Catwoman: When in Rome (2004-2005), is a six issue miniseries, published by DC Comics, and composed by the award winning creative team of Jeph Loeb and Tim Sale. It was the third part of the Critically Acclaimed series, with The Long Halloween and Dark Victory being the first two parts.
Many spoilers in summary ahead:
In Chapter 1, Catwoman is awoken by a Batman nightmare following the events of Long Halloween, Selina Kyle AKA Catwoman and Edward Nigma AKA The Riddler, travel to Rome to uncover the secrets surrounding Selina's parentage. When they arrive in Rome they meet up with Selina's contact, an excellent hitman known as "The Blond", who doesn't know about Selina's motives or her secret identity, that night Selina ventures the night in a makeshift Catwoman outfit, and pays a visit to Italian Capo Don Verinni, before she can even interrogate him , he dies from a Joker Juice laced wine and Catwoman's name soars to the top of the mafia's hit list.
In Chapter 2, Selina has a second Batman Nightmare. When she awakens, the house is ablaze and she has to jump out of the third story window. The three relocate to the Blond's yacht, where two more attempts on Selina's life, one by a sniper and one by Don Verinni's son shooting Catwoman with Mr. Freeze's SubZero gun.
In Chapter 3, after being freed from the block of ice, Catwoman breaks into the Vatican and steals the "Boss of all Bosses" ring, which gives control of the entire mafia over to the wearer, and is immediately knocked out by Supervillian the Cheetah.
In Chapter 4, Hallucinates again, fights, and almost gets killed by The Cheetah.
In chapter 5, Selina meets her possible mother Louisa Falcone, wife of Carmine Falcon, where she is disappointed, when Louisa states rather unconvincingly that she couldn't be her daughter. Catwoman hallucinates again, but she realizes five nightmares in five days is too much and realizes she's been hit with the scarecrow's fear toxin, by The Riddler.
In Chapter 6, Catwoman has her final showdown with The Riddler, The Cheetah, The Scarecrow, and the man with Mr. Freeze's gun. The Riddler explains how he has been using this trip as a plot to learn batman's identity, secrets about Selina, have her pay his tab, and acquire the "Boss of all bosses" Ring. Selina defeats them and with the yacht ablaze is saved by "The Blond", who had been ordered to kill Selina, but instead kisses her, now knowing her identity. "The Blond" actually has some proof that Selina may be Louisa's daughter.
In the last scene, Selina is standing at the airport gate waiting for "The Blond" to join. The Riddler appears, holds a knife to Selina's throat and makes her give him the ring. Selina double crosses him and actually gives him a fake ring laces with fear toxins. The Blond is killed for not taking out Selina, and Selina boards the plane.The epilogue has Selina at Carmine Falcone's grave and explaining why she became Catwoman.While not as critically acclaimed as the first two parts, it still has nothing but great reviews under its belt.
This comic provides examples of:
Accidental Kiss: At the end of chapter 4, Selina hallucinates and believes she's kissing Batman but it's actually The Riddler.
Big "NO!": When Selina hallucinates Batman shooting her.
Butt Monkey: Double Subverted, It seems like The Riddler is this, then we learn he is behind all of Selina's problems and he seems like he is the Manipulative Bastard, but by his last appearance he retains his former Butt Monkey role.
The Scarecrow is this even though he only appears in three or four panels.
Continuity Overlap: As noted earlier, the mini-series runs concurrently with the second half of Dark Victory. At one point, the Riddler leaves Italy to attend Two-Face's mock trial during Dark Victory #7 before returning (and thus explaining why the Riddler vanishes from Gotham after April Fools' Day).
The Determinator: Selina has a lot of setbacks, but she never gives up on her mission.
Foregone Conclusion: Anyone who's read Dark Victory knows that Selina will not be able to conclusively prove that Carmine Falcone is her biological father.
Likewise, anyone who's read Batman: Hush knows that the Riddler won't discover Batman's secret identity until years later.
Foreshadowing: The Riddler asking Selina if she knew Batman's identity, him being in every one of her hallucinations, and him returning to Gotham all of a sudden.
Freudian Excuse: Since the Falcones didn't claim Selina, she began a life a crime to make a life that she would have had.
Fridge Brilliance: When in Rome overlaps with the second half of Dark Victory, which means the Gotham rogues are all united under Two-Face's banner at this point. Riddler's return to Gotham during April Fools' Day shows he's still allied with Harvey Dent and it also explains Nygma's easy access to Mr. Freeze's weaponry and Scarecrow being loaned out. While the Riddler's ultimate goal is to determine if Selina knows Batman's identity, Two-Face wouldn't have been able to pass up the chance to cause chaos among the Falcones' Italian allies.
Genre Blindness: The Riddler doesn't realize that Selina is much smarter than he gives her credit for.