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- "Lucky" Garnett's lucky quarter in Swing Time. His friend "Pop" seems to take it more seriously than Lucky himself does, since Lucky is willing to have it changed so Pop can buy cigarettes.
- Felix Felicis potion from the Harry Potter series.
- In Skies Unbroken there's an entire religion venerating Lady Luck, of which the protagonist is a follower. He carries a coin as his Good Luck Charm, as is the custom. Also, northern Ossporians believe a ship needs a good-luck cat, which Kor considers rubbish.
- Big Nate of all things has this in the form of a broken-off foot from an action figure. It's left ambiguous whether the charm is genuine or a combination of psychosomatics and coincidence.
- Grimm: In a world of Were-Beastmen, there's an old myth about tearing off the foot of some humble were-rabbit and using it as an extremely potent fertility charm. Unfortunately, the rich couple who sponsored the mercenary to hunt down innocent were-rabbits and hacksaw their feet didn't realize that he proceeded to murder them violently soon after.
- In Robot Wars, Diotoir was a robot known for being coated in red and black polka dot fur. Strips of this fur would often be seen tacked onto other robots as lucky charms, either as Battle Trophies or as gifts from the team (Team Diotoir were known for assisting other teams with their own mechanical problems). Diotoir itself wasn't always so lucky.
- In Supernatural Sam Winchester finds a lucky rabbit's foot that endows its owner with good luck until the charm is passed to someone else.
- Devin's headband in The Kicks. Her team back in Connecticut got it for her after an injury and she made a quick recovery. In "Head Games", she loses it and The Kicks get her a new one, which she decides is just as lucky.
- Averted in one episode of How I Met Your Mother (I don't remember the name) in which Ted lists a series of unfortunate things that happened because he stopped to pick up a "lucky" penny.
- In Marginal #4, L has his "omamori marimo", which he's quick to talk about in interviews and other supplementary material. Atom has his lucky underwear. When they discovered that Rui has a stuffed animal in his room in the anime, they thought this might be the reason, but it turns out not to be the case.
- In A Tale of Two Kingdoms, to win a gambling game you need to find a horseshoe for luck first.
- The Legend of Kyrandia also has a horseshoe as lucky charm (and magnet) which is a component in one of the potions.
- Terraria: Has an item called the Lucky Horseshoe which looks like a traditional good luck charm. However instead of affecting luck in the game it negates fall damage.
- In Star Ocean: The Second Story, being the Born Unlucky character of the cast, Ashton Anchors likes to collect lucky charms, especially after having been possessed the two dragons on his back.
- Resident Evil 2 has Sherry's gold locket which subverts the crap out of this trope. It secretly contains a sample of the G Virus, which is the reason the Tyrant T-103 Type is hunting her down.
- In Dragon Age: Inquisition, ex-Templar Cullen shows a romanced female Inquisitor a coin given to him as a good-luck charm by his brother when he left to join the Templars - the only thing his brother had in his pocket at the time, Cullen recalls wryly. Although Templars are not allowed to carry such charms, since they're expected to rely entirely on their faith, he nevertheless kept the coin with him through all of his experiences in the previous two games, and muses that for whatever reason he survived when he should have died twice over. He then attempts to give the coin to the Inquisitor, if she'll accept it.
- In Super Mario 64 DS, this is the in-game justification for Mario taking more damage without his hat. One of the toads mentions that Mario's hat is special, and bad luck will befall him should he lose it.
- In Darkest Dungeon, the Highwayman can give his "lucky coin" to a teammate to reduce their stress. Given that he can do this, potentially, in every Medium or longer dungeon he goes to, it's likely that he's just pretending it has some significance, in order to cheer up his allies.
- In Apollo Justice: Ace Attorney, Vera Misham was given by Kristoph Gavin a bottle of nail polish she considers as a good luck charm and a Security Blanket. However, he had ulterior motives in making her that gift: as she made a forgery for him and he planned to Leave No Witnesses, he put poison in the bottle knowing that, whenever she feels nervous, such as getting out of her home, she instinctively bit her nails and thus would ingest the poison.
- Mindmistress: Mindmistress designed but never built this luck charm. When it is colorful, it brings good luck, but if it goes gray... it brings bad luck. She refused to make it because she could not stop it from flipping modes. However her design was stolen and used. The user had massive good luck, till it turned gray. He kept wearing it for a full month, casing a massive bad luck storm for him. Page where she explains it.