D.O.A can refer to:
- D.O.A.: A 1950 Film Noir drama about a man targeted for murder. Also called Dead On Arrival.
- Dead or Alive: A 3D Fighting Game Best Known for the Fanservice. See also Dead or Alive for more examples.
- DOA: Dead or Alive: The 2006 Live-Action Adaptation of the Dead or Alive franchise.
- Dumbing of Age: A Slice of Life webcomic by David Willis.