the half-celestial template. Special Snowflake Syndrome can really run amok here if a GM allows it to.
Pathfinder Sorcerers can be either this or Lamarck Was Right. So the Undead bloodline, for example, can (thankfully) be as a result of a curse or an ancestor who turned himself into a Lich.
That said, the game does take it further than just Sorcerers. Human characters can be given a trait that basically lets them pick up genetic feats and traits from any of the Humanoid races in the game.
Munchkin offers a Half-Breed card that will allow a character to be two species or one species without any of that race's disadvantages.
The seventh expansion, Even More Good Cards, gave us the Chimaera and One-Third-Breed cards. Does it make your brain hurt? It should.
Cthulhu Tech features both positive and negative examples. Nazzadi, essentially humans engineered to match the Proud Warrior RaceRubber-Forehead Aliens tropes that ended up a bit too good on the Honest Warrior Poet side of the scale, are essentially recognized and treated as humans by almost all of the New Earth Government. They're genetically similar enough to interbreed with humans. Such hybrids are supposedly treated like anyone else. Outsider Taint is a more magical sort of hybrid, formed either the natural way with The Deep Ones or through the wrong sorcery roll, and are treated a bit less kindly by the NEG—the lightest Outsider Taint makes you legally inhuman. Since it tends to come with unnatural cravings, freakish appearances, and whispers of ancient gods in the ear, that might be justified.
This might be an aversion regarding the Nazzadi hybrids, since Nazzadi are humans with very slightly altered DNA. It's similar to two humans with different color skin having kids.
Exalted has lots of these, but with a slight twist: God-Bloods, Fae-Bloods, Demon-Bloods, Beastmen, and Ghost-Bloods are actually significantly weaker than the "normal" races available for play. They're a step above ordinary humans, sure, but the titular Exalted outclass them by far. Beastmen, by the way, are exactly what they sound like.
Also a bit more realistic in terms of viable hybrids than most; humans can, under normal circumstances, only interbreed with beings made of Essence (like spirits and raksha) and with the Mountain Folk (who were created before humans and which humans were based off of). Breeding with actually non-human races (such as the Dragon Kings) is impossible without powerful magic. Even the breeding with animals generally requires one to be in the Wyld (which is also an environment where animals can breed with rocks).
Averted for the most part in Rifts; Dog Boys and their ilk are NOT Half Human Hybrids. They look it, and in the hands of lesser players may act it, but they're really just very smart dogs who were genetically engineered and raised by humans. Hybrids are specifically said to be impossible, unless one parent is a God or Demon.
Played with in a typically horrible fashion with genestealer hybrids, though in an unusual take the original Genestealer itself is never a parent—it infects another creature with its genetic material, and when that creature reproduces normally with another of its kind, the offspring will be part Genestealer.
Necron Pariahs are horrifying hybrids of Untouchable humans and Necron technology.
The idea of human/Eldar hybrids is something that flip-flops back and forth, Depending on the Writer. Old Rogue Trader fluff had a Space Marine Librarian who was hinted to be one, and one of the Black Library books, "The Chapter's Due" had a minor character, a Corsair leader who was rumoured in-universe to be half-Eldar. The newest Eldar/Dark Eldar fluff writer Phil Kelly seems to support the idea of such unions, although given the less-than-stellar relationship between the two races note the average Imperial official would likely execute you on the spot for even thinking about such vile heresies, and the fact that Eldar call us "mon'keigh" kind of says everything you need to know about their views on us, it's highly likely that one of them would not be a willing participant, especially if a Dark Eldar was involved.
Speaking of the Updated Re-release, Ghouls in both games are an aversion—while they do have some vampire-like powers and are immortal, that's beacuse they're normal humans who have drunk vampire blood—more Touched By The Undead then Half Vampire. They are occasionally referred to as halfbreeds by ignorant Hunters.
The NWOD's version of half-vampires turn up in Night Horrors: Wicked Dead: Dampyr, the children of vampires and humans, walking curses on the Kindred. The presence of a Dampyr can utterly ruin a vampire's life, and the Dampyr may never realise what happened, because the effect they have on the Kindred is completely unconscious on their part.
Changeling The Dreaming featured kinain, changeling-human hybrids whose closest claim to fame was not driving fae sane.
Changelings themselves were half-human hybrids, as they were the result of a fae soul merging with a human soul. The Dark Ages book contrasts changeling with fae by showing how... well, off some of the Good People could be.
While the changelings in Changeling: The Lost are, for the most part, sterile, other creatures in the setting can have kids with humans. Fetches, the impostors the Gentry leave behind when they take humans, can occasionally produce fetch-children (just a little bit odd) and fetch-spawn (evil incarnate). Incubi, likewise, can occasionally produce cambions, children who can see fae things and who have an innate connection to the world of dreams.
Then there are "Les Enfants Diaboliques", the Lucifuge's evil counterparts - they're the ones who chose to embrace their heritage...
Averted in Shadowrun, where the various metatypes (humans included) can breed freely with one another, but their offspring don't blend the traits of their parental strains. A child of different metatypes will have the type of its father, that of its mother, or (rarely) a completely different type. This is because metatypes are really more akin to breeds than separate species - elves and dwarves spontaneously began to show up in human births around 2010, while the first orcs and trolls were caused by a bizarre biological process called "Goblinization" that struck random humans shortly afterward.
This was already being parodied by the Victorian period: in Gilbert and Sullivan's Iolanthe, Strephon is half a fairy, "The upper half, down to the waistcoat", and worriedly ponders what he'll do when his lower half grows old and dies.
The computer game Arcanum carries the usual run of fantasy hybrids - half-elves, half-orcs, etc. Of particular interest here are the half-ogre race as an example of hybrids viewed in a negative light: Half-ogres are a race created by a crude eugenics program. The game's rich gnomish society required a race of bodyguards, and found the rare half-ogres ideal. Because human mothers were a lot easier to obtain, this led to the mass kidnapping, rape, and eventually fatal impregnation of human women until there were enough half-ogres to continue the race in perpetuity. Gnomes are not nice people in this game.
All the races are evolved from either humans or dwarves. Orcs, ogres and elves all came from humans; gnomes and halflings from dwarves. (Why we don't see gnome-halfling hybrids is less clear.)
They wouldn't be much different from either race, one can assume.
Alucard, Dracula's half-vampire son in the Castlevania games, though the vampires may not neccesarily be a non-human species in Castlevania.
It is stated in at least one of the games that Dacula was a human, but when he lost his faith in God, he became something akin to a demon/vampire.
In The Elder Scrolls, the Bretons are a racial blend of men and Aldmer (elves), a result of generations of humans being enslaved by elves. As a result, the Bretons have more skill with magic than any of the other human races but lack the physical vulnerabilities of the elves.
It might not be accurate to call them Half-Human Hybrids, however. They're aren't so much "Half Elf", but rather humans who have some Aldmeri ancestry way back. Most are no more Aldmer than Imperials are Tsaesci (in fact, the Imperials' Tsaesci ancestry is more recent).
Positive example from Oblivion: the Septim Emperors, who are worshiped and claim a divine right to rule by virtue of being hybrids, in this case, between man and dragon (the god Akatosh). Their heritage also happens to make them the only ones who can use the game's MacGuffins to raise and maintain the barrier between Tamriel and Oblivion. Failing that, Tamriel gets overrun by hordes of daedra.
Also Agronak gro-Malog, "the Gray Prince", is half-orc, half-human. Or rather, half-vampire.
Karliah of Skyrim's Thieves guild is rumoured to be one as she has violet eyes, opposed to the black and red eyes universal among Dunmer. However it may also be because she is a direct descendant of Queen Barenziah, who also shared this unique trait.
In Skyrim, the Dragonborn is often mistaken for one of these, even in-universe, with various characters joking questioning which parent was the Dragon? The truth however, is that their parents were always mortals, and biologically the Dragonborn is also mortal. However, the Dragonborn's soul is that of a dragon.
True half-breeds are rare, since in most cases the mother's race determines what the child will be born as.
However it is stated via in-game material that all species of Men and Mer are biologically compatible and will generally be the mothers species with some traits from the father. This includes Orcs, Khajiit Dunmer who were changed via divine intervention for various deeds, misdeeds and whims.
Asellus from SaGa Frontier, is a Half-mystic. In her case, she was an ordinary human given a blood transfusion from the Mystic who accidentally ran her over with his carriage. She became a hybrid as a result. Humans generally fear and hate the mystics due to their magic and oppressive nature (as noted when Asellus tries to visit her aunt), but despite what guides tell you, the mystics, while somewhat mocking, mostly accept her. Canonically, she remains half-mystic, but the game has three endings that can either have her remain that way or become fully human/fully mystic. Asellus, as a hybrid, can use both a limited movepool of magic and a bunch of human techniques.
The Shokan in the Mortal Kombat series are said to be half-human dragons, despite looking like the long-lost children of the Hindu cosmology's Shiva (which, coincidentally, one of the more popular Shokan is named after). Furthermore, the Shokan Kintaro is also part tiger, thus further muddling the waters of Shokan DNA. (To be fair, though, Kintaro was originally going to be a simple tiger-man, which would still make him a Half-Human Hybrid.)
Similarly, Mileena is a half-Edenian, half-Tarkatan Mutant, though due to her nature as an artificial clone, she could also be considered a Mix-and-Match Critter.
Finally, Mortal Kombat Armageddon protagonist/antagonist Taven and Daegon are half-Edenian, half God. Technically, Rain is also one, but that goes into retcon territory.
Final Fantasy IV, Cecil and his brother Golbez are half-human and half-Lunarian. They're the same as regular humans mostly, but Cecil doesn't know of his heritage for most of the game, while Golbez and Fusoya are both damn powerful mages.
Final Fantasy VI has the character Terra, half-human and half-Esper. This mostly manifests as occasionally losing control of her powers and being controlled by a Superpowered Evil Side, as well as the power to use magic innately. The game also has a number of Magitek soldiers, though Celes and Kefka are the two most reputable. In order for Magitek soldiers to even go into production, the Gestahlian Empire needed a living sample as a template — the half-Esper. Celes is what happens when they get it right; Kefka's the result when they get it wrong.
Final Fantasy VII has Aerith, the last of the Cetra or "Ancients," who had a human father and a Cetra mother. According to Professor Hojo, she's 18% less Ancient-y than her mother. She's mostly normal aside from the fact she hears the planet speak to her, and can use magic without Materia.
In Final Fantasy VII, regular humans are an offshoot of the Cetra anyway, descended from those who gave up their nomadic lifestyle and close connection to the Planet and thus lost the accompanying powers of empathy and healing.
Final Fantasy X had a typical villainous example in the form of Seymour, a half-human, half-Guado.
The Final Fantasy XI expansion Wings of the Goddess features Lilisette, a young woman who was part Hume, part Elvaan.
In Tales of Symphonia, half-elves are treated as their own race, distinct from either humans or elves. They're also subject to prejudice from both species. It's never outright stated what degree of the other species makes one a half-blood, but there was a testing system in place to see if they were. Ironically, it's revealed that one has to have elven blood to use magic; thus, almost every single member of the team is descended from the offspring of elves and humans.
Other than Genis and Raine (who are of elven blood), and Sheena (a far-removed descendant of elves), everyone eventually manages to work around this limitation in some way to use magic anyway. Zelos and Kratos both have magitek implants which let them cast spells, whereas Collete, Kratos, Presea, and Lloyd all learn non-traditional magic abilities due to the Cruxis Crystals slowly turning them into "angels" and/or eating them from the inside. Regal is the only one that never uses any real magic, as all of his techniques are ki attacks. In the sequel, Marta has far-removed elven ancestors like Sheena, and Emil is actually a summon spirit.
In Tales of Rebirth, elves are replaced by beastmen/Gajuma. Those born between Huma (humans) and Gajuma are called 'Halves', and not only they suffer the heavy prejudice, they're also stuck with a weak body, which means, unless miracle happens, they tend to have short lifespans. There are two Halves existing in the game: one of the Four Shields Militsa, and fortune-teller Hilda Rhambling, the latter joins you.
The party also finds a village with a significant population of halves.
Dante and Vergil of Devil May Cry, sons of the devil Sparda and his human wife Eva.
If you're willing to look past some story difficulties, Nero's a quarter-devil.
Averted, subverted AND played straight in the 9th and 10th Fire Emblem games, the Laguz can only breed within a tribe (Beast Birds and Dragons) but each can breed with other groups in the tribe(Ravens with Herons, Red Dragons with Black Dragons) but can't breed with other tribes (no Hawk/Dragons), but any of them can breed with beorc. They play the 'outcast of society part' to a T as well, and that for whatever reason a Laguz that breeds with a Human loses their ability to transform. Branded (as Half-Human/Half-Laguz are known in the games) are outcasts of society and generally pitied or hated (or both). Turns out that the reasoning behind the hatred towards Branded is entirely false. As Yune (a godly being) explains there was no great god-made edict that everyone thinks there is. Notable Branded characters include Micaiah, whose grandmother was the Apostle of Begnion, who had planned to reveal her Branded status to the nation before she was assassinated, Soren, who is the son of Ashnard and Almedha, a princess of the Dragon Laguz tribe, Stefan, who is heavily implied to be descended from Soan, one of Ashera's three heroes, and lives in a village of branded that he eventually turns into a powerful country that he rules over as king, and Zelgius, whose Branded status is what led him to becoming Sephiran's most trusted servant.
Fire Emblem also had a few human-dragon hybrids in the 6th and 7th games: Sofiya in Fuuin no Tsurugi and Ninian and Nils in Rekka no Ken.
Furthermore in the 6th game, depending on your pairing preferences, Roy can end up three quarters human and one quarter dragon, since Ninian is one of the three main characters that Eliwood can end with.
In Fire Emblem Awakening, Nowi and Tiki of the Manakete race, and Panne of the Taguel race can each potentially become the wife of one of the human males in the cast, which eventually leads to their hybrid children from the future assisting them.
Mass Effect normally averts this. Most interspecies couples have to take steps to avoid poisoning each other with their bodily fluids. Bearing children is right out of the question. The asari, however, can mate with and produce offspring with any species, but that offspring is always an asari; the mating process randomizes the asari partner's DNA; no DNA from the other partner is carried on. Asari culture even encourages mating with other species, leading to a great deal of prejudice against the daughters of asari/asari unions. The reason for this prejudice is due to asari/asari unions having the rare chance to produce Ardat-Yakshi, who possess a birth defect that causes them to burn out the nervous system of anyone they mate with, causing their death.
While offspring are always asari, they often seem to have traits taken from their fathers. A matriarch you can meet who had a krogan father is gleefully coarse and violent and has had more children than her species normally seem to give birth to, from several different alien partners (including Hanar). Whether this is due to genetics or being raised by said Krogan is up in the air. Mordin once sings a snippet of a patter song that included the lyrics "Asari-vorcha offspring have an allergy to dairy", implying that there is some physiological difference.
Parodied when Matriarch Aethyta half-jokingly suggests that she passed some of her own Krogan traits onto her daughter, Liara, who has taken several levels in badass since the first game. When Liara gets irritated at the suggestion that this might explain if she's ever had the bizarre urge to headbutt people, Aethyta then jokes that she's starting to go all "Blood Rage" on her.
Samus Aran, the protagonist of the Metroid series of videogames, technically qualifies. Though born to human colonists, she was raised by a race of humanoid birds called the Chozo; at the age of three, she was genetically manipulated into a half-Chozo hybrid, to allow her to survive the harsh conditions of the Chozo colony world Zebes. Despite being a hybrid, the changes to her DNA haven't altered her appearance. It's pretty clear she's not entirely human when she can jump twice her own height outside of the Power Suit, though.
Complicated to the point of Mix-and-Match Critter in Metroid Fusion, wherein Samus is injected with Metroid DNA in order to save her life from a parasitic organism. This actually does alter her appearance somewhat, in that her Power Suit—which is biologically linked to her—grows a layer of Metroid flesh on its exterior.
Youmu Konpaku, a half-ghost (don't ask) bodyguard from the Touhou shooting-game series. Youmu is described as "half-human and half-ghost, half-dead and half-alive, half-phantom and half-reality, and altogether half-baked. Yet she has two swords." The supplemental serial, Curiosities of Lotus Asia, stars the half-youkai Rinnosuke Morichika; however, this latter example is more notable for being the onlycanon humanoid male (aside from a couple of Posthumous Characters who exist only as names in the backstory) in the entire series, and a Non-Action Guy to boot.
Instead of one body like most hybrids, Youmu's ghost half exists as a separate entity that follows her around. Kind of like a daemon in His Dark Materials.
Backstory also gives us Youki Konpaku, Youmu's half-ghost father. And that just raises further questions.
Canonically though, we don't know whether Youki is Youmu's father or not even if they share the same family name. Backstory only mentioned that Youki is Youmu's predecessor and former teacher which means he can be either her father, grand father, or even uncle.
It is entirely possible that Youki and Youmu are unrelated. One of the two could have simply been adopted by the Konpaku house, either for potential, skill, or their species.
In Dragon Ball Online which takes place in the future, Saiyan DNA has pretty well proliferated a sizable portion of humanity due to ancestry from Goku or Vegeta(talk about explosive breeding), giving them exceptional combat strength and the ability to go Super Saiyan.
Laharl of the Disgaea series is this.He has a human mother. Beyond a single character noting he is half-human after being told of his mother, no one ever refers to him as anything but a demon.Though being an overlord/prince might have something to with why he always called a demon(or for simplicity's sake). Plus, call him anything else, and he will send you straight to hell.
Lilica (half-demon) and Konoha (half-dog) from Arcana Heart.
In a rare example of a hybrid between two non-human species, the World of Warcraft universe includes the Mok'Nathal, who are half-orc and half-ogre.
Orc/ogres also exist in D&D: the offspring of a male ogre and female orc is a large, intelligent orc called an orog, whereas a female ogre and male orc produce a short, stupid ogre (covered, for no apparent reason, with bony protrusions) called an ogrillon.
Warcraft also features Garona Halforcen. Originally she was described as half-orc and half-human; when changes in the timeline made that impossible, she was said to instead be half-orc and half-draenei. Later continuity changes made this seem unlikely...but it was finally confirmed in the latest issue of the comic series. Which would also explain why she still looks fairly young.
Also, consider that draenei males look, well, more draenei than the females.
In the Burning Crusade expansion of World of Warcraft, there is one half-orc half-draenei. He looks mostly like an orc but with a different skin color and a slightly different face.
Warcraft also has half-elves, whose most famous example is the paladin Arator the Redeemer (the half-elven son of Turalyon and Alleria Windrunner).
Dragon Fable gives us Nythera, a half dragon NPC. In a rather hilarious scene in one of her flashback quests, Nythera's parents, a human wizard and a dragon mother are sitting down at dinner. Said dinner is a live Chickencow (half chicken, half cow), and her mother is in dragon form about to devour it. Her father sees nothing unusual about this at all.
Spoofed in "Reality 2.0" of Sam & Max Save The World, in which Bosco's avatar in an MMORPG is elf on one half of his body, and human on the other, as seen in the image for this page. Also used straight in a later episode, where Bosco changes time so that he's part cow. Dialogue in this part also implies that Sam and Max are "freakish animal-human hybrids", not just funny animals.
In the final episode of "The Devil's Toybox", Sybil Pandemik shows up pregnant with the child of the mechanically animated Lincoln's statue.
Happens a few times in the Star Ocean series. First is the second game where in one of Claude and Rena's endings Rena is six months pregnant. The third game reveals that modern Expellians are the result of several millennia of this. Last is a hidden ending in the fourth game where Crowe not only survives, but marries Elayna, thus becoming Roddick's ancestor.
The Tohno and Kishima families in Tsukihime and the supplementary materials like Kagetsu Tohya. Part demon, incidentally. Also Altrouge Brunestud, who is half Dead Apostle and half True Ancestor. In her case it's not actually entirely clear if True Ancestors are a genetically different species, however. Or if it was actually a cross breeding, though at least one has been confirmed.
In the Myst / Uru games, the D'ni are capable of interbreeding with humans, despite their far longer lifespans and light-sensitivity. Gehn, a half-human, seems to have lived nearly as long as a full-blooded D'ni (350+ ), whereas his quarter-D'ni son Atrus was an old man before 200. Atrus's children, being 1/8 D'ni, lack the light-sensitivity of their father and grandfather; their potential lifespan is unknown, but longer than a full-blooded human's.
Partially subverted in Dragon Age. The offspring of elves and humans are always human, although there appears to have been rare cases of half-dwarves.
Dragon Age II, though, includes Feynriel, the son of a human man and an elven woman, whose features are a mix of the two races. He may still be fully human but with having a hybrid appearance (namely, a more angular face and pointy ears).
Sands of Destruction's Naja is half-feral, being the offspring of a human woman and the previous Lupus Rex.
Brutal Legend has Eddie, the offspring of a human and a demon. Considering what the demons look like, the romance between Succoria and Riggnarok must have been a very, very special one.
Phantasy Star IV has the eventual offspring of Chaz, an ordinary human, and Rika, a genetic construct. This doesn't really explain all the Newmans in the Phantasy Star Online games, though.
This is the premise of Hybrid Heaven, in which synthesized, half-human Hybrids are living in a secret underground facility underneath Manhattan, and each and every one of them (well, not ALL of them) have a superiority complex to humans, and simply want to take over the world because they think they're better. They plan to replace the President of the United States with an analogue so he can launch a world-wide invasion. In reality, they are led by 'the Master', a Gargatuan who is ultimately revealed to be a parasite that took over the Master's body who is called 'the Traitor' by fellow Gargatuans because of his take over the world plans. You, as Secret Service Agent Johnny Slater, who the Hybrids cloned to get close to the President can't let this happen.
In Golden Sun: Dark Dawn, Sveta, Volechek, and to varying extents, a majority of the Beastman populace all fall under this trope, having been formerly human just before and just following the Golden Sun event. It's uncertain if perhaps Volechek, as a boy (or if he's even the right age), underwent the transformation that many elderly Beastman recall throughout the game. It's also never mentioned if both of their parents were Beastman (their father definitely was), which might explain why Sveta appears as human as she does. It's also heavily implied at the end of the game that a majority of Belinsk's inhabitants — including all members of the band that played 'Arangoa Prelude' earlier — were formerly human, as only the 'human-borns' developed aesthetic, and in some cases, 'super-Beastman' ([seemingly] only increases in vitality, IQ, etc.) alterations following the blast from the Apollo Lens and the end of the Grave Eclipse.
The protagonist of the second Onimusha, Jubei Yagyu, is part demon (or Oni) by way of his mother, Takajo.
Despite fitting into the standard Mass Effect-y Star-Trekky milieu, this is happily averted in Sword of the Stars - interbreeding is impossible (obviously with the insect and aquatic races) but refreshingly so with the two ape-based humanoids, the Humans and th Tarka - they can, hypothetically, have intercourse but without offspring due to genetic differences.
For reference, the Tarka may be similar to primates, but they look like Lizard Folk, and their females lay eggs.
Aselia expresses a wish to bear Yuuto's child in Eien no Aselia, however, it's unclear whether spirits can actually bear children at all since they are a One-Gender Race that merely pops into being rather than being born.
In The Sims 2, if a male Sim gets abducted there is a small chance they will be impregnated and have one of these. The aliens have black eyes, similar to The Greys. They also often have extreme facial appearances (no nose, small nose) and personality (often will be mean and neat).
One of the bosses of The Gunstringer is a half-lumberjack, half-alligator monstrosity.
In the Assassin's Creed series, Adam and Eve were two humans who were part of a breeding program that was started by the First Civilization to create hybrids of the master and slave races that possessed the sixth sense of "knowledge." Unfortunately, all that the humans carried over was the "Eagle Vision" that their descendants would possess, coupled with a natural resistance to the powers of the Pieces of Eden.
Roddy, the main character of the Playstation sequel to Blaster Master, and his sister Elfie are the offspring of the previous game's protagonist, Jason, and an alien female. However, Eve was a Human Alien and the two have no discernible features from full humans, unless one counts that nonsense Eve tells Roddy how his alien half makes him more susceptible to evil.
Expressly defied, for the most part, in Rift: No hybrids between races unless planar beings such as shalastir (or, by extension, bahmi) are involved.
In Xenoblade, the royal family of the High Entia race has a tradition of accepting a Homs consort for the purpose of bearing hybrids. The only distinguishing trait most of them have are slightly smaller headwings, and they still possess the long lifespans and ether manipulating abilities of their pureblooded kin. They also have no risk of becoming monstrous Telethia, which is the primary reason that they were created.
The Shining Series is filled with various human/animal mixes. Some of which are playable characters but most are enemies.
Dark Souls has Crossbreed Priscilla◊, who is half dragon half humanoid of vague origin. She was shunned and hated her entire life for being an "abomination", eventually ending up within a Pocket Dimension called the Painted World of Ariamas. Interestingly, she is a Non-Malicious Monster, and the only boss who doesn't immediately try to murder the player, instead kindly explaining how to escape the Painted World.
Magical Diary has Damien, a demon/human hybrid. He claims that he's a changeling and has no idea who his real parents are. He later admits that he was a deliberate hybrid, created to try and remove the weaknesses in his demon ancestry. It worked, too. From the looks of some other students, he's not the only hybrid in the school either.
Being based on Dungeons & Dragons, the Neverwinter Nights series has them by the truckload. Aribeth de Tylmarande in the first game may be a half-elf (she's either that or full-blood, and the game is never clear which). Xanos Messarmos from Shadows of Undrentide is a half-orc. Valen Shadowbreath from Hordes of the Underdark is a tiefling (he's specifically part demon).
The sequel has Neeshka, another tiefling (one-quarter devil this time), and the NPC aasimar twins Joy and Light of Heavens. Mask of the Betrayer has Gannayev-of-Dreams, a hagspawn (male offspring of a hag and a human male), and Kaelyn the Dove, a half-celestial. Storm of Zehir goes to town on it: Finch the half-elf bard, Quarrel the half-drow warlock, Belueth the aasimar rogue, and Grykk the half-orc paladin. Plus a couple of genasi NPCs.
The main focus of Icewind Dale 2 is on two half-demon antagonists who gather up an entire army, which includes hybrids, to get revenge on the rest of the world because they felt they were treated poorly.
In Heroes of Might and Magic V and VI, the beastmen races were created by wizards, experimenting on criminals in order to create new species that could be used as slaves. Variants of beastmen known to exist include goblins,orcs and Cyclops (all created from crossing humans with various types of demon), harpies, centaurs (human/nightmare), minotaurs, sharkpeople, Lamasu (human/manticore hybrids that look like winged sphinxes), and mermaids (supposedly human/dolphin hybrids, although they look nothing like dolphins).
And then there's Yog from III, who's half-human, half-genie. And Gelu, who is half-human, half-snow elf.
In Binary Domain, Faye is a half human half machine hybrid which is born from an artifical womb of a female hollow child, granting immunity to diseases, greater strength, speed and intelligence.
Kokonoe from Blazblue is the only half-human, half-cat hybrid in the series.
Dungeon Maker II: The Hidden War: In addition to creatures like the centaur enemies, there are also a few half human hybrids as named characters: notably Niko the apprentice at the magic shop who is half witch, as well as the Dungeon Maker and the Big Bad, who are both half demon.
In Shin Super Robot Wars, Eiji and Julia are part alien, thanks to a "genetic equalizer" device and a woman into Interspecies Romance among the "Boazan empire" folk who rescued their Earthling father from deep space.
The title character of the Shantae series. As the name of her fourth game proclaims, she is a half-genie hero. Little is seen of full-blood genies and Shantae has many magical abilities, but dialogue (as well as a battle with a full-genie Shantae) suggests that full geniues are much more powerful.
The Wasp Lady in Harvester is the Crazy Cat Lady of the town, utterly obsessed with wasps and keeping entire hives in her house. If the player kills her, she falls over from the table she was sitting at, and Steve finds out there's another reason she's called that...
Cade Masters from Twice Blessed is 3/4 human, 1/4 elf. (His father was a human and his mother a half-elf).
Akaino Fenrir, from Academicon Ex Virtus As revealed in his character profile, Akaino's parents were a Mage and a Werewolf. Assuming Mages are human, that qualifies him for this trope.
Dan at least explored some less glamorous possibilities — in more or less ideal circumstances of the Second Life Alternate Universe, a lot of awkwardness and heart-breaking happened just because Archie inherited anatomy mostly from human ancestors and psychophysiology mostly from tele-empathic shapeshifting androgynous Uryuoms. Vlad was a broken result of the same progeny-shaping experiment as Grace.
In Triquetra Cats, the Soricha family has an :adopted" sister named Vyolette who is half demon. Vyolette was raised by Ariel Soricha after Ariel was contracted to kill Vyolette's demon father.
And the whole reason that the Errants were formed was because it was found that Elves could breed more easily with Humans than with other Elves for some unknown reason. It was only decades later that Errants suddenly started going bad at random.
Part of the appeal for a human lover was that elves idolized the concept of losing a lover before you grew tired of each other, so you could remember them for how much you loved them. Humans, with their comparatively short life spans, were very well suited for this.
First-generation hybrids are usually healthy. But repeated interbreeding between Errants can cause defects, some very severe. Exacerbated by the fact that Errants tend to be 'stuck' in their original 'mold', so it is nearly impossible to permanently heal congenital defects.
And then there's Kevin & Kell. The central family is itself several mixed species, and while the setting has a bias against interspecies romances, it really is more inter-diet relationships (carnivore vs herbivore vs insectivore). As far as strict species goes...
Rudy Dewclaw: half grey wolf, half red fox. Lives and looks like a wolf.
Fiona Fennec, his girlfriend: half red fox, half fennec. Lives as fox and fennec, and aside from an ethnic pride group, no one cares.
Coney Dewclaw, his half-sister: half grey wolf, half rabbit. Rabbit looks, wolf appetite.
Lindesfarne Dewclaw, his adopted stepsister: former human, then hedgehog, then talked into being a porcupine, then realised is a hedgehog, dating a bat. 'Diaper a flying hedgehog', indeed.
Corrie Dewclaw, Rudy's ... cousin, I guess. Half grey wolf, half sheep. Lives and looks like a sheep, but don't get her mad.
Yes, she's Rudy's cousin. Corrie's father Ralph and Rudy's mother Kell are brother and sister.
Francis Fennec, Fiona's new half-brother. God knows what he is—the geneticists can't figure it out either. Looks like a ball of fluff. Father is a fennec, mother's a former human, current rabbit with the old human preferences.
Turns out, he's human, due to Danielle being originally human. Lindesfarne theorizes the same would happen to her children.
And there's some minor mixes, like a half-moth half-firefly who orbits himself, or the illicit baby between a turtle and a weasel. Confused yet?
There is a bit of a subversion though: as revealed on Lindefarne's blog, human genes are dominant — no matter what the offspring of a human or former-human relationship looks like at birth they will always become completely human within a few months. This is based off of the discredited theory that people "evolve" from single-celled organisms, to fish, to reptiles, to mammals, to monkeys, and so-forth, all while they're still in the womb, but it certainly makes for a few interesting plot points.
Lorenda is half-demon mare, half... cow. This essentially makes her a carnivorous cow, but to the chagrin of her demonic mother, she only eats evil creatures — like door-to-door salesmen! Now she's grown wings... but they're hilariously tiny and useless. Her demon mom is embarrassed.
Also Jyrras, whose father is a pureblood Kangaroo Rat, but his mother is only half that... the first half.
Creator Amber Williams has created a side comic arc to describe exactly what species of furre can inter-breed and exactly what will result from such a breeding.
In Yet Another Fantasy Gamer Comic, the character of Glon is a (much put-upon) half-human half-orc. There are also half-brothers Cadugan and Taidor. They share a human mother, but Cadugan's father is an elf (Prince Glitterbranch of the Wood-Elves, no less!) and Taidor's father was a Satyr.
Sara Greenhilt: I want to be able to hear the pitter-patter of little feet — or the whoosh-whoosh of little wings, as the case may be.
A literal-minded orc also lampshades the assumption that "half-X" assumes the other half is human. "Grog half orc. Other half, also orc."
Enor the bounty hunter is a Half-Dragon Half-Ogre: Half blue dragon, half ogre... or one quarter ogre, one quarter human, it's not entirely clear.
Most recently, Girard Draketooth's surname is revealed to have originated from him being the son of a half-dragon. Unfortunately, his dragon grandfather was a Black Dragon of a certain family tree...
Parodied in 8-Bit Theater, where the character Ranger is half-elf, who is also one-quarter Leifinish. The final quarter is "half-orc". (He is also actually a dual-class character, but both classes are "ranger".)
Parodied in a Sev Trek cartoon about what characters might appear in the next Star Trek series. The winner was: a Klingon/tribble hybrid torn by hatred for its two sides and constantly annoyed by questions of how its parents got together to mate.
Benn'Joon, the priestess from Looking for Group. If we go by appearances, she's a Blizzard troll...but she's definitely not one of the setting's trolls. Her race is never out-and-out stated; she's referred to as a "female of unknown pedigree." And speculating about her ancestry on any appropriate forum will lead to heated debate.
Although according to a recent comic, it appears that she may be at least Half-Elven. Assuming her mother is indeed Captain Tah'Vraay.
The genetic cocktail that spawned Molly and Galatea in The Inexplicable Adventures of Bob! did contain some human DNA, albeit not much. In fact, it was Jean's, making her their biological mother, just "a little bit."
In Juathuur, Thoss and Thlassa are half-solluu (fish people) and half-juathuur (humans with powers).
A Magical Roommate has an interesting example in the case of X and Alexis. Their mother, who was born a black fairy, shapeshifted to a human form she kept for her pregnancy... well, for the most part. This has made the twins roughly ninety-eight percent human and two percent fairy.
And parodied in Ansem Retort; when Zexion insists that Hercules be one of these, Hercules replies that his top half is centaur and his bottom half is human.
The amorphs from Schlock Mercenary are capable of creating offspring with any species, although the children are identical to normal amorphs. An offer to make children to Breya by Schlock causes a lot of squick reactions, but although she turns him down, they are able to talk about it in friendly terms after the humans realize amorph reproduction doesn't involve sex.
Schlock himself apparently has a human grandmother.
For explanation, the amorph would imprint desired personality traits from their partner onto an asexually-produced amorph spawn.
In Wapsi Square, Shelly is a human/sphinx hybrid. This gives her most of the powers of a sphinx, but with a human lifespan. Later revealed to be a human/sphinx/Titan hybrid (her mother was lying).
Fans! deconstructs the trope with Zaha, an engineering student who was merged with her pet cat in a freak accident, and ended up a Cat Girl. She has to take several kinds of medicine daily just so her body can function, and longs for humanity. Eventually she exchanges bodies with a member of Furry Fandom, who is thrilled.
One of the main Characters of Fungus Grotto has ended up in world dominated by faeries, and a scene that was shown with her mother implies that she might be some kind of Human/Fey hybrid
Wyrmspawn in Wizard School is a half-dragon, half-human hybrid leading the Dragonkin.
Keti of Footloose is half human, quarter werewolf and quarter nymph. Unfortunately that leaves her vulnerable to bouts of violent insanity.
Underling leads one to believe this of Lazarus, though he ends up not being so.
Leraje Que'vann from Zelfia is a demon-human hybrid.
In Dragon Mango, Mango herself was the first, but not the last, child of a human and a Dragonslayer.
In Fairy Dust, all humanoid races can breed with most others, and humans aren't shy to do so. One extra character appears to be half troll, with a few scars hinting that he had surgery to look more typically human.
In the Hotblood! universe, this is deconstructed. If a human/centaur couple defies societal norms and gets together, any attempt at having biological kids are hampered by the mechanics first, but if conception somehow takes place, the pregnancy will be full of complications and biological defects.
New Vindicators has a lot of these running around-the primary source for superpowers comes from being a Neo-Sapien, which are all descended from Nephilim, who are half human, half fallen angel.
Elcenia: Rhysel is a halfblood, which is an interesting version of this trope. Though she, specifically, is half-elf and half-human, she would have the same characteristics were she 1/256th human or elf, hence "halfblood", since "half-elf" would limit the term to genotype rather than phenotype.
Yet another joke◊ on the subject of the other half being assumed human. Half-elf, yes...
A complicated version in the French novel "Les Animaux Denaturés", variously translated as "You Shall Know Them", "The Murder of the Missing Link", and "Borderline". A scientific expedition finds a new species of primate called tropis that can be impregnated by both humans and apes. A businessman comes forward to basically enslave them since they're as suitable for hard work as humans, but he wouldn't have to pay them. In order to push the debate further, one of the scientists (artificially) impregnates a female tropi and kills the child, standing trial on whether he killed an animal or committed murder on a human. It's determined that the tropis are human, foiling the businessman, but as their status was determined after the fact, the scientist can't be retroactively condemned.
Averted, however, in a human/gargoyle relationship, which cannot normally produce children. (Note that gargoyles lay eggs.) Word of God does leave some room open for magical and/or scientific advancements in that area, though. Goliath and Elisa apparently adopt a human son at some point, however, as that kid's descendant would have been a main character in a proposed Spin-Off.
Fox, on the other hand, is a straight version, with a human father who unwittingly married a Child of Oberon (or ex-wife of Oberon as the case may be). By extension this makes her son Alexander magical as well.
Word of God also says that Oberon himself had two children with human women: Merlin and the changeling boy from A Midsummer Night's Dream. Apparently members of this race can mate with just about anything, since the New Olympians are also descended from them.
Rex Stewart aka Warhawk, the son of Green Lantern John Stewart and Hawkgirl Shayera Hol.
Static: "Shayera was one cranky pregnant lady. Although to be fair, if I'd laid an egg that size..."
Robotech naturally picked this up from Macross, but had notable examples of its own.
Komillia Jenius from Macross became Dana Sterling, both in her initial appearances during the Macross Saga and in the overwritten Robotech dub of Super Dimensional Cavalry Southern Cross, renamed "The Masters Saga". The reason given for her hair changing from blue-green (in the Macross segments) to blonde was the increasing amounts of anti-Zentraedi (and Zentraedi-hybrid, naturally) prejudice in the Armies of the Southern Cross. As a result, Dana dyed her hair to avoid the hassle. As both Southern Cross and The Masters Saga had a rather anti-alien, xenophobic military as a major plot point, this Retcon was actually rather well done.
Near the end of The Masters Saga, Dana has a protoculture-induced vision of a sister she's never known, born to her parents after they left Earth on the SDF-3. In the Robotech novel continuity, this character became Aurora Sterling. In the animated continuity as progressed by Robotech: The Shadow Chronicles, this became hot shot fighter ace Maia Sterling.
In the "The Next Generation" saga that made up the last third of Robotech, we were treated to Marlene, an amnesiac young woman who was actually Ariel, the first attempt of the Invid Regis to further evolve her race into human form. Furthermore, the Invid prince Corg and Invid Princess Sera are both Invid-human hybrids, due to the Invid Regis's belief in humanity's evolutionary superiority to her own race's original form.
Ben 10: Alien Force has Ben training a band of kids with powers similar to his original aliens (or at least he SHOULD be training them, but the animators don't seem to want to have to draw massive amounts of cast members each episode, so the status quo of three is maintained) to fight the alien Big Bad. Interestingly, these kids are all hybrids of aliens of varying species and children of Plumbers (who have all been given badges that act as tracking devices, making them easy to find), which makes you wonder if an interest in alien reproduction is a requirement to join the Plumbers... And the fact that a human shouldn't even be able to touch an alien made of lava can be handwaved with the use of alien technology, should any fan get a case of Fridge Logic.
Manny is half-Tetramand (Fourarms's species), Helen is half-Kineceleran (XLR8's species), and Alan is half-Pyronite (Heatblast's species). While Alan can switch between his human and alien forms, Manny and Helen stay looking like Kineceleran and Tetramand.
Ben and Gwen's grandmother was an Anodite, making them only three quarters human.
Ben, Gwen, and her brother Ken are a headache to think about. The Anodite are energy beings, and therefore don't have genetics as such. It's implied that Grandma made a human form. If she made it genetically Terran Human, that means the kids are genetically full human, but still one fourth alien. Yeah
Used disgustingly in Superjail!. During the season one finale, the Warden—who has been stuck in an extra-dimensional temporal prison—returns to the titular Superjail to find that the inmates have been forced to rebuild society in his absence. They didn't have any women, so they had to make do with the canary.
Warden: What has gotten into the inmates?
Alice: Looks like a whole lot of bird dick.
Earlier in the same episode, it's revealed that the scientists have been trying (with little success) to make these in an effort to create more docile inmates.
The Dathomirian species is the result of generations of crossbreeding between the human Nightsisters and the Zabrak Nightbrothers. They're also a case of Bizarre Sexual Dimorphism and Gender Equals Breed, as the Nightsisters look like extremely pale-skinned humans, while the Nightbrothers look like full-blooded Zabraks.
Marceline from Adventure Time was born a half-human, half-demon. She became a vampire at some point during the gap before her debut in the show.
In The Legend of Korra, we find out that spirits can do a version without reproduction. They possess a human, and the human takes on some of the spirit's traits, which remain once the spirit leaves. If the spirit doesn't leave, the human dies. During the Harmonic Convergence, however, a spirit can permanently fuse with a human without hurting them. This is the source of the Avatars: They are humans fused with the light spirit Raava. The (internal) mutations this causes is what allows them to bend all four elements. In the season 2 finale, not only does Unalaq become a Dark Avatar by mirroring the process with Raava's opposite Vaatu, but Raava is ripped from Korra and destroyed. However, Korra remains a human/light spirit hybrid, and retains her bending abilities.
Steven Universe stars a boy with a human father, whose mother was one of the Crystal Gems. He looks entirely human, except that he has a Gem in his navel which gives him magical powers.
This blog post on Shakespeare Geek claims, among other things, that Shakespeare was half human, half Australian Frilled Lizard.
Conspiracy Theorist David Icke claims in his book The Biggest Secret that the world is secretly ruled by reptilian aliens who can take human shape and interbreed with humans.
Specifically, 12-foot tall specimens that drink human blood. Apparently, the Jewish Anti-Defamation League got annoyed, and cited the whole Elder Protocols schtick to suggest that when talking about reptilians, he meant Jews. Those that know him suggest that when he talks about reptilians, he means it.
Sounds like he read a little too much Robert E. Howard pulp novels. 'King Kull'' has the same plot points.
There was a Russian scientist in the early 20th century who attempted to create a Humanzee, but apparently none of his experiments panned out & his funding was eventually cut.
Interesting that in all accounts of trying to inseminate human women with ape sperm, the ape always happen to die shortly before the scheduled date.
For the curious, said scientist was Ilya Ivanovich Ivanov (#5 on the list, bottom of the first page). Apparently, the story gets even stranger.
Thoroughly examined here. Ivanov can be conservatively described as having been a completely insane crackpot, but stories of surviving Humanzee creations are the accounts of conspiracy theories with no evidence behind them and most of what we know of biology arguing for its near impossibility.
Subverted with Oliver, a wild-born chimpanzee raised in a human household. Because of his bald features and preference for bipedal walking, he was long suspected to be a human/chimp hybrid, but DNA tests eventually determined that he's a chimpanzee from a wild population with slightly less fur and smaller heads than most. Walking upright is a behavior he learned by copying humans.
Just to clinch the argument, he ended up with crippling arthritis in his back and feet from walking upright, and had to spend his twilight years knuckle walking like a normal chimp. He just wasn't built for that stunt, and it wore his body down like ballet wears down a ballet dancer.
State Representative William "Tracy" Arnold R-MS attempted to introduce House Bill 819, the Protection of the Human Person Act, to prevent this trope. The response from anyone in Congress who actually knew anything about science amounted to "You're trying to solve a problem that doesn't exist."
Apart from human+animal sperm+egg nonsense, it broadly outlaws genetically engineered embryos and intelligent nonhumans.
Most people from northern Europe can trace up 4% of their DNA to neandrathals, and it is believed that there was interbreeding in the past.
Not that that amounts to much. Humans are still 99.9% identical genetically when you get right down to it, and since Neanderthals were virtually identical to humans anyway, most of that DNA was identical to the DNA we already had just came from a different source. The few new genes we got from Neanderthals still fall into that one-tenth of a percent that makes us distinct.
Or rather, Neanderthals were humans, just a separate subspecies from the Cro-Magnons who were the first "modern" humans. The ancestors of Neanderthals were the first humans to leave Africa, while the Cro-Magnons evolved and left Africa later. Interbreeding was apparently relatively common when they met, as all humans of non-African descent today have at least some Neanderthal DNA.