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Anime and Manga
- Daily Life with Monster Girl: out of all the girls, Lala does the least fanservice, doesn't have a nickname for Kimihito, and doesn't try to pursue him because she's fine with the fact that she'll have him forever once he dies.
- Most Time Bokan series share the same kind of situations, but the fifth series, Yattodetaman, changed around multiple things:
- First, for the first time the main character actually transforms into the titular hero becoming stronger and braver than usual, rather than just donning different clothes and a mask like the other Time Bokan main characters did.
- Also, it's the first time there is a single hero: while there's a female main character, she doesn't transform when fighting the bad guys.
- Speaking about the bad guys, the two male members of the Terrible Trio look completely different than the usual: Julie haves a smaller nose, lacks a moustache and stands more upright compared to Boyakki and all its expies, while Alain, instead of being a short hunch with broad shoulders with a five o' clock shade like Tonzula and his derivates, it's a tall, fat guy with a prominent beard.
- As a last difference, instead of a bunch of different Funny Animal mechas, Yattodetaman haves a single Humongous Mecha. This change was kept around in the subsequent Ippatsuman, only to come back with the old style in Itadakiman.
- In Captain America: Civil War, Zemo becomes the first main villain of a Marvel Cinematic Universe movie since Loki from the Thor movies to not be killed off at the end of the film.
- Cars 3: Unlike the first two, this exchange is absent.
Old character: If there's anything you need, just let me know.Main character: I sure appreciate that. Thank you. (Beat) Actually, there is one thing... (Gilligan Cuts to the request, usually a Brick Joke from earlier, being fulfilled)
- Same with this:
- Chorocojo used the male trainer during his Pokemon Black 2 LP, as opposed to the female trainer he was using in his previous LP's. However, by this point he was tired of doing female characters, viciously lampshading it the last two times beforehand, but during Pokestar Studios filming he used the female trainer.
- The Hobo Bros' "Hobo Theater" videos originally had Kevin read a list of words relating to the video's theme, with Luke having to work each word into the story. However, this eventually led to Kevin saying phrases, or even full sentences, instead of single words, and they seem to have abandoned the idea of using single words despite doing it for many videos.
Live Action TV
- Britain's Got Talent: 2016 was the first year that David used his golden buzzer on a performance where none of the judges buzzed the act.
- American Horror Story: Hotel:
- This is the very first season without both Jessica Lange and Frances Conroy, the latter of which could not return due to a prior commitment.
- This is the first season where Sarah Paulson's character is killed. She previously survived all four seasons. Though, this is also downplayed. Paulson plays two characters this season. One was killed before the series started, and one survives. So, she's still never been killed during the series.
- Despite the casting of Lady Gaga, there's no musical number in this season.
- Burn Notice spent six seasons with a familiar pattern; Michael and company face an overriding arc for the season which they make incremental progress on during each episode while most of the episode is spent dealing with a Villain of the Week criminal or whatever. The final season dumped this pattern, became much Darker and Edgier, and focused almost entirely on a single long arc of Michael working for the CIA. There were some occasional side issues to deal with, but they were generally quite brief and quickly resolved.
- Pokémon Sun and Moon changed the formula from the first six generations. Gym Battles were replaced with the Island Challenge Trials and Grand Trials. In addition, Hidden Machines have been replaced with the Ride Pager, and the villain team is actually a surprise.
- In Five Nights at Freddy's: Sister Location, the player has to do tasks to progress with the nights, and not survive until 6 A.M. At least, not until Night 5's fake ending... In addition, Bonnie is only Funtime Freddy's handpuppet, Chica is nowhere to be found, and the animatronics are almost entirely brand new.
- Dragon Age: Inquisition has been a departure from many traditions established by the previous two and a half installments of the Dragon Age series, such as a Wide Open Sandbox replacing previous tightly-scripted levels, a complete removal of healing magic, and the artsy blood red-saturated covers being ditched for a green-dominated palette.
- The Legend of Zelda: Breath of the Wild is a lot more open world than the other Zelda games and features RPG Elements, such as equippable weapons and armor as well as cookable food.
- Assassin's Creed: Unity has the first player character in the main console series not to be an ancestor of Desmond Miles. He is also the first since Altair to have only one Hidden Blade, and isn't a Walking Armory.
- New Dangan Ronpa V3:
- This is the first main series game to not have an Ultimate Lucky Student in the main cast.
- This is also the first game where Megumi Ogata doesn't play a character. At least, not one introduced in this game, anyway.
- Unlike Leon Kuwata and Teruteru Hanamura, the culprit of Chapter 1 is prepared to be executed. And unlike Mondo Owada and Peko Pekoyama, the culprit of Chapter 2 tries their hardest to escape execution.
- In the main series, this game is the first one to allow you to play as a female protagonist.
- This game is also the first game in the franchise's history where not only does the player character die, but they are also the culprit! However it turns out they were actually successfully framed by the mastermind. Which means that this is the first game of the franchise where a character successfully gets away with murder in a class trial.
- This game is the only game to have more than three playable characters, even if it's temporary.
- In Archer, the running gag of shouting "Phrasing" after a line of dialog that could be taken the wrong way was broken in Season Five, when after a long string of lines that would provoke the gag were said without anyone saying "Phrasing," it was lampshaded and the gag is now wondering out loud if their Phrasing gag was still a thing.
- South Park would famously kill off Kenny Once an Episode for the first four seasons or so. Then Kenny got Killed Off for Real for one season before reviving him. Since then, Kenny has only been killed occasionally, usually with a huge lampshade hung on it.
- My Little Pony: Friendship Is Magic: Starting in Season 4, much of the series formula was changed drastically, such as the Mane Six giving up the Elements of Harmony, and of the Aesop changing from the "Dear Princess Celestia" format to a diary format, which was then abandoned by Season 5.
- Total Drama: The third season, Total Drama World Tour was the first one to introduce new contestants: Sierra and Alejandro. It also featured songs.