[[quoteright:350:[[WesternAnimation/GravityFalls http://static.tvtropes.org/pmwiki/pub/images/dipper2_5426.png]]]]
[[caption-width-right:350:Always make sure the mechanism is clear of paper jams before copying.]]
->''"You know how when you make a copy of a copy, it's not as sharp as, well, the original?"''
-->-- '''Doug Kinney #3''', ''Film/{{Multiplicity}}''

When dealing with fiction that {{clon|ingBlues}}es things, the assumption is often made that clones must, after time, decay. That is, with each copy you make whatever AppliedPhlebotinum you are using to create the clones will either decrease in effectiveness, or the clones themselves become less coherent since eventually everything is just a copy of a copy. This goes double for dead clones, who [[EverythingFades tend to dissolve]] because they're "[[WhatMeasureIsANonHuman less than human]]" rather than leave a proper corpse.

When dealing with a character who has the ability to [[SelfDuplication create clones apparently out of thin air]], this weakness is usually the only thing holding them back from whatever it is they're trying to do.

Uses very similar logic to SuperPrototype and ConservationOfNinjutsu. The SuperPrototype, when it is a one-of-a-kind machine, is awesome and unstoppable. Clones, likewise, seem really great at first-- but the more of them you get, the more common and boring the idea of a clone is in the first place. As a result, they inevitably lose effectiveness because several copies of the same thing just wouldn't be all that interesting.

In some instances it may be a JustifiedTrope: the creator may "program" a shortened lifespan into the clone to protect their property from getting away or [[KillAndReplace trying to take his place]]. Relatedly, the degeneration may be because the process used to make the clone resulted in a FlawedPrototype, making all the clones a form of KeystoneArmy that will croak on some future date or circumstance. If the hero has [[ExpendableClone qualms about killing clones]], their degeneration lays them to rest. Whether out of being a MercyKill or making them seem ''less real'' varies.

See also PowerDegeneration, which also applies to clones designed with powers. Compare PossessionBurnout, when being possessed damages the host in a sometimes accelerated manner each time it's done.

Note that this trope does have some grounding in RealLife: Cloning isn't a fully documented science yet, and genetic kinks in the cloning process, such as shortened telomeres and genomic imprinting, remain factors that may lead to clones having shorter life expectancies than their originals. Clones of clones tend to be even worse off.

Note, this is not the same as a [[EvilKnockoff Degenerate Clone]].


[[folder:Anime and Manga]]
* In ''Manga/AhMyGoddess'':
** In the "Adventures of the Mini-Goddesses'' manga, one of the goddesses is able to make a duplicate of herself, which can make a duplicate of herself, etc, each of which is a bit shorter and squishier than its parent. In the main series, goddesses and demons can also divide themselves into avatars -- smaller, less powerful versions of themselves. Before leaving, Hild splits off a 1/1000 avatar of herself in the form of a child to keep track of things on Earth. In chapter 248, her 1/1000 avatar then splits off a 1/1000 avatar which takes the form of a small crystal.
** The main manga and series feature a clone of Urd. The Urd clone can use all the same magic as Urd, but her inferior body can't handle the stress.
* Clones in ''Anime/MobileSuitGundamSEED'' tend to have physical or mental problems. Case in Point: [[spoiler:Rau Le Cruset]].
** Another example would be Prayer Reverie in the [[Manga/MobileSuitGundamSEEDAstray Astray mangas]], who was okay in the head, but was basically an IllGirl for most of the Astray X series, [[spoiler: and was able to convincingly fake a death of "natural causes" at the apparent age of nine]]
* This is the reason why [[spoiler:Zest Grangaitz]] of ''Anime/MagicalGirlLyricalNanohaStrikers'' was considered an imperfect [[SuperSoldier Artificial Mage]]. He got the memories, abilities, and personality of the original, but his body was suffering from severe health problems.
** Averted with [[spoiler:Fate Testarossa]], who appears completely healthy over a decade and a half after her creation, as well as [[spoiler:Erio Mondial]], who has been alive for at least a decade as of ''Force''.
*** [[spoiler: Fate]] is an interesting example. Although she has none of the issues seen in this trope, she isn't a perfect clone, either. Changes in personality, which hand is dominant, and other small details mark her as a distinctly unique individual, which led to her ultimate classification as 'failed clone' despite the fact that her incredible raw magical aptitude perhaps make her even better than the original. Although that was because her creator wanted a ReplacementGoldfish and didn't care about anything else.
* In ''VisualNovel/FateStayNight'', [[spoiler:Ilya]] will eventually die young because of her nature as a [[spoiler:modified homunculi Holy Grail.]]
* In her last few scenes in ''Anime/NeonGenesisEvangelion'', Rei Ayanami's limbs had a tendency to ... fall off. Her body, being a [[spoiler:mishmash of Lilith and Yui's [=DNA=],]] isn't capable to holding together without Rei's [=AT=] field to counter the effects of imperfect cloning. After [[HeroicRROD expending so much of her energy to counter Kaworu the previous day]], she can't hold herself together.
* The Sisters in ''LightNovel/ACertainMagicalIndex'' have to go through body adjustments specifically to prevent this. {{Justified|Trope}} because they were only made so that [[spoiler: Accelerator could kill them]].
* In the ''Franchise/GhostInTheShell'' universe, it is possible for people to 'clone' their ghosts (what amounts to their souls) by copying the memory data of their cyberbrains, however this process leads to the eventual corruption of both the original and the copies created, and ultimately leads to the death of the original. As a result, the process, known as "ghost dubbing," is highly illegal, punishable by life in prison or brain-wipe.
* In the fifth ''LightNovel/KaraNoKyoukai'' movie, [[spoiler:Enjou learns of his clone status the hard way. And then his arm falls off.]]
* Negi of ''Manga/MahouSenseiNegima'' employs several paper doll clones of himself in chapter 36, without knowing exactly how it works. This trope ensues...
** This trope may be the reason of [[WeHardlyKnewYe Quartum's and Quintum's]] {{Curb Stomp|Battle}}ing.
* Manga/{{Naruto}} can create up to a couple thousand copies of himself, but they dispel whenever they take a direct hit. He also doesn't trust them enough to let them out of his sight, which suggests that they're not as smart as the original. [[IdiotHero Which is saying something, considering who we're dealing with.]]
** Given how they can fight against each other, they're probably capable of independent thought and, given Naruto's natural rebelliousness, prone to disobeying.
*** By the time of manga chapter 550 his clones have received a sizeable upgrade, becoming capable of taking out Kage-level opponents on their own without the original present.
*** In the special chapter, which happens before the beginning of the ''Road to Ninja'' movie, Naruto plays a card game with two clones. Naruto claims if he or one of his clones wins, he says they all win since they are him. The clones think otherwise about it. After they vanished, even Naruto is confused if he actually lost or won.
* ''Anime/TheMysteryOfMamo'' plays this straight, when Mamo reveals towards the end that even his methods of cloning to reach immortality come with their limits.
-->'''Dying Mamo clone:''' The transfer of the chromosomal data is never accomplished with complete fidelity. There are anomalies, infectiously small in each case, with accumulative effect of such chaotic pollution, can be observed after only a dozen or so generations and what you see before you is a 130th generation facsimile. I am but a faint, distorted echo of myself.\\
'''Lupin:''' But you are always distorted by your obsession.\\
'''Dying Mamo clone:''' [[WhoWantsToLiveForever But is it not... everyone's obsession]]?
* In the manga of ''Anime/LostUniverse'', this is the fate of [[spoiler: Anise]], who was created as a clone of [[spoiler: Kane's [[CoolOldLady grandmother,]] Alisia]]. Or at least, it would have been if it hadn't been for [[spoiler: her using the Swordbreaker's [[CastFromHitPoints ultimate attack]]]] and [[NoBodyLeftBehind disappearing]] [[DyingMomentOfAwesome forever.]]
** The Spreader of Darkness averts this. But then again, he's secretly [[spoiler: [[EldritchAbomination Dark Star in a human body.]]]]
* In the ''Anime/DragonBallZ'' movie ''Bio-Broly'', Android #18, Goten, Trunks and Mr. Satan end up meeting the clone of the Legendary Super Saiyan Broly. However, he isn't completed and, when he spots Goten and mistakes him for Goku, Broly breaks own and immediately starts falling apart when he goes Super Saiyan. He gets worse when he's doused in the fluid that held him and is ultimately defeated when normal old water (or rather, sea water) is brought into the mix, destroying him and ending the evil legacy of Broly.

[[folder:Comic Books]]
* Palpatine's clones in ''Franchise/StarWars Comicbook/DarkEmpire'' suffer from this. As each generation is less natural than the last, they have diminishing ability to withstand the detrimental effects of his Dark Side powers, resulting in shorter and shorter lifespans before they burn out. This is in part because one of his guards betrayed him and sabotaged the cloning machine.
* This is how Bizarro is often depicted in Franchise/TheDCU.
* ''ComicBook/SpiderMan'': Every clone [[Comicbook/TheCloneSaga created by the Jackal]] was subject to this. Some of them were almost identical to the originals but aged / disfigured, while others would last so long and then spontaneously collapse into a pile of mush -- Jackal triggered this in his "mini-me", Jack, as punishment for giving Ben Reilly information. It even drove one, [[MeaningfulName Kaine]], insane. Ben Reilly succumbed to it when he died. (And in ''ComicBook/SpiderGirl'', passed it on to his kid.)
* Slo-Bo from ''ComicBook/YoungJustice'' admitted to suffering from this near the end of the series. He would have died soon anyway had [[spoiler:Darkseid not Omega Beamed him. [[AndIMustScream Might have been preferable.]]]]
* In a crossover of ''[[Comicbook/TheSimpsons Simpsons]] Comics'' and ''Bartman'', Celebrity Troy [=McClure=] gained the [[ILoveNuclearPower radiation explosion]] created identity of "The Sequelizer". His sequel-generating powers allowed him to create duplicates of himself, but [[{{Sequelitis}} each copy was only half as strong as the previous one]].
* ''Comicbook/JudgeDredd'' ''Total War''. Nimrod is a Dredd clone that has been modified with super senses. However, neural decay happens frequently with genetically modified clones and Nimrod has seizures a lot. And MegaCity One's cloning programme is the world's most advanced. Soviet clones are apparently subject to SturgeonsLaw.
* Comicbook/{{Azrael}} buys it from a combination of this (he was artificially engineered and grown) and poison bullets, but they NeverFoundTheBody and it's implied he AscendedToAHigherPlaneOfExistence.
* In ''ComicBook/{{Madman}}'', Dr. Flem tries to clone himself. Because of the chemicals that he uses to try and make the clones grow more rapidly, almost all of them end up going berserk. For added horror, one of them bites him, infecting him with a disease that ravages his body.
* Gloo from ''ComicBook/AstroCity'' is a BlobMonster who was originally created by criminals in an attempt to clone the heroic Jack-in-the-Box and make him into the ultimate henchman. [[EpicFail They failed spectacularly.]]
* In the PostCrisis ''Franchise/{{Superman}}'' comics, cloning isn't completely perfect, especially with Kryptonians. The only perfect clone was that of James Harper, the Golden Age hero known as the Guardian -- he bolted soon after and Cadmus ended up making other clones of him that weren't perfect. Kryptonian clones, because their DNA wasn't fully understood, fell apart after awhile, as was the case of the original Bizarros and later of Match. Lex Luthor had a cloned body, but it, too, suffered from this trope until he sold his soul to Neron during ''ComicBook/UnderworldUnleashed''

[[folder:Fan Works]]
* Very evident in ''[[FanFic/SovereignGFCOrigins Origins]]'', a ''MassEffect''[=/=]''StarWars''[=/=]''VideoGame/{{Borderlands}}''[[spoiler:[=/=]''[=Halo=]'']] MassiveMultiplayerCrossover--copies of Athena that are grown too quickly suffer from mental instability, physical deformities, and imprinting defects. Shown in graphic detail to students of Jack and Brick as they tour the facility producing said clones.
* In ''FanFic/IWarrior'', [[spoiler: this turns out to be why [[BigBad the Master's]] body is [[BodyHorror slowly rotting]], as he's revealed to be an evil clone of Anakin Solo.]]

* The Nexus 6 generation of replicants in ''Film/BladeRunner'', though potentially physically and mentally superior to humans, have four year life expectancies thanks to kill switches designed into their genes. Their creator describes it as a "[[PowerAtAPrice light that burns twice as bright burns half as long, and you have burned so very brightly]]". The androids of ''Do Androids Dream of Electric Sheep?'', upon which the movie was loosely based, have a similar life expectancy, but this is due to technological limitations.
* The Creator/MichaelKeaton film ''Film/{{Multiplicity}}'', about a man who has himself cloned, has one of the clones cloned, and he came out rather... [[TheDitz special]].
* "[=GEFs=]", clone bodies used for hazardous occupations in the movie ''[[BodySurf XChange]]'', have a life span of only three days, after which they begin rapidly decomposing. Naturally, the protagonist gets stuck in one that's already been alive for two days. [[spoiler: The villain ends up in this body just as its time runs out--then appears not to dying at first because its timer is a few minutes off.]]
** Same with the clones in the original novel ''{{Mindswap}}'' by Creator/RobertSheckley, on which the movie is ''very'' loosely based.
* ''Film/{{Moon}}'' (2009). [[spoiler:Each Sam Bell clone begins to break down physically and emotionally after three years. It's not clear whether this is a limitation of the cloning process or a built-in fail-safe in case the clones discover their true nature. Either way each clone believes they're the real Sam Bell, and after putting themselves in the hibernation chamber for return to Earth are painlessly incinerated and replaced by another Sam Bell who believes he's at the beginning of his three-year contract on the Moon.]]
* WordOfGod for ''Film/{{Primer}}'' states that doubles created via TimeTravel are imperfect copies. This is the reason for Aaron and Abe's earbleeds and the degradation of their handwriting when they begin altering their past.
* Shinzon in ''Film/StarTrekNemesis'' suffers this, and one of the main complaints about the film is that he displays a bizarre lack of urgency over the fact that he has just a few days left to live if he doesn't complete his plan, while his not-dying ally urges him to hurry things along.
* In Don Hertzfeldt's short film ''WesternAnimation/WorldOfTomorrow'', future Emily explains that clones deteriorated more and more with each generation.

* Problems occur with the Spaarti cloning cylinders which appear in ''Literature/TheThrawnTrilogy''. A clone that is aged too quickly succumbs to what gets termed "clone madness," leaving them insane, and which proved to be a major problem during the Clone Wars. Thrawn eventually discovers that this is caused by some strange interaction with the Force as the clone matures, and growing the clones in an environment completely devoid of the Force such as that created by the salamander-like ysalamiri (or at least, one where the Force is suppressed, it seems to vary widely within the literature how exactly it works) will prevent the deterioration.
* In David Brin's novel, ''Literature/KilnPeople'', humans are able to create duplicates of themselves that are fashioned from a type of clay. The duplicates, called golems or "dittoes", possess the memories of their original from the time of their creation, but degrade after a day. Before this happens, golems are able to reintegrate their accumulated memories with their original using a special device.
* Invoked in F.M. Busby's ''Rissa Kerguelen'' series. The Hulzein clan learns through painful experience that they have to alternate cloned generations with ones produced the normal way, or else they wind up with mentally unstable kids--which, given the resources and intelligence levels that all the Hulzeins possess, is just a bad idea for ''everyone''.
* In Creator/WilliamSleator's ''Literature/TheDuplicate'', the duplicates are less sane the farther they are from the original. They also get black markings on their hands shortly before they die, but they tend to go crazy and get themselves killed before that step occurs.
* Discussed in ''Literature/BlackLegion'', as Khayon notes that Primarchs' genome is so unusual and complex that any attempts at cloning them end like this with the first clone. Ultimately, however, inverted - while first attempts failed, the final [[spoiler:clone of Horus]] is nearly indistinguishable from the original.
* In Suzanne Weyn's ''The Bar Code Rebellion'', several clones are made of a single woman, each one with more and more bird DNA added to them. The first few are somewhat normal, though with notable strange behaviors and abilities. Once we reach the fifth clone, KM-5, it's become quite clear that the more bird DNA they possess, the crazier they are. The final clone, KM-6, is extremely weak, thin, and pale, and speaks only in bursts of birdlike noise.
* ''Literature/WhoCensoredRogerRabbit'': Toons can make duplicates of themselves for doing stunts, but the duplicates are very short-lived.
* The novel ''Literature/WhereLateTheSweetBirdsSang'' centers around this, in a way. A post-apocalyptic society rendered sterile by disease discovers that, though clones do display this in the form of sterility after a few generations, they actually reverse the trend after a few more. The society uses this to attempt to set up a sustaining population of fertile humans.
** The clones display a form of this in another way, as well. After deciding that cloning is superior to sexual reproduction and building a society based around the health of the group and the destruction of the individual, they find that the younger clone generations lose the ability for abstract thought, to the point where the youngest generations are incapable of drawing maps or devising solutions for problems.
* The Styx Drones from ''Literature/{{Colony}}'' are this. Each batch suffers from further deterioration of intelligence, leaving the present batch TooDumbToLive.
* In ''Literature/TheTrueMeaningOfSmekday'', [[spoiler: the Gorg, having reproduced via cloning, have degraded from superstrong aliens with NighInvulnerability to superstrong aliens with a severe cat allergy]].
* Mitosis of ''Literature/TheReckonersTrilogy'' can clone himself an infinite number of times, but the clones grow [[MadeOfPlasticine molecularly unstable]] if too many exist at any one time.
* In Michael Chrichton's Timeline, the time travel mechanism is based on scanning the time-traveler and then sending the information back to be reconstructed. As is explained, like a fax, the time traveler will inevitably accumulate transcription errors, which leads to greater and greater disorders as more and more travels occur. This is explained to potentially cause everything from fatal heart defects to incurable mental illness.
* ''Literature/ThePrestige'': Averted. [[spoiler:Tesla's cloning machine is so perfect it's impossible to tell which is the original, even after years of cloning clones of clones. ]]
* ''Literature/WeAreLegionWeAreBob'': Not quite degeneration, but each Bob clone has different elements of Bob's core personality emphasized. Riker is pragmatic, Bill enjoys pure science, Milo is less cautious, and Mario is anti-social. Their clones continue to be variants of the original Bob; Riker's clone Homer, for example, has a big sense of humor while Riker has practically none.


[[folder:Live Action TV]]
* In ''Series/StarTrekTheNextGeneration'', this is what will inevitably doom one planet. The founders, reduced to five in number because of a spacecraft accident, had to resort to cloning themselves in order to have a sustainable population. When they try to "solve" (ultimately, just delay) the problem by getting clones of Riker and Doctor Pulaski, the Starfleet officers are not particularly happy with it. (Episode: "Up the Long Ladder")
* ''Series/StargateSG1''.
** The Asgard are a benevolent race who once looked like six-foot humanoid elf folk. They've repeatedly transferred their consciousness into new clone bodies with increasingly diminishing returns, so that in the present they're tiny, fragile aliens of TheGreys kind.
** Beckett's cellular degeneration issues [[spoiler:were eventually solved, effectively making him the original BackFromTheDead]].
** O'Neill was kidnapped and replaced with a younger clone by the rogue Asgard scientist Loki. The degeneration is a case of having YouHaveOutlivedYourUsefulness literally encoded in his genes. In fact, he's overcome with pain within ''minutes'' of being recovered by Loki.
** Kull Warriors are created in nonliving form and animated via Ancient technology They live for several days or weeks, though they're [[SuperSoldier extremely hard to kill]] before their time.
* The single-clone degeneration is addressed but ultimately averted in ''Series/{{Farscape}}''. When Crichton is "twinned" during season three, the MadScientist Kaarvok claims that the resulting duplicates are "equal and original," with no defects or imperfections. However, in a later episode, one of the two Crichtons experiences spontaneous bleeding and blackouts, leading him to believe this is at work: fortunately, it's just the [[MonsterOfTheWeek villain of the week]] causing chaos across Moya. As [[spoiler: one of the Crichtons has died in a HeroicSacrifice and the other has suffered no ill effects]] it can be assumed that Kaarvok was correct. However, the multiple-clone degeneration is used in the episode Kaarvok was introduced in, specifically in the form of the feral, degenerate remains of the crew of the ship he'd been imprisoned aboard. Apparently after "twinning" the twin of a twin and so on a certain amount of error did emerge.
* In an episode of ''Series/HoneyIShrunkTheKids'' that seems to have been losely based on ''Film/{{Multiplicity}}'', Wayne creates a molecular duplication machine that has the side effect of making the target's molecules unstable, causing them to create more duplicates whenever they are bumped hard against something or jolted. This results in a good number of extra Waynes, nearly all of which are a bit dense. This is explained as the clones having Wayne's knowledge, but none of his practical experience - when Wayne tells his duplicate that the moon's made of green cheese, he buys it, even though he always thought it was made of various strata of rocks and magma around an iron core. "Why are my clones such ''dorks''?"
* On ''Series/OrphanBlack'':
** Many of the clones suffer from a mysterious lung disease and all but two of them are infertile as far as anyone knows. Statements made by one character in the second season imply that the latter is intentional (or at least to be expected) because the only exceptions are [[spoiler: Sarah and Helena, who were twins. If they came from the same cloned fertilized egg that split into two embryos the way that non-cloned identical twins do, that technically could be considered to make them into copies of a copy.]]
** The male clones of Project CASTOR suffer from a neurological disorder that causes seizures and also can pass on a protein that causes infertility.

[[folder:Tabletop Games]]
* The fetches of ''TabletopGame/ChangelingTheLost'' are ''always'' missing something of the personality they were meant to replace. It could be a negative trait (quickness to anger) or a positive trait (dedication to a task), but there's always going to be something missing.
* ''TabletopGame/{{Paranoia}} XP'' has this as a mechanic in order to convince characters to try not to get killed ''quite'' as much (if the GM is letting the [[PlayerCharacter PCs]] buy clones rather than simply going through a 6-pack and then handing out new sheets.) After the first seven or so, things start to go south in a hurry, with extra fingers, hideous deformities, and (worst of all in Alpha Complex) colour blindness. Luckily, BLUE-clearance [=PCs=] can pay to have the template cleaned up. Others have to depend upon secret societies and underhanded business that may well result in termination for treason.
** The reason that bit about colour blindness isn't potholed to ArsonMurderAndJaywalking? In Alpha Complex, social rank is ColourCodedForYourConvenience. Social rank is also taken ''very'' seriously - if you're Red clearance and step into an Orange-rank area, that's treason.

[[folder:Video Games]]
* ''Franchise/{{Halo}}'':
** This is the reason you don't make copies of [=AIs=]. In ''Literature/HaloFirstStrike'', Cortana actually weaponizes this; she used alien technology to create new (slightly flawed) instances of herself in a Covenant warship so she could be in two places at once. The copies made copies. The copies of the copies made copies. The quickly-growing swarm of [=AIs=] started forking off copies for specialized tasks, having those copies be overwhelmed by Covie [=AIs=], and spinning off more copies. Eventually the alien ship filled its computers to the roof with Cortana clones, segfaulted, and blew up. On top of that, those flawed copies did actually manage to complete their assigned missions. What's really wacky is that it's implied that Cortana got the copy program from one of her own (completely insane) [[StableTimeLoop time-lost copies]], thanks to the presence of a [[{{Precursors}} Forerunner]] time-manipulation device.
** This also applies to human clones. Individual organs can be cloned and used for transplants without a problem, it's when you clone the whole body that things go south. Flash-cloning (which is the only method of cloning seen in the ''Halo'' universe) is when the clones are aged up to the original person who supplied the DNA. The clone will have the mind of an infant, given that it has zero memories, and the body will deteriorate and usually die within a couple months. Apparently the cloned body's metabolism just can't stabilize itself correctly. Despite this procedure being highly illegal, flash clones were used to cover up the SPARTAN-II project; ONI took the children, and gave the parents clones. As far as any of the parents could guess, their children inexplicably went into a vegetative state and died from an unknown disease.
** Human-made "smart" [=AIs=] are an interesting example, as they are usually created by brain-scanning dead people (though Cortana herself was created from the flash-cloned brain of the still-alive Dr. Halsey): After a period of roughly [[ArcNumber seven]] years, all "Smart" [=AIs=] will eventually accumulate so much information that they basically think themselves to death; during this terminal phase, the [=AI=] falls into a state of "rampancy" in which it develops both "delusions of godlike power" and utter contempt for its mentally inferior makers.
*** Much of ''VideoGame/{{Halo 4}}''[='s=] plot is about Cortana dealing with her ever-worsening rampancy.
*** The novel ''Literature/HaloTheColeProtocol'' also demonstrates a "Smart" AI past its lifespan. Juliana, the AI of the Rubble (a conglomeration of hollowed-out asteroids joined by tubes), has been active for at least 8 years and is definitely showing signs of instability. The only thing keeping Juliana "sane" is her primary task of keeping the Rubble from breaking apart and protecting the people living there. [[spoiler:After the Rubble is evacuated so that it can be {{Colony Drop}}ped on the local Covenant base, Juliana chooses to go down with the "ship", as she no longer has anything to keep her from going into full rampancy.]] The novel also establishes that it's common among humans to indicate that an AI is going into rampancy by showing "seven" with their fingers. Oh, and the [=AIs=] also know the gesture, and Juliana gets pissed off when a Spartan shows it to his team.
* Solid Snake, Liquid Snake, and Solidus Snake from ''VideoGame/MetalGearSolid'' are clones of Big Boss. Liquid got killed off prior to degeneration, however Solidus aging has accelerated to the point he looks like someone in his sixties or seventies, he's actually in his thirties, but by ''VideoGame/MetalGearSolid4GunsOfThePatriots'', Solid Snake's aging has accelerated to the point where Big Boss himself looks younger than he does. Compounding this, he goes through a truly horrific gauntlet throughout the game. And yet, he still gets the job done. Unlike some other cases, this degeneration was deliberate. The clones were made with genetic flaws designed to limit their lifespan in hopes of keeping them under The Patriots' control.
* ''VideoGame/TalesOfTheAbyss'' features this, along with everything else from the CloningBlues vat. But since this ''is'' a Tales game, it plays around with the trope too: [[spoiler:it turns out that getting a clone made can cause just as many problems to the original as it does to the copy. In the best case, the original develops severe health problems after a while. In the worst, the original dies ''as soon as the data required to create a clone in the first place is extracted'']].
** [[spoiler:Actually, in the best case, the replica is weaker but there is no particular degeneration in the original. In the very worst case, however, that of complete isofons, a different effect occurs. The original and replica are so entirely identical that both gradually begin to destabilize due to the interference of their matching fonon frequencies. Eventually, one or both will die, and their fonons merge, creating an individual with the memories of both the original and the replica. This is what the universe's physics says happened to Luke fon Fabre at the end of the game, according to some easily-missable sidequests with Jade.]]
* This is the premise of ''VideoGame/DestroyAllHumans''. The Blisk had mutated Furon DNA so that they can't propagate due to lack of genitalia. Fortunately, they perfected the art of cloning, rendering them virtually immortal. Unfortunately, each new clone has degraded Furon DNA, making the results more unpredictable and eventually leading to the extinction of the Furon race. Fortunately, this could be fixed via infusion of uncorrupted DNA, and a Furon mothership happened upon another planet eons earlier and frolicked with the planets' inhabitants, giving their descendants Furon DNA. Unfortunately for us but fortunately for them, that planet is Earth.
* Not necessarily clones, but close enough: In the ''VideoGame/LegacyOfKain'' series, Kain used parts of his soul to resurrect a group of long-dead Sarafan warrior priests as his lieutenants, each receiving a smaller part of his soul than the last, which would directly affect their evolution in vampiric unlife: Raziel received the most of his soul and evolved the quickest, while Melchiah received the smallest part, making his body vulnerable to decay.
* This may explain why Taokaka from ''VideoGame/BlazBlue'' is [[CloudCuckooLander so]] [[GenkiGirl very]] [[TheDitz odd]]. Though the rest of the Kaka clan, also clones of [[spoiler:Jubei]] seem more put together.
* The God of ''VideoGame/TheNeverhood'' eventually ended up creating the whole world's population this way. He was trying to duplicate himself, but the duplicate just assumed that he was really God, and went through the whole process all over again. This continued until eventually a duplicate was created that was not alive.
** That was just one God of one world that was not the Neverhood. The Neverhood itself was created by someone who took the opposite approach and personally crafted each thing to be completely unique and everlasting.
* ''VideoGame/{{Fallout 3}}'' gives us Vault 108, which contains nothing but very aggressive clones. Notes left throughout the vault state that the first clone was fine, but copies made after that became more violent the farther they were from the original.
* Alluded to in ''VideoGame/StarWarsRepublicCommando'' whenever the player performs some suicidally dumb action.
--> '''Scorch:''' Maybe 38's a copy of a copy of a copy...
* Justified in the usual manner in ''VideoGame/{{Dystopia}}'', where clones are given a maximum life span of about 20 minutes, and their bodies decay very rapidly. This prevents enemies from finding any of the technology hidden in their bodies or any information hidden in their brains. In addition, combat clones are hastily assembled from cheap materials in about 15 seconds; and normal clones can take a few weeks to build but are intended for use by soldiers after they shed their combat clone bodies. At least, that's what they're promised by their [[MegaCorp employers]].
* ''VideoGame/FinalFantasyVII VideoGame/CrisisCore'' is a prequel, giving us background on stuff like why Sephiroth went crazy and destroyed Cloud's hometown. A huge part of it turns out to be the emotional blows he suffered when losing his two closest friends to MistreatmentInducedBetrayal against [[MegaCorp Shinra]]; the primary mistreatment in this case being that Shinra had created them via genetic hacking and then, at some point in their thirties, their bodies started to break down. And that was when they found out they weren't just naturally talented best friends from Banora, where the scientist running the project apparently retired after Hojo got all the funding in order to make [[SuperPrototype Sephiroth]].
** Genesis, the one who actually went AxCrazy, may have minded that Sephiroth was perfect and the project that wasn't abandoned as much as the dying part. Never mind that Project G being mostly-canceled meant ''he'' got a ''childhood''; he had a GreenEyedMonster problem.
** The degeneration condition is like this, but Angeal and Genesis aren't actually clones, as such. Angeal may even be his mother's natural son, she just messed with her own body so much to get the cells to make Genesis that he came out weird. Or not. (Incidentally, this means Angeal and Genesis are at least 1/3 brothers, which is not a fraction that's possible in nature and which also makes the fact that they're a popular ship a lot {{squick}}ier.)
* Your uncle in ''VideoGame/QuantumConundrum'' cloned his cat after its death. The first iteration was okay, but the third iteration earned the nickname "Derp".
-->'''Quadwrangle''': I want to clarify that [=DOLLI=] is great for cloning inanimate objects, but she's not entirely capable with organic ones.
* Several gangs and factions in ''VideoGame/SaintsRowTheThird'' have clones of a hugely muscular man that is so strong and large that the clones can shrug off most weaponry, vehicular assaults, and explosions, which would make them perfect candidates for gang warfare. Because the cloning process hasn't been perfected, all the clones lack intelligence and are nothing more than mindless monsters.
** And in stark contrast, the original one, Oleg Kirrlov, is pretty much a GeniusBruiser.
* The Grineer Empire in ''Videogame/{{Warframe}}'' collectively suffers from it, due to every single Grineer being a clone of a clone of "[[ANaziByAnyOtherName perfection]]" birthed in industrial quantitites. Their degeneration is so bad that they have to use extensive cybernetics to survive; Grineer soldiers almost always have cybernetic feet, and the only thing left of the Grineer Councilor Vay Hek is his ([[BodyHorror visibly cracking and flaking]]) face and lungs.
* ''VideoGame/SuperMetroid'' has the Space Pirates capturing the only living Metroid in existence. They attempt to clone it and... fail. The resulting creatures, dubbed "Mochtroids" are very slow, lack the Metroids' characteristic NighInvulnerability, and can't even latch on to their target properly. At the end of the game, in the deepest part of the Pirate base, we see some successful clones that lack any downsides compared to the original, so apparently the Mochtroids were just "Phase 1".
* In ''VideoGame/AkatsukiBlitzkampf'', this is what happens to [[spoiler: the playable Elektrosoldat. He's one of several clones of the local EvilAlbino, Adler, and is revealed in his ending to [[WoundThatWillNotHeal be unable to heal from his injuries]].]]
* The Haltmann Works Company in ''VideoGame/KirbyPlanetRobobot'' experiments with clones of powerful individuals on the planets they invade to [[UnwillingRoboticization convert the organic life into more efficient mechanical beings]]. However, their cloning process is imperfect. The most apparent case is their clones of King Dedede, in which every single attempt was some form of failure and the one they settled on was molecularly unstable to the point of splitting into three gooey copies of each other. [[spoiler:They also made much more successful (though still imperfect) copies of [[VideoGame/KirbyTripleDeluxe Queen Sectonia]] and [[VideoGame/KirbysDreamLand2 Dark Matter]]. The latter of the two could only be replicated in its weaker swordsman form, since the original was an EldritchAbomination so alien in form that even the most powerful supercomputer in the galaxy couldn't properly analyze it.]]
* In ''VideoGame/SatelliteReign'', you possess an earlier iteration of the BigBad's resurrection technology, which means it still has some bugs. Specifically, your agents' clone bodies take increasing stat penalties with each death, meaning you have to abduct people off the streets to provide new cloning stock.
* ''VideoGame/TransformersFallOfCybertron'': The insecticons have the ability to copy themselves ([[ShoutOut a nod the G1 insecticons]]) in a manner vaguely similar to reproduction but as [[EvilGenius Shockwave's]] audio logs reveal they become progressively inferior, the [[MonsterProgenitor original insecticons]] are sentient and can transform but the rest are just a hungry mindless swarm under the control of the original three.

[[folder:Web Animation]]
* In ''WebAnimation/TheDementedCartoonMovie'', this problem plagues Evil Blah's Auto-Damsel-Maker, ultimately resulting in a damsel who's a little... weird.
* While it's not really cloning, ''per se'', the Texas Drones in ''Machinima/RedVsBlue'' are nowhere near at the level of the original [[TheAce Texas]][[spoiler:/Allison/Beta]], who in no small way, kicked '''EVERYBODY'S''' ass. Carolina takes down several of them with the assistance of [[spoiler:Epsilon-Church]], and the Reds, Blues and Wash show up just in time to help take down the rest.
* In ''Toys/TheGrosseryGang'' webseries, Doc Broc's cloning machine creates clones that only last for an hour, before expiring into a cloud of dust.

* Meta example: any sufficiently popular webcomic will inevitably spawn imitators, which are generally not as good as the original. The more popular ones in turn will eventually spawn their own imitators, which are even worse. The most famous example of this is ''Webcomic/PennyArcade'', which started off the TwoGamersOnACouch Trope.
* The space arc version of the False Guenevere storyline in Webcomic/ArthurKingOfTimeAndSpace suffered this, paralleling the illness of the one in the fantasy arc.
* {{Lampshade|Hanging}}d in [[http://bobadventures.comicgenesis.com/d/20080621.html this]] strip from ''Webcomic/TheInexplicableAdventuresOfBob,'' where Molly's [[CloningBlues clone]] Galatea insists on using Molly's tissues for an experiment rather than her own.
* In ''Webcomic/TheAdventuresOfDrMcNinja'' [[spoiler: the doctor uses this to explain why killing off all his clones wasn't as bad as it seems, because the clones created with the old process were highly unstable. To illustrate this he shows a video where clone of Benjamin Franklin made with that technology accidentally kills himself by biting too hard into a sandwich. Which causes the top of his head to fall off. Old [=McNinja=], a clone of the Doctor, was created with newer technology, which is greatly improved, but he initially believes himself to be suffering from this.]]
* In ''Webcomic/KevinAndKell'', Corrie's clone, Dolly, begins RapidAging as a result of being a clone. Dolly becomes concerned about how her adoptive parents (who don't know she's a clone) will feel about this, so Corrie switches with Dolly, who poses as her birth mother to take her away. An accident with a TimeMachine results in Dolly reverting to a baby, which gives her a fresh start on life even if her rapid aging resumes (which is somewhat unlikely to happen, given how little time progresses in the strip).
* Subverted in ''Webcomic/ElGoonishShive'', when Elliot accidentally creates a female version of himself, dubbed Ellen. Ellen realizes that the effect that led to her creation was only intended to last a month, and decides to become Elliot's greatest rival and villain. Shortly after this completely fails, she learns that she won't die after a month, and is offered a life as Elliot's twin sister, which she gladly accepts. She's been a part of the main cast ever since.
* In a ''Webcomic/QuentynQuinnSpaceRanger'' arc that parodies ''Franchise/StarTrek'', Quentyn refuses to beam down, partly (though hardly primarily) because he doesn't trust the "disintegrating fax machine" to make a perfect copy each time. TheCaptain cluelessly introduces him to a RedShirt who has gone through it many times. [[TheDitz It shows.]]
** Replicating replicators is also a bad idea; past a couple generations they start producing toxic chemicals, radiation and, obviously, unusable products.
* In ''Webcomic/{{Homestuck}}'', Rose Lalonde's mother's attempt to clone her cat Jaspers resulted in a four-eyed kitten. When [[spoiler: Roxy Lalonde]] tried this on a mass scale, it created a bunch of four-eyed cats, and more than a few seriously deformed ones.
* On [[http://nonadventures.com/2008/05/31/bad-to-the-clone/ this page]] of ''Webcomic/TheNonAdventuresOfWonderella'', Dr. Shark claims a clone of Wonderella is actually the original. Ritagirl cites this trope to determine if this is true, and gives the two Wonderellas a written test. [[spoiler: Wonderella stabs her duplicate with a pencil and writes "I Win!" on her paper.]]
-->'''Ritagirl:''' Clones are never as smart as the original, right Dr. Shark? Like how paper copies are never as clear?
-->'''Dr. Shark:''' A simplistic analogy by a liberal arts major! ''Go on...''
* Agatha's Dingbots in ''Webcomic/GirlGenius'' can build more of themselves out of spare parts and bits, but each subsequent generation is of slightly lower quality, maxxing out at about six generations. [[spoiler: Eventually it's discovered that the first generation Dingbots are the clank equivalent to [[MadScientist Sparks]].]]

[[folder:Web Original]]
* ''WebVideo/TheSpoonyExperiment'': While watching ''Film/TheClonesOfBruceLee'', Spoony points out the logic gap in the mad professor cloning Bruce Lee several times, only to demand they fight to prove who's the strongest. [[HypocriticalHumor He points this out while sharing a sofa with two of his other characters.]]
--> '''Chester D. Bum:''' It's kinda like when they cloned [[Franchise/StarWars Jango Fett]], and turned him into all those Stormtroopers, only they were kinda lame.
--> '''Dr. Insano:''' This is why I prefer robots to cloning. Clones are crap! It's like filling out a form in triplicate but only getting to keep the pink copy.
* Wiki/{{SCP|Foundation}}-[[http://scp-wiki.wikidot.com/scp-038 038]], an apple tree that grows clones like fruit of whatever touches it's bark. Human and animal clones age rapidly and only last about two weeks.
** [[http://www.scp-wiki.net/scp-726 SCP-726]] are [[MakesJustAsMuchSenseInContext magically appearing/disappearing maggots which regurgitate clones]]. Enough iterations of cloning results in something resembling a slug.
* With the ''[[WebVideo/RoosterTeethShorts Secret Door]]'' short of Creator/RoosterTeeth, Gavin is cloned to improve efficiency, but when they find out, they're bound and gagged, and thrown into the closet. When Gavin finds out, they throw him in there, but remember they need the original, otherwise the clones will degenerate. [[spoiler:Problem is, they grab Ben for re-cloning instead, who was mistaken for a Gavin clone due to their UsefulNotes/BritishAccents.]]
--> '''Gus:''' Oh fuck! We need the original out here so we can make another clone!
--> '''Burnie:''' Oh, right. Gotta go from the source, otherwise the copy DNA gets bad.
** Averted in their flagship series, Machinima/RedVsBlue, which is based on the Halo series. In season 6, Church is revealed to be Alpha, a smart AI created from the mind of Dr. Leonard Church, the director of Project Freelancer. Alpha was tortured by his creators until it went crazy, shedding parts of his mind into AI fragments, and using the Director's lingering memories to rebuild his mind. An exact timeline hasn't been given, but a line from Tucker in season 8 about the teams fighting each other for eight years, suggests that Alpha-Church was alive for longer the seven year life-span of smart AIs before it was erased by an {{EMP}}. The surviving fragment Epsilon, which has since assumed the Church identity, has existed even longer, and has been confirmed by WordOfGod to have become Metastable.
* [[JustifiedTrope Justified]] in the ''Literature/WhateleyUniverse'': the faster you force the maturation of a clone, the more likely it is to suffer from 'protein antagonism', a form or auto-immune problem that can lead to rapid breakdown. Clones grown normally will usually live a normal lifespan, but quick-clones may fall apart after even a minor bit of physical trauma. The fact that Belphoebe does ''not'' appear to suffer from protein antagonism despite a very fast maturation is a key plot point in "The Second Book of Jobe".
* ''WebVideo/LostInAdaptation'': The Dom's hunchback clone butler Reginald's {{belated backstory}} is revealed to be a result of this. After discovering a clone machine in a deep underground expedition, The Dom decided to use it to make a clone of himself to do chores. Said clone was not content with his lot, so he made a clone of himself to replace himself so he could sneak off without The Dom noticing. The next clone did the same thing, and the one after that, and the one after that, until eventually, thanks to CloneDegeneration, the newest Reginald couldn't figure out how to operate the cloning machine (it's powered a green and red "On/Off" button), so he's stuck in The Dom's service.

[[folder:Western Animation]]
* The "[[Recap/TheSimpsonsS14E1TreehouseOfHorrorXIII Treehouse of Horror XIII]]" segment "Send in the Clones" on ''WesternAnimation/TheSimpsons'' has Homer with a cloning mechanism which results in him creating duplicates who are progressively dumber than he is. Eventually they get to be so stupid that one of them is [[TakeThat Peter]] [[WesternAnimation/FamilyGuy Griffin]]. Special mention should be made that [[spoiler:the surviving Homer is ''a clone''. The original Homer, who knew of the plot to fly a fake giant donut over a cliff to have the clones runs after it and off the cliff, was the first one off the cliff.]]
* This seemed to be inherent to present-day cloning in ''WesternAnimation/TeenageMutantNinjaTurtles2003''. In the fourth season of the show, it was revealed that Agent Bishop's body was slowly degenerating, and therefore needed to transfer his mind to a new one, which eventually happened, dissolving skin and all. Later on, Baxter Stockman cloned himself a new body to replace the one he had systematically lost during the course of the series, only to find it decaying as well.
* Done with the incomplete April clones in ''WesternAnimation/TeenageMutantNinjaTurtles2012'', as they tend to turn into black goo when damaged, and one "reject" (who the turtles call "April Derp") is a giant monstrosity with extra heads and mouths. However, these were ''incomplete'' clones created from ''partial'' DNA, and presumably, if the Kraang managed to get their hands on her complete DNA sequence, these issues would not occur.
* In ''WesternAnimation/ExoSquad'', Neosapiens ran a risk of contracting a disease where their bodies decompose, seeing as it's entire species is a clone race, it made [[spoiler:coming BackFromTheDead via implanted memory recordings]] a bit of a gamble.
* The Ring of the Nine Dragons from ''WesternAnimation/XiaolinShowdown'' can divide one person into at most nine, but their intelligence is also divided, so in the end, you have nine people with only a ninth of your intelligence... and getting them back together is really hard.
** The notable thing said ring is that it only does this to your average person while Jack Spicer's clones were at least able to operate like normal people except for one bad one and demons are apparently immune as Mala Mala Jong's clones didn't display any differing behavior from the original.
* In the rather bizarre miniseries ''House Of Cosbys'', the Bill Cosby clones get increasingly bizarre defects, however the main character keeps making them as every tenth Cosby has superpowers. Unfortunately, Cosby #100 happens to be pure evil.
* ''WesternAnimation/AquaTeenHungerForce'':
** In an episode Frylock reveals that he's been cloning televisions every time the other Aqua Teens destroy one. Eventually the latest television they make turns evil. Later in the episode the Aqua Teens clone a dollar bill and eventually end up making George Washington out of dollar bills. This is also why their television (and so many other objects around the house) explodes with the slightest jostling.
** An earlier episode spoofs the trope with a physically mutated and clearly failed clone of Shake. Not only are the clone's attempts to pass himself off as the original [[PaperThinDisguise pathetically obvious,]] he also turns out to be much kinder and more rational than Shake, and Shake's friends actually like him ''better'' than the Jerkass original.
* ''WesternAnimation/MenInBlack'' the Animated Series has Quick Clones. Each clone was indistinguishable from the original, but after time, the clone would begin [[TalkativeLoon speaking nonsensically]] before melting into a pile of goo. The time until melting varied based on stress and physical exertion. Alternatively, any clone could be terminated by pushing a button located behind the ear.
* In ''WesternAnimation/TheJetsons'', George had a clone made in one episode, only to find it could do stuff far better than him. He wanted to leave his life to the clone but it turned out that the clone has a very limited lifespan.
* WesternAnimation/DannyPhantom's OppositeSexClone Danni Phantom melts whenever she uses her superpowers. [[spoiler:She gets better.]]
* An experiment in ''WesternAnimation/LiloAndStitchTheSeries'' has this when Stitch get hit by a duplicating ray, splitting into multiple copies of himself. His creator, Jumba, explains that the more duplicates there are the more their strength is divided between them. Lilo uses this later against Gantu when he gets a hold of the experiment and tries to create an army with the experiments he's captured. But they're all so pathetically weak that the heroes easily waltz right through them.
* Drakken tried this in ''WesternAnimation/KimPossible'' making "clones" (the show admits it isn't really cloning but called that for simplicity) of Kim, Ron, Rufus and Bonnie and modifying them to be [[EvilKnockoff mindless attack drones]]. It works till its revealed they're [[WeaksauceWeakness weak against soda]], dissolving into green puddles when its sprayed on them. Later on they get renamed "synthodrones", which becomes a major plot point of [[WesternAnimation/KimPossibleMovieSoTheDrama the movie]].
* In ''WesternAnimation/TheFlintstones'', Fred was cloned by an alien in one episode. The clones were very much like real people, and are never seen physically degenerating, but were little more than mindless mooks, incapable of anything other than following their creator's orders, causing trouble and saying Fred's catchphrase in a very monotonous fashion.
* A very {{Squick}}y version happens in ''WesternAnimation/FamilyGuy''. Stewie has decided to clone himself, creating "Bitch Stewie," a deformed, moronic servant to the original. Later, Stewie makes one of Brian, which is arguably more messed up. Eventually, both clones melt into a pile of disgusting, fleshy goo.
-->'''Brian''': I'm not proud of this, but, I have to lick that up.
** Later, Stewie makes a perfect clone of himself- but this one is [[EvilKnockoff immensely more evil]] [[GoneHorriblyRight than him]]- complete with SlasherSmile.
* The ''WesternAnimation/GravityFalls'' episode "Double Dipper" had Dipper make use of a magic copy machine when he needed a few extra hands. This works fine until he gets a paper jam [[FourIsDeath on the fourth clone]], resulting in a lumpy, wrinkled version of himself that speaks in incomprehensible "NYANG NYANG NYANG!" sounds. When it's destroyed near the end, it treats its death as a MercyKill.
-->'''Dipper #4 (subtitled):''' It's better this way for Paper Jam Dipper!
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'', "Too Many Pinkie Pies", Pinkie uses the reflection in a magic pool to clone herself (and that clone clones herself, and those clones clone themselves...). All the clones look identical to the original Pinkie, but behave like [[{{Flanderization}} flat, exaggerated versions of the original]].
* In ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'' episode "Mandy the Merciless", in the future Mandy has achieved immortality and became ruler of the world, and keeps clones of Billy around. When the newest clone is incapable of noticing that Mandy is now an enormous half-worm half-human hybrid, Grim comments that they get dumber with each cloning.
* The CloningBlues episode of ''WesternAnimation/JimmyTwoShoes'' "Too Many Jimmys" is a good example. When Jimmy borrows Heloise's people copier, the resulting clones are deformed and misshapen. For example one had no head, another had legs for arms with an oversized nose, and another one had a single eye with no body separating his limbs from his head. The justification for this though is that Jimmy had damaged the machine before the cloning process was completed. Yet for some reason, everyone in Miseryville seems oblivious to the differences between the clones and the real Jimmy.
* ''WesternAnimation/SpongeBobSquarePants'': In "[=CopyBob DittoPants=]", Plankton photocopies a bunch of [=SpongeBob=] clones to get the Krabby Patty formula. He used cheap toner to make them, so after a while they all roll up and disappear from existence.
* The ''WesternAnimation/BatmanBeyond'' episode "Meltdown" sees Mr. Freeze cloned into a new body that seemed to lack the condition that require a special suit for survival in above zero temperatures, but the body began to show signs of this trope as it redeveloped the condition. Considering a piece of BackportedDevelopment was Victor Fries being bald despite a pre-Freeze Victor having hair in ''WesternAnimation/BatmanTheAnimatedSeries'', the baldness might've been an early sign of this.
* ''WesternAnimation/{{Sealab 2021}}'': In "Lost in Time", Stormy and Quinn go through a fifteen-minute GroundhogDayLoop repeatedly trying (and failing) to prevent the accident that destroyed Sealab and blew them back into the past, with multiple clones of Stormy and Quinn eventually ending up in the brig. After over a dozen iterations, the timeline gets so screwed up that strange alternate versions of Stormy and Quinn start appearing, including pixie versions, ones dressed as a cowboy and an Indian, and a pair where [[Franchise/StarWars Quinn and Stormy resemble Jabba the Hutt and Salacious Crumb]].

[[folder:Real Life]]
* TruthInTelevision: Some speculate that this occurred with the cloned sheep Dolly, that she died early due to being born with a genetic age of six. [[http://en.wikipedia.org/wiki/Dolly_(sheep)#Death The Roslin Institute disagrees, however.]]
** Distressingly, an attempt to revive the extinct Pyrenean Ibex succumbed to lung problems (in this case shortly after birth) which is also what killed Dolly.
** Apparently, aged cells have shorted telomeres compared to new ones, which means that they won't be able to replicate as much as a "newborn" cell will over its life time. Besides that, DNA is unstable and only stays mostly intact when you're alive, so the extraction and freezing processes to preserve it actually damage it. Since the last Pyrenean Ibex died in 2000 and the clone wasn't made until 2009 (and even the first attempts was in 2003), there was little chance that the DNA would even be viable anymore. For this same reason, many biologists doubt that long-extinct animals like the wooly mammoth will ever be successfully cloned.
* Most parthenogenetic species in nature do retain the capacity for sexual reproduction, often resorting to this method of breeding when conditions become harsh. It's thought that species which lose this ability usually get wiped out by infectious diseases that can easily spread among genetically-identical hosts, or by changes in their environment they'd otherwise lack the diversity to cope with: thus, while ''individual'' clones may thrive, all-clone species decline over time.
* There are periodic science-community scares that the human Y chromosome - already a tiny, shriveled thing relative to the mighty female X - decays slightly with each generation, and will eventually [[{{gendercide}} disappear entirely, wiping out males]] [[ApocalypseHow and the human race along with them.]] At the moment, this is believed to be false, but we've only known about DNA for a few generations.
** Some scientists speculate that this will take so long that by the time it happens, we won't need men and women for reproduction. Or maybe we'll be able to change gender at will, like in Film/JurassicPark. It's important to remember that the Y Chromosome has existed for more than 100 million years with no apparent issues.