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- "Lucky" Garnett's lucky quarter in Swing Time. His friend "Pop" seems to take it more seriously than Lucky himself does, since Lucky is willing to have it changed so Pop can buy cigarettes.
- Felix Felicis potion from the Harry Potter series.
- Grimm: In a world of Were-Beastmen, there's an old myth about tearing off the foot of some humble were-rabbit and using it as an extremely potent fertility charm. Unfortunately, the rich couple who sponsored the mercenary to hunt down innocent were-rabbits and hacksaw their feet didn't realize that he proceeded to murder them violently soon after.
- In A Tale of Two Kingdoms, to win a gambling game you need to find a horseshoe for luck first.
- The Legend of Kyrandia also has a horseshoe as lucky charm (and magnet) which is a component in one of the potions.
- Terraria: Has an item called the Lucky Horseshoe which looks like a traditional good luck charm. However instead of affecting luck in the game it negates fall damage.
- In Star Ocean: The Second Story, being the Born Unlucky character of the cast, Ashton Anchors likes to collect lucky charms, especially after having been possessed the two dragons on his back.
- Resident Evil 2 has Sherry's gold locket which subverts the crap out of this trope. It secretly contains a sample of the G Virus, which is the reason the Tyrant T-103 Type is hunting her down.
- In Dragon Age: Inquisition, ex-Templar Cullen shows a romanced female Inquisitor a coin given to him as a good-luck charm by his brother when he left to join the Templars - the only thing his brother had in his pocket at the time, Cullen recalls wryly. Although Templars are not allowed to carry such charms, since they're expected to rely entirely on their faith, he nevertheless kept the coin with him through all of his experiences in the previous two games, and muses that for whatever reason he survived when he should have died twice over. He then attempts to give the coin to the Inquisitor, if she'll accept it.
- In Super Mario 64 DS, this is the in-game justification for Mario taking more damage without his hat. One of the toads mentions that Mario's hat is special, and bad luck will befall him should he lose it.
- In Apollo Justice: Ace Attorney, Vera Misham was given by Kristoph Gavin a bottle of nail polish she considers as a good luck charm and a Security Blanket. However, he had ulterior motives in making her that gift: as she made a forgery for him and he planned to Leave No Witnesses, he put poison in the bottle knowing that, whenever she feels nervous, such as getting out of her home, she instinctively bit her nails and thus would ingest the poison.
- Mindmistress: Mindmistress designed but never built this luck charm. When it is colorful, it brings good luck, but if it goes gray... it brings bad luck. She refused to make it because she could not stop it from flipping modes. However her design was stolen and used. The user had massive good luck, till it turned gray. He kept wearing it for a full month, casing a massive bad luck storm for him. Page where she explains it.