[[quoteright:328:[[Film/{{Underworld}} http://static.tvtropes.org/pmwiki/pub/images/UVRounds.jpg]]]]
[-[[caption-width-right:328:Ultraviolet light-emitting bullets. From vampire to Extra Crispy in twenty seconds.]]-]

->''"Perfect job for these babies. Made 'em myself. Holy water, clover leaf, silver shavings, white oak... the works."''
-->-- '''Film/{{Hellboy}}'''

Our weapons are useless! The enemy is ImmuneToBullets! What can we mere humans do against the [[MonsterOfTheWeek unending]] [[TheLegionsOfHell procession]] [[SuperRobot of]] [[ImplacableMan impervious]] [[TheJuggernaut foes]]?

Quite a lot, apparently. By making modifications to our puny earth weapons (or, more commonly, to the ammunition) the world can be saved [[NuclearWeaponsTaboo without]] having to NukeEm (which usually doesn't work anyway since 'nukes are bad').

Said modification usually include using the target's WeaksauceWeakness in the weapon, such as [[GoodHurtsEvil silver melted from crosses]], [[WeakenedByTheLight UV ammunition]], and ColdIron. Expect the [[ContractualBossImmunity boss monster to be immune]] thanks to their CrossMeltingAura.

This is one of the major mechanics/themes of settings in which the protagonists or [=PCs=] are mortals in a world full of nasty supernatural or superpowered enemies, with the progression from knowing nothing about the mysterious bullet-immune creatures to exploding a dozen of them with each shot being one of the major progress indicators of the story.

SilverBullet is a subtrope. See also AbnormalAmmo, ArmorPiercingAttack, ElementalWeapon, KillItWithFire and KillItWithIce.

Name based on [[http://en.wikipedia.org/wiki/Depleted_uranium#Military_applications depleted uranium ammunition]] used by various nations since the 1970s.



Hard to work with, [[VampiresHateGarlic but great against vampires]]. There's even a certain basis in reality for this -- garlic contains [[http://en.wikipedia.org/wiki/Allicin Allicin]], a potent anti-biotic and anti-fungal agent. Remember that the original vampire myths described them as [[LooksLikeOrlok plague carriers]] instead of [[ClassicalMovieVampire angsty nobility]] or [[OurVampiresAreDifferent teenage estrogen bait]].

[[AC:Comic Books]]
* ''Franchise/{{Batman}}'': soaks his Batarangs in crushed garlic for dealing with vampires.
* ''ComicBook/{{Blade}}'': Blade's opponents are sent into anaphylactic shock by garlic based pepper spray.

[[AC:Films -- Live-Action]]
* Played with against non-supernatural opponents in the Creator/RogerCorman film ''The St. Valentine's Day Massacre'': a croaky-voiced gangster (played by a young Creator/JackNicholson) notes the belief that the garlic he's rubbed his bullets with will poison the wounds-- kind of strange given what's known now about garlic...

* ''Literature/TheDresdenFiles'': Try this for a cheap, effective vampire-slaying tool -- paintballs filled with garlic and holy water!
* ''Literature/SabinaKane'' has a variation with bullets containing apple cider instead of garlic. Same basic idea, but in this setting vampires are weak to apple-related substances rather than garlic, due to having an ancestral connection to [[Myth/HebrewMythology Lilith]] and the [[Literature/BookOfGenesis Garden of Eden]].

[[AC:Live-Action TV]]
* ''Series/{{Ultraviolet}}'': Instead of putting garlic in bullets, they put it in smoke canisters. Minimal effect on troopies, knocks the [[NotUsingTheZWord "leeches"]] flat on their backs.
* ''Series/ForeverKnight'': In the episode "Hunted", a hunter shoots Nick with bullets stuffed with garlic.

[[AC:Video Games]]
* ''Franchise/{{Castlevania}}'': [[AllThereInTheManual The manual]] for the [[VideoGame/CastlevaniaI first game]] stated that Simon Belmont soaked his signature whip in garlic juice and holy water for seventeen weeks before assaulting Dracula's castle. This is kind of undone since one of the first powerups the game will give you after every respawn is a ball and chain weapon that replaces the whip, and retconned out almost entirely with the increasingly-complex history of the whip in later games.
* Played with in ''VideoGame/TheElderScrollsIVOblivion''. One quest requires you to kill a vampire, and reading his diary indicates that he has a weakness to garlic. He's annoyed at the fact that he's the only vampire who possesses this weakness (so far as he knows), making him a walking cliche.
* In ''VideoGame/WarioLand 3'' and ''4'', one of Wario's forms is to turn into a vampire upon being bitten by a bat. One of the ways to turn back is to touch a hanging string of garlic bulbs. Depending on the situation, this may be good or bad.

[[folder:Holy Items]]
Weapons made from [[ReligionIsMagic religious relics]] or containing pieces of such are often used against supernatural foes, often in combination with special materials.

[[AC:Anime & Manga]]
* ''Manga/ChronoCrusade'':
** The Magdalene Order uses scripture-inscribed bullets laced with holy water as standard ammunition against demons. They also have a small number of bullets which use the power of one demon to blow up another, with near-nuclear effects.
** The demon bullet was deemed a failure, however, another bullet called The Gospel is perhaps the most powerful anti-demon bullet around, which is described as "a magic bullet made of a rare kind of silver that's synthesized using alchemy which has a spell inscribed on it at an atomic level." The results are quite devastating.
* In ''Anime/GaReiZero'', SOP for gun-wielding exorcists is the application of spirit water (sometimes via [[HolyHandGrenade grenade]]) in addition to scripture-inscribed bullets. These elements extend beyond gunplay, notably with inscribed motorcycle wheels and a weaponized iron.
* ''Manga/{{Hellsing}}'': Alucard's bullets, like his gun(s), are made to order - each is made from the metal of a Lancaster cross that was specially melted down for the purpose. The fact that the rounds are also ''explosive-tipped'' helps as well.
** He later receives a gun which fires Macedonium silver-jacketed bullets with blessed mercury (quicksilver) cores. Those don't need an explosive added, since mercury, being a liquid with about the same density as lead, virtually explodes upon terminal impact anyway.
** Similarly, Father Alexander Anderson uses bayonets that have been blessed which causes instant death to the fake vampires and causes intense damage and pain to true vampires, if they try to remove the blade, they will burn themselves. He also uses pages of religious scriptures, in the TV version it prevents vampires from using their powers and in the OVA it simply creates barriers that vampires cannot cross.

[[AC:Comic Books]]
* ''ComicBook/AstroCity'': "Confession" story arc, a squad of alien invaders is armed with holographic crucifixes, restraining cables soaked in holy water, and a two-handed stake-launching revolver. They are thus armed because [[spoiler:they know that the nocturnal super-hero Confessor is actually a vampire.]]
* ''[[ComicBook/BatmanVampire Batman: Bloodstorm]]'': Joker wears a squirting flower on his lapel that shoots holy water.

[[AC:Films -- Live-Action]]
* ''Film/{{Constantine}}'' melts gold from crosses to make shotgun shells.
** He also blesses the water tank in a building's sprinkler system (by adding another gold cross to the cistern) in order to spray all the demons there with holy water.
* ''Film/{{Dogma}}'': SilentBob kills the demon Azrael with a golf club he stole from a cardinal. As it turns out, the previous owner blessed it to improve his score.
** In that same scene, Bethany blesses the sink, turning the whole contents into holy water, which the skater-demons are promptly shoved face-first into.
* ''Film/VanHelsing'': used a gas-powered fully-auto crossbow. It was only effective after dipping it in holy water.
* ''Film/FromDuskTillDawn'': The pastor with a [[CrisisOfFaith Crisis of Faith]] manages to bless condoms filled with water to be used as holy hand grenades against the vampires, and holds them at bay with a shotgun and baseball bat taped in the shape of a cross. [[ShotgunsAreJustBetter The shotgun does a fair bit of damage itself.]] Carving crosses on the tips of bullets makes vampires shot with them ''explode.''

* In Swedish folklore, lead bullets are not only "lucky", they are also the only way to hit various supernatural menaces like shapeshifters, witches and their familiars, and animals protected by fairies. But it can't just be any lead; it has to be taken from a church window.

* ''Literature/TheDresdenFiles'':
** The Knights of the Cross each carry one of three swords: a broadsword, a katana, and a saber[[note]]Also known as Excalibur, Kusanagi, and Durendal[[/note]]. Each sword has one of the nails used in Christ's crucifixion worked into the hilt. While Harry used to believe that the swords had little power on their own, acting more as a symbol [[ClapYourHandsIfYouBelieve being powered by their wielder's faith]], the swords have shown that they are more than mere pieces of steel. Especially when [[spoiler:the katana is now turned into a ''lightsaber'']].
** It also provides us with an ''awesome'' vampire-slaying tool: a paintball gun loaded with garlic and holy water balls. It's up there with the stake machine-gun in ''Webcomic/SluggyFreelance''.
** And then there's [[WaterGunsAndBalloons holy water]] [[ImprobableWeapon balloons]]...
** In ''Cold Days'' Harry infuses a bullet [[spoiler:with Soulfire, the Fires of Creation to banish a powerful demon]] and fires it right at the target's head.
* ''Literature/JohnDiesAtTheEnd'': Dave and John use a Bible duct-taped to a baseball bat to fight supernatural monsters. Oh, and breath mints with the Lord's Prayer printed on them.
* ''Literature/FelixCastor'': Felix's landlord Pen fends off a [[HornyDevils succubus]] with a shotgun full of filed-down rosary beads. It seriously ruins the succubus's day.
* In the ''Literature/AnitaBlake'' books, in order to better kill vampires, Edward has been known to take a hollow point bullet, fill it with holy water and silver nitrate, and then seal it with wax.
* George Macdonald Fraser's ''The Candlemas Road'' has an interesting inversion: a dying border reiver begs the narrator (a priest) to baptize his ''right hand.'' You see, his parents only baptized the rest of his body at birth: they wanted their son to strike "unblessed blows" (presumably in the hope that this would in some way damn his enemies to hell.)
* ''Literature/{{Discworld}}''
** In ''Discworld/CarpeJugulum'', we encounter GenreSavvy vampyres who have trained themselves to resist holy symbols. However, at one point, a vampire is beheaded with a holy item created on the spur of the moment due to the powerful faith of the wielder.
** In ''Discworld/FeetOfClay'', Vimes [[spoiler:claims to have used the vampire villain's "poisoned candles to weaken someone" trick against him. He knew the vampire would smell garlic before it had any effect, so tries holy water candles, "the water burns away, just leaves holiness". The vampire isn't entirely sure this could work, but the point is [[INeverSaidItWasPoison he looks at the candles before Vimes explains it]].]]
* ''Literature/MonsterHunterInternational'': Holy symbols in general work against undead and [[spoiler:warding stones]] which specifically work against anything that's actually unnatural/eldritch in nature to the point of being an effective FantasticNuke. An actual bullet made of silver has horrible ballistics; so they get around this by by making hollow-point normal bullets with a silver ball (basically, a modified [[http://www.thegunzone.com/powrball.html Corbon Pow'r Ball]]).

[[AC:Real Life]]
* This one [[TruthInTelevision actually happened]] in the Middle Ages, with relics (bones and personal items from saints) being used in the ornamentation of swords and other weapons. They were intended to be "blessed" with special powers (notably [[CaptainObvious less successful than in fiction]]).

[[AC:Tabletop Games]]
* ''TabletopGame/Warhammer40000'':
** Many weapons for dealing with the [[TheLegionsOfHell daemons]], who, while not ImmuneToBullets, are [[ImplacableMan damn hard to kill]]. The most obvious are the psycannon shells used by the Ordo Malleus. Depending on the source, these are either filled with various blessed materials or have anti-daemon runes and prayers carved onto them.
** Combining with KillItWithFire gives flamethrowers loaded with Holy [[ElementsDoNotWorkThatWay Promethium]] (napalm with the mystical properties of Holy Water). The Grey Knights' Incinerator is the best known example.
** The Imperium also has special psych-out grenades that [[PowerNullifier negate]] the PsychicPowers of those who are hit. It is said they are made using a material that is created as waste by the life support system of the Golden Throne and emanates negative psychic energy. Yes, The Emperor's shit kills psykers. He's ''that'' badass.
** The forces of Chaos sometimes make use of daemon shells, which are bullets or artillery shells with a daemon bound within them. When the shell hits the target, the daemon's energy is released, causing a very large explosion of warp energy.

[[AC:Web Comics]]
* ''WebComic/TheAdventuresOfDrMcNinja'':
** One quest featured:
### [[IncrediblyLamePun Nun]]chucks made from Mother Teresa's bones,
### A Bo staff made from the largest known piece of The True Cross,
### Sai made out of St. Peter's sword,
### And bullets that had been in the Pope's mouth(wash).
** The finale took it up a notch by weaponizing ''the Pope himself!''

Iron, often ColdIron or [[ThunderboltIron meteoric iron]], is a traditional ward and weapon against magic, especially TheFairFolk.

[[AC:Comic Books]]
* In one ''ComicBook/{{Wolverine}}'' comic, the protagonist is facing an opponent who is immune to any weapon forged by mortal man. He uses a weapon made of meteorite iron and forged by a demon to ruin said opponent's day.

* In at least some versions of the stories, [[OurVampiresAreDifferent vampires]] are slain with an iron pike rather than a wooden stake, and/or iron filings may be placed under a child's bed to ward off vampires. In folklore, wood stakes and iron nails are used to pin the vampire in its coffin (and then other things can be done to the body). It then dies and decomposes (and isn't coming back).

* ''Literature/TheSagaOfRecluce'': features two distinct types of magic: Order-mage and Chaos-mage. Chaos energy has difficulty working on iron due to the natural Order energy woven into it, making it a solid defense. Additionally, Chaos-mages tend to build up a large amount of the energy in their body, so direct contact with iron causes their skin to blister painfully, and in extreme cases can lead to death.
* ''Literature/{{Redwall}}'': Martin's ancestral sword is reforged by the badger lord of Salamandastron using [[ThunderboltIron meteoric steel]] in ''Mossflower''. The same sword is used by nearly every protagonist and has always slain the BigBad of each particular novel (though not always directly, sometimes it is just used to, say, cut a rope holding a giant bell directly above the Big Bad).
* ''Literature/{{Discworld}}'': any iron can be harmful to TheFairFolk (which makes Tiffany Aching's choice of a frying pan as a weapon an apt choice). However, some places are protected by a powerful magnetic field to keep any iron from entering. Nanny Ogg uses one of [[AC:Binky's]] horseshoes, which can go anywhere (like [[AC:[[TheGrimReaper Binky's Owner]]]]).
** Considering an explanation, "cold iron" on ''Literature/{{Discworld}}'' is an overstatement and means just "below [[http://www.britannica.com/EBchecked/topic/146902/Curie-point Curie point]]".
* ''Born to Run'': humans fighting TheFairFolk with, among other things, shotgun shells loaded with "Cold Iron, holy herbs, and blessed rock-salt." One character also has a seltzer bottle that's been filled with iron filings and given a "pagan blessing." When he sprays the blessed and iron-laced water directly into a banshee's mouth, its head melts.
** In the same series, elves contemplating battle with gun-wielding humans had to be reminded of how dangerous steel-jacketed bullets would be to elves with a ColdIron allergy. And that's [[AchievementsInIgnorance without the humans even being aware what they're up against]].
* ''Literature/TheSoldierSon'' trilogy: iron beats any kind of magic and mages are "allergic" to iron. At the beginning of the series, the protagonist's country Gernia has subdued most of the magic-using peoples around them by switching from lead to iron bullets.
* ''Literature/TheSpiderwickChronicles'' book four: Jared confronts a faerie by pulling out a steel knife. His reasoning was that faeries don't like iron, and steel is at least part iron. It worked.
* ''Literature/TheDresdenFiles'':
** Anything with a high-enough iron content is potentially lethal to faeries; Mab, Queen of Winter and one of the most powerful magical beings on earth, recoils from a steel nail in fright the second before it touches her skin. Harry explains in one book that iron is to faeries what nuclear waste is to humans -- horribly wracking, and to be avoided at all costs. He even takes down [[spoiler:Aurora, the Summer Maiden and a powerful foe in her own right]] with nothing more than [[spoiler:a fleet of pixies armed with box cutters]].
** Charity and her nail gun.
** As long as they have iron, ordinary bullets do extra damage against the fae as well -- even if your opponent is the size of a semi.
* ''Literature/TheBible'': [[http://www.thebricktestament.com/judges/iron_chariots/jg01_19a.html iron chariots]] are just better. Just ask the men of Judah, or, God himself. It means this trope is OlderThanFeudalism.
* ''SteelMagic'': modern day steel utensils (like forks) are effective against magical creatures.
* ''Literature/TheWitcher'': the main character carries an iron sword that is quite effective against certain enemies.

[[AC:Live-Action TV]]
* In an episode of ''Series/BloodTies'', the protagonists find out that a [[OurElvesAreDifferent dark elf]] is impregnating women at a fertility clinic. [[PerkyGoth Coreen]] does her research and hands them a weapon to be used against the elf - a large and heavy iron spike. When they ask if there's anything more compact, she points out that the only other source of research about killing dark elves involves [[TabletopGame/DungeonsAndDragons using 20-sided dice]].

[[AC:Tabletop Games]]
* ''TabletopGame/ChangelingTheDreaming'': Cold iron (defined as "wrought iron") does aggravated damage to changelings... and if they die by it, their fae soul never reincarnates. The explanation is that the discovery of Iron working (and the coming of the Iron Age) was responsible for the end of the Fae golden age on Earth. Changelings, being creatures of dream and symbol, are especially vulnerable to it as a result. Later supplements explain steel not being so dangerous by the fact that it was invented by a powerful fairy long ago who sacrificed his life to ensure it would be harmless.
* ''TabletopGame/ChangelingTheLost'', "cold" iron (material that's 95% iron at least) pierces fae defenses and hand-wrought iron does aggravated damage to [[TheFairFolk the True Fae]]. One of the explanations is that the True Fae made a deal with Iron to gain mystical benefits from it as long as they made sure no human hand could change its essence. Once humans discovered smelting, however, the deal was broken and Iron decided it wanted to do some interesting things to the kneecaps of the True Fae...
* ''TabletopGame/HunterTheVigil'' notes that the high-tech Hunter compacts and conspiracies, like The Cheiron Group and Task Force: VALKYRIE, occasionally use pure iron slugs in their guns when expecting fae activity.
* ''TabletopGame/{{Exalted}}'':
** Fair Folk take extra damage from pure iron weapons (not steel or other alloys), and are resistant to non-iron. Woe betide the Exalt who's stocked up on magical artifacts with no iron weapons.
** There's a hearthstone called "Cold Iron Bauble" that can be mounted in said artifacts, which makes them act like iron to Fair Folk.
* In ''TabletopGame/DungeonsAndDragons'', fae and ChaoticEvil demons usually have some measure of damage resistance that applies to all attacks, except for those made with cold iron weapons.
** For balance, cold iron weapons are not only more expensive, but harder to enchant, which makes perfect sense for a material with AntiMagic properties.

[[AC:Web Comics]]
* ''Webcomic/TalesOfTheQuestor'' has an interesting theory on "cold iron"; somebody [[BlindIdiotTranslation mistranslated]] [[http://www.rhjunior.com/totq/00474.html "north-pointing" as "cold"]], meaning [[http://www.rhjunior.com/totq/00480.html "cold iron" is ''lodestone'' -- '''North Pointing Iron'''.]]

[[AC:Web Original]]
* ''Literature/TheSalvationWar'': gives us iron-tipped artillery in the form of High-Explosive Anti-Demon rounds. Normal High-Explosive-Anti-Tank (HEAT) rounds have a shaped charge with a copper liner so when they detonate they burn through the enemy armour with a jet of molten copper. HEAD rounds replace the copper liner with iron so instead of just burning through the demon like a HEAT round they burned through it with something that was poisonous to the demon and prevented its flesh from [[HealingFactor regenerating]]. Not that conventional (military-grade) firearms were any less effective against demons, over penetration of APFSDS rounds aside.

[[AC:Western Animation]]
* In ''WesternAnimation/{{Gargoyles}}'', Xanatos tends to cut out the middle-man and have most of his weapons made of iron composites, just in case. Oberon may be a PhysicalGod but even he takes major damage from anything forged from iron. At one (slightly depowered to impress his wife) point he is brought to his knees by [[BadassNormal Elisa Maza]] ringing an iron ''bell.'' In later episode he's toying with the main cast but finally decides to [[GameFace fight for real]] when someone impales him on a home-made harpoon gun.

[[folder:Kryptonite and other GreenRocks]]
If the enemy is an alien or monster with a very specific, non-mythological [[KryptoniteFactor weakness]], be it Kryptonite, Music, or Water.

[[AC:Anime & Manga]]
* ''Anime/CowboyBebop'' once features a CreepyChild that is really a boy that stopped aging and gained [[TheAgeless ageless]] immortality from the Lunar Astral Gate accident (which bombarded Earth with debris, killing most of its population and rendering it virtually uninhabitable). A stone from the incident is the only thing that can kill him, and Jet and Spike carve it into a bullet to use it.
* In ''Manga/OnePiece'', Devil Fruit users are all [[WeaksauceWeakness weak to submersion in water]], and Sea-Prism Stone is [[KryptoniteFactor a rock that causes people touched by it to suffer the same effect as being submerged]]. Usually, it's used in handcuffs, restraints, and cages, but the marine Smoker walks around with a weapon tipped with the stuff despite being a Devil Fruit user himself.
* ''VisualNovel/TearsToTiara'' has both the [[TheEmpire Holy Empire]] and [[spoiler:the [[OurAngelsAreDifferent angels]]]] use weapons made of Electrum, a holy metal, against NobleDemon protagonist Arawn. ([[spoiler:The latter made it the ammunition of a biological "[[TankGoodness divine tank]]", which was used killed him [[DeathIsCheap the first time]]]]). In-game, any equipment made of Electrum given to non-human characters (elves, dragons, demons, etc.) is only as good as whatever they were wearing earlier. It doesn't lower their stats, but it doesn't boost them either.
* ''Manga/KnightsOfSidonia'': The Gauna can only be harmed by an exotic metal known as "Kabi". Unfortunately, the crew of the ''Sidonia'' has no idea how to manufacture this metal, and are forced to rely on a set of spears tipped with the stuff to fight off any Gauna they encounter. Even those they only happened upon by chance, in an abandoned alien artifact. [[spoiler:Dr. Oochiai later discovers how to manufacture Kabi using captured Gauna-based life forms, which leads to the ''Sidonia'' creating kabi-tipped bullets that prove very successful at killing Gauna.]]

[[AC:Comic Books]]
* ''Franchise/{{Superman}}'': [[KryptoniteFactor Kryptonite]] is Superman's one true weakness (usually), so it's hardly surprising that it's been weaponized against him. The most spectacular being the occasionally mentioned K-Bomb, a Kryptonite-tipped [[NukeEm nuclear bomb]].
* At the beginning of ''ComicBook/FinalCrisis'', Darkseid kills [[spoiler:his son Orion]] with a time traveling Radion bullet -- Radion being the one thing that can kill any New God no matter how powerful. Near the end of ''ComicBook/FinalCrisis'', [[spoiler:Franchise/{{Batman}}]] shoots Darkseid with the same bullet which jump-starts the latter's RasputinianDeath.
* In an interesting inversion, Bloodscream seems to be able to recover from attacks by Wolverine's adamantium claws. Guess what happens when he faces Wolverine without the adamantium.
* ''ComicBook/MightyAvengers:'' The Blue Marvel's last encounter with his arch-nemesis Evald Skorpion has the mad scientist shooting him with a bullet of neutronium -- essentially raw proto-matter, and Blue Marvel's weakness.

[[AC:Fan Works]]
* ''FanFic/AeonEntelechyEvangelion'': there are warheads enhanced with ''Literature/TheColourOutOfSpace''.

[[AC:Films -- Live-Action]]
* In ''Film/XMenOriginsWolverine'', Stryker manages to bypass both Wolverine's adamantium bones and healing factor by shooting him in the head with adamantium bullets. The bullets pierce his skull, and while Logan's brain can heal, his memories can't.

* ''Literature/BattlefieldEarth'': the Psychlos are very resistant to damage due to their inhuman physiology, but anything radioactive would react explosively to the 'breathe-gas' that they used for respiration. In this case, the humans defeat all the Psychlos by simply [[spoiler:detonating a nuclear bomb on their homeworld, and the destruction spread through their teleporter network.]] Though really, an ounce of plutonium in a lead box would have worked equally well.

[[AC:Live-Action TV]]
* ''Series/StargateSG1'':
** The mission of the entire SG project is to exploit alien technology or hybridize it with conventional weaponry to defend the Earth.
--->'''Gen. Vidrine:''' You're telling me that a ''slammer missile'' could take out a Goa'uld mothership?\\
'''Maj. Carter:''' When equipped with shield frequency modulators and naquadah-enhanced warheads... yes sir.
** By the final season, they have bombs capable of destroying stargates, which are {{nigh invulnerab|ility}}le.
** By ''Series/StargateAtlantis'', they've developed the Horizon system, a starship-deployed [[RecursiveAmmo MIRV]] tipped with six 280 gigaton warheads and four decoys. For reference, that's over [[HiroshimaAsAUnitOfMeasure 13 million times the power of the Hiroshima bomb]] '''''per warhead'''''.
** Also in this category is the energy weapon the SGC develops in ''SG-1'' season 7 to kill [[BossInMookClothing Kull Warriors]]. Since Kull armor is, for all intents and purposes, invincible (one of them stepped on a claymore and [[TheJuggernaut didn't even break stride]]), they develop a weapon that disrupts the energy keeping the clone body alive. Since the Warriors' are rapid-grown clones with hyperaccelerated bodies to give them super-strength and durability, the only thing keeping them alive is the healing powers of a Goa'uld symbiote and ancient technology used to "imbue them with life" in the first place. Disrupting the latter kills them instantly. Also, since their body armor is very similar to kevlar, it can be pierced with a tranquilizer dart, which is attempted to capture a Kull at one point.
** Finally, after Season 8 of ''SG-1'', the SGC has access to ARG's: Anti-Replicator Guns. Rather than firing a slug or a harmful energy burst, they fire what amounts to a localized jamming signal, shutting off the communication between the Replicators' component pieces and causing them to fall apart and become inert. Unfortunately, Replicators are able to update their communication modulation when they realize this is happening, so the ARG's have to be constantly updated in turn as the Replicators "grow immune" to the previous modulation.
* In ''Series/LegendsOfTomorrow'', an Old West outlaw named Turnbull uses a futuristic device (obtained from a time pirate) to locate a vein of dwarf star alloy, the same material Ray used to build his ATOM suit. Turnbull discovers the material's explosive properties and starts building bullets with it. In addition to being explosive, the bullets also go right through Nate's ChromeChampion skin, as dwarf star alloy is incredibly dense.

[[AC:Tabletop Games]]
* ''TabletopGame/{{Rifts}}'': The New German Republic has discovered that hot uranium(ironically for the trope title, ''non''-depleted) rounds prevent supernatural beings from [[HealingFactor regenerating]] or even healing damage.
* ''TabletopGame/HunterTheVigil'': Task Force: VALKYRIE uses bullets treated with the power of SCIENCE! to turn them into super-high-energy rounds that can strike and harm incorporeal targets like ghosts.

[[AC:Video Games]]
* ''VideoGame/CommandAndConquerTiberianSeries'': both Nod and GDI use specialized munitions. In Nod's case, they have a love for filling missiles with various breeds of [[GreenRocks Tiberium]]-based explosives or gases, while GDI has developed sonic-based and EMP artillery shells and grenades.
* ''VideoGame/{{Factorio}}'' features Uranium ammunition, made by taking conventional Piercing Ammunition and processing it to put U-238 tips on the bullets. They hit incredibly hard and shred Biters and Spitters easily.
* ''VideoGame/MonkeyIsland'' series: root beer is an extremely effective ectocide. It ''only'' works on ghosts-- when Guybrush tries this on the resurrected Zombie Pirate [=LeChuck=], he shakes it off and chastises Guybrush for trying to off a zombie with a mere soft drink.
* ''[[VideoGame/SuperRobotWarsOriginalGeneration Super Robot Wars OG Saga]]: VideoGame/EndlessFrontier'': Though not particularly used against live targets, Haken's Night Fowl requires special bullets to destroy the Mild Keil crystals causing BrokenBridge antics and other chaos in-game. To ensure they're strong enough for the job, they're made from (or based on the composition of) fragments of the crystal type they're made to break.
* ''VideoGame/{{Rage}}'': Feltrite tipped bullets are more effective than lead, but rarer, more expensive and you are not able to carry as many of them.

[[AC:Web Comics]]
* ''Webcomic/NobodyScores'': one of the characters acquires a hunk of Kryptonite and goes to sell it to Lex Luthor. Superman takes them out from long range with a traditional sniper rifle of his own [[FailureIsTheOnlyOption before they even spot him]].

[[AC:Web Original]]
* In ''TabletopGame/NewVindicators'', the Nephilim are children of fallen angels and men, with the power to channel hellfire for all kinds of super powers. However, they are vulnerable to a specific type of tektite, called mithral. More than one character has made mithral into weapons, such as nunchaku, as there are groups that specifically hunt Nephilim.

[[folder:Magic Imbued]]
When only magic can affect a monster, sometimes infusing magic into a more mundane weapon will do a better job.

[[AC:Anime & Manga]]
* ''Franchise/{{Nasuverse}}'':
** ''Literature/FateZero'': Emiya Kiritsugu's custom "Origin Bullets" were filled with his own powdered bones, which contains Kiritsugu's dual Origins (base 'orientations' of an individual) of 'Binding' and 'Severing'. A magus uses magecraft to defend against the bullet? The Origins are forced directly onto his [[FunctionalMagic Magic Circuits]], overloading them and ripping them apart, then binding them back imperfectly, thus making them permanently unusable.
** The ''Nasuverse'' also contains "Conceptual Weapons", the highest class of offensive magical artifacts. One of the most powerful is a gun known as the "Black Barrel", which is specifically designed to kill immortal things, and becomes more powerful the more supernatural power its target possesses. In other words, it can OneHitKill {{Eldritch Abomination}}s. The catch is that only an ordinary human can wield it: anyone with magical power finds it harmful to the touch. This is important in the story where it is featured, ''Literature/AngelNotes'', set during a PostApocalyptic war against {{Eldritch Abomination}}s, where it is wielded by the protagonist, [[TheLastOfHisKind the one single normal human left]]. The rest of earth's population has since become transhuman, and thus, can't use it.
* ''Manga/MahouSenseiNegima'': Tatsumiya creates her own spell-imbued bullets for [[DemonSlaying exorcisms]] and the like. [[spoiler:Later, she gains a special ''time-displacement rounds'' use within one day, which work as an effective OneHitKill for the ultimate in battlefield removal]].
* ''Manga/OutlawStar'' featured Caster shells. Although the exact terminology fluctuated slightly depending on who was doing the talking (and who was dubbing/subtitling the episode), it all boiled down to "big ass guns that fired bullets which exploded into magical spells." The guns themselves were rare, but the more simple Caster rounds were relatively easy to find; when Gene needed to get the ''really'' good ones to take on the BigBad he needed to track down the trio of semi-ageless techno-sorcerers that made them in the first place. And there's a reason the more powerful ones are hard to find: [[spoiler:[[CastFromHitPoints they're powered by the wielder's life force]] since there isn't a ready supply of Mana that strong]]

[[AC:Comic Books]]
* ''Franchise/{{Hellraiser}}'': In the "Razing Hell" comic mini-series, written by the [[RetroactiveRecognition Wachowski Brothers]], the protagonists manage to make bullets out of some of their own bones (starting with a fallen comrade who tells them how to do it with his dying breath, and later, in one desperate situation, a character uses his own pinky finger to make more ammo), since one of the only things that can hurt the LegionsOfHell is Leviathan's own power (which has tainted them too, since they were its prisoners). They use this knowledge to begin a grim but very effective LaResistance campaign against the cenobites and the puzzle-box guardians.
* ''Franchise/{{Superman}}'': in UsefulNotes/{{the Silver Age|of Comic Books}} Kryptonians could only be harmed by three things: other Kryptonians, kryptonite, and magic. So if you don't have any green rocks handy, get that Billy Batson kid to shout "ComicBook/{{Shazam}}" near him. This is PlayedWith in ''ComicBook/KingdomCome'', with Superman accidentally cutting his finger while admiring ComicBook/WonderWoman's magic sword. [[spoiler:Possibly intended as foreshadowing for his later battle with Captain Marvel.]]
* To take down ComicBook/BlackAdam, a bullet was made from a piece of the Rock of Eternity.

* ''Literature/TheDresdenFiles'': The enchanted silver swords the Wardens use can cut through enchantments and dispel physical attacks... as well as cut through nearly anything else (such as trees).
* ''Literature/TheHollows'': Rachel injects paintballs with potions, usually Sleepy-Time potions; they take effect on contact as opposed to ingestion.
* ''Literature/NightWatch'': it's very difficult for an Other to be killed with human weapons, as their instinct is to jump into the magical dimension of the Gloom at the first sign of danger, where physical objects cannot reach. Only enchanted bullets have a real chance of killing an Other. A human working for an Other is given enchanted bullets for his submachinegun. These bullets end up killing a werewolf. Besides that, only a nuke can definitively kill an Other, because nuclear explosions somehow reach even the deepest levels of Gloom.
* ''Literature/ASongOfIceAndFire'': The Others are creatures born of winter and hate everything warm. Though they fear fire, their speed and combat skill makes them difficult to set alight. Fortunately, in this world [[LostTechnology Valyrian steel]] and obsidian ([[CallARabbitASmeerp also called dragonglass]]) are associated with dragon fire and can slay them. A flimsy obsidian dagger wielded by [[TheSoCalledCoward the obese and combat-aversive Samwell Tarly]] pierces an Others' ice of armor like butter and actually ''melts its hands when it tries to pull the knife out''.
* ''Literature/SpecialCircumstances'': Generally speaking, weapons imbued with the spirit of a member of the titular organization are often either the only way or the best way of slaying a supernatural beastie. There's also a discussion, at one point, of how normal, non-spiritual FBI agents could battle the supernatural, using "ColdIron" bayonets for their rifles.
* ''Literature/TortallUniverse'': griffin-fletched arrows always hit their targets, and Stormwing-fletched arrows go through magic shielding.
* ''Literature/TheGirlFromTheMiraclesDistrict'': The mercenaries hunting Nikita in the second book are using bullets imbued with magic crystals that nullify her HealingFactor.

[[AC:Live-Action TV]]
* While it's not explicitly stated to be magical, a Chinese-made artifact in ''Series/BloodTies'' called L'Iluminacion del Sol seriously weakens a vampire when stuck into his or her chest and opened.

[[AC:Tabletop Games]]
* ''TabletopGame/GURPSTechnomancer'': The magical metal Necronium, is used primarily as a power source (and can sometimes poison those exposed to it and bring them back as the [[ZombieApocalypse living dead]]), whilst depleted Necronium is toxic to all magical creatures. Depleted Necronium is also completely unaffected by magic, allowing it to penetrate nearly all protective spells.
* ''TabletopGame/MageTheAscension'': Primium for the Technocracy, which is essentially a kills-supernaturals-dead weapon. Using it in a laser makes its wounds as agonizing to vampires as sunlight, Primium bullets hurt werewolves like silver does, and if you're afraid of magic users, plating yourself with Primium stops magic dead (some of the time at least.)
* ''TabletopGame/MageTheAwakening'': (the new World of Darkness's version of the above game) we are given Thaumium. It stores magical energy, it's resistant to magic, and it can [[AbsurdlySharpBlade cut through anything]]. Just for added punch, it's made from silver, gold, ''and'' mercury, all of which have to be mystically purified to produce the essential platonic essence of their being. Yes. Thaumium is made from a mixture of ''depleted'' precious metals.
* ''TabletopGame/{{Warhammer 40000}}'': Thousand Sons chaos marines use inferno bolts, bolt rounds infused with chaos power which can pierce power armour with ease.
* ''TabletopGame/DungeonsAndDragons'':
** Anything under rules with DR x/Magic (Damage Resistance of x points negated by Magic) will have a certain number of damage points deducted from any incoming non-magical attack. In extreme cases, a RedshirtArmy's worth of mundane arrows will be unable to harm a monster. On the other hand, one PlayerCharacter using a magical bow to negate the resistance can defeat the same monster using the same arrows. It's also possible for a monster to have damage reduction that can only be overcome by a weapon that is both magical AND has some other property. Unenchanted silver weapons will take down lycanthropes, but a vampire will just laugh it off unless it's both magic AND silver.
** Earlier editions had numerous monsters flat-out immune to non-magical weapons, or even magical ones below a certain threshold. The ability to hurt such otherwise "invulnerable" creatures was a major factor of what made magical weapons, even a lowly +1 sword, special.
** Whatever the edition, incorporeal creatures can only be wounded at all with a magical weapon. From 3.0 and further, ordinary magical weapon have only 50% of hurting an incorporeal being, unless they have specifically the "ghost touch" enchantment.
** Magic potions can sometimes be used as throwing weapons, taking effect when the vial shatters and spills on the target. This is primarily useful with [[ReviveKillsZombie healing potions against the undead]], because [[CrazyPrepared who carries around potions of Inflict Serious Wounds]]?

[[AC:Video Games]]
* In ''VideoGame/EternalDarkness'', any weapon can be enhanced with magick. Imbued projectile weapons, including crossbows, rifles and shotguns, launch/fire imbued projectiles. It's not necessary for killing monsters, but sure helps.
* In ''VideoGame/FatalFrame/Project Zero'', the character is often an otherwise ordinary person who has the misfortune to "see things other people can't see", which inevitably leads to trouble when they stumble into the haunted house/village/island populated by the restless spirits of the dead. The main weapon used to fight these incorporeal nightmares? A camera. Yes, a camera. One which uses some sort of special crystal or mirror in its makeup so that the user can see ghosts, dispel mystical barriers, and drive off the dead with the snap of a picture.
* Biotics in ''Franchise/MassEffect'' aren't ''exactly'' magic, but they're close enough for government work, so Warp Ammo - bullets imbued with biotic power - would qualify. Warp Ammunition is a signature power of Jack in ''VideoGame/MassEffect2'' and Liara in ''VideoGame/MassEffect3''.
* The ''Dawnguard'' DLC for ''VideoGame/{{Skyrim}}'' adds fire, lightning and ice-imbued ''crossbow bolts''. Y'know, for when those vampires just don't die fast enough.

[[AC:Web Comics]]
* ''Webcomic/TwoKinds'': the most efficient way to take down one of the series [[EvilTowerOfOminousness Evil Towers of Ominousness]] is to shoot the tower's core with a magic-imbued arrow.

[[folder:Silver and Other Precious Metals]]
Silver weapons, including {{Silver Bullet}}s, are commonly used on [[OurWerewolvesAreDifferent Werewolves]] and (less frequently) [[OurVampiresAreDifferent Vampires]], stemming back to the idea of silver being a pure metal and/or associated with the moon. (Note that in RealLife, silver and copper do have biocidal properties. The idiomatic "silver spoon", as well as the common brass doorknob, is very effective at killing bacteria on contact. [[http://en.wikipedia.org/wiki/Silver_nitrate Silver nitrate]] is not only one of the oldest disinfectants, but the one of the few ancient remedies still commonly used.)

[[AC:Comic Books]]
* ''Franchise/{{Batman}}'': One story [[note]]"written by Bob Kane"[[/note]] pits Batman against a vampire, whom he kills (he did that back in the day) by melting down some silver candlesticks, forging bullets out of them, and shooting the vampire.
* ''ComicBook/BatmanVampire'': During the final showdown with Dracula in ''Red Rain'', Batman attacks him with silver Batarangs. In ''Bloodstorm'', his primary weapons are wooden throwing daggers weighted with silver.
* ''ComicBook/FiendsOfTheEasternFront'': the main character melts down silverware and forges them [[SilverBullet into bullets]] for his machine gun to fight Constanta's vampire troops.
* ''ComicBook/WerewolfByNight'': the armor and weaponry of Comicbook/MoonKnight was specifically tailored for werewolf fighting, laced with silver throughout.

[[AC:Films -- Animation]]
* In ''WesternAnimation/TheCurseOfTheWereRabbit'', the bullets needed are gold. ''Twenty-four [[{{Pun}} carat]] gold.''

[[AC:Films -- Live-Action]]
* ''Film/{{Blade}}'': at least the film and TV adaptations, uses silver-coated steel in his melee weapons (spikes and swords).
* ''Film/{{Underworld}}'': the vampires fight with bullets filled with silver nitrate [[note]]better known for its real world use in the eyes of newborn babies to prevent infection right after birth, and in photography[[/note]]. Considering how thick and silvery it is, one assumes this ammo is rather stale (silver nitrate looks like table salt, but gradually forms black deposits of pure silver over time, or more quickly when exposed to light). They initially use regular silver, but those require a lot of bullets to be pumped into Lycans to be effective. Some powerful Lycans have even learned to push silver bullets out of their bodies. It also generally depends on how far away from a doctor a Lycan is, since leaving silver bullets in their bodies too long can result in silver poisoning, which is fatal to them. Then the vampires get their hands on the above-mentioned UV rounds and copy them with liquid silver nitrate. A single bullet can then be fatal (after time), since there is no solid silver to dig out.
* In the movie ''Film/SilverBullet, Gary Busey forges a silver bullet from some necklaces [[spoiler:to use against the werewolf]]. When the gun shop owner looks at him strangely, he tries to pass it off as "the kids really like the Lone Ranger." The other guy has a smirk that says, "Yeah, right."
* During the climax of ''Film/MyBestFriendIsAVampire'', a VampireHunter armed with silver bullets (played by Creator/DavidWarner) shoots the head vampire Modoc (played by Creator/ReneAuberjonois). The latter falls, apparently dead. In a minute, though, he gets up to the surprised protagonist and shocked hunter. When asked by the protagonist (an inexperienced vampire) why a silver bullet didn't kill him, Modoc reminds him that silver is for werewolves.

* ''Literature/TheDresdenFiles'' tightens the qualifications by having a cursed werewolf[[note]]As opposed to one of the other three different kinds, which are all vulnerable to normal weaponry[[/note]] that can only be killed by ''inherited'' silver. Karrin wounds it with her .22 sidearm using bullets made from her grandmother's candlesticks, but a .22 doesn't have the raw power for a killshot. [[spoiler:Harry eventually kills it by propelling his silver pentacle pendant, inherited from his mother, with magical wind.]]
* ''Literature/TheBartimaeusTrilogy'': Silver is used as a weapon against spirits, since Silver actually causes damage to their essence, and can destroy them if given enough time. Iron also works to a lesser degree.
* ''Literature/JillKismet'': Hunters like Jill go through a lot of blessed silver since it's the only thing that can penetrate a [[OurDemonsAreDifferent hellbreed]]'s etheric shell and wound them. Jill uses a pair of Glock {{Hand Cannon}}s loaded with silver bullets, a bullwhip tipped with silver flechettes, and several silver-alloy knives for close-in work. Due to her own hellbreed pact, silver is also one of the few things that can potentially give Jill herself an instantly lethal wound; [[HealingFactor she'll heal up from nearly anything else]], even [[NighInvulnerability assault rifle rounds to center of mass]].

[[AC:Live-Action TV]]
* ''Series/BloodTies'': Detective Mike Sellucci is given silver bullets made for his police-issue Glock 9mm to kill a wendigo. He pumps it full of silver before the creature explodes.
* ''Series/FridayThe13thTheSeries'': A werewolf was strangled with a [[Creator/EastmanKodak Kodak]] film roll with silver in it.
* In ''Series/TrueBlood'', the Fellowship of the Sun sent a suicide bomber whose bomb-vest was layered with silver shrapnel to attack a social gathering of vampires and friends.
* In ''Series/{{Supernatural}}'', silver blades and bullets will dispatch zombies (reanimated by dark magic), shapeshifters, werewolves and more.
* ''Series/DoctorWho'': In the classic series, the Cybermen's breathing apparatus intake was readily clogged by any gold which might accumulate there. Gold dust could be used to clog up the works if you could get your hands on it. However, the effectiveness of this weakness became {{Flanderized}} to the point that by the end, you had a handful of gold coins and a slingshot making a whole platoon of Cybermen a non-issue; when touched by gold they fall down screaming and sparking. When the Cybermen were brought back for the new series, they were an alternate universe breed who had the weakness dealt with in R&D according to a FreezeFrameBonus shot. However, a recent Cyberman appearance gives them some weakness to gold, though much much ''much'' milder than in the old series. (according to the writers, the two breeds have worked together for some time and this new breed that comes from that collaboration has aspects of both.)

[[AC:Tabletop Games]]
* ''TabletopGame/WerewolfTheApocalypse'': Werewolves use silver knives on each other. More specifically, silver prevents a Werewolf from rolling to reduce the damage of an attack. The silver knives werewolves like to use (called "klaives") have War Spirits bound to them, letting them deal aggravated damage on top of that.
* ''TabletopGame/WerewolfTheForsaken'': if silver touches a werewolf's blood, it burns them for aggravated damage and has a rare chance of messing up their HealingFactor. Unlike in ''Apocalypse'', however, using silver on another werewolf is a ''major'' sin on the KarmaMeter. It's also implied that the Pure get messed up ''worse'' than the Forsaken because they never sought forgiveness from Luna for the death of Father Wolf.
* ''TabletopGame/HunterTheVigil'': even the lower-tech groups, are known to use silver bullets in their guns, though they don't always use them against the right enemies (i.e. werewolves).
* ''TabletopGame/TheWitcherGameOfImagination'': Weapons coated in or made of silver are extra effective against [[FantasticFragility all kinds of monsters]]. Sometimes silver is the only thing those creatures can be hurt with. Silver also seriously mess up all shapeshifting abilities.
* ''TabletopGame/DungeonsAndDragons'':
** There are rules for coating any weapon with "alchemical" silver. This applies a penalty to using the weapon so many players will carry a silver-coated sidearm. Magical weapons typically don't need coating.
** There are also spells from the ''Book of Exalted Deeds'' that confer temporarily alchemical silver properties to ordinary weapons or to natural attacks.
* In ''TabletopGame/MagicTheGathering's'' setting of ''Innistrad,'' the distinction is made that only ''blessed'' silver is useful against the various horrific threats to humanity, with the largest prison for demons and such in the land being the Helvault; a massive spire composed of blessed meteoric silver. In vampire-controlled areas, knockoff holy pendants are a hot item on the black market, though the fact that they aren't blessed and therefore [[AllNaturalSnakeOil useless as a protective ward]] is typically not mentioned at time of purchase. Curiously, runes etched with silver are a necessary component to the creation of alchemically-reanimated zombies.

[[AC:Web Original]]
* Blog/ThingsMrWelchIsNoLongerAllowedToDoInAnRPG: ''[[http://theglen.livejournal.com/131998.html Some]]'' variants apparently are over the top:
--> 1117. Can't strangle a werewolf with a roll of Kodak film, no matter what we all know it's [[https://en.wikipedia.org/wiki/Silver_halide made out of]].

[[AC:Video Games]]
* In ''VideoGame/{{Bloodborne}}'', Quicksilver (which is essentially mercury) is used for making bullets against beast, since [[GunsAreUseless ordinary bullets do not work]] against them. Although proven effective, [[RealityEnsues firing liquid metal onto anyone]] wouldn't deal that much of damage as one might think.
* In ''VideoGame/BloodRayne'', Agent Rayne has blades either coated with silver or made of a silver alloy.
* ''VideoGame/SilentHill4: The Room'' has Silver Bullets, which will knock down a Victim in one shot. However, there are only two in the game.
* ''Franchise/TheElderScrolls'':
** Throughout the series (though the exact specifics can vary by game), ghosts can only be harmed by silver, [[FantasyMetals Daedric]], or magically enchanted weaponry. Alternatively, using the [[BarefistedMonk Hand-to-Hand skill]], you kill them ''with your bare hands''.
** ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'' has silver weapons deal additional damage to other forms of undead as well.
* ''VideoGame/TheWitcher:'' Witchers usually carry two swords on their back: one made of steel to fight mortal foes, an one made of silver to fight monsters.

[[AC:Western Animation]]
* Parodied in a ''WesternAnimation/RobotChicken'' sketch: A werewolf is shown running from some kind of hunter and gets shot. The werewolf then claims "Only a silver bullet can kill a werewolf!" The hunter then proceeds to shoot the werewolf into a bloody pulp with a chain gun, light the mess on fire, snort the ashes, crap it out on a toilet and get processed in a sewage plant. Cut to 3 kids playing some sort of tabletop game, with the game master reading from the book and saying: "It says it's STILL not dead!"

[[folder:Ultra-Violet Light]]
A common way to kill vamps, using UV rounds, grenades, lamps, or other tricks. The implication is that a number of supernatural creatures are susceptible to [[http://en.wikipedia.org/wiki/Ionizing_radiation ionizing radiation]] (by definition, light capable of tanning skin is ionizing), which is often used to sterilize tools and food - cloth hung in the sun to dry is cleansed of bacteria nearly as efficiently as soap - tying into the concept of supernatural creatures as plague carriers. It also means that someone should perhaps attempt to kill vampires with X-ray machines or plain 'ol [[http://en.wikipedia.org/wiki/Depleted_uranium depleted uranium]].

* [[http://www.youtube.com/watch?v=lw9ZeXB2uKs&feature=player_embedded This]] Audi commercial.

[[AC:Anime & Manga]]
* ''Anime/ErgoProxy'': the only way to kill a Proxy is with shells that emit UV radiation, because the Proxies [[spoiler:were designed to terraform the world back to normal and then disintegrate when the sunlight came back]].
* In ''Manga/{{Gantz}}'' Kei at one point uses a UV lamp to great effect against vampires.

[[AC:Comic Books]]
* ''ComicBook/{{Blade}}'' has flashbangs and UV flashlights.
* Paralleled on occasion in some weapons against Superman developed from the spectograph of [[http://en.wikipedia.org/wiki/Rao_(comics) Rao]] ([[http://en.wikipedia.org/wiki/Krypton_(comics) Krypton's]] red sun) which takes away his powers until he is again exposed to solar rays. Notoriously used by the Soviet Union in Frank Miller's classic, ''[[Comicbook/BatmanTheDarkKnightReturns Batman: The Dark Knight Returns]]'' [[note]]in which Superman took his devotion to ''Truth, Justice and the American Way'' to include enforcing US Policy abroad.[[/note]] who had tempered a high-yield nuke to do as much ecological damage as possible. Effects included a hemisphere covering EMP and a dust cloud that blocked out the sun in very literal nuclear "winter" way. Since Superman was trying to intercept and redirect the ICBM, it almost kills him because he is left with almost no exposure to his solar power source (he somehow drains energy from some plants to get back on his feet, but is still noted to be operating well below his peak power weeks later).
* Twice in ''ComicBook/SupermanUnchained'':
** The U.S. military under General Sam Lane has been working on "black hole" technologies to fight Superman. These include "max-grav-photon-emitters", a.k.a. "black hole lasers", and "black hole bullets", which are 50 caliber rockets with light vacuums inside of them.
** The Russian military has also been working on anti-Superman technology, specifically the "XR" drones. These unmanned drones have shielding that protects them from Superman's HeatVision and SuperSenses, as well as firing bullets that emit red sun radiation just before impact to be able to pierce Kryptonian skin and armor.

[[AC:Films -- Live-Action]]
* ''Film/{{Blade}}'' has UV lights on his car and weapon-mounted tactical light. Hannibal King's guns shoot UV-radiating bullets, while Abigail Whistler uses a [[Franchise/StarTrek bat'leth]]-like weapon with a UV laser beam running through it. In the second film, Whistler and Scud design phosphorus-based flash grenades that can also deal severe burns to non-vampires, especially when a dozen blow up at once. Even Blade, who's immune to sunlight, is seriously hurt by the blast.
* ''Film/{{Nightlife}}'': a hematologist creates a "prison cell" for a vampire by strategically positioning ultraviolet lamps.
* ''Film/ThirtyDaysOfNight'': ultraviolet causes severe burns to vampire. Unfortunately the protagonists couldn't (or just plain didn't) use it effectively
* ''Film/{{Underworld}}'': As pictured above, the Lycans go armed with bullets filled with a liquid that emits ultraviolet radiation. It works very well.
* ''Film/VanHelsing'': had a full spectrum sunlight grenade. He didn't know what it could be used for, but he thought it would come in handy.

[[AC:Live-Action TV]]
* In ''Series/BloodTies'', a young vampire, made and abandoned by Henry's marker and ex-lover, tries to exact revenge on her by rigging the bright runway lights during a fashion show to produce a UV flash, which would have killed her had Henry not intervened. Her arm still gets burned.

[[AC:Tabletop Games]]
* ''TabletopGame/DarkConspiracy'' has ultraviolet lasers for use against vampires.
* In ''TabletopGame/HunterTheVigil'', Task Force Valkyrie uses UV lights to stun vampires. It's noted that only true, natural sunlight will actually harm a vampire, but an artificial light that replicates sunlight exactly can still trigger their inherent terror at being confronted by the sun.
* One of the example Wonders in ''[[TabletopGame/GeniusTheTransgression Genius: The Transgression]]'' is a UV "Sungun" Lamp, capable of disintegrating vampires after just a few sweeps. And, since this ''is'' intended to be played in the New World of Darkness, Geniuses with bigger plans will probably need these, and more.

[[AC:Vide oGames]]
* In ''VideoGame/VampireRain'', the protagonists fight the titular vampires with UV knives (which can [[BreakableWeapons only be]] [[TooAwesomeToUse used once]]) in addition to their arsenal of conventional firearms.

[[AC:Web Comics]]
* In ''Webcomic/{{Derelict}}'' UV crossbow bolts appear to be the protagonist's chosen weapon against her robed and masked enemies.

If the enemy, usually a vampire, is vulnerable to wood, the solution is to upgrade the stake into a wood-tipped bullet or more powerful and faster reloading crossbow.

[[AC:Comic Books]]
* ''ComicBook/{{Blade}}'': In his original comic book appearances, ComicBook/{{Blade}} used knives made from the hardest teak wood against Dracula and pals.

[[AC:Films -- Live-Action]]
* In ''Film/{{Daybreakers}}, LaResistance uses automatic crossbows that fire wood-tipped bolts to kill vampire soldiers with impressive accuracy. Their advantage is that vampires won't shoot to kill, since they need every surviving human to feed hundreds of millions of vampires across the world.
* In ''Film/OnlyLoversLeftAlive'', the vampire Adam has a wooden bullet specially made, in case he ever decides to kill himself.

* ''Franchise/SherlockHolmes'': wooden bullets were used to threaten the Count in ''The Holmes-Dracula File''. The Count himself notes (either in that novel or in one of the others set in the same continuity) that wood is deadly to his kind while metal cannot truly harm them. This is, in fact, what he takes advantage of to [[spoiler:fake his death at the end of ''Literature/TheDraculaTape'', Saberhagen's take on Stoker's original tale,]] to throw his dogged pursuers off his trail for good.
* ''Discworld/FeetOfClay'': Vimes threatens to kill the BigBad, who is a vampire, with a wooden arrow.

[[AC:Live-Action TV]]
* ''Series/{{Buffy|the vampire slayer}}'' and its SpinOff ''Series/{{Angel}}'': both use crossbows, and Angel has two devices that extend stakes hidden in his sleeves. Connor also used an automatic-staker in his first appearance as a teenager.
** A later episode of Angel shows that members of the Wolfram and Hart Spec Ops Team carry wooden combat knives.
* In ''Series/TrueBlood'', the Fellowship of the Sun developed quite an arsenal of wood-tipped projectile weapons.
** They're not the only ones. When Bill decides to kill Sophie-Anne, the Vampire Queen of Louisiana, he brings in a whole SWAT team armed with assaut rifles with wood ammo. Even an experienced and powerful vampire like her can't do much against MoreDakka of wood. Later, we're shown the the Vampire Authority has plenty of soldiers armed with similar guns.
* Wood is used against vampires all over ''Series/TheVampireDiaries'', in forms ranging from a standard hand-driven stake to a crossbow to ''wooden bullets'' that can be fired from a standard pistol. The wooden bullets aren't enough to kill; however, the homemade stake gun is.
* The paramilitary vampire hunters in ''{{Series/Ultraviolet}}'' use charcoal-nosed bullets.

[[AC:Myths & Religion]]
* Myth/NorseMythology: only mistletoe can harm Balder; everything else in the Nine Worlds has promised not to hurt him, because Balder is [[{{Bishonen}} just so damn pretty]]. (The mistletoe probably would have promised too, but Frigga forgot to ask it.) MagnificentBastard Loki simply cannot resist the opportunity this presented...

[[AC:Tabletop Games]]
* ''TabletopGame/{{Rifts}}'' has wood-firing railguns ([[JustifiedTrope with embedded metal cores for the magnets to work on]]) on occasion for dealing with vampires. It also has actual depleted uranium shells (Not ''quite'' depleted, as these were described as still being more radioactive than normal DU rounds), which for reasons unknown retard magical abilities to heal. These are great for those pesky critters that fight you down to their last MD point and then teleport off and return an hour later fully healed, giving you the time to hunt them down and finish the job. There are also shells made of non-depleted uranium that actively interfere with magic use by anything they embed in. Both can be cured by physically removing the round, however digging into your side with your own claws is generally A Bad Idea.
* ''TabletopGame/HunterTheVigil Task Force'': VALKYRIE sometimes uses specially treated wood bullets against vampires-the bullets can come in all sizes, and can be used to effectively "stake" a vampire at range.

[[AC:Video Games]]
* ''VideoGame/SaGaFrontier2'': Wooden swords are the weapon of choice for most people the world, since magic cannot be channeled through steel weapons. [[TheChessmaster One character]] uses this limitation to his advantage, however.

[[AC:Web Comics]]
* ''Webcomic/SluggyFreelance'': Riff comes up with [[http://www.sluggy.com/comics/archives/daily/981004 this baby]]. Too bad it only holds one second's worth of ammo and takes two days to reload.

[[folder:Everything at Once]]
For weapons that combine various weaknesses into one shotgun shell, sword, or what have you. Just to cover all the bases.

[[AC:Comic Books]]
* ''ComicBook/AstroCity'' "Confession" story arc (see above): Mordecai Chalk, a cyborg monster-hunter. He had a shotgun that fired shells with wolfsbane and holy water, mechanical parts etched with holy symbols and crafted in iron and silver, and an on-board computer that references thousands of occult tomes. [[spoiler:It doesn't do him any good.]]

[[AC: Fan Works]]
* In ''[[http://www.grandt.com/Journey/stories/WhenTitansClash.html When Titans Clash]]'' by Tenhawk, the Knighthood used counter-supernatural artillery rounds that were "... ''based around a core of three kilos of military grade high explosive which was surrounded by a sphere of blessed silver segmented into frangible pieces approximately one cubic inch in volume. This was in turn surrounded by pure meteoric iron in a second sphere, segmented into similar pieces''."
* In ''[[http://www.tthfanfic.org/Story-28404-107/DianeCastle+Xendra.htm Xendra]]'', Willow and Xander/Xendra load shotgun shells with quebracho (the hardest wood in the world), lead, cold iron, silver, and little steel crosses, plus shards of magnesium that ignite when fired. It is noted that making the shells requires a huge amount of time.
* In the ''Fanfic/ThisTimeRound'' fic "Friendly Hopes", William Starr's shotgun contains a mix of lead, gold, silver, iron, hardwood, platinum and diamonds. He's not aware of anything with a vulnerability to platinum or diamonds, but you never know.

[[AC:Films -- Live-Action]]
* The titular character of ''Film/{{Hellboy}}'' fights most demonic creatures using a big honking gun (forged from a church bell, no less) with ammunition comprising of glass bullets filled with ''"holy water, clover leaf, silver shavings, white oak... the works."''

* ''Literature/{{Discworld}}'':
** In the undead bar of Ankh-Morpork, the bartender, Igor, has a weapon as follows:
--->''Like many barmen, Igor kept a club under the bar to deal with those little upsets that occurred around closing time... Igor's weapon of choice was a little different. It was tipped with silver (for werewolves), hung with garlic (for vampires) and wrapped around with a strip of blanket (for bogeymen). For everyone else, the fact that it was two feet of solid bog-oak usually sufficed.''
* ''Series/StarTrekTheNextGeneration'': "Greater Than the Sum" introduces a "multivector weapon" designed to use everything against the Borg that had ever been somewhat effective. Then the Borg get ahold of it before it could be used against them -- and do what they always do -- they adapt.
** The EU, specifically ''Literature/StarTrekDestiny'', tries to explain how ''[[Series/StarTrekVoyager Voyager's]]'' Transphasic Torpedos are so effective against the Borg. Basically they're Quantum Torpedos which use subspace to simultaneously explode with every possible frequency. Meaning that no shield modulation can possibly block the full force of the detonation, only parts of it. The only way to defend against them would be a shield that simultaneously covers all modulations. [[spoiler: Naturally, the Borg do finally adapt to them and it takes a DeusExMachina to save the Federation.]]
* ''Literature/TheBartimaeusTrilogy'': All spirits from the weakest mite to the greatest marid can be severely hurt by silver, iron, and certain types of herbs and spices, such as rosemary. Magicians, commoners, and other spirits exploit this to no end. It gets to the point where powerful spirits are taken down by improvised use of everyday metals more often than they are by the devastatingly destructive spells these entities can employ.
* ''Literature/ElementalMasters'':
** In ''Literature/ReservedForTheCat'', the heroine carries a revolver loaded with two ColdIron bullets, two {{Silver Bullet}}s, and two Blessed Lead bullets, plus extra ammo of all three types. It's anyone's guess which type offed the mystical BigBad at the end of the novel.
** In ''Literature/UnnaturalIssue'', the Kerridge family have similar bullets for their shotguns, and they along with their friend Peter and his valet Garrick also have shotgun shells filled with [[SaltSolution blessed salt to take down the undead]].
* In ''Literature/TheGoodTheBadAndTheMediochre'', the tempomancer threatens to shoot [[{{Dhampyr}} Dhampinella]] with a tranquiliser dart loaded with garlic oil, citric acid and holy water. [[NoKillLikeOverkill With a crucifix motif]].
* While Vampires and Werewolves have largely integrated into the alternate Victorian setting of ''Literature/TheParasolProtectorate'', there are still quite a few characters who like to be prepared. Alexia's signature parasol, for example, [[ParasolOfPain has retractable spikes of both silver and wood]] along with a chemical spray tailored to each, one of which doubles as a powerful acid. Other examples include sundowner bullets (wooden musket balls banded with silver) and, amusingly, [[EdibleAmmunition pesto sauce]] (Werewolves in this universe are allergic to basil. Throw in some garlic...).

[[AC:Live-Action TV]]
* ''Series/{{Supernatural}}'':
** The hunters have to improvise a variety of weapons to kill a variety of creatures. The hunter's arsenal makes use of most of the above, ''except'' [[OurVampiresAreDifferent garlic]]. The most frequent example is their use of shotgun shells loaded with rock salt against ghosts. Ghosts cannot act on iron, and are killed when their remains are salted and burned. Bobby's saferoom is walled with Iron treated with rock salt. Holy weapons can be found with holy water, which cannot be crossed by demons, or holy ''oil'', which cannot be crossed by ''angels''. This has even been weaponized into a [[Funny/{{Supernatural}} molotov cocktail]]. And when all else fails, there's a magical gun and knife that kill ''everything''. [[spoiler:[[ContractualBossImmunity Except when they don't]].]]
** The alpha shifter proves vulnerable to iridium.
** The general method seems to be -- if it's a demon, apply holy water followed by magic knife or exorcism (if you have time). If not, apply iron, silver, and liberal amounts of salt (often loaded into shotguns) and fire. All that said, the one thing that seems to have been capable of taking down anything a hunter faces (with a few exceptions) is relatively mundane - [[OffWithHisHead beheading.]] It's the only way to kill a vampire (aside from the [[TooAwesomeToUse Colt]]). Okami are susceptible to being run through a wood chipper. Wood chippers pretty much trump...everything. Presumably, they would work on a fair amount of monsters but the Okami is the only one ever shown in the show.

[[AC:Tabletop Games]]
* ''TabletopGame/DungeonsAndDragons'' includes a plethora of monsters with varying types of damage reduction, such as werecreatures, demons, fey and others, which often results in adventurers carrying around extensive collections of weapons ("No, we need a ''silver'' magical weapon that does piercing damage, not a cold iron one!"). Both melee weapons and ammunition for projectiles are often made from these special materials.
** An insanely genius item introduced in one of the guides by [[HunterOfMonsters Van Richten]] of ''TabletopGame/{{Ravenloft}}'' was a weakness-detecting arrow. Rather than a traditional point, it had needles from over a dozen different substances, like cold iron, gold, silver, wood, and so on. When fired, it does minimal damage to its target, but also does not embed itself. After it is recovered, the wielder can see what substance did the harm based on which other needles are broken or bent, and (depending on the target) which needle has the blood stain.
** Epic-level monsters (i.e. challenges for level 21+ characters) sometimes require truly bizarre weapons to deal normal damage to them. A time-elemental Phane can only take normal damage from weapons from an alternate history, for example, and a mind-consuming Dream Larva only takes real damage from weapons forged by a ''sleepwalking blacksmith.''
** The [[HealingFactor Regeneration Ability]] that stops a creature from being killed by attacks that do not overcome it. For example [[AllTrollsAreDifferent trolls]] can only be killed by fire or acid damage.
** There are magical weapon enhancements that can compensate for the "golf bag scabbard" problem. Metalline weapons overcome any damage reduction based on the material composition of the weapon, Transforming weapons can change shape into other types of weapons which deal damage in a different manner (bludgeoning, piercing, slashing, or some combination), and Shadowstriking weapons can temporarily attune themselves to a particular creature and overcome whatever damage reduction it happens to have.
* In the ''TabletopGame/DresdenFiles'' RPG, many types of supernatural creature have a power that improves their toughness and/or regeneration. Every one of these is required to have a "Catch" or critical weakness, which will prevent their durability or recovery from taking effect. Catches are rated on a [[PointBuy points system]] (helping to offset the cost of the original powers), with more common weaknesses providing a bigger refund. For instance, a creature that's weak against fire or sunlight gets a 4-point discount, because this is well-known and easy to find; one vulnerable to something more esoteric like True Love might only get 2 points, and someone vulnerable to only a specific, difficult-to-find object (such as the Noose of Barrabas) gets nothing. However, certain rare artifacts and powers allow a player to spend a fate point to simply ''declare'' that their next attack matches a given target's Catch, allowing them to penetrate whatever supernatural defenses it might have.
* The anti-vampire kit in ''TabletopGame/{{GURPS}} Steam-Tech'' includes a revolver with a selection of silver bullets, lead bullets inscribed with crosses, hardwood bullets, and actual miniature stakes which can be fired with a blank cartridge. How well they work depends on the kind of vampire and the quality of the specific kit (in the accompanying vignette, an unfortunate vampire hunter discovers - among several other problems with his kit - that the stakes don't actually fit the gun, and tend to fall out).
* In ''TabletopGame/HunterTheVigil'', this is one of [[TheMenInBlack Task Force: VALKYRIE's]] Endowments, called Compound Rounds, which deal Lethal damage against supernatural targets that would usually only take Bashing damage from bullets. Come in various sizes for extra fun.

[[AC:Video Games]]
* ''VideoGame/CityOfHeroes'': This may be the only explanation for heroes with assault rifles being able to take anything down at all. Unfortunately this works the other way, too, as mooks and bosses of a high enough level can worry heroes protected by magical forces, power armor, and the like with [[MundaneSolution ordinary guns]].

[[AC:Web Comics]]
* ''Webcomic/ParallelDementia'': Fall and other Nightmare hunters use blessed weapons (to combat demons), obsidian (for angels), garlic (for undead), iron (for fey), amethyst (for spawn), and silver (for therians) to combat the various types of Nightmares. On at least one occasion, Fall is given specially made ammunition incorporating all of these at once, because she's about to head into an extremely tense situation and standard operating procedure (using a test clip loaded with one of each kind of ammo, in a specific order, so that you can switch to full clips of the appropriate variety when you find the one that works) would be dangerously time-consuming.

[[AC:Web Original]]
* The legendary Usenet poster "Gharlane of Eddore" once proposed a design for a Standard Generic Monster Load, which was:
-->Silver bullet; hex-scored jacketed hollow-point filled with a gel made of Holy Water, wolfsbane, garlic, fugu toxin and curare, laced with dimethyl sulfoxide to provide tractor-solvent Spreading Factor. Traditionalists can also cut crosses in the bases of the bullets, and have them blessed by a priest. .44 magnum 240-grain load over the standard Elmer Keith hunting load, 24 grains of IMR 2400 (the manual says 21.8 grains is maximum, so don't use the 24-grain load if you have a cheap revolver). These work reliably on Vampires, Werewolves, the generic Undead, and Evil Human Minions like [[TheRenfield Renfield]], with sublime indifference.

If bullets won't kill it, then obviously the answer is to make better bullets. If they're just really well protected, use a harder material like bronze or tungsten. If somebody's playing tricks with magnets, use compressed plastic. With magnesium, you can KillItWithFire! Or perhaps you can recycle their phlebotinum and [[HoistByHisOwnPetard Hoist Them By Their Own Petard]].

[[AC:Anime & Manga]]
* Sven from ''Manga/BlackCat'' packs an array of interesting bullets, and among these there are blue-tipped ones that [[InstantIceJustAddCold freezes]] the opponent on contact.
* ''Manga/ElfenLied'': When traditional firearms [[ImmuneToBullets prove useless against the diclonii]], the antagonists resort to [[{{BFG}} anti-tank rifles]] loaded with purpose-made tungsten slugs, which are too heavy for the diclonii's [[PsychicPower Vectors]] to easily deflect.
* Kittan in ''Anime/TengenToppaGurrenLagann'' at one point attempts to hold off a Mugann with a shotgun packing "Spiral shells." A more impressive one is issued to Grapearls, producing huge explosions ''and'' a shell to contain the aftermath of a Mugann going blooie.
* In ''Manga/MagicalRecordLyricalNanohaForce'', [[MageMarksman Teana]] gains bullets that inject anti-Eclipse drugs. [[MageKiller Eclipse Drivers]] that are shot by these will have their HealingFactor drastically reduced and could now receive lasting damage.
* A FreezeFrameBonus in ''Anime/MobileSuitGundamWingEndlessWaltz'' shows that Heavyarms Kai's [[MoreDakka Double]] [[GatlingGood Gatling Guns]] use Gundanium-jacketed bullets; since Gundanium is exceptionally tough, this presumably makes the bullets hit harder.
* Kiritsugu Emiya of ''Anime/FateZero'' uses bullets containing one of his ribs (powdered, of course), which hit exponentially harder as his opponents dedicate more of their magic circuits to defense - and destroys those magic circuits in the process.

[[AC:Comic Books]]
* ''ComicBook/XMen'': ComicBook/{{Magneto}}, Master of Magnetism is often faced with plastic or composite weapons, and was locked in a "plastic prison" on more than one occasion. In the original animated series a Sentinel boasts about how its plastic coating stops Magneto's powers... Magneto's response is an annoyed "You fools, this whole ''ship'' is my ''weapon!'' and promptly throws the huge generators nearby through the Sentinels.
* ''ComicBook/TheMighty'': Gabriel Cole was given some special bullets. It turns out that it's [[spoiler:special condensed nitrogen bullets to use against the invulnerable Alpha One since he needs to breathe more oxygen than most people.]]
* The Daximites, a race of aliens which has Franchise/{{Superman}}'s powers, only weakness is LEAD, which means that any attempt to take over the Earth while firearms and lead bullets are the most common weaponry on the planet is pretty futile.

[[AC:Films -- Live-Action]]
* ''Film/TransformersFilmSeries'''':
** The "6000-degree magnesium burn" of "high-heat 105mm sabot rounds" fired from an AC-130 gunship allowed the US military to hurt the marauding Decepticons in the movie (it's not much, but it works rather better than normal bullets). Discarding-sabot rounds being neither hot, magnesium-laden or used by AC-130s, this has little to do with military practice or actual physics, though it is implied that weapons technology in the movie-verse is different because many human technological advancements came from studying Megatron's body.
** By the second movie, the human NEST teams are shown carrying heavily-upgraded, large-caliber assault rifles and machineguns that can actually inflict damage on Decepticons; the NEST units and Marines fighting the Decepticons at the end of the movie prove surprisingly effective against the Decepticons in the all-out battle that results.
** By the third film, a number of a key Decepticons are taken down ''without'' any help from Autobots beyond training shown earlier in the film.
** By the time the fourth film rolls around, [[spoiler:a rogue anti-Cybertronian organization has used trained soldiers and new tech to exterminate most Cybertronians on Earth]].
* In ''Film/{{Posse}}'', Jesse Lee has some of the stolen gold recast into golden bullets he intends to use on his father's killers. Father Time explains that, according to New Orleans voodoo ladies, gold is the only way to kill a demon. In Jesse's case, the demons are symbolic rather than actual.
* The shells for the ''Götterdämmerung'''s main gun in ''Film/IronSky'' are said to be made from metastable metallic hydrogen. They are powerful enough to [[DefaceOfTheMoon tear our huge chunks of the Moon]] with each shot.

* ''Literature/HammersSlammers'': there's all sorts of strange weapons and ammo. One example is the "osmium penetrator" used by some of the other merc companies. These weapons take a rod of osmium, put behind it roughly a liter of propellant, and force it down a diamond-coated barrel to flechette thickness. It emerges as an osmium needle well capable of getting through tank armor, though it has little effect on personnel (the needle just blasts through people as if they weren't there, and since it doesn't splash, it just makes a very small hole). And powerguns, that fire ''bolts of energy'' from polyurethane wafers as ammo.
* ''Literature/TheDresdenFiles'':
** Kincaid at one point uses Dragonsbreath shotgun rounds to turn his disposable shotguns into flamethrowers. This inspires Harry to read up on ''other'' unusual shotgun rounds, including flares.
** Dresden also keeps around some ''actual'' depleted uranium, in powder form, because it apparently has spiritual as well as physical weight and can dispel ghosts.
* ''Literature/TheAlloyOfLaw'': Anti-Allomancer rounds. The expensive ones are made out of Aluminum, the cheap ones vary based on target: Coinshot rounds are fronted with ceramics that will keep going when they push on the metal, Lurcher rounds contain ceramics surrounded by metal and fragment when pulled, Tineye rounds are excessively loud, Thug rounds are enormously over-sized.
* In Creator/SergeyLukyanenko's ''Literature/NightWatch'', most of the stuff mentioned above is useless against vampires (in fact, they deliberately let {{Muggles}} think it works). Even silver doesn't kill them, though being shot with a SilverBullet hurts like hell. What's deadly against a vampire? Vodka. Luckily most of the novels take place in Russia, where [[VodkaDrunkenski vodka is everywhere]].
* The Confederation military in ''Literature/TheNightsDawnTrilogy'' is initially ineffective when fighting the [[DemonicPossession Possessed]] except through [[OrbitalBombardment massive overkill]] due to the Possessed [[WalkingTechbane scrambling nearby high-tech equipment]] and their sheer durability. The military eventually discover that the Possessed are crippled by large amounts of (static) electricity, and develop bullets with internal capacitors for fighting off the Possessed.
* In ''Literature/AncillaryJustice'', [[spoiler:the bullets fired by the Garseddai guns will, after impact, go through ''anything'' for exactly 1.11 meters, by simply creating as much energy as they need. In the third book it is revealed that the 1.11 meters were just a side effect of their even more exotic intended function of specifically destroying Radchaai ships while not being able to harm the gunsí Presger creators.]]

[[AC:Live-Action TV]]
* ''Series/DoctorWho'':
** For UNIT's final appearance in the old version, following an absence of some years, it is shown that they got tired of facing ImmuneToBullets menaces and developed special bullets to even the playing field. These include teflon-coated armor-piercing rounds for robots and Daleks ("A non-stick bullet?" the Doctor muses[[note]]Teflon-coated rounds are a real thing, but the teflon has nothing to do with the actual armor-piercing capabilities. It is there to protect the barrel of the gun, as armor-piercing rounds are made of very hard metals and would quickly wear out a barrel when scraping against it.[[/note]]), high-explosive rounds for Yetis, [[WeaksauceWeakness gold-tipped bullets for Cybermen]], and {{silver bullet}}s just in case. [[spoiler:The silver bullets turn out to be very useful.]]
** This continues in the new series, where UNIT uses rad-steel coated bullets [[spoiler:to counter the Sontarans' anti-bullet field (that expands the copper casing of normal rounds and stops the guns firing)]].
** In "Revenge of the Cybermen", the Doctor mentions the "glittergun", which turns Cybermen into gold-plated statues as it clogs their vents.
* In ''Series/KamenRiderKuuga'', a particularly persistent MonsterOfTheWeek (introduced in episode 2, finally offed in episode 39, though he doesn't appear in every episode) winds up getting its corpse analyzed to create special ammunition that can actually affect Grongi.
* In ''Series/KamenRiderOOO'', Kamen Rider Birth uses a gun which fires Cell Medals at Yummies. Given that the term phlebotinum seems to be a play on phlebotomy (drawing of blood), and that Yummies (and the Greeed who created them) tend to "bleed" Cell Medals, this seems to be a fairly direct invocation.
* At one point in ''[[Series/{{V 1983}} V: The Final Battle]]'', the heroes discover that Visitor body armor is now impervious to conventional bullets. Teflon-coated bullets solve this problem rather quickly.
* In ''Series/FallingSkies'', the alien mechs can't be damaged by conventional bullets. Bullets made from salvaged mech armor, however, are quite effective.
* In ''Series/LukeCage2016'', Luke Cage is ImmuneToBullets, except for the Judas, which is a line of special bullets designed by Hammer Industries and engineered from salvaged Chitauri metals.

[[AC:Tabletop Games]]
* ''TabletopGame/Warhammer40000'' has several examples, like Hellfire rounds, shells filled with a mutagenic acid that causes a near-instant and very painful death to anybody unfortunate enough to get hit by one, Dragonfire shells, which explode in a burst of superheated gas and Kraken bolts, which contain cores made of ThunderboltIron.
* In ''TabletopGame/{{GURPS}} Ogre'', the standard anti-personnel round is "ap-fizz dizzy-doo" (APFSDSDU): armor-piercing, fin-stabilized, discarding sabot, depleted uranium.

[[AC:Video Games]]
* ''VideoGame/ResidentEvil3Nemesis'', in addition to normal grenade rounds, also has acid, fire, and [[KillItWithIce ice]] grenades. ''VideoGame/ResidentEvilCodeVeronica'' also features anti-BOW gas rounds.
* The [[EleventhHourSuperpower tail end]] of ''VideoGame/ParasiteEve'' features bullets laced with the protagonist's mitochondria. And that's not even touching the fact that the game's main feature is [[EliteTweak elite gun tweaking]] to make bullets that freeze, burn, tranquilize, or poison with acid and cyanide. (Then there's the crazy things the guns themselves can do, barring the already-powerful-enough rocket launchers.)
* ''VideoGame/ChexQuest'': Originally the flemoids/phlemoids (Whichever you prefer) were immune to conventional weapons. However, the "Zorcher" works by [[ReversePolarity remodulating the dimensional frequencies]] of the creatures, sending them back to whatever realm they came from. Therefore, [[NeverSayDie no killing]] the... green... slimy mucus things that want to eat the main character alive, and Ta-Da! It's kid-friendly!
* ''VideoGame/{{BioShock|1}}'' has ammo for weapons ranging from (relatively) realistic things like armour piercing bullets to things like electric shotgun shells, exploding shotgun shells, a flamethrower that also fires liquid nitrogen and electric gel, and a crossbow with fire bolts and bolts that shoot wires. And then there's [[LegoGenetics plasmids]]...
* ''VideoGame/{{Stars}}!'' has depleted '''neutronium''' ammo -- presumably, dense far beyond the bounds of normal matter. (How you deplete neutronium is unknown to modern science.)
* ''VideoGame/JaggedAlliance 2'' v1.13: introduced AET (Advanced Energy Transfer) ammunition. They pierce armor better and do more damage than standard AP rounds although less than hollow-point rounds when they strike flesh. Their price is huge and they also wear off guns faster then normal bullets. The developers suggest [[MST3KMantra not thinking too hard]] about how that works. [[DownplayedTrope On a more mundane level]], there's also [[https://en.wikipedia.org/wiki/Glaser_Safety_Slug Glaser ammunition]], which is even more powerful than hollowpoints against an unarmoured enemy -[[NecessaryDrawback and even weaker against one who does]]- and is also guaranteed to never punch right through the target and hit a civilian or friendly who happened to be standing behind them.
* ''VideoGame/{{Singularity}}'': is powered up with the time-warping abilities of "Element 99". Some of the weapons have special abilities because of this (like a sniper rifle that slows down time so you can shoot a moving target) but for most, it just makes their bullets hit harder.
* ''VideoGame/NinjaGaiden'': when Ryu used APFSDS cores as ''arrows'', to destroy heavily armored ''tanks and helicopters''. But then, that whole section of the game is an exercise in RefugeInAudacity. There are also explosive arrows for when getting through armour is less important than AOE.
* In ''VideoGame/StarCraft'', the "U-238 Shells" upgrade swaps out the standard Terran Marine rifle round for [[ExactlyWhatItSaysOnTheTin one made from depleted uranium]]. This increases Marines' attack range by 25%.
* Railgun rounds in ''VideoGame/EscapeVelocity Nova'' are stated in flavor text to be forged of metals that are highly conductive but cheap, such as copper and gold. The rounds come in 100, 150, 200, and (with the [[GameMod ARPIA plug-in]]) 400 millimeter sizes.
* ''VideoGame/TheGodfather 2'' has incendiary rounds as a reward for completing a certain crime ring.
* ''VideoGame/XComApocalypse'':
** The ultimate anti-alien weapons are anti-alien toxins and anti-alien gas. The former requires a special pistol and has to be upgraded twice to be effective against advanced forms, the latter is discovered fairly late, but can be used in grenades and missiles for existing launchers. Both completely bypass aliens' force field shields and pose almost no threat whatsoever to allied forces in the event of psionic attack. With those the last missions are a breeze. You still need conventional weapons, explosives or rayguns to disable alien structures, though. Good thing you can borrow them from dead aliens.
** Equally, it takes multiple disruptor blasts or devastator missiles to take down ''your'' troopers at that stage, thanks to your NighInvulnerable disruption armor and stolen shield technology... and then the aliens bust out ''their'' enzyme guns, which shoot target-seeking organic "missiles" loaded with nasty stuff that can melt through your super-armor in seconds. They may still be stopped by shields, but the moment you see them on the field, you take notice.
* ''VideoGame/{{Evolve}}'' has super material rounds, or super-mat for short. How they work exactly isn't explained, but a super-mat pistol [[HandCannon packs enough of a punch]] for a multi-story tall monster to take notice.
* ''VideoGame/EarthAndBeyond'' had Projectile (read: bullets) and Missile ammunition (as well as beams) that came in a wide variety of flavors, each of which behaved differently and was effective against different targets. It did at least try to be "realistic" by limiting which damage types could fit into which ammunition. Damage types were: Impact, Explosive, Energy, Plasma, Chemical, and EMP. Impact Explosive and Energy were the basic type that did instant upfront damage equally on all targets; no Impact/Explosive Beams, Explosive Projectiles, or Energy Missiles existed with only 1 extremely rare Energy Projectile existing. Plasma and Chemical each did [=DoT=] with Plasma doing extra damage to metal hulls and Chemical doing extra damage to organic Space Whales; all weapons could fire Plasma ammo, but there were no chemical Beams. EMP did extra damage to shields and ScratchDamage to anything else; only 1 rare EMP Projectile existed but were common for Beams and Missiles.

[[AC:Web Original]]
* Jack Yaeger's gun in ''WebVideo/TheMercuryMen'' fires bullets made of solid light, apparently the only thing that can kill the Mercury men.

[[AC:Western Animation]]
* In ''WesternAnimation/{{Centurions}}'', energy specialist Rex Charger had assault weapon systems that fired missiles that contained... energy-changing stuff. Magnetic shields, light, [[EnergyAbsorption energy that was absorbed by a gun]]--the missiles were {{Technobabble}} shells. This meant that they were exactly as powerful as the plot demanded: on separate occasions, Rex blew up a SwirlyEnergyThingy and ''killed a black hole.''

[[AC:Real Life]]
* The TropeNamer, Depleted Uranium Sabots. Not only do they one-up the usual materials used for tank shells, such as steel and tungsten in terms of density, and thus potential kinetic energy, it's also self-sharpening and pyrophoric, meaning while conventional steel or tungsten rounds blunt as they dig into armor, Depleted Uranium melts in a pattern that keeps it sharp, and when it penetrates, it drags all that molten metal along with it into the innards of its target. It also happens to be slightly radioactive, and a toxic compound, but those are largely irrelevant.